Inhibition of ristocetin-induced platelet agglutination by vancomycin.

abstract：:In a previous multicenter phase III trial comparing peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT) from HLA-matched related donors, we found no statistically significant difference in the cumulative incidence of clinical extensive chronic graft-versus-host disease (GVHD) in the...

journal_title：Blood

authors： Flowers ME,Parker PM,Johnston LJ,Matos AV,Storer B,Bensinger WI,Storb R,Appelbaum FR,Forman SJ,Blume KG,Martin PJ

更新日期：2002-07-15 00:00:00

abstract：:A large number of alterations in genes encoding receptor tyrosine kinase (RTK), namely FLT3, c-KIT, platelet-derived growth factor (PDGF) receptors, fibroblast growth factor (FGF) receptors, and the anaplastic large cell lymphoma kinase (ALK), have been found in hematopoietic malignancies. They have drawn much attenti...

journal_title：Blood

authors： Toffalini F,Demoulin JB

更新日期：2010-10-07 00:00:00

abstract：:We describe two assays to detect the action of colony-inhibiting cells. In the first assay, we used a simple density separation technique to remove dense neutrophils (PMN) from suspensions of blood and of bone marrow cells prior to culture in semisolid agar. Conditions were arranged to ensure that control suspensions ...

journal_title：Blood

authors： Broxmeyer HE,Baker FL,Galbraith PR

更新日期：1976-03-01 00:00:00

abstract：:Internal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% of acute myeloid leukemias (AMLs) and confers a poor prognosis. Thirteen relapsed or chemo-refractory FLT3-ITD(+) AML patients were treated with sorafenib (200-400 mg twice daily). Twelve patients showed clearance or near ...

journal_title：Blood

authors： Man CH,Fung TK,Ho C,Han HH,Chow HC,Ma AC,Choi WW,Lok S,Cheung AM,Eaves C,Kwong YL,Leung AY

更新日期：2012-05-31 00:00:00

abstract：:To develop safer and more effective vectors for gene therapy of X-linked severe combined immunodeficiency (SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on the HIV virus. The CL20i4-hgamma(c)-Revgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by t...

journal_title：Blood

authors： Zhou S,Mody D,DeRavin SS,Hauer J,Lu T,Ma Z,Hacein-Bey Abina S,Gray JT,Greene MR,Cavazzana-Calvo M,Malech HL,Sorrentino BP

更新日期：2010-08-12 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is expressed in almost all types of malignancies, making this protein a useful tool for the development of broadly applicable vaccination therapies. We used a recently identified HLA-A2 binding peptide and dendritic cells (DCs) from healthy donors to ind...

journal_title：Blood

authors： Schmidt SM,Schag K,Müller MR,Weck MM,Appel S,Kanz L,Grünebach F,Brossart P

更新日期：2003-07-15 00:00:00

abstract：:Donor lymphocyte infusions (DLIs) induce potent graft versus tumor (GVT) effects for relapsed chronic myelogenous leukemia (CML) after allogeneic stem cell transplantation (SCT) but are disappointing for other diseases. Disease resistance can occur if donor T cells are not appropriately activated in vivo. Ex vivo T-ce...

journal_title：Blood

authors： Porter DL,Levine BL,Bunin N,Stadtmauer EA,Luger SM,Goldstein S,Loren A,Phillips J,Nasta S,Perl A,Schuster S,Tsai D,Sohal A,Veloso E,Emerson S,June CH

更新日期：2006-02-15 00:00:00

abstract：:Recent data suggest that CD8+ T-cell effector activity is an important component in the control of HIV replication in elite controllers (ECs). One critical element of CD8+ T-cell effector function and differentiation is the T-box transcription factor T-bet. In the present study, we assessed T-bet expression, together ...

journal_title：Blood

authors： Hersperger AR,Martin JN,Shin LY,Sheth PM,Kovacs CM,Cosma GL,Makedonas G,Pereyra F,Walker BD,Kaul R,Deeks SG,Betts MR

更新日期：2011-04-07 00:00:00

abstract：:We studied the expression of the two tumor necrosis factor (TNF) receptors, p55 and p75, on B cells from patients with chronic lymphocytic leukemia (CLL), and the presence of soluble TNF receptors in serum. Expression of membrane-associated receptors was quantified by double labeling of peripheral blood mononuclear ce...

journal_title：Blood

authors： Waage A,Liabakk N,Lien E,Lamvik J,Espevik T

更新日期：1992-11-15 00:00:00

abstract：:The leukemia-specific AML1/ETO fusion gene has been shown to be detected by reverse transcriptase polymerase chain reaction (RT-PCR) analysis in patients with t(8;21) acute myelogenous leukemia (AML) in long-term remission. In the present study, the AML1/ETO mRNA could be detected by RT-PCR in bone marrow (BM) and/or ...

