Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation.

abstract：:Chronic myelomonocytic leukemia (CMML) is a hematological malignancy characterized by uncontrolled proliferation of dysplastic myelomonocytes and frequent progression to acute myeloid leukemia (AML). We identified mutations in the Cbl gene, which encodes a negative regulator of cytokine signaling, in a subset of CMML ...

journal_title：Blood

authors： Nakata Y,Ueda T,Nagamachi A,Yamasaki N,Ikeda KI,Sera Y,Takubo K,Kanai A,Oda H,Sanada M,Ogawa S,Tsuji K,Ebihara Y,Wolff L,Honda ZI,Suda T,Inaba T,Honda H

更新日期：2017-04-13 00:00:00

abstract：:A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions an...

journal_title：Blood

authors： Boukerche H,Berthier-Vergnes O,Tabone E,Doré JF,Leung LL,McGregor JL

更新日期：1989-08-01 00:00:00

abstract：:A pivotal role has been assigned to Myb in the control of myeloid cell growth. Although Myb is a target of retinoic acid, little is known about the mechanisms by which it may contribute to induced growth arrest in leukemia cells. Indeed, few Myb target genes are known to be linked to proliferation. Myeloblastin is inv...

journal_title：Blood

authors： Lutz PG,Houzel-Charavel A,Moog-Lutz C,Cayre YE

更新日期：2001-04-15 00:00:00

abstract：:The EVI1 gene encodes a zinc-finger, DNA-binding protein originally described as the transforming gene associated with a common ecotropic viral insertion site in myeloid leukemias. Previous studies demonstrated EVI1 expression in human leukemias in cases with 3q26 translocations, but not in normal blood or bone marrow...

journal_title：Blood

authors： Russell M,List A,Greenberg P,Woodward S,Glinsmann B,Parganas E,Ihle J,Taetle R

更新日期：1994-08-15 00:00:00

abstract：:Macrophages and dendritic cells play an important role in regulating B-cell responses, including proliferation to antigens such as trinitrophenyl (TNP)-Ficoll and TNP-Brucella abortus. However, the mechanisms and molecule(s) that regulate these processes are relatively undefined. In this report, we show that human mac...

journal_title：Blood

authors： Craxton A,Magaletti D,Ryan EJ,Clark EA

更新日期：2003-06-01 00:00:00

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00

abstract：:The inv(11)(p15q22) is a recurrent chromosomal abnormality associated with de novo and therapy-related myeloid malignancies. Here we report the molecular definition of this chromosomal aberration in four patients. Positional cloning showed the consistent rearrangement of the DDX10 gene on chromosome 11q22, which encod...

journal_title：Blood

authors： Arai Y,Hosoda F,Kobayashi H,Arai K,Hayashi Y,Kamada N,Kaneko Y,Ohki M

更新日期：1997-06-01 00:00:00

abstract：:In this issue of Blood, Acharya and colleagues provide evidence for the role of angiogenesis in the pathophysiology of hemophilic joint disease. Is this the linchpin that unravels this important clinical condition or merely a cog in a not so stepwise process? ...

journal_title：Blood

authors： Abshire T

更新日期：2011-02-24 00:00:00

abstract：:The urokinase receptor (uPAR) plays an important role in regulation of fibronolysis, cell migration, and adhesion. In this study, we examined whether uPAR plays a role in modulating efferocytosis of neutrophils. Macrophages from uPAR(-/-) mice demonstrated enhanced ability to engulf viable wild-type (WT) neutrophils i...

journal_title：Blood

authors： Park YJ,Liu G,Tsuruta Y,Lorne E,Abraham E

更新日期：2009-07-23 00:00:00

abstract：:Among dendritic cell (DC) subsets, CD8alpha(+) DCs and plasmacytoid DCs (pDCs) produce high levels of IL12 and type I interferons (IFNs), respectively, and confer early innate immunity. Development of CD8alpha(+) DCs and pDCs requires the interferon regulatory factor 8 (IRF8). Recently, a spontaneous point mutation wa...

journal_title：Blood

authors： Tailor P,Tamura T,Morse HC 3rd,Ozato K

更新日期：2008-02-15 00:00:00

abstract：:The combined blockade of the IL-6R/STAT3 and the MAPK signaling pathways has been shown to inhibit bone marrow microenvironment (BMM)-mediated survival of multiple myeloma (MM) cells. Here, we identify the molecular chaperones heat shock proteins (Hsp) 90alpha and beta as target genes of both pathways. The siRNA-media...

