Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML.


:Nucleophosmin-mutated acute myeloid leukemia (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Because miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs could predict chemotherapy response in AML. We found that high baseline miR-10 family expression in 54 untreated cytogenetically heterogeneous AML patients was associated with achieving CR. However, when we included NPM1 mutation status in the multivariable model, there was a significant interaction effect between miR-10a-5p expression and NPM1 mutation status. Similar results were observed when using a second cohort of 183 cytogenetically normal older (age ≥ 60 years) AML patients. Loss- and gain-of-function experiments using miR-10a-5p in cell lines and primary blasts did not demonstrate any effect in apoptosis or cell proliferation at baseline or after chemotherapy. These data support a bystander role for the miR-10 family in NPM1mut-AML.






Havelange V,Ranganathan P,Geyer S,Nicolet D,Huang X,Yu X,Volinia S,Kornblau SM,Andreeff M,Croce CM,Marcucci G,Bloomfield CD,Garzon R




Has Abstract


2014-04-10 00:00:00
















  • Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies.

    abstract::We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia (AML) in the context of the current World Health Organization (WHO) classification and to evaluate the outcome of MK(+) patients after allogeneic HSCT. Of 1058 patients with abnormal cytogenetics, 319 (30%) were MK MK(+)....


    pub_type: 杂志文章,多中心研究


    authors: Kayser S,Zucknick M,Döhner K,Krauter J,Köhne CH,Horst HA,Held G,von Lilienfeld-Toal M,Wilhelm S,Rummel M,Germing U,Götze K,Nachbaur D,Schlegelberger B,Göhring G,Späth D,Morlok C,Teleanu V,Ganser A,Döhner H,Schlenk

    更新日期:2012-01-12 00:00:00

  • Proximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of von Willebrand factor secretion.

    abstract::Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular hemostasis and local inflammation. Endothelial activation triggers rapid exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rolling (P-selectin) and pl...


    pub_type: 杂志文章


    authors: Holthenrich A,Drexler HCA,Chehab T,Naß J,Gerke V

    更新日期:2019-09-19 00:00:00

  • Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.

    abstract::Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non-self-antigens. Interleukin-10 (IL-10) is the crucial driving factor for Tr1 cell differentiation, but the molecular mechanisms underlying this induction remain unknown. We identi...


    pub_type: 杂志文章


    authors: Gregori S,Tomasoni D,Pacciani V,Scirpoli M,Battaglia M,Magnani CF,Hauben E,Roncarolo MG

    更新日期:2010-08-12 00:00:00

  • An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

    abstract::Mutations in HFE lead to hereditary hemochromatosis (HH) because of inappropriately high iron uptake from the diet resulting from decreased hepatic expression of the iron-regulatory hormone hepcidin. -thalassemia is a congenital anemia caused by partial or complete loss of -globin synthesis causing ineffective erythro...


    pub_type: 杂志文章


    authors: Schmidt PJ,Toudjarska I,Sendamarai AK,Racie T,Milstein S,Bettencourt BR,Hettinger J,Bumcrot D,Fleming MD

    更新日期:2013-02-14 00:00:00

  • Development of a marrow transplant regimen for acute leukemia using targeted hematopoietic irradiation delivered by 131I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation.

    abstract::In an attempt to decrease the relapse rate after bone marrow transplantation (BMT) for advanced acute leukemia, we initiated studies using 131I-labeled anti-CD45 antibody (BC8) to deliver radiation specifically to hematopoietic tissues, followed by a standard transplant preparative regimen. Biodistribution studies wer...


    pub_type: 临床试验,杂志文章


    authors: Matthews DC,Appelbaum FR,Eary JF,Fisher DR,Durack LD,Bush SA,Hui TE,Martin PJ,Mitchell D,Press OW

    更新日期:1995-02-15 00:00:00

  • Ultrastructural localization of nonspecific esterase activity in guinea pig and human monocytes, macrophages, and lymphocytes.

    abstract::Using either hexazotized pararosaniline or new fuchsin as coupling agents, we investigated the ultrastructural localization of alpha-naphthyl acetate esterase (ANAE) activity in guinea pig bone marrow and peritoneal exudates, and in human peripheral blood cells. DFP-inhibitable ANAE activity was present on the cell su...


    pub_type: 杂志文章


    authors: Monahan RA,Dvorak HF,Dvorak AM

    更新日期:1981-12-01 00:00:00

  • Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro.

