Inhibition of restenosis by tissue factor pathway inhibitor: in vivo and in vitro evidence for suppressed monocyte chemoattraction and reduced gelatinolytic activity.

abstract：:Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed on how the radiotherapy-related risk is affected by other breast cancer risk factors. Genome-wide ...

journal_title：Blood

authors： Ma YP,van Leeuwen FE,Cooke R,Broeks A,Enciso-Mora V,Olver B,Lloyd A,Broderick P,Russell NS,Janus C,Ashworth A,Houlston RS,Swerdlow AJ

更新日期：2012-01-26 00:00:00

abstract：:An effective response to extreme hematopoietic stress requires an extreme elevation in hematopoiesis and preservation of hematopoietic stem cells (HSCs). These diametrically opposed processes are likely to be regulated by genes that mediate cellular adaptation to physiologic stress. Herein, we show that heme oxygenase...

journal_title：Blood

authors： Cao YA,Wagers AJ,Karsunky H,Zhao H,Reeves R,Wong RJ,Stevenson DK,Weissman IL,Contag CH

更新日期：2008-12-01 00:00:00

abstract：:Inherited type 1 antithrombin (AT) deficiency is characterized by a reduction in both immunologically and functionally detectable protein. The disorder is associated with a high risk of thromboembolic disease. We have investigated the molecular basis of type 1 AT deficiency in three unrelated families. We have used th...

journal_title：Blood

authors： Jochmans K,Lissens W,Yin T,Michiels JJ,van der Luit L,Peerlinck K,De Waele M,Liebaers I

更新日期：1994-12-01 00:00:00

abstract：:Commercial porcine factor VIII concentrate (Hyate:C) is effective in treatment of patients with hemophilia A who have circulating antibodies to factor VIII. The molecular forms of factor VIII in the concentrate were identified and evaluated in light of the known properties of porcine and human factor VIII. The factor ...

journal_title：Blood

authors： Lollar P,Parker CG,Tracy RP

更新日期：1988-01-01 00:00:00

abstract：:Normal human B cell proliferation is controlled by various immunoregulatory signals including the T cell-derived lymphokine B cell growth factor (BCGF). The role of BCGF in the regulation of malignant B cell proliferation is unclear. Therefore, we studied the proliferative response of purified chronic lymphocytic leuk...

journal_title：Blood

authors： Perri RT

更新日期：1986-04-01 00:00:00

abstract：:Rabbit platelets were aggregated by adenosine diphosphate (ADP), allowed to deaggregate and then separated into density subpopulations by centrifugation through discontinuous Stractan density gradients. Although ADP causes little or no release of the contents of the amine storage granules of rabbit platelets, ADP caus...

journal_title：Blood

authors： Packham MA,Perry DW,Kinlough-Rathbone RL,Rand ML,Guccione MA,Evans RM,Mustard JF

更新日期：1985-03-01 00:00:00

abstract：:In this single-center, cross-sectional study, we evaluated 44 very long-term survivors with a median follow-up of 17.5 years (range, 11-26 years) after hematopoietic stem cell transplantation. We assessed the telomere length difference in human leukocyte antigen-identical donor and recipient sibling pairs and searched...

journal_title：Blood

authors： Baerlocher GM,Rovó A,Müller A,Matthey S,Stern M,Halter J,Heim D,Rischewski J,Gratwohl A,Tichelli A

更新日期：2009-07-02 00:00:00

abstract：:Approximately 25% of patients with hemophilia A develop inhibitory antibodies after treatment with factor VIII. Most of the inhibitory activity is directed against epitopes in the A2 and C2 domains. Anti-A2 inhibitory antibodies recognize a 25-residue segment bounded by R484-I508. Several antigenic residues in this se...

journal_title：Blood

authors： Parker ET,Healey JF,Barrow RT,Craddock HN,Lollar P

更新日期：2004-08-01 00:00:00

abstract：:Gimap4, a member of the newly identified GTPase of the immunity-associated protein family (Gimap), is strongly induced by the pre-T-cell receptor in precursor T lymphocytes, transiently shut off in double-positive thymocytes, and reappears after TCR-mediated positive selection. Here, we show that Gimap4 remains expres...

journal_title：Blood

authors： Schnell S,Démollière C,van den Berk P,Jacobs H

更新日期：2006-07-15 00:00:00

abstract：:Vascular endothelial growth factor-A is widely used in clinical trials for the treatment of cardiac ischemia. VEGF-A was recently suggested to act in a proinflammatory manner, which could aggravate adjacent atherogenesis in VEGF-A-based therapy. To assess potential bystander effects, VEGF-A was focally overexpressed i...

journal_title：Blood

authors： Lucerna M,Zernecke A,de Nooijer R,de Jager SC,Bot I,van der Lans C,Kholova I,Liehn EA,van Berkel TJ,Yla-Herttuala S,Weber C,Biessen EA

