Abstract:
:Anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a CD30-positive T-cell non-Hodgkin lymphoma that morphologically resembles ALK-positive ALCL but lacks chromosomal rearrangements of the ALK gene. The genetic and clinical heterogeneity of ALK-negative ALCL has not been delineated. We performed immunohistochemistry and fluorescence in situ hybridization on 73 ALK-negative ALCLs and 32 ALK-positive ALCLs and evaluated the associations among pathology, genetics, and clinical outcome. Chromosomal rearrangements of DUSP22 and TP63 were identified in 30% and 8% of ALK-negative ALCLs, respectively. These rearrangements were mutually exclusive and were absent in ALK-positive ALCLs. Five-year overall survival rates were 85% for ALK-positive ALCLs, 90% for DUSP22-rearranged ALCLs, 17% for TP63-rearranged ALCLs, and 42% for cases lacking all 3 genetic markers (P < .0001). Hazard ratios for death in these 4 groups after adjusting for International Prognostic Index and age were 1.0 (reference group), 0.58, 8.63, and 4.16, respectively (P = 7.10 × 10(-5)). These results were similar when restricted to patients receiving anthracycline-based chemotherapy, as well as to patients not receiving stem cell transplantation. Thus, ALK-negative ALCL is a genetically heterogeneous disease with widely disparate outcomes following standard therapy. DUSP22 and TP63 rearrangements may serve as predictive biomarkers to help guide patient management.
journal_name
Bloodjournal_title
Bloodauthors
Parrilla Castellar ER,Jaffe ES,Said JW,Swerdlow SH,Ketterling RP,Knudson RA,Sidhu JS,Hsi ED,Karikehalli S,Jiang L,Vasmatzis G,Gibson SE,Ondrejka S,Nicolae A,Grogg KL,Allmer C,Ristow KM,Wilson WH,Macon WR,Law ME,Cedoi
10.1182/blood-2014-04-571091subject
Has Abstractpub_date
2014-08-28 00:00:00pages
1473-80issue
9eissn
0006-4971issn
1528-0020pii
blood-2014-04-571091journal_volume
124pub_type
杂志文章相关文献
BLOOD文献大全abstract::Four of 9 PAX transcription factor genes have been associated with chromosomal translocations in human tumors, although their oncogenic potential has not yet been demonstrated in transgenic mouse models. The B-lymphoidPAX5 gene participates in the generation of the t(9;14)(p13;q32) translocation in germinal center B c...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2006-03-009670
更新日期:2007-01-01 00:00:00
abstract::Conflicting data have been reported on the risk for venous thrombosis in subjects with low free protein S levels. We performed a post-hoc analysis in a single-center retrospective thrombophilic family cohort, to define the optimal free protein S level that can identify subjects at risk for venous thrombosis. Relatives...
journal_title:Blood
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1182/blood-2008-08-174128
更新日期:2009-02-05 00:00:00
abstract::The erythroid Krüppel-like factor (EKLF) is a key regulatory protein in globin gene expression. This zinc finger transcription factor is required for expression of the adult beta globin gene, and it has been suggested that it plays an important role in the developmental switch from fetal gamma to adult beta globin gen...
journal_title:Blood
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::Despite increasing use of targeted therapies to treat cancer, anemia remains a common complication of cancer therapy. Physician concerns about the safety of intravenous (IV) iron products and erythropoiesis-stimulating agents (ESAs) have resulted in many patients with cancer receiving no or suboptimal anemia therapy. ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood.2019004017
更新日期:2020-08-13 00:00:00
abstract::Interleukin-10 (IL-10) selectively inhibited lipopolysaccharide (LPS)-induced chemoattractant cytokine gene expression: levels of IP-10 mRNA were markedly suppressed in IL-10-treated mouse peritoneal macrophages, whereas the expression of the RANTES mRNA was only modestly reduced. IL-10 inhibited IP-10 mRNA accumulati...
journal_title:Blood
pub_type: 杂志文章
doi:
更新日期:1998-12-15 00:00:00
abstract::The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) is challenging, because persistent intravascular abnormalities after previous DVT often hinder a diagnosis by compression ultrasonography. Magnetic resonance direct thrombus imaging (MRDTI), a technique without intravenous contrast and with a 10-minute ...