    abstract::Recombinant gibbon interleukin-3 (IL-3) is a multilineage hematopoietic colony-stimulating factor (CSF) that recently was cloned and found to be highly homologous with human IL-3. Gibbon IL-3, as well as human granulocyte-CSF (G-CSF) and human granulocyte-macrophage CSF (GM-CSF), stimulated normal human bone marrow ce...


    pub_type: 杂志文章


    authors: Paquette RL,Zhou JY,Yang YC,Clark SC,Koeffler HP

    更新日期:1988-06-01 00:00:00

  • Randomized study on hydroxyurea alone versus hydroxyurea combined with low-dose interferon-alpha 2b for chronic myeloid leukemia. The Benelux CML Study Group.

    abstract::Interferon-alpha (IFN-alpha) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation. From 1987 through 1992, 195 patients in the Benelux with recent untreated CML were randomized between low-dose IFN-alpha2b (3 MIU, 5 days/wk) or hydroxyurea...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验



    更新日期:1998-04-15 00:00:00

  • Granulopoietic progenitors in suspension culture: a comparison of stimulatory cells and conditioned media.

    abstract::Kinetic studies have been carried out to investigate the functional heterogeneity previously observed in populations of human marrow or peripheral blood cells separated by velocity sedimentation. The results obtained confirm the earlier results, in that slowly-sedimenting cells were found to stimulate both colony form...


    pub_type: 杂志文章


    authors: Niho Y,Till JE,McCulloch EA

    更新日期:1975-06-01 00:00:00

  • MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells.

    abstract::Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B...


    pub_type: 杂志文章


    authors: Merkenschlager J,Eksmond U,Danelli L,Attig J,Young GR,Nowosad C,Tolar P,Kassiotis G

    更新日期:2019-03-07 00:00:00

  • Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut.

    abstract::Increasing evidence indicates that the gut microbiota is closely associated with acute graft-versus-host disease (aGVHD) in stem cell transplantation (SCT). Fecal microbiota transplantation (FMT) could represent an alternative treatment option for aGVHD. However, FMT for SCT patients carries a potential risk of infect...


    pub_type: 临床试验,杂志文章


    authors: Kakihana K,Fujioka Y,Suda W,Najima Y,Kuwata G,Sasajima S,Mimura I,Morita H,Sugiyama D,Nishikawa H,Hattori M,Hino Y,Ikegawa S,Yamamoto K,Toya T,Doki N,Koizumi K,Honda K,Ohashi K

    更新日期:2016-10-20 00:00:00

  • Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage.

    abstract::Platelet glycoprotein (GP) V is a major surface protein cleaved during thrombin-induced platelet activation. GPV associates noncovalently with the GPIb-IX complex to form GPIb-V-IX, a receptor for von Willebrand factor and thrombin. We describe the cloning of the genes coding for rat and mouse GPV and compare them wit...


    pub_type: 杂志文章


    authors: Ravanat C,Morales M,Azorsa DO,Moog S,Schuhler S,Grunert P,Loew D,Van Dorsselaer A,Cazenave JP,Lanza F

    更新日期:1997-05-01 00:00:00

  • High rate of clinical and molecular remissions in follicular lymphoma patients receiving high-dose sequential chemotherapy and autografting at diagnosis: a multicenter, prospective study by the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    abstract::Single-center experiences have shown that intensified treatments with autologous transplantation are a promising therapeutic strategy for patients with high-risk follicle-center lymphoma (FCL) at diagnosis, whereas data from prospective multicenter trials are still lacking. This paper describes the results of a prospe...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Ladetto M,Corradini P,Vallet S,Benedetti F,Vitolo U,Martelli M,Brugiatelli M,Coser P,Perrotti A,Majolino I,Fioritoni G,Morandi S,Musso M,Zambello R,Chisesi T,Di Renzo N,Vivaldi P,De Crescenzo A,Gallamini A,Salvi F,

    更新日期:2002-09-01 00:00:00

  • CD38 antibodies in multiple myeloma: back to the future.

    abstract::CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of nonhematopoietic origin. CD38 is a transmembrane glycoprotein with ectoenzymatic activity, and also functions as a receptor and adhesion molecule. Altogether,...


    pub_type: 杂志文章,评审


    authors: van de Donk NWCJ,Richardson PG,Malavasi F

    更新日期:2018-01-04 00:00:00

  • The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 downregulation.

    abstract::Wiskott-Aldrich syndrome (WAS) pediatric patients exhibit a deficiency in humoral immune memory. However, the mechanism by which Wiskott-Aldrich syndrome protein (WASP) regulates the differentiation and activation of memory B cells remains elusive. Here we examine the early activation events of memory B cells from the...


