Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy.

abstract：:Inhibitors of cyclin-dependent kinases (Cdks) have been reported to have activities in chronic lymphocytic leukemia cells by inhibiting Cdk7 and Cdk9, which control transcription. Here we studied the novel Cdk inhibitor SNS-032, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. We h...

journal_title：Blood

authors： Chen R,Wierda WG,Chubb S,Hawtin RE,Fox JA,Keating MJ,Gandhi V,Plunkett W

更新日期：2009-05-07 00:00:00

abstract：:Expression patterns of interleukin-6 (IL-6), IL-6 receptor (IL-6R), and gp130 genes in 39 patients with acute myeloid leukemia (AML), in 23 patients with acute lymphoblastic leukemia (ALL), and in 7 patients with acute mixed lineage leukemia (AMLL) were studied by quantitative reverse transcriptase-polymerase chain re...

journal_title：Blood

authors： Inoue K,Sugiyama H,Ogawa H,Yamagami T,Azuma T,Oka Y,Miwa H,Kita K,Hiraoka A,Masaoka T

更新日期：1994-10-15 00:00:00

abstract：:Incubation of human platelets, human neutrophils, or highly metastatic mouse lymphoma cells with sulfate-labeled extracellular matrix (ECM) results in heparanase-mediated release of labeled heparan sulfate cleavage fragments (0.5 less than Kav less than 0.85 on Sepharose 6B). This degradation was inhibited by native h...

journal_title：Blood

authors： Bar-Ner M,Eldor A,Wasserman L,Matzner Y,Cohen IR,Fuks Z,Vlodavsky I

更新日期：1987-08-01 00:00:00

abstract：:Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical presentation in a uniquely vulnerable host, its poor response to current therapies, and its fascinating biology. Increasingly, these biological insights are pointing the way toward novel therapeutic approaches. Using represent...

journal_title：Blood

authors： Brown P,Pieters R,Biondi A

更新日期：2019-01-17 00:00:00

abstract：:Proteolytic fragments of fibronectin (Fn) can possess properties not inherent to intact Fn. Previously, only mixtures of low molecular weight Fn fragments, and the 120-Kd fibroblastic cell-binding segment, but not intact Fn, were shown to be selectively chemotactic for human monocytes (MOs). In order to determine if o...

journal_title：Blood

authors： Lohr KM,Kurth CA,Xie DL,Seyer JM,Homandberg GA

更新日期：1990-11-15 00:00:00

abstract：:Microarray gene expression profiling studies have demonstrated immune response gene signatures that appear predictive of outcome in follicular lymphoma (FL). However, measurement of these marker genes in routine practice remains difficult. We have therefore investigated the immune response in FL using real-time polyme...

journal_title：Blood

authors： Byers RJ,Sakhinia E,Joseph P,Glennie C,Hoyland JA,Menasce LP,Radford JA,Illidge T

更新日期：2008-05-01 00:00:00

abstract：:Haploinsufficiency of ribosomal proteins (RPs) has been proposed to be the common basis for the anemia observed in Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome with loss of chromosome 5q [del(5q) MDS]. We have modeled DBA and del(5q) MDS in zebrafish using antisense morpholinos to rps19 and rps14, respec...

journal_title：Blood

authors： Payne EM,Virgilio M,Narla A,Sun H,Levine M,Paw BH,Berliner N,Look AT,Ebert BL,Khanna-Gupta A

更新日期：2012-09-13 00:00:00

abstract：:STI571 induces sustained hematologic remission in patients with chronic myeloid leukemia (CML) in chronic phase. However, in advanced phases, especially blast crisis, the leukemia usually becomes resistant within months. It has been investigated whether resistance to STI571 is stable and immutable or whether it can be...

journal_title：Blood

authors： Tipping AJ,Mahon FX,Lagarde V,Goldman JM,Melo JV

更新日期：2001-12-15 00:00:00

abstract：:Deregulation of signal transduction pathways (STPs) may promote leukemogenesis by conferring cell proliferation and survival advantages in acute myelogenous leukemia (AML). Several agents targeting STPs are under development; however, redundancy and cross-talk between STPs could activate multiple downstream effectors ...

journal_title：Blood

authors： Kornblau SM,Womble M,Qiu YH,Jackson CE,Chen W,Konopleva M,Estey EH,Andreeff M

更新日期：2006-10-01 00:00:00

abstract：:A common genetic risk factor for venous thrombosis among Caucasoid subpopulations is a polymorphism, nt G1691A, in blood coagulation factor V that replaces Arg506 with Gln and imparts resistance of factor Va to the anticoagulant, activated protein C. Haplotype analyses using six dimorphic sites in the factor V gene fo...

journal_title：Blood

authors： Zivelin A,Griffin JH,Xu X,Pabinger I,Samama M,Conard J,Brenner B,Eldor A,Seligsohn U

更新日期：1997-01-15 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation. From 1987 through 1992, 195 patients in the Benelux with recent untreated CML were randomized between low-dose IFN-alpha2b (3 MIU, 5 days/wk) or hydroxyurea...

journal_title：Blood

authors：

更新日期：1998-04-15 00:00:00

abstract：:Diverse human cancers with poor prognosis, including many lymphoid and myeloid malignancies, exhibit high levels of Mcl-1. To explore the impact of Mcl-1 overexpression on the hematopoietic compartment, we have generated vavP-Mcl-1 transgenic mice. Their lymphoid and myeloid cells displayed increased resistance to a v...

journal_title：Blood

authors： Campbell KJ,Bath ML,Turner ML,Vandenberg CJ,Bouillet P