journal_title:Blood
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1182/blood.2019004114
更新日期:2020-04-16 00:00:00
abstract::Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults. Patients with newly diagnosed B-cell ALL (B-ALL) who received frontline chemotherapy at MD Anderson Cancer Center underwent...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2016-07-726588
更新日期:2017-02-02 00:00:00
abstract::Because there is no known genetic abnormality common to all patients with myeloma, it is important to understand how genetic heterogeneity may lead to differences in signal transduction, cell cycle, and response to therapy. Model cell lines have been used to study the effect that mutations in p53 and ras can have on g...
journal_title:Blood
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::To screen for point mutations causing protein S deficiency, we used a sequence of techniques specifically for the study of the protein S active gene, PS alpha. This strategy comprises amplification of exons and intron/exon junctions by means of the polymerase chain reaction (PCR) and electrophoresis of the amplified f...
journal_title:Blood
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Erythroid Kruppel-like factor (EKLF) is a transcription factor of the C2H2 zinc-finger class that is essential for definitive erythropoiesis. We generated immortal erythroid cell lines from EKLF(-/-) fetal liver progenitor cells that harbor a single copy of the entire human beta-globin locus and then reintroduced EKLF...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood.v97.6.1861
更新日期:2001-03-15 00:00:00
abstract::The incidence and role of p53 abnormalities have not been reported in splenic lymphoma with villous lymphocytes (SLVL), the leukemic counterpart of splenic marginal zone lymphoma. Because p53 abnormalities correlate with progressive and refractory disease in cancer and isochromosome 17q has been described in SLVL, a l...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood.v97.11.3552
更新日期:2001-06-01 00:00:00
abstract::The t(8;21)(q22;q22) is common in adult acute myeloid leukemia (AML). The RUNX1-ETO fusion protein that is expressed by this translocation is poorly leukemogenic and requires additional mutations for transformation. Loss of sex chromosome (LOS) is frequently observed in t(8;21) AML. In the present study, to evaluate w...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2011-04-350694
更新日期:2012-03-29 00:00:00
abstract::In this issue of Blood, Sehgal et al report on the clinical and pharmacodynamics analysis of pomalidomide dosing strategies in multiple myeloma (MM) and their impact on immune activation and cereblon targets. The particular novelty of this study lies in the direct correlation of immune effects triggered by pomalidomid...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-05-641746
更新日期:2015-06-25 00:00:00
abstract::In an attempt to decrease the relapse rate after bone marrow transplantation (BMT) for advanced acute leukemia, we initiated studies using 131I-labeled anti-CD45 antibody (BC8) to deliver radiation specifically to hematopoietic tissues, followed by a standard transplant preparative regimen. Biodistribution studies wer...
journal_title:Blood
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-02-15 00:00:00
abstract::Neutrophils recruited from the blood are key players in the innate immune response. Selectins play critical roles in neutrophil recruitment by mediating their tethering and rolling in inflamed venules. While the roles of P- and E-selectin in this process are well established, the mechanisms of L-selectin-mediated neut...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2008-04-153866
更新日期:2008-12-15 00:00:00
abstract::Peripheral blood and bone marrow mononuclear cells from patients with refractory anemia (RA) or RA with sideroblasts (defined according to the revised French-American-British classification with less than 5% blast cells in the bone marrow) were analyzed using a panel of monoclonal antibodies directed against leukocyte...
journal_title:Blood
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract::Using Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) as a model, our aim has been to develop a molecular cytogenetic method of high resolution analysis for monitoring the frequency of cells with nonrandom chromosome rearrangements in the bone marrow of patients receiving treatment for hemato...
journal_title:Blood
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-09-15 00:00:00
abstract::The glycoprotein CD47 (integrin-associated protein, IAP) is present on the surface of virtually all cells, including red blood cells (RBCs). CD47 acts like a marker of self by ligating the macrophage inhibitory receptor signal regulatory protein alpha (SIRPalpha). In this manner mild reactivity of wild-type RBCs with ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood.v99.10.3500
更新日期:2002-05-15 00:00:00
abstract::It has been reported that the activation of multiple myeloma (MM) cells by CD40 induces proliferation, growth arrest, and apoptosis. To determine whether the biologic sequelae of CD40 activation in MM cells depends on p53 function, we identified temperature-sensitive p53 mutations in the RPMI 8226 (tsp53E285K) and the...
