Thrombosis in primary myelofibrosis: incidence and risk factors.

abstract：:Phosphoinositide 3-kinase gamma (PI3Kgamma) in neutrophils plays a critical role in the directed migration of these cells into inflamed tissues. In this study, we demonstrate the importance of the endothelial component of PI3Kgamma activity relative to its leukocyte counterpart in supporting neutrophil interactions wi...

journal_title：Blood

authors： Puri KD,Doggett TA,Huang CY,Douangpanya J,Hayflick JS,Turner M,Penninger J,Diacovo TG

更新日期：2005-07-01 00:00:00

abstract：:Eosinophils are associated with type 2 immune responses to allergens and helminths. They release various proinflammatory mediators and toxic proteins on activation and are therefore considered proinflammatory effector cells. Eosinophilia is promoted by the cytokines interleukin (IL)-3, IL-5, and granulocyte macrophage...

journal_title：Blood

authors： Schwartz C,Willebrand R,Huber S,Rupec RA,Wu D,Locksley R,Voehringer D

更新日期：2015-06-18 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is typified by the t(15;17) translocation, which leads to the formation of the PML/RARA fusion gene and predicts a beneficial response to retinoids. However, approximately 10% of all APL cases lack the classic t(15;17). This group includes (1) cases with cryptic PML/RARA gene rearran...

journal_title：Blood

authors： Sainty D,Liso V,Cantù-Rajnoldi A,Head D,Mozziconacci MJ,Arnoulet C,Benattar L,Fenu S,Mancini M,Duchayne E,Mahon FX,Gutierrez N,Birg F,Biondi A,Grimwade D,Lafage-Pochitaloff M,Hagemeijer A,Flandrin G,Groupe Français d'

更新日期：2000-08-15 00:00:00

abstract：:The human immunodeficiency virus (HIV) causes impairment of the immune system in part by targeting CD4(+) T cells for infection and dysfunction. HIV envelope (Env) present on free virions and infected cells causes dysfunction of uninfected bystander CD4(+) T cells via interaction with both CD4 and coreceptors. Env is ...

journal_title：Blood

authors： Fernando K,Hu H,Ni H,Hoxie JA,Weissman D

更新日期：2007-03-15 00:00:00

abstract：:Hypodiploidy <40 chromosomes is an uncommon genetic feature of acute lymphoblastic leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses, and recently confirmed by mutational profiling, that these cases may be further subdivided into 2 subtypes: near-haploid ALL with 24 to 30 chrom...

journal_title：Blood

authors： Safavi S,Paulsson K

更新日期：2017-01-26 00:00:00

abstract：:Receptors for the Fc portion of IgG (FcγRs) are mandatory for the induction of various IgG-dependent models of autoimmunity, inflammation, anaphylaxis, and cancer immunotherapy. A few FcγRs have the ability to bind monomeric IgG: high-affinity mouse mFcγRI, mFcγRIV, and human hFcγRI. All others bind IgG only when aggr...

journal_title：Blood

authors： Mancardi DA,Albanesi M,Jönsson F,Iannascoli B,Van Rooijen N,Kang X,England P,Daëron M,Bruhns P

更新日期：2013-02-28 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV)-related multicentric Castleman disease (MCD) is potentially lethal. Growing evidence indicates that, as in Epstein-Barr virus-driven lymphoproliferative disorders after transplantation, KSHV DNA burden in peripheral blood mononuclear cells (PBMCs) may represent the most acc...

journal_title：Blood

authors： Corbellino M,Bestetti G,Scalamogna C,Calattini S,Galazzi M,Meroni L,Manganaro D,Fasan M,Moroni M,Galli M,Parravicini C

更新日期：2001-12-01 00:00:00

abstract：:CD27, a transmembrane disulfide-linked 55-kD homodimer, belongs to the nerve growth factor-receptor family, a group of homologous molecules involved in lymphocyte differentiation and selection. It is expressed on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. We investigated the expressio...

journal_title：Blood

authors： van Oers MH,Pals ST,Evers LM,van der Schoot CE,Koopman G,Bonfrer JM,Hintzen RQ,von dem Borne AE,van Lier RA

更新日期：1993-12-01 00:00:00

abstract：:The kidney is involved in 70% of patients with immunoglobulin light-chain (AL) amyloidosis, but little is known on progression or reversibility of renal involvement, and criteria for renal response have never been validated. Newly diagnosed patients from the Pavia (n = 461, testing cohort) and Heidelberg (n = 271, val...

journal_title：Blood

authors： Palladini G,Hegenbart U,Milani P,Kimmich C,Foli A,Ho AD,Vidus Rosin M,Albertini R,Moratti R,Merlini G,Schönland S

更新日期：2014-10-09 00:00:00

abstract：:Custom-made monoclonal anti-idiotype antibodies (anti-Id MoAbs) have been tested as a treatment modality in 34 non-Hodgkin's lymphoma (NHL) patients. Partial or complete tumor remissions have been induced with this treatment in 68% of these patients. One mechanism by which anti-idiotype antibodies may have induced the...

