Molecular insights into regulation of JAK2 in myeloproliferative neoplasms.

abstract：:In this issue of Blood, Larocca et al in a large prospective study show that thromboprophylaxis with low-dose aspirin is very effective in previously untreated myeloma patients with a low thromboembolic risk receiving lenalidomide with low-dose dexamethasone. ...

journal_title：Blood

authors： Kastritis E,Dimopoulos MA

更新日期：2012-01-26 00:00:00

abstract：:We tested the ability of CD34+lin- precursor cells isolated from marrow after treatment with 4-hydroperoxycyclophosphamide (4HC) to generate colony-forming cells (CFC). In liquid cultures, recombinant human stem cell factor (SCF), in combination with interleukin-1 (IL-1), IL-3, IL-6, granulocyte-macrophage colony-stim...

journal_title：Blood

authors： Rowley SD,Brashem-Stein C,Andrews R,Bernstein ID

更新日期：1993-07-01 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation. From 1987 through 1992, 195 patients in the Benelux with recent untreated CML were randomized between low-dose IFN-alpha2b (3 MIU, 5 days/wk) or hydroxyurea...

journal_title：Blood

authors：

更新日期：1998-04-15 00:00:00

abstract：:Angiotensin II (Ang-II) exerts inflammatory activity and is involved in different cardiovascular disorders. This study has evaluated the involvement of tumor necrosis factor alpha (TNFalpha) in the leukocyte accumulation elicited by Ang-II. Ang-II (1 nM intraperitoneally in rats) induced TNFalpha release at 1 hour fol...

journal_title：Blood

authors： Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

更新日期：2007-09-15 00:00:00

abstract：:We demonstrate here that EL4-6.1 cells, a mouse thymoma that expresses high levels of membrane interleukin (IL)-1 receptors, produce IL-1 beta as an autocrine regulatory factor. Endogenous IL-1 beta sustains both proliferation and apoptosis: during the exponential phase, it mainly promotes proliferation, while during ...

journal_title：Blood

authors： Fratelli M,Gagliardini V,Galli G,Gnocchi P,Ghiara P,Ghezzi P

更新日期：1995-06-15 00:00:00

abstract：:It is difficult to imagine a greater challenge to the transplantation of haploidentical cells than thalassemia. ...

journal_title：Blood

authors： Woolfrey A

更新日期：2010-02-11 00:00:00

abstract：:Protein tyrosine phosphorylation plays a crucial role in signaling from the receptor for erythropoietin (Epo), although the Epo receptor (EpoR) lacks the tyrosine kinase domain. We have previously shown that the Jak2 tyrosine kinase couples with the EpoR to transduce a growth signal. In the present study, we demonstra...

journal_title：Blood

authors： Chin H,Arai A,Wakao H,Kamiyama R,Miyasaka N,Miura O

更新日期：1998-05-15 00:00:00

abstract：:Despite multiple disparate prognostic risk analysis systems for evaluating clinical outcome for patients with myelodysplastic syndrome (MDS), imprecision persists with such analyses. To attempt to improve on these systems, an International MDS Risk Analysis Workshop combined cytogenetic, morphological, and clinical da...

journal_title：Blood

authors： Greenberg P,Cox C,LeBeau MM,Fenaux P,Morel P,Sanz G,Sanz M,Vallespi T,Hamblin T,Oscier D,Ohyashiki K,Toyama K,Aul C,Mufti G,Bennett J

更新日期：1997-03-15 00:00:00

abstract：:The primate erythrocyte (E) complement receptor, CR1, is a transmembrane glycoprotein located in clusters on the surface of E. In vivo studies have demonstrated that during processing and clearance of complement-opsonized immune complexes, large amounts of immunoglobulin G (IgG) can be bound to primate E via CR1 with ...

journal_title：Blood

authors： Reinagel ML,Gezen M,Ferguson PJ,Kuhn S,Martin EN,Taylor RP

更新日期：1997-02-01 00:00:00

abstract：:CD40 is present on both normal and neoplastic B-lineage cells. CD40 stimulation of normal B cells has been shown to promote normal growth and differentiation, whereas aggressive histology B lymphomas are growth inhibited. The inhibition of neoplastic B-cell growth is believed to occur via activation-induced cell death...

journal_title：Blood

authors： Szocinski JL,Khaled AR,Hixon J,Halverson D,Funakoshi S,Fanslow WC,Boyd A,Taub DD,Durum SK,Siegall CB,Longo DL,Murphy WJ

更新日期：2002-07-01 00:00:00

abstract：:To assess the influence of graft-versus-host disease (GVHD) on recurrent leukemia and survival after allogeneic marrow transplantation, we studied 1,202 patients with acute nonlymphocytic leukemia (ANL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML) given unmodified marrow grafts from HLA-id...

