Abstract:
:We here report the initiation of hematopoietic recovery in congenitally hypoplastic S1/S1d mice by the cytotoxic ablation of cells bearing the natural killer (NK) phenotype (NK 1.1+). The most striking finding was the early several-fold increase in the cycling fraction of stem and progenitor cells (with the exception of progenitors committed to megakaryocytopoiesis) in the anti-NK 1.1+ antibody-treated group. This increase resulted in an early, complete restoration of total marrow cellularity to the normal (+/+) littermate level. Our data suggest that NK 1.1+ cells exert functions critical to the negative control of hematopoietic cell proliferation in S1/S1d mice.
journal_name
Bloodjournal_title
Bloodauthors
Pantel K,Boertman J,Nakeff Asubject
Has Abstractpub_date
1991-09-15 00:00:00pages
1428-31issue
6eissn
0006-4971issn
1528-0020journal_volume
78pub_type
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