更新日期：2007-01-01 00:00:00

abstract：:Intravital microscopy was used to monitor leukocyte traffic across rat mesenteric postcapillary venules induced by the inactive terminal complement (C) complex (iTCC) topically applied to ileal mesentery. Leukocytes started rolling within 15 minutes from the administration of iTCC, and by 1 hour they adhered almost co...

journal_title：Blood

authors： Dobrina A,Pausa M,Fischetti F,Bulla R,Vecile E,Ferrero E,Mantovani A,Tedesco F

更新日期：2002-01-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is f...

journal_title：Blood

authors： Morales-Ortíz J,Deal V,Reyes F,Maldonado-Martínez G,Ledesma N,Staback F,Croft C,Pacheco A,Ortiz-Zuazaga H,Yost CC,Rowley JW,Madera B,John AS,Chen J,Lopez J,Rondina MT,Hunter R,Gibson A,Washington AV

更新日期：2018-12-06 00:00:00

abstract：:Deletion of Runx1 in adult mice produces a myeloproliferative phenotype. We now find that Runx1 gene deletion increases marrow monocyte while reducing granulocyte progenitors and that exogenous RUNX1 rescues granulopoiesis. Deletion of Runx1 reduces Cebpa mRNA in lineage-negative marrow cells and in granulocyte-monocy...

journal_title：Blood

authors： Guo H,Ma O,Speck NA,Friedman AD

更新日期：2012-05-10 00:00:00

abstract：:Self-renewal is a feature of cancer and can be assessed by cell transplantation into immune-compromised or immune-matched animals. However, studies in zebrafish have been severely limited by lack of these reagents. Here, Myc-induced T-cell acute lymphoblastic leukemias (T-ALLs) have been made in syngeneic, clonal zebr...

journal_title：Blood

authors： Smith AC,Raimondi AR,Salthouse CD,Ignatius MS,Blackburn JS,Mizgirev IV,Storer NY,de Jong JL,Chen AT,Zhou Y,Revskoy S,Zon LI,Langenau DM

更新日期：2010-04-22 00:00:00

abstract：:Diaspirin cross-linked hemoglobin (DCLHb) is an intramolecularly cross-linked hemoglobin-based oxygen carrier being developed as a therapy for acute blood loss. We report here the absence of immunogenicity of DCLHb in patients enrolled in phase II and III clinical trials of DCLHb. Two very sensitive immunoassays, an e...

journal_title：Blood

authors： Patel MJ,Webb EJ,Shelbourn TE,Mattia-Goldberg C,George AJ,Zhang F,Moore EG,Nelson DJ

更新日期：1998-01-15 00:00:00

abstract：:Venous limb gangrene (VLG) can occur in cancer patients, but the clinical picture and pathogenesis remain uncertain. We identified 10 patients with metastatic cancer (7 pathologically proven) who developed severe venous limb ischemia (phlegmasia/VLG) after initiating treatment of deep-vein thrombosis (DVT); in 8 patie...

journal_title：Blood

authors： Warkentin TE,Cook RJ,Sarode R,Sloane DA,Crowther MA

更新日期：2015-07-23 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) lymphocytes manifest anomalous motility and cap formation. Since these processes involve cytoskeletal proteins, vimentin from intermediate filaments of normal and CLL lymphocytes was investigated using hetero- and monoclonal antisera. The antisera reacted predominantly with a 60-kD p...

journal_title：Blood

authors： Stark RS,Liebes LF,Shelanski ML,Silber R

更新日期：1984-02-01 00:00:00

abstract：:The hematopoietically expressed homeobox gene, Hhex, is a transcription factor that is important for development of definitive hematopoietic stem cells (HSCs) and B cells, and that causes T-cell leukemia when overexpressed. Here, we have used an Hhex inducible knockout mouse model to study the role of Hhex in adult he...

journal_title：Blood

authors： Jackson JT,Nasa C,Shi W,Huntington ND,Bogue CW,Alexander WS,McCormack MP

更新日期：2015-01-29 00:00:00

abstract：:A 72-yr-old male with a lifelong history of easy bruisability and posttraumatic bleeding had a prolonged prothrombin time and activated partial thromboplastin time. His plasma Stypven, Taipan, and Echis carinatus venom clotting times were prolonged. The presence of a dysprothrombin was confirmed by the discrepancy bet...

journal_title：Blood

authors： Weinger RS,Rudy C,Moake JL,Olson JD,Cimo PL

更新日期：1980-05-01 00:00:00

abstract：:Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from patients, are dependent on Bcr-Abl. In the tr...

journal_title：Blood

authors： Hamilton A,Helgason GV,Schemionek M,Zhang B,Myssina S,Allan EK,Nicolini FE,Müller-Tidow C,Bhatia R,Brunton VG,Koschmieder S,Holyoake TL