journal_title：Blood

authors： Vuist WM,Levy R,Maloney DG

更新日期：1994-02-15 00:00:00

abstract：:Genetic variation in the PEAR1 locus is linked to platelet reactivity and cardiovascular disease. The major G allele of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG-SNP), is associated with higher PEAR1 expression in platelets and endothelial cells than the minor A allele. ...

journal_title：Blood

authors： Izzi B,Pistoni M,Cludts K,Akkor P,Lambrechts D,Verfaillie C,Verhamme P,Freson K,Hoylaerts MF

更新日期：2016-08-18 00:00:00

abstract：:Gene therapy for hemophilia A requires efficient delivery of the factor VIII gene and sustained protein expression at circulating levels of at least 1% to 2% of normal. Adeno-associated viral type 2 (AAV2) vectors have a number of advantages over other viral vectors, including an excellent safety profile and persisten...

journal_title：Blood

authors： Scallan CD,Lillicrap D,Jiang H,Qian X,Patarroyo-White SL,Parker AE,Liu T,Vargas J,Nagy D,Powell SK,Wright JF,Turner PV,Tinlin SJ,Webster SE,McClelland A,Couto LB

更新日期：2003-09-15 00:00:00

abstract：:Activated ras genes are often associated with human myeloid leukemias with a monocytic differentiated phenotype. To investigate the role of the activated ras gene in leukemogenesis, a myeloid nontumorigenic cell line (FDC-P1) was infected with a selectable retroviral vector carrying the v-Ha-ras gene (H1neo). Infected...

journal_title：Blood

authors： Hibi S,Löhler J,Friel J,Stocking C,Ostertag W

更新日期：1993-04-01 00:00:00

abstract：:Thalidomide has been reported to be an effective agent for treatment of chronic graft-versus-host disease (CGVHD). To determine the efficacy of this agent in patients with refractory CGVHD a total of 80 patients who failed to respond to prednisone (PSE) or PSE and cyclosporine (CSA) were treated with thalidomide. Sixt...

journal_title：Blood

authors： Parker PM,Chao N,Nademanee A,O'Donnell MR,Schmidt GM,Snyder DS,Stein AS,Smith EP,Molina A,Stepan DE,Kashyap A,Planas I,Spielberger R,Somlo G,Margolin K,Zwingenberger K,Wilsman K,Negrin RS,Long GD,Niland JC,Blume K

更新日期：1995-11-01 00:00:00

abstract：:Recruitment of polymorphonuclear neutrophils (PMNs) to sites of acute inflammation critically depends on β2 integrins (CD11/CD18). Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as an important adaptor protein regulating PMN trafficking downstream of β2 integrins. Here, we show that mAbp1 const...

journal_title：Blood

authors： Jakob SM,Pick R,Brechtefeld D,Nussbaum C,Kiefer F,Sperandio M,Walzog B

更新日期：2013-05-16 00:00:00

abstract：:Angiogenesis, the development of new blood vessels from existing vasculature, is crucial for the development and metastasis of solid tumors. Here, we show for the first time that a 24-amino acid peptide derived from the amino terminus of the alpha chain of human fibrinogen (termed "alphastatin") has potent antiangioge...

journal_title：Blood

authors： Staton CA,Brown NJ,Rodgers GR,Corke KP,Tazzyman S,Underwood JC,Lewis CE

更新日期：2004-01-15 00:00:00

abstract：:The receptors for interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are heterodimers comprised of ligand specific alpha chains and a common beta chain. The genes encoding the IL-5 receptor alpha chain and the common beta chain reside on chromosome 3 and 22 respectively, while th...

journal_title：Blood

authors： Kremer E,Baker E,D'Andrea RJ,Slim R,Phillips H,Moretti PA,Lopez AF,Petit C,Vadas MA,Sutherland GR

更新日期：1993-07-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is an aggressive malignancy with a relapse rate approaching 50%, despite aggressive chemotherapy. New therapies for AML are targeted at signal transduction pathways known to support blast survival, such as the Stat3 pathway. Aberrant activation of Stat3 has been demonstrated in many differ...

journal_title：Blood

authors： Redell MS,Ruiz MJ,Alonzo TA,Gerbing RB,Tweardy DJ

更新日期：2011-05-26 00:00:00

abstract：:Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotrophic factor constitute the IL-6 family of cytokines and play important roles in hematopoiesis, immune response, and nervous system. The receptors for the IL-6 family of cytokines share gp130 through which signals are generated, ...

journal_title：Blood

authors： Matsuda T,Takahashi-Tezuka M,Fukada T,Okuyama Y,Fujitani Y,Tsukada S,Mano H,Hirai H,Witte ON,Hirano T

更新日期：1995-02-01 00:00:00

abstract：:Folylpoly-gamma-gluatamate synthetase (FPGS) catalyzes the polyglutamylation and thus intracellular retention of folates and antifolates (eg, methotrexate; MTX) through the addition of multiple glutamate equivalents to their gamma-carboxyl residue. Since polyglutamylation of antifolates is crucial for their pharmacolo...