journal_title：Blood

authors： Chatterjee M,Jain S,Stühmer T,Andrulis M,Ungethüm U,Kuban RJ,Lorentz H,Bommert K,Topp M,Krämer D,Müller-Hermelink HK,Einsele H,Greiner A,Bargou RC

更新日期：2007-01-15 00:00:00

abstract：:Congenital blood disorders are common and yet clinically challenging globin disorders. Gene therapy continues to serve as a potential therapeutic method to treat these disorders. While tremendous advances have been made in vivo, gene delivery protocols and vector prototypes still require optimization. Alternative cis-...

journal_title：Blood

authors： Staplin WR,Knezetic JA

更新日期：2003-03-01 00:00:00

abstract：:We compared 48-hour urinary iron excretion after a twice-daily subcutaneous bolus injection of deferoxamine and after 12 hours of subcutaneous continuous infusion of the drug in 27 patients with iron overload (mean age, 55.7 years). In most patients, the iron overload was due to multiple transfusions administered duri...

journal_title：Blood

authors： Franchini M,Gandini G,de Gironcoli M,Vassanelli A,Borgna-Pignatti C,Aprili G

更新日期：2000-05-01 00:00:00

abstract：:We here investigate the occurrence of fluoride intake-associated alterations in patients with hematologic disease on triazol antifungal medication. Clinical, laboratory, and radiology data of overall 43 patients with hematologic malignancies taking voriconazole (n = 20), posaconazole (n = 8), and itraconazole (n = 4),...

journal_title：Blood

authors： Gerber B,Guggenberger R,Fasler D,Nair G,Manz MG,Stussi G,Schanz U

更新日期：2012-09-20 00:00:00

abstract：:Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America. Here we describe a protocol for an ex vivo P vivax invasion assay that can be easily deployed in laboratories located in endemic countries. Th...

journal_title：Blood

authors： Russell B,Suwanarusk R,Borlon C,Costa FT,Chu CS,Rijken MJ,Sriprawat K,Warter L,Koh EG,Malleret B,Colin Y,Bertrand O,Adams JH,D'Alessandro U,Snounou G,Nosten F,Rénia L

更新日期：2011-09-29 00:00:00

abstract：:Precursor B-cell acute lymphoblastic leukemias (B-ALLs) have been shown to be oligoclonal at the Ig heavy-chain (IgH) gene level in up to 40% of cases by Southern blot hybridization. In contrast, oligoclonality as deduced from diversity of T-cell receptor (TcR)-delta gene rearrangements of the immature types (ie, V de...

journal_title：Blood

authors： Ghali DW,Panzer S,Fischer S,Argyriou-Tirita A,Haas OA,Kovar H,Gadner H,Panzer-Grümayer ER

更新日期：1995-05-15 00:00:00

abstract：:Myelofibrosis in myeloproliferative neoplasms (MPNs) with mutations such as JAK2V617F is an unfavorable sign for uncontrollable disease progression in the clinic and is complicated with osteosclerosis whose pathogenesis is largely unknown. Because several studies have revealed that macrophages are an indispensable sup...

journal_title：Blood

authors： Wakahashi K,Minagawa K,Kawano Y,Kawano H,Suzuki T,Ishii S,Sada A,Asada N,Sato M,Kato S,Shide K,Shimoda K,Matsui T,Katayama Y

更新日期：2019-04-11 00:00:00

abstract：:A patient with recurrent pulmonary abscess, weight loss, and alcoholism was found to have extremely high serum vitamin B12 and unsaturated vitamin B12-binding capacity (UBBC) levels. While transcobalamin (TC) II was also increased, most of his UBBC was due to an abnormal binding protein which carried greater than 80% ...

journal_title：Blood

authors： Carmel R,Tatsis B,Baril L

更新日期：1977-06-01 00:00:00

abstract：:T-cell production depends on the recruitment of hematopoietic progenitors into the thymus. T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT), but the reasons for this delay are not well understood. Under normal physiologic conditions, thymic settling is selecti...

journal_title：Blood

authors： Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A

更新日期：2011-08-18 00:00:00

abstract：:In order to determine if mutant hemoglobins can be identified by relatively simple methods, a Working Group of the ICSH Expert Panel on Abnormal Hemoglobins and Thalassemia analyzed 17 hemolysates containing 14 different mutant hemoglobins by four electrophoretic methods: (1) cellulose acetate in alkaline buffers, (2)...

journal_title：Blood

authors：

更新日期：1978-11-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) introduced in association with the luciferase reporter gene into Jurkat T cells was strongly activated by a combination of human neutrophils and phorbol myristate acetate (PMA). Activation was not observed when normal neutrophils were replaced ...