更新日期：2012-02-09 00:00:00

abstract：:We tested the ability of CD34+lin- precursor cells isolated from marrow after treatment with 4-hydroperoxycyclophosphamide (4HC) to generate colony-forming cells (CFC). In liquid cultures, recombinant human stem cell factor (SCF), in combination with interleukin-1 (IL-1), IL-3, IL-6, granulocyte-macrophage colony-stim...

journal_title：Blood

authors： Rowley SD,Brashem-Stein C,Andrews R,Bernstein ID

更新日期：1993-07-01 00:00:00

abstract：:Recent studies suggest that the evolutionary history of a cancer is important in forecasting clinical outlook. To gain insight into the clonal dynamics of multiple myeloma (MM) and its possible influence on patient outcomes, we analyzed whole exome sequencing tumor data for 333 patients from Myeloma XI, a UK phase 3 t...

journal_title：Blood

authors： Johnson DC,Lenive O,Mitchell J,Jackson G,Owen R,Drayson M,Cook G,Jones JR,Pawlyn C,Davies FE,Walker BA,Wardell C,Gregory WM,Cairns D,Morgan GJ,Houlston RS,Kaiser MF

更新日期：2017-10-05 00:00:00

abstract：:The effects of interleukin (IL)-8 on spontaneous IgE and IgG4 production in atopic patients were studied. IL-8 inhibited IgE and IgG4 production by purified surface (s) IgE+ and sIgG4+ B cells, respectively, while it had no effect on IgG1, IgG2, IgG3, IgM, IgA1, and IgA2 production by corresponding sIg+ B cells. The I...

journal_title：Blood

authors： Kimata H,Lindley I,Furusho K

更新日期：1995-06-01 00:00:00

abstract：:We have established four hybridoma cells that produce monoclonal antibodies (MoAbs) R2, R4, R6, and R12 directed toward recombinant human erythropoietin (rHuEPO). MoAbs R2, R4, and R6 bound to EPO with high affinities (kd = approximately 2, 4, and 1 nmol/L, respectively) but MoAb R12 had a low affinity (240 nmol/L). T...

journal_title：Blood

authors： Goto M,Murakami A,Akai K,Kawanishi G,Ueda M,Chiba H,Sasaki R

更新日期：1989-09-01 00:00:00

abstract：:The effects of factor IX concentrate therapy on hemostasis in hemophilia patients were studied by means of the radiometric factor IXa assay, the coupled amidolytic assay for factor VIIa, and coagulant assays for factors II, IX, and X, and antithrombin III. Both activated and unactivated concentrates contained factors ...

journal_title：Blood

authors： Hultin MB

更新日期：1983-09-01 00:00:00

abstract：:An immunotoxin specific for human T lymphocytes was prepared by coupling an IgG2a anti-CD3 murine monoclonal antibody (64.1) to purified ricin A chain (64.1-A). Treatment of blood mononuclear cells with this immunotoxin at a concentration of 1.7 X 10(-9) mol/L for two hours at 37 degrees C in the presence of 20 mmol/L...

journal_title：Blood

authors： Martin PJ,Hansen JA,Vitetta ES

更新日期：1985-10-01 00:00:00

abstract：:Fc receptors play an important role in leukocyte activation and the modulation of ligand binding ("activation") is a critical point of regulation. Previous studies demonstrated that the Fc receptor for IgA (FcalphaRI/CD89) is regulated by cytokine stimulation, switching it to a high-binding state. To investigate the m...

journal_title：Blood

authors： Bracke M,Lammers JW,Coffer PJ,Koenderman L

更新日期：2001-06-01 00:00:00

abstract：:Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...

journal_title：Blood

authors： Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

更新日期：2013-10-31 00:00:00

abstract：:The healthy mother of a child with transient immune neutropenia was found to be "NA-null." The mother's neutrophils did not react with anti-NA1 and anti-NA2 antibodies (polyclonal human alloantibodies and mouse monoclonal antibodies). A healthy donor was discovered during routine neutrophil antigen typing whose neutro...

journal_title：Blood

authors： Huizinga TW,Kuijpers RW,Kleijer M,Schulpen TW,Cuypers HT,Roos D,von dem Borne AE

更新日期：1990-11-15 00:00:00

abstract：:Chronic myeloid leukemia (CML) is composed of 3% of pediatric leukemias, making evidence-based recommendations difficult. Imatinib has revolutionized the treatment for adult CML by eliminating allogeneic stem cell transplantation for almost all patients in chronic phase. Shown effective in pediatric CML, imatinib and ...

journal_title：Blood

authors： Andolina JR,Neudorf SM,Corey SJ

更新日期：2012-02-23 00:00:00