journal_title：Blood

authors： Stark M,Wichman C,Avivi I,Assaraf YG

更新日期：2009-04-30 00:00:00

abstract：:Studying human antigen-specific memory B cells has been challenging because of low frequencies in peripheral blood, slow proliferation, and lack of antibody secretion. Therefore, most studies have relied on conversion of memory B cells into antibody-secreting cells by in vitro culture. To facilitate direct ex vivo iso...

journal_title：Blood

authors： Franz B,May KF Jr,Dranoff G,Wucherpfennig K

更新日期：2011-07-14 00:00:00

abstract：:Recently G alpha 16, a new guanosine triphosphate (GTP) binding protein alpha subunit has been described to be specifically expressed in human hematopoietic cells. Expression of G alpha 16 was observed in human cell lines of myelomonocytic and T-lymphocytic origin, but not in human B-cell lines Raji and IM9. We studie...

journal_title：Blood

authors： Mapara MY,Bommert K,Bargou RC,Leng C,Beck C,Ludwig WD,Gierschik P,Dörken B

更新日期：1995-04-01 00:00:00

abstract：:Factor VIII procoagulant protein (VIII:C) purified from commercial factor VIII concentrate contained multiple polypeptides ranging in mol wt from 79,000 to 188,000, all of which were removed from solution by a monoclonal anti-VIII:C antibody specific for a thrombin-sensitive epitope. In a time-course digest of the pur...

journal_title：Blood

authors： Fulcher CA,Roberts JR,Zimmerman TS

更新日期：1983-04-01 00:00:00

abstract：:The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used most commonly for this purpose, but causes systemic toxicity and preferentially drives the expansion of CD4(+)CD25(+)Foxp3(+) regulatory T cel...

journal_title：Blood

authors： Berger C,Berger M,Hackman RC,Gough M,Elliott C,Jensen MC,Riddell SR

更新日期：2009-09-17 00:00:00

abstract：:Induction of transplantation tolerance by means of bone marrow (BM) transplantation could become a reality if it was possible to achieve engraftment of hematopoietic stem cells under nonlethal preparatory cytoreduction of the recipient. To that end, BM facilitating cells, veto cells, or other tolerance-inducing cells,...

journal_title：Blood

authors： Bachar-Lustig E,Li HW,Gur H,Krauthgamer R,Marcus H,Reisner Y

更新日期：1999-11-01 00:00:00

abstract：:The presence and physiologic role of cyclic GMP-dependent protein kinase (G-kinase) in human neutrophils was investigated by Western blot analysis and immunocytochemistry. Small quantities of G-kinase were found in the cytoskeletal-enriched fraction of neutrophil lysates as detected by Western blots using a polyclonal...

journal_title：Blood

authors： Pryzwansky KB,Wyatt TA,Nichols H,Lincoln TM

更新日期：1990-08-01 00:00:00

abstract：:Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here, we isolated 4 distinct populations at successive erythropoietin-dependent stages of erythropoiesis, including the terminal, pyknotic stage. The transcriptome was determined using Affy...

journal_title：Blood

authors： Merryweather-Clarke AT,Atzberger A,Soneji S,Gray N,Clark K,Waugh C,McGowan SJ,Taylor S,Nandi AK,Wood WG,Roberts DJ,Higgs DR,Buckle VJ,Robson KJ

更新日期：2011-03-31 00:00:00

abstract：:Endothelial cell-mediated coagulation and leukocyte adhesion are processes that might be connected by the generation of thrombin. To examine the interaction of procoagulant and proadhesive activity, cultures of endothelial cells were stimulated with tumor necrosis factor-alpha, which resulted in the surface expression...

journal_title：Blood

authors： Kirchhofer D,Sakariassen KS,Clozel M,Tschopp TB,Hadváry P,Nemerson Y,Baumgartner HR

更新日期：1993-04-15 00:00:00

abstract：:P-selectin (CD62P) is a member of the selectin family of adhesion molecules involved in the regulation of leukocyte traffic. P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin-like molecule that is thought to be a primary ligand for P-selectin. The interaction of P-selectin with PSGL-1 results in leukocyte rolling a...

journal_title：Blood

authors： Snapp KR,Wagers AJ,Craig R,Stoolman LM,Kansas GS

更新日期：1997-02-01 00:00:00

abstract：:Mutations in the SH2D1A gene have been described in most patients with the clinical syndrome of X-linked lymphoproliferative disease (XLP). The diagnosis of XLP is still difficult given its clinical heterogeneity and the lack of a readily available rapid diagnostic laboratory test, particularly in patients without a f...

journal_title：Blood

authors： Tabata Y,Villanueva J,Lee SM,Zhang K,Kanegane H,Miyawaki T,Sumegi J,Filipovich AH

更新日期：2005-04-15 00:00:00