journal_title：Blood

authors： Sullivan KM,Weiden PL,Storb R,Witherspoon RP,Fefer A,Fisher L,Buckner CD,Anasetti C,Appelbaum FR,Badger C

更新日期：1989-05-01 00:00:00

abstract：:Gene therapy for inherited disorders of blood cells will require both efficient methods for stable gene transfer and nonablative bone marrow conditioning regimens to allow engraftment of modified hematopoietic progenitor cells (HPCs). We have used a sensitive murine system for detecting HPC engraftment using congenic ...

journal_title：Blood

authors： Mardiney M 3rd,Malech HL

更新日期：1996-05-15 00:00:00

abstract：:Variations of the partial thromboplastin time (PTT) were tested to determine the best screening method for detection of inhibitors of factor VIII. Variables tested included the duration of preincubation of a mixture of patient plasma and factor VIII source (normal plasma), the ratio of the patient plasma to the normal...

journal_title：Blood

authors： Lossing TS,Kasper CK,Feinstein DI

更新日期：1977-05-01 00:00:00

abstract：:The therapeutic potential of hematopoietic stem cell (HSC) gene therapy can be fully exploited only by reaching efficient gene transfer into HSCs without compromising their biologic properties. Although HSCs can be transduced by HIV-derived lentiviral vectors (LVs) in short ex vivo culture, they display low permissivi...

journal_title：Blood

authors： Santoni de Sio FR,Cascio P,Zingale A,Gasparini M,Naldini L

更新日期：2006-06-01 00:00:00

abstract：:In human immunodeficiency virus (HIV)-1 infection, decrease of telomere length is mainly found in CD8(+) T cells and not in CD4(+) T cells. Telomerase, a ribonucleoprotein enzyme that can synthesize telomeric sequence onto chromosomal ends, can compensate for telomere loss. Here, we investigated if telomerase activity...

journal_title：Blood

authors： Wolthers KC,Otto SA,Wisman GB,Fleury S,Reiss P,ten Kate RW,van der Zee AG,Miedema F

更新日期：1999-02-01 00:00:00

abstract：:To evaluate the association between fetal hemoglobin (HbF) levels and morbidity in β-thalassemia intermedia (TI), we analyzed data from 63 untransfused patients who had also never received HbF induction therapy. Patient records were reviewed for any history of 10 predefined morbidities. Laboratory measurements for mar...

journal_title：Blood

authors： Musallam KM,Sankaran VG,Cappellini MD,Duca L,Nathan DG,Taher AT

更新日期：2012-01-12 00:00:00

abstract：:Parasitic worms of the genus Schistosoma excrete relatively large amounts of immunogenic glycoproteins (circulating cathodic antigen [CCA]) that contain polysaccharide side chains with the trisaccharide Lewis-x (L(ex)) as a repeating unit. These carbohydrates evoke high titers of specific IgM antibodies that cross-rea...

journal_title：Blood

authors： van Dam GJ,Claas FH,Yazdanbakhsh M,Kruize YC,van Keulen AC,Ferreira ST,Rotmans JP,Deelder AM

更新日期：1996-12-01 00:00:00

abstract：:Human herpesvirus-8 (HHV-8)-negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction caused by a cytokine storm often including interleukin-6. iMCD accou...

journal_title：Blood

authors： Fajgenbaum DC,Uldrick TS,Bagg A,Frank D,Wu D,Srkalovic G,Simpson D,Liu AY,Menke D,Chandrakasan S,Lechowicz MJ,Wong RS,Pierson S,Paessler M,Rossi JF,Ide M,Ruth J,Croglio M,Suarez A,Krymskaya V,Chadburn A,Colleoni

更新日期：2017-03-23 00:00:00

abstract：:The efficacy of the addition of intensive therapy with daunorubicin (45 mg/m2 IV on days 1, 2, 3) to an otherwise identical induction program consisting of vincristine, prednisone, and L-asparaginase was assessed in 177 previously untreated adults (greater than or equal to 20 years of age) with acute lymphocytic leuke...

journal_title：Blood

authors： Gottlieb AJ,Weinberg V,Ellison RR,Henderson ES,Terebelo H,Rafla S,Cuttner J,Silver RT,Carey RW,Levy RN

更新日期：1984-07-01 00:00:00

abstract：:Studies were performed on 15 untreated and 14 treated patients with multiple myeloma. The monocyte content was normal in blood but elevated in mononuclear leukocytes (MNL) from treated but not untreated patients (p less than 0.001). This correlated with the severity of lymphopenia in blood (p less than 0.01). Three pa...

