Sialylated O-glycans and L-selectin sequentially mediate myeloid cell rolling in vivo.

abstract：:The efficacy of the addition of intensive therapy with daunorubicin (45 mg/m2 IV on days 1, 2, 3) to an otherwise identical induction program consisting of vincristine, prednisone, and L-asparaginase was assessed in 177 previously untreated adults (greater than or equal to 20 years of age) with acute lymphocytic leuke...

journal_title：Blood

authors： Gottlieb AJ,Weinberg V,Ellison RR,Henderson ES,Terebelo H,Rafla S,Cuttner J,Silver RT,Carey RW,Levy RN

更新日期：1984-07-01 00:00:00

abstract：:The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML). We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a. Here, we confirm miR-30c as a novel...

journal_title：Blood

authors： Katzerke C,Madan V,Gerloff D,Bräuer-Hartmann D,Hartmann JU,Wurm AA,Müller-Tidow C,Schnittger S,Tenen DG,Niederwieser D,Behre G

更新日期：2013-10-03 00:00:00

abstract：:In this issue of Blood, den Exter et al highlight the importance of subsegmental pulmonary emboli. ...

journal_title：Blood

authors： Raskob GE

更新日期：2013-08-15 00:00:00

abstract：:Oncogenic transformation of CD4(+) T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. In search of nove...

journal_title：Blood

authors： Kress AK,Kalmer M,Rowan AG,Grassmann R,Fleckenstein B

更新日期：2011-03-31 00:00:00

abstract：:The physical interactions between B cells and stromal cells from the lymphoid tissue microenvironment are critical to the survival of normal and malignant B cells. They are principally mediated by integrins expressed on B cells and counterreceptors on stromal cells. Specifically, alpha4beta1 integrin engagement rescue...

journal_title：Blood

authors： Astier AL,Xu R,Svoboda M,Hinds E,Munoz O,de Beaumont R,Crean CD,Gabig T,Freedman AS

更新日期：2003-02-01 00:00:00

abstract：:The composition of the erythrocyte plasma membrane is extensively modified during the intracellular growth of the malaria parasite Plasmodium falciparum. It has been previously shown that an 80-kD phosphoprotein is associated with the plasma membrane of human red blood cells (RBCs) infected with trophozoite/schizont s...

journal_title：Blood

authors： Chishti AH,Maalouf GJ,Marfatia S,Palek J,Wang W,Fisher D,Liu SC

更新日期：1994-06-01 00:00:00

abstract：:Ruxolitinib is JAK1/JAK2 inhibitor with established clinical benefit in myelofibrosis (MF). We analyzed long-term outcomes of 107 patients with intermediate-2 or high-risk MF receiving ruxolitinib at MD Anderson Cancer Center (MDACC) on phase 1/2 trial. After a median of 32 months of follow-up, 58 patients (54%) were ...

journal_title：Blood

authors： Verstovsek S,Kantarjian HM,Estrov Z,Cortes JE,Thomas DA,Kadia T,Pierce S,Jabbour E,Borthakur G,Rumi E,Pungolino E,Morra E,Caramazza D,Cazzola M,Passamonti F

更新日期：2012-08-09 00:00:00

abstract：:The primate erythrocyte (E) complement receptor, CR1, is a transmembrane glycoprotein located in clusters on the surface of E. In vivo studies have demonstrated that during processing and clearance of complement-opsonized immune complexes, large amounts of immunoglobulin G (IgG) can be bound to primate E via CR1 with ...

journal_title：Blood

authors： Reinagel ML,Gezen M,Ferguson PJ,Kuhn S,Martin EN,Taylor RP

更新日期：1997-02-01 00:00:00

abstract：:Approximately one fourth of children with newly diagnosed acute lymphoblastic leukemia (ALL) have hyperdiploid (greater than 50 chromosomes) blasts and a relatively favorable prognosis. Nonetheless, a substantial proportion of these patients fail therapy. We studied 138 children (70 male, 68 female) with hyperdiploid ...

journal_title：Blood

authors： Pui CH,Raimondi SC,Dodge RK,Rivera GK,Fuchs LA,Abromowitch M,Look AT,Furman WL,Crist WM,Williams DL

更新日期：1989-05-15 00:00:00

abstract：:Prophylactic treatment in severe hemophilia is very effective but is limited by cost issues. The implementation of 2 different prophylactic regimens in The Netherlands and Sweden since the 1970s may be considered a natural experiment. We compared the costs and outcomes of Dutch intermediate- and Swedish high-dose prop...

journal_title：Blood

authors： Fischer K,Steen Carlsson K,Petrini P,Holmström M,Ljung R,van den Berg HM,Berntorp E

更新日期：2013-08-15 00:00:00

abstract：:Hematopoietic suppression is one of the serious problems induced by whole body irradiation. Granulocyte colony-stimulating factor (G-CSF) stimulates the progenitors of granulocytes and accelerates their recovery from bone marrow suppression induced by cytotoxic chemotherapy or radiation. On the other hand, G-CSF stimu...