journal_title：Blood

authors： Klebanoff SJ,Headley CM

更新日期：1999-01-01 00:00:00

abstract：:The clinical approach to older patients with myeloma has to be modified to take into account comorbidities and the likelihood of higher treatment-related toxicity. Individualization of management and adequate supportive therapy are important to obtain the best response while minimizing adverse effects. Corticosteroids...

journal_title：Blood

authors： Mehta J,Cavo M,Singhal S

更新日期：2010-09-30 00:00:00

abstract：:Rituximab therapy is associated with a long in vivo persistence, yet little is known about the effect of circulating rituximab on B-cell non-Hodgkin lymphoma (B-NHL) targeting by the other available anti-CD20 monoclonal antibodies (MoAbs) (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan. Therefore we asses...

journal_title：Blood

authors： Gopal AK,Press OW,Wilbur SM,Maloney DG,Pagel JM

更新日期：2008-08-01 00:00:00

abstract：:The combination of imatinib with chemotherapy has been recently reported as very promising in patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). During 2004 and 2005, 45 patients with newly diagnosed Ph+ ALL were treated in the Group for Research on Adult Acute Lymphoblastic Leuke...

journal_title：Blood

authors： de Labarthe A,Rousselot P,Huguet-Rigal F,Delabesse E,Witz F,Maury S,Réa D,Cayuela JM,Vekemans MC,Reman O,Buzyn A,Pigneux A,Escoffre M,Chalandon Y,MacIntyre E,Lhéritier V,Vernant JP,Thomas X,Ifrah N,Dombret H,Group

更新日期：2007-02-15 00:00:00

abstract：:The variability of laboratory findings in von Willebrand's disease (vWd) was evaluated by performing serial studies of bleeding time (BT), factor VIII coagulant activity (VIII:C), factor-VIII-related antigen (VIIIR:Ag) and ristocetin cofactor (VIIIR:Rcof) in 50 individuals from 25 families with this disorder. The type...

journal_title：Blood

authors： Abildgaard CF,Suzuki Z,Harrison J,Jefcoat K,Zimmerman TS

更新日期：1980-10-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, or 5-HT), released from activated platelets, not only accelerates aggregation of platelets but also is known to promote mitosis, migration, and contraction of vascular smooth muscle cells (VSMCs). These effects are considered to contribute to thrombus formation and atherosclerosis. The ...

journal_title：Blood

authors： Kawano H,Tsuji H,Nishimura H,Kimura S,Yano S,Ukimura N,Kunieda Y,Yoshizumi M,Sugano T,Nakagawa K,Masuda H,Sawada S,Nakagawa M

更新日期：2001-03-15 00:00:00

abstract：:Neutrophilic differentiation is dependent on CCAAT enhancer-binding protein α (C/EBPα), a transcription factor expressed in multiple organs including the bone marrow. Using functional genomic technologies in combination with clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 ...

journal_title：Blood

authors： Avellino R,Havermans M,Erpelinck C,Sanders MA,Hoogenboezem R,van de Werken HJ,Rombouts E,van Lom K,van Strien PM,Gebhard C,Rehli M,Pimanda J,Beck D,Erkeland S,Kuiken T,de Looper H,Gröschel S,Touw I,Bindels E,Delwel

更新日期：2016-06-16 00:00:00

abstract：:The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hep...

journal_title：Blood

authors： Pippard MJ,Johnson DK,Finch CA

更新日期：1981-10-01 00:00:00

abstract：:Specific monoclonal and polyclonal antibody reagents and a double antigen indirect immunofluorescence microscopy technique were used to visualize coagulation factor V in human bone marrow. Marrow aspirates were smeared directly on glass slides, or washed and cytospun onto glass slides, or processed and plated into a p...

journal_title：Blood

authors： Nichols WL,Gastineau DA,Solberg LA Jr,Mann KG

更新日期：1985-06-01 00:00:00

abstract：:The c-kit proto-oncogene encodes a receptor tyrosine kinase that is thought to play an important role in hematopoiesis. In a series of human acute myeloblastic leukemia (AML), the expression of the c-kit proto-oncogene and its product was studied by means of Northern blot and immunoblot analyses. The c-kit mRNA was ex...

journal_title：Blood

authors： Ikeda H,Kanakura Y,Tamaki T,Kuriu A,Kitayama H,Ishikawa J,Kanayama Y,Yonezawa T,Tarui S,Griffin JD

更新日期：1991-12-01 00:00:00