    pub_type: 杂志文章


    authors: Bai X,Zhang Y,Huang L,Wang J,Li W,Niu L,Jiang H,Dai R,Zhou L,Zhang Z,Miller H,Song W,Zhao X,Liu C

    更新日期:2016-09-29 00:00:00

  • Myeloma bone disease and proteasome inhibition therapies.

    abstract::Bone disease is one of the most debilitating manifestations of multiple myeloma. A complex interdependence exists between myeloma bone disease and tumor growth, creating a vicious circle of extensive bone destruction and myeloma progression. Proteasome inhibitors have recently been shown to promote bone formation in v...


    pub_type: 杂志文章,评审


    authors: Terpos E,Sezer O,Croucher P,Dimopoulos MA

    更新日期:2007-08-15 00:00:00

  • Myc-Miz1 signaling promotes self-renewal of leukemia stem cells by repressing Cebpα and Cebpδ.

    abstract::c-Myc (Myc hereafter) is found to be deregulated and/or amplified in most acute myeloid leukemias (AMLs). Almost all AML cells are dependent upon Myc for their proliferation and survival. Thus, Myc has been proposed as a critical anti-AML target. Myc has Max-mediated transactivational and Myc-interacting zinc finger p...


    pub_type: 杂志文章


    authors: Zhang L,Li J,Xu H,Shao X,Fu L,Hou Y,Hao C,Li W,Joshi K,Wei W,Xu Y,Zhang F,Dai S,Breslin P,Zhang J,Zhang J

    更新日期:2020-04-02 00:00:00

  • Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells.

    abstract::Multiple myeloma (MM) is characterized by accumulation and dissemination of malignant plasma cells (PCs) in the bone marrow (BM). Gene expression profiling of 2 MM cell lines (OH-2 and IH-1) indicated that expression of PRL-3, a metastasis-associated tyrosine phosphatase, was induced by several mitogenic cytokines. Cy...


    pub_type: 杂志文章,多中心研究


    authors: Fagerli UM,Holt RU,Holien T,Vaatsveen TK,Zhan F,Egeberg KW,Barlogie B,Waage A,Aarset H,Dai HY,Shaughnessy JD Jr,Sundan A,Børset M

    更新日期:2008-01-15 00:00:00

  • Role of allogeneic stem cell transplantation in adult patients with Ph-negative acute lymphoblastic leukemia.

    abstract::Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-...


    pub_type: 杂志文章


    authors: Dhédin N,Huynh A,Maury S,Tabrizi R,Beldjord K,Asnafi V,Thomas X,Chevallier P,Nguyen S,Coiteux V,Bourhis JH,Hichri Y,Escoffre-Barbe M,Reman O,Graux C,Chalandon Y,Blaise D,Schanz U,Lhéritier V,Cahn JY,Dombret H,If

    更新日期:2015-04-16 00:00:00

  • Chloroma (granulocytic sarcoma) without evidence of leukemia: facilitated light microscopic diagnosis.

    abstract::Localized tumors composed of immature cells of the myelogenous series have been recognized for many years as an uncommon manifestation of granulocytic leukemia. The histologic diagnosis of chloroma (granulocytic sarcoma) may be extremely difficult when the myeloblastic cells are poorly differentiated and the tumor lac...


    pub_type: 杂志文章


    authors: McCarty KS Jr,Wortman J,Daly J,Rundles RW,Hanker JS

    更新日期:1980-07-01 00:00:00

  • BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.

    abstract::Follicular lymphoma (FL) is characterized by a relatively indolent clinical course, but the disease often transforms into a more aggressive large cell lymphoma with a rapidly progressive clinical course. In the present study, we analyzed 41 cases of FL known to have subsequently transformed to aggressive lymphoma and ...


    pub_type: 杂志文章


    authors: Akasaka T,Lossos IS,Levy R

    更新日期:2003-08-15 00:00:00

  • Differential requirements for the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin.

    abstract::Selectins are carbohydrate-binding adhesion molecules that play important roles in control of leukocyte traffic. Glycosyltransferases involved in selectin ligand biosynthesis include the alpha1,3-fucosyltransferases FucT-VII and FucT-IV, one or more sialyltransferases, and at least one O-linked branching enzyme. Previ...


    pub_type: 杂志文章


    authors: Snapp KR,Heitzig CE,Ellies LG,Marth JD,Kansas GS

    更新日期:2001-06-15 00:00:00

  • Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.