journal_title：Blood

authors： Miyamoto T,Nagafuji K,Akashi K,Harada M,Kyo T,Akashi T,Takenaka K,Mizuno S,Gondo H,Okamura T,Dohy H,Niho Y

更新日期：1996-06-01 00:00:00

abstract：:Cutaneous T-cell lymphomas (CTCLs) primarily affect skin and are characterized by proliferation of mature CD4(+) T-helper cells. The pattern of cytokine production in the skin and blood is considered to be of major importance for the pathogenesis of CTCLs. Abnormal cytokine expression in CTCLs may be responsible for e...

journal_title：Blood

authors： Geskin LJ,Viragova S,Stolz DB,Fuschiotti P

更新日期：2015-04-30 00:00:00

abstract：:Antiangiogenic agents and therapeutic strategies have entered the clinical oncology arena. The classical tumor size measurements defined to monitor efficacy of chemotherapy, however, might not be appropriate for these newer therapeutics. We previously found that circulating endothelial cells (CECs) were increased in n...

journal_title：Blood

authors： Mancuso P,Colleoni M,Calleri A,Orlando L,Maisonneuve P,Pruneri G,Agliano A,Goldhirsch A,Shaked Y,Kerbel RS,Bertolini F

更新日期：2006-07-15 00:00:00

abstract：:JAK3 is a tyrosine kinase that associates with the common γ chain of cytokine receptors and is recurrently mutated in T-cell acute lymphoblastic leukemia (T-ALL). We tested the transforming properties of JAK3 pseudokinase and kinase domain mutants using in vitro and in vivo assays. Most, but not all, JAK3 mutants tran...

journal_title：Blood

authors： Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J

更新日期：2014-11-13 00:00:00

abstract：:The reduced folate carrier (RFC) is involved in the transport of methotrexate (MTX) across the cell membrane. The RFC gene (SLC19A1) is located on chromosome 21, and we hypothesized that the RFC80 G>A polymorphism would affect outcome and toxicity in childhood leukemia and that this could interact with chromosome 21 c...

journal_title：Blood

authors： Gregers J,Christensen IJ,Dalhoff K,Lausen B,Schroeder H,Rosthoej S,Carlsen N,Schmiegelow K,Peterson C

更新日期：2010-06-10 00:00:00

abstract：:Murine myeloid cells can be transformed in vitro by infection with recombinant retroviruses carrying activated myb genes. While these myb-transformed hematopoietic cells (MTHCs) can proliferate continuously in culture, they exhibit several characteristics of progenitor cells of the granulocyte-macrophage (GM) lineage,...

journal_title：Blood

authors： Macmillan EM,Gonda TJ

更新日期：1994-01-01 00:00:00

abstract：:Monocytes and T helper (T(H)) cells rapidly infiltrate inflamed tissues where monocytes differentiate into inflammatory dendritic cells (DCs) through undefined mechanisms. Our studies indicate that T(H) cells frequently interact with monocytes in inflamed skin and elicit the differentiation of specialized DC subsets c...

journal_title：Blood

authors： Alonso MN,Wong MT,Zhang AL,Winer D,Suhoski MM,Tolentino LL,Gaitan J,Davidson MG,Kung TH,Galel DM,Nadeau KC,Kim J,Utz PJ,Söderström K,Engleman EG

更新日期：2011-09-22 00:00:00

abstract：:Hematofluorometric determination of zinc protoporphyrin (ZPP) is a screening method for the assessment of iron deficiency (ID). Chronic disorders are frequently accompanied by anemias of unclear origin, most probably caused by an impairment of iron metabolism. We investigated the relevance of ZPP for the detection of ...

journal_title：Blood

authors： Hastka J,Lasserre JJ,Schwarzbeck A,Strauch M,Hehlmann R

更新日期：1993-03-01 00:00:00

abstract：:All cases of multiple myeloma (MM) are preceded by precursor states termed monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). Genetic analyses of MGUS cells have provided evidence that it is a genetically advanced lesion, wherein tumor cells carry many of the genetic changes found i...

journal_title：Blood

authors： Dhodapkar MV

更新日期：2016-12-08 00:00:00

abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

journal_title：Blood

authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

更新日期：2007-05-15 00:00:00

abstract：:Aberrant regulation of endogenous survival pathways plays a major role in progression of chronic lymphocytic leukemia (CLL). Signaling via conjugation of surface receptors within the tumor environmental niche activates survival and proliferation pathways in CLL. Of these, the phosphoinositide 3-kinase (PI3K)/protein k...

journal_title：Blood

authors： Liu TM,Ling Y,Woyach JA,Beckwith K,Yeh YY,Hertlein E,Zhang X,Lehman A,Awan F,Jones JA,Andritsos LA,Maddocks K,MacMurray J,Salunke SB,Chen CS,Phelps MA,Byrd JC,Johnson AJ

更新日期：2015-01-08 00:00:00

abstract：:Seventy-one patients with acute myeloid leukemia (AML), most of them (63/71) considered ineligible for conventional allogeneic hematopoietic stem cell transplantation (HSCT), were enrolled into a phase 2 study on reduced-intensity myeloablative conditioning with fractionated 8-Gy total body irradiation (TBI) and fluda...

journal_title：Blood

authors： Stelljes M,Bornhauser M,Kroger M,Beyer J,Sauerland MC,Heinecke A,Berning B,Scheffold C,Silling G,Buchner T,Neubauer A,Fauser AA,Ehninger G,Berdel WE,Kienast J,Cooperative German Transplant Study Group.