journal_title:Blood
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Primary mediastinal B-cell lymphoma (PMBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is putatively derived from a thymic B cell. Accounting for up to 10% of cases of DLBCL, this subtype predominantly affects women in the third and fourth decades of life. Its clinical and molecular characteristics are ...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2014-05-575092
更新日期:2015-01-01 00:00:00
abstract::Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the pathogenesis of acute myeloid leukemia (AML). To address the role of clonal evolution in relapsed NPM1-mutated (NPM1mut) AML, we applied high-resolution, genome-wide, single-nucleotide polymorphism array profiling to detect copy number ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-01-479188
更新日期:2013-07-04 00:00:00
abstract::T-cell dysfunction after human hematopoietic stem-cell transplantation (HSCT) is generally attributed to intrinsic T-cell defects. Here we show that the characteristic impaired proliferative responses to polyclonal stimulation of post-HSCT peripheral blood mononuclear cells (PB-MCs) were markedly (4-fold) improved by ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2004-05-1726
更新日期:2005-05-15 00:00:00
abstract::In this issue of Blood, Finn et al have taken a factor IX variant with increased specific activity associated with thrombophilia and used it to improve gene therapy of hemophilia B in dogs, and Cantore et al have shown similar results in mice. ...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2012-09-452821
更新日期:2012-11-29 00:00:00
abstract::The nonobese diabetic/severe combined immunodeficient (NOD/SCID) assay is the current model for assessment of human normal and leukemic stem cells. We explored why 51% of 59 acute myeloid leukemia (AML) patients were unable to initiate leukemia in NOD/SCID mice. Increasing the cell dose, using more permissive recipien...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2005-06-2325
更新日期:2006-02-01 00:00:00
abstract::We explored adeno-associated viral vector (AAV)-mediated gene transfer in the perinatal period in animal models of severe congenital factor VII (FVII) deficiency, a disease associated with early postnatal life-threatening hemorrhage. In young adult mice with plasma FVII < 1% of normal, a single tail vein administratio...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2011-09-377630
更新日期:2012-01-26 00:00:00
abstract::Primitive chronic myeloid leukemia cells display a unique autocrine interleukin 3 (IL-3)/granulocyte-colony-stimluating factor (G-CSF) mechanism that may explain their abnormal proliferation and differentiation control. Here we show that BCR-ABL transduction of primitive Sca-1(+) lin(-) mouse bone marrow (BM) cells ca...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2002-05-1324
更新日期:2002-11-15 00:00:00
abstract::The plasma membrane calcium pump (PMCA) is the only active Ca2+ transporter in human red blood cells (RBCs). Previous measurements of maximal Ca2+ extrusion rates (Vmax) reported only mean values in the RBC population. Despite early evidence for differences in Ca2+ extrusion capacity among RBCs, the precise Vmax distr...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2003-06-1787
更新日期:2003-12-01 00:00:00
abstract::Mutations of IDH1 and IDH2, which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors, including acute myeloid leukemia. Recent studies have shown that expression of the IDH mutant enzymes results in high levels of 2HG and a block in cellular differentiation that can be reversed...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-10-533604
更新日期:2015-01-08 00:00:00
abstract::Burkitt lymphoma (BL) is classified into 3 clinical subsets: endemic, sporadic, and immunodeficiency-associated BL. So far, possible differences in their gene expression profiles (GEPs) have not been investigated. We studied GEPs of BL subtypes, other B-cell lymphomas, and B lymphocytes; first, we found that BL is a u...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2010-08-301556
更新日期:2011-03-31 00:00:00
abstract::Direct sequencing of VWF genomic DNA in 21 patients with type 3 von Willebrand disease (VWD) failed to reveal a causative homozygous or compound heterozygous VWF genotype in 5 cases. Subsequent analysis of VWF mRNA led to the discovery of a deletion (c.221-977_532 + 7059del [p.Asp75_Gly178del]) of VWF in 7 of 12 white...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2008-08-173278
更新日期:2009-07-30 00:00:00