journal_title：Blood

authors： Kawase Y,Akashi M,Ohtsu H,Aoki Y,Akanuma A,Suzuki G

更新日期：1993-10-01 00:00:00

abstract：:Ectopic expression of c-Myc (Myc) in most primary cell types results in programmed cell death, and malignant transformation cannot occur without additional mutations that block apoptosis. The development of Myc-induced lymphoid tumors has been well studied and supports this model. Myc can be upregulated in acute myelo...

journal_title：Blood

authors： Luo H,Li Q,O'Neal J,Kreisel F,Le Beau MM,Tomasson MH

更新日期：2005-10-01 00:00:00

abstract：:An 81-year-old woman, who presented with sudden episodes of spontaneous bleeding, was found to have a specific inhibitor of factor XIII. Her fibrin clots had approximately 70% gamma-gamma and no alpha polymer formation, under conditions where normal fibrin was fully cross-linked; the patient's clots were soluble in ur...

journal_title：Blood

authors： Fukue H,Anderson K,McPhedran P,Clyne L,McDonagh J

更新日期：1992-01-01 00:00:00

abstract：:RUNX1 is crucial for the regulation of megakaryocyte specification, maturation, and thrombopoiesis. Runx1 possesses 2 promoters: the distal P1 and proximal P2 promoters. The major protein isoforms generated by P1 and P2 are RUNX1C and RUNX1B, respectively, which differ solely in their N-terminal amino acid sequences. ...

journal_title：Blood

authors： Draper JE,Sroczynska P,Leong HS,Fadlullah MZH,Miller C,Kouskoff V,Lacaud G

更新日期：2017-07-20 00:00:00

abstract：:Children with Philadelphia chromosome (Ph+) acute lymphoblastic leukemia (ALL) have a poorer prognosis than do most pediatric patients with ALL. Because of this poor prognosis and the presence of the Ph chromosome, we have asked whether or not Ph + ALL involves a multipotential stem cell. We cultured hematopoietic pro...

journal_title：Blood

authors： Tachibana N,Raimondi SC,Lauer SJ,Sartain P,Dow LW

更新日期：1987-11-01 00:00:00

abstract：:Pharmaceutical preparations of normal human immunoglobulin (IgG) are known to contain high-avidity and neutralizing antibodies (Ab) to the cytokines interleukin (IL)-1alpha, IL-6, and interferon (IFN)alpha. To test for other cytokine Ab, 23 batches of IgG were tested for saturable binding to eight 125I-labeled recombi...

journal_title：Blood

authors： Svenson M,Hansen MB,Ross C,Diamant M,Rieneck K,Nielsen H,Bendtzen K

更新日期：1998-03-15 00:00:00

abstract：:The terminal differentiation of B cells into antibody-secreting cells (ASCs) is a critical component of adaptive immune responses. However, it is a very sensitive process, which dysfunctions lead to a great variety of lymphoproliferative neoplasia including germinal center-derived lymphomas. To better characterize the...

journal_title：Blood

authors： Pignarre A,Chatonnet F,Caron G,Haas M,Desmots-Loyer F,Fest T

更新日期：2020-11-04 00:00:00

abstract：:In search of a possible involvement of the human herpesvirus type 6 (HHV-6) in human Hodgkin's and non-Hodgkin's lymphomas, we studied the levels of anti-HHV-6 antibodies in the sera of 94 cases by an immunofluorescence assay, as well as the presence of HHV-6 sequences in the affected tissues of 66 cases by polymerase...

journal_title：Blood

authors： Torelli G,Marasca R,Luppi M,Selleri L,Ferrari S,Narni F,Mariano MT,Federico M,Ceccherini-Nelli L,Bendinelli M

更新日期：1991-05-15 00:00:00

abstract：:Immunoglobulin E (IgE) bound to multivalent antigen (Ag) elicits mast cell degranulation but not survival; on the contrary, IgE in the absence of Ag (IgE(-Ag)) induces survival only but not degranulation. Although these distinct responses are mediated through the same receptor, FcepsilonRI, the molecular mechanism gen...

journal_title：Blood

authors： Yamasaki S,Ishikawa E,Kohno M,Saito T

更新日期：2004-04-15 00:00:00

abstract：:Myelotoxic injury in the bone marrow (BM) as a consequence of total body irradiation (TBI) or granulocyte colony-stimulating factor (G-CSF) mobilization results in the deposition of iC3b on BM stroma (stroma-iC3b). In the present study, we have examined how stroma-iC3b interacts with hematopoietic progenitor cells (HP...

journal_title：Blood

authors： Cramer DE,Allendorf DJ,Baran JT,Hansen R,Marroquin J,Li B,Ratajczak J,Ratajczak MZ,Yan J