    abstract::Primary myelofibrosis (PMF) is the most serious myeloproliferative disorder, characterized by clonal myeloproliferation associated with cytokine-mediated bone marrow stromal reaction including fibrosis and osteosclerosis. Current drug therapy remains mainly palliative. Because the NF-kappaB pathway is implicated in th...


    pub_type: 杂志文章


    authors: Wagner-Ballon O,Pisani DF,Gastinne T,Tulliez M,Chaligné R,Lacout C,Auradé F,Villeval JL,Gonin P,Vainchenker W,Giraudier S

    更新日期:2007-07-01 00:00:00

  • Increased β4GALT1 expression associates with platelet surface galactosylation and thrombopoietin plasma levels in MPNs.

    abstract::Aberrant megakaryopoiesis is a hallmark of the myeloproliferative neoplasms (MPNs), a group of clonal haematological malignancies originating from haematopoietic stem cells, leading to an increase in mature blood cells in the peripheral blood. Sialylated derivatives of the glycan structure β4-N-acetyllactosamine (Galβ...


    pub_type: 杂志文章


    authors: Di Buduo CA,Giannini S,Abbonante V,Rosti V,Hoffmeister K,Balduini A

    更新日期:2020-11-25 00:00:00

  • HLA associations with leukemia.

    abstract::Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (...


    pub_type: 杂志文章


    authors: Bortin MM,D'Amaro J,Bach FH,Rimm AA,van Rood JJ

    更新日期:1987-07-01 00:00:00

  • The human cardiac mast cell: localization, isolation, phenotype, and functional characterization.

    abstract::We have isolated and characterized the human cardiac mast cell (CMC) and compared this novel mast cell (MC type with MC obtained from uterus, skin, and lung. Heart tissue was obtained from 14 patients with cardiomyopathy (CMP, heart transplantation). CMC were isolated by enzymatic digestion using collagenase, pronase-...


    pub_type: 杂志文章


    authors: Sperr WR,Bankl HC,Mundigler G,Klappacher G,Grossschmidt K,Agis H,Simon P,Laufer P,Imhof M,Radaszkiewicz T,Glogar D,Lechner K,Valent P

    更新日期:1994-12-01 00:00:00

  • Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program.

    abstract::Granzyme H (GzmH) belongs to a family of 5 human serine proteases that are expressed by cytotoxic immune effector cells. Although GzmH is most closely related to the caspase-activating granzyme B (GzmB), neither a natural substrate nor a role in immune defense reactions has been demonstrated for this orphan granzyme. ...


    pub_type: 杂志文章


    authors: Fellows E,Gil-Parrado S,Jenne DE,Kurschus FC

    更新日期:2007-07-15 00:00:00

  • Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma.

    abstract::Although molecular biologic techniques can now detect minimal numbers of residual cancer cells in patients in complete clinical remission, the clinical significance of minimal residual disease has never been conclusively established. If the detection of minimal residual disease predicts which patients will relapse, th...


    pub_type: 杂志文章


    authors: Gribben JG,Neuberg D,Freedman AS,Gimmi CD,Pesek KW,Barber M,Saporito L,Woo SD,Coral F,Spector N

    更新日期:1993-06-15 00:00:00

  • Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas.

    abstract::The incidence of follicular lymphoma (FL) in industrialized countries has been increasing since the 1950s. Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism, including methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS or MTR), serine hydroxymethyltransferase (SHMT)...


    pub_type: 杂志文章


    authors: Niclot S,Pruvot Q,Besson C,Savoy D,Macintyre E,Salles G,Brousse N,Varet B,Landais P,Taupin P,Junien C,Baudry-Bluteau D

    更新日期:2006-07-01 00:00:00

  • Constitutive expression of GATA-1, EPOR, alpha-globin, and gamma-globin genes in myeloid clonogenic cells from juvenile chronic myelocytic leukemia.

    abstract::Juvenile chronic myelocytic leukemia (JCML) is a rare disorder of early childhood. Characteristic of JCML are the progressive appearance of high levels of fetal hemoglobin (HbF), reflecting a true reversion to a fetal type of erythropoiesis, and the presence of colony-forming cells able to grow in vitro spontaneously ...


    pub_type: 杂志文章


    authors: Privitera E,Schirò R,Longoni D,Ronchi A,Rambaldi A,Bernasconi S,Ottolenghi S,Masera G,Biondi A

    更新日期:1995-07-01 00:00:00