journal_title：Blood

authors： Twomey JJ,Laughter AH,Rice L,Ford RJ

更新日期：1982-08-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cells targeting CD19 have emerged as a leading engineered T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma. The phase 1/2 clinical trials that led to US Food and Drug Administration approval excluded patients with central nervous system (CNS) involvement, due to stri...

journal_title：Blood

authors： Frigault MJ,Dietrich J,Martinez-Lage M,Leick M,Choi BD,DeFilipp Z,Chen YB,Abramson J,Crombie J,Armand P,Nayak L,Panzini C,Riley LS,Gallagher K,Maus MV

更新日期：2019-09-12 00:00:00

abstract：:The past 40 years have witnessed major advances in defining the cytogenetic aberrations, mutational landscape, epigenetic profiles, and expression changes underlying hematological malignancies. Although it has become apparent that acute myeloid leukemia (AML) is highly heterogeneous at the molecular level, the standar...

journal_title：Blood

authors： Grimwade D,Freeman SD

更新日期：2014-11-27 00:00:00

abstract：:Eosinophils are involved in the inflammatory response seen in allergy and helminthic infestations. Eosinophils synthesize transforming growth factor-alpha (TGF-alpha), which may play a role in the development of the characteristic fibrosis seen in longstanding high eosinophilia. Using immunoelectron microscopic techni...

journal_title：Blood

authors： Egesten A,Calafat J,Knol EF,Janssen H,Walz TM

更新日期：1996-05-01 00:00:00

abstract：:Pluripotent hematopoietic progenitor cells (CFU-GEMM), myeloid progenitor cells (CFU-GM), and erythroid progenitors (BFU-E) were studied in midtrimester human fetuses using the mixed colony assay. All three progenitor cell populations were detected at high levels in the fetal liver from 12 to 23 wk of gestation. Stem ...

journal_title：Blood

authors： Hann IM,Bodger MP,Hoffbrand AV

更新日期：1983-07-01 00:00:00

abstract：:The Leukemia and Lymphoma Molecular Profiling Project recently published results from DNA microarray analyses of 240 diffuse large B-cell lymphomas (DLBCLs). Four gene expression "signatures" were identified as correlated with patient outcome, including the major histocompatibility complex (MHC) class II genes (eg, HL...

journal_title：Blood

authors： Rimsza LM,Roberts RA,Miller TP,Unger JM,LeBlanc M,Braziel RM,Weisenberger DD,Chan WC,Muller-Hermelink HK,Jaffe ES,Gascoyne RD,Campo E,Fuchs DA,Spier CM,Fisher RI,Delabie J,Rosenwald A,Staudt LM,Grogan TM

更新日期：2004-06-01 00:00:00

abstract：:Rabbit kidney tissue either from normal rabbits or from rabbits "programmed" by phlebotomy or varying periods of hypoxia was cultured and shown to release into the culture medium an erythropoietically active substance. The cultures established from rabbits programmed by 6-12 hr of hypoxia yielded the highest levels of...

journal_title：Blood

authors： Ogle JW,Lange RD,Dunn CD

更新日期：1978-07-01 00:00:00

abstract：:DNA amplification combined with hybridization with 32P-labeled synthetic oligonucleotide probes has been used to identify base substitutions in the 5' promoter region of the A gamma globin gene in members of eleven families from China, Sardinia, Canada, and the United States who had a heterozygosity for the A gamma-be...

journal_title：Blood

authors： Yang KG,Stoming TA,Fei YJ,Liang S,Wong SC,Masala B,Huang RB,Wei ZP,Huisman TH

更新日期：1988-05-01 00:00:00

abstract：:Allelic loss at nonrandom chromosomal sites is thought to mark the position of tumor suppressor genes involved in the pathogenesis and progression of human malignancies. Solid tumors in particular have been found to harbor multiple genetic changes resulting in loss of function mutations. Tumor suppressor genes have al...

journal_title：Blood

authors： Bullrich F,Veronese ML,Kitada S,Jurlander J,Caligiuri MA,Reed JC,Croce CM

更新日期：1996-10-15 00:00:00

abstract：:The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic oxidative DNA damage resulting in double-strand breaks (DSBs) in S and G(2)/M cell cycle phases. These lesions are rep...

journal_title：Blood

authors： Nowicki MO,Falinski R,Koptyra M,Slupianek A,Stoklosa T,Gloc E,Nieborowska-Skorska M,Blasiak J,Skorski T

更新日期：2004-12-01 00:00:00

abstract：:Viral infections are common and are potentially life-threatening in patients with moderate to severe primary immunodeficiency disorders. Because T-cell immunity contributes to the control of many viral pathogens, adoptive immunotherapy with virus-specific T cells (VSTs) has been a logical and effective way of combatin...

journal_title：Blood

authors： Keller MD,Bollard CM

更新日期：2020-02-27 00:00:00