更新日期：2006-01-15 00:00:00

abstract：:Human T-cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL), an aggressive lymphoproliferative disease. MicroRNAs (miRNAs) are differentially expressed during hematopoiesis and lineage commitment of hematopoietic stem cell progenitors (HSCPs). Here, we report aberrant expression o...

journal_title：Blood

authors： Bellon M,Lepelletier Y,Hermine O,Nicot C

更新日期：2009-05-14 00:00:00

abstract：:Continuous treatment of malignancies with tyrosine kinase inhibitors (TKIs) may select for resistant clones (ie, imatinib mesylate). To study resistance to TKIs targeting FLT3, a receptor tyrosine kinase that is frequently mutated in acute myelogenous leukemia (AML), we developed resistant human cell lines through pro...

journal_title：Blood

authors： Piloto O,Wright M,Brown P,Kim KT,Levis M,Small D

更新日期：2007-02-15 00:00:00

abstract：:The POEMS syndrome is associated with elevated vascular endothelial growth factor (VEGF) levels. Several studies have compared serum VEGF levels between POEMS patients and other disease entities showing higher serum VEGF in POEMS syndrome; however, it is unknown whether serum levels are reliable and reproducible given...

journal_title：Blood

authors： D'Souza A,Hayman SR,Buadi F,Mauermann M,Lacy MQ,Gertz MA,Kyle RA,Kumar S,Greipp PR,Lust JA,Russell SJ,Zeldenrust S,Dingli D,Witzig TE,Rajkumar SV,Dispenzieri A

更新日期：2011-10-27 00:00:00

abstract：:Conditioned medium derived from peripheral mononuclear low-density cells stimulated with phytohemagglutinin (PHA) supports the growth of noncommitted hematopoietic progenitors from marrow and peripheral blood cells. These immature progenitors (CFU-GEMM) can be identified in culture as multilineage hematopoietic coloni...

journal_title：Blood

authors： Kanz L,Löhr GW,Fauser AA

更新日期：1986-11-01 00:00:00

abstract：:New Zealand Black (NZB) autoimmune mice exhibit progressive, age-dependent reduction in bone marrow pre-B cells. To ascertain the capacity of NZB bone marrow B220- cells to generate pre-B cells in a supportive environment, B-lineage (B220+) cell-depleted and T-cell-depleted bone marrow cells from NZB mice at 1 to 3, 6...

journal_title：Blood

authors： Merchant MS,Garvy BA,Riley RL

更新日期：1995-04-01 00:00:00

abstract：:The mutation status and usage of specific VH genes such as V3-21 and V1-69 are potentially independent pathogenic and prognostic factors in chronic lymphocytic leukemia (CLL). To investigate the role of antigenic stimulation, we analyzed the expression of genes involved in B-cell receptor (BCR) signaling/activation, c...

journal_title：Blood

authors： Kienle D,Benner A,Kröber A,Winkler D,Mertens D,Bühler A,Seiler T,Jäger U,Lichter P,Döhner H,Stilgenbauer S

更新日期：2006-03-01 00:00:00

abstract：:Human erythrocyte p55 is a peripheral membrane protein that contains three distinct domains in its primary structure: an N-terminal domain, an SH3 motif, and a C-terminal guanylate kinase domain. We used naturally mutated red blood cells (RBCs) with primary genetic defects resulting in the absence of protein 4.1 (4.1[...

journal_title：Blood

authors： Alloisio N,Dalla Venezia N,Rana A,Andrabi K,Texier P,Gilsanz F,Cartron JP,Delaunay J,Chishti AH

更新日期：1993-08-15 00:00:00

abstract：:Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence...

journal_title：Blood

authors： Kundu M,Lindsten T,Yang CY,Wu J,Zhao F,Zhang J,Selak MA,Ney PA,Thompson CB

更新日期：2008-08-15 00:00:00

abstract：:Transcription factor GATA-2 is implicated in the survival and growth of multipotential progenitors. Here we report that the promyelocytic leukemia zinc finger (PLZF) protein can interact with GATA-2 and can modify its transactivation capacity. Fanconi anemia zinc finger (FAZF), a PLZF-homologous protein that has been ...

journal_title：Blood

authors： Tsuzuki S,Enver T

更新日期：2002-05-01 00:00:00

abstract：:Our previous studies have identified mechanisms by which cytokine production, blocked by Ly49G2 receptor cross-linking, can be overridden. In this study we analyzed the regulation of other ITAM-positive receptor signaling on NK, NKT, and T cells and characterized the biochemical pathways involved in this signaling. Ou...

journal_title：Blood

authors： Ortaldo JR,Winkler-Pickett R,Wigginton J,Horner M,Bere EW,Mason AT,Bhat N,Cherry J,Sanford M,Hodge DL,Young HA

更新日期：2006-02-15 00:00:00