更新日期：2005-11-01 00:00:00

abstract：:Hepatitis B virus (HBV)-infected individuals are occasionally used as donors for bone marrow transplantation (BMT). We studied the rate of HBV infection and the clinical expression of the associated liver disease in patients receiving marrow from HBsAg+ donors. We performed a retrospective survey in 14 BMT units in It...

journal_title：Blood

authors： Locasciulli A,Alberti A,Bandini G,Polchi P,Arcese W,Alessandrino P,Bosi A,Testa M,Bacigalupo A

更新日期：1995-10-15 00:00:00

abstract：:Activated factor XII (FXIIa) has plasminogen activator capacity but its relative contribution to fibrinolysis is considered marginal compared with urokinase and tissue plasminogen activator. Polyphosphate (polyP) is released from activated platelets and mediates FXII activation. Here, we investigate the contribution o...

journal_title：Blood

authors： Mitchell JL,Lionikiene AS,Georgiev G,Klemmer A,Brain C,Kim PY,Mutch NJ

更新日期：2016-12-15 00:00:00

abstract：:The initiation and progression of diffuse large B-cell lymphoma (DLBCL) is governed by genetic and epigenetic aberrations. As the most abundant eukaryotic message RNA modification, N6-methyladenosine (m6A) is known to influence various fundamental bioprocesses by regulating target gene; however, the function of m6A mo...

journal_title：Blood

authors： Han H,Fan G,Song S,Jiang Y,Qian C,Zhang W,Su Q,Xue X,Zhuang W,Li B

更新日期：2020-09-23 00:00:00

abstract：:Fetal/neonatal immune responses generally are considered to be immature and weaker than that of adults. We have studied the cord-blood T cells of newborns congenitally infected with Trypanosoma cruzi, the protozoan agent of Chagas disease. Our data demonstrate a predominant activation of CD8 T cells expressing activat...

journal_title：Blood

authors： Hermann E,Truyens C,Alonso-Vega C,Even J,Rodriguez P,Berthe A,Gonzalez-Merino E,Torrico F,Carlier Y

更新日期：2002-09-15 00:00:00

abstract：:Pluripotent hematopoietic progenitor cells (CFU-GEMM), myeloid progenitor cells (CFU-GM), and erythroid progenitors (BFU-E) were studied in midtrimester human fetuses using the mixed colony assay. All three progenitor cell populations were detected at high levels in the fetal liver from 12 to 23 wk of gestation. Stem ...

journal_title：Blood

authors： Hann IM,Bodger MP,Hoffbrand AV

更新日期：1983-07-01 00:00:00

abstract：:Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. ADAMTS13 inhibits the ...

journal_title：Blood

authors： Zhu J,Muia J,Gupta G,Westfield LA,Vanhoorelbeke K,Tolia NH,Sadler JE

更新日期：2019-04-25 00:00:00

abstract：:Rap family GTPases consist of multiple members with substantial functional redundancy. With the use of transgenic mice conditionally expressing a bona fide dominant-negative Rap1 mutant, Rap1A17, capable of inhibiting the activation of all Rap family members in B-lineage cells (mb.1-Rap1A17 Tg), we demonstrate that th...

journal_title：Blood

authors： Katayama Y,Sekai M,Hattori M,Miyoshi I,Hamazaki Y,Minato N

更新日期：2009-08-27 00:00:00

abstract：:Immunosenescence is the functional deterioration of the immune system during natural aging. Despite increased susceptibility to bacterial infections in older adults, age-associated changes to neutrophil responses are only partially understood, and neutrophil migration has not been characterized in detail. Here we desc...

journal_title：Blood

authors： Sapey E,Greenwood H,Walton G,Mann E,Love A,Aaronson N,Insall RH,Stockley RA,Lord JM

更新日期：2014-01-09 00:00:00

abstract：:The number of CD34+ cells in the peripheral blood of cancer patients is known to be increased following the administration of high dose chemotherapy and hematopoietic growth factors. These so-called peripheral blood stem cell grafts are now frequently used for autologous transplantation of patients with malignancies. ...

journal_title：Blood

authors： Murray L,Chen B,Galy A,Chen S,Tushinski R,Uchida N,Negrin R,Tricot G,Jagannath S,Vesole D

更新日期：1995-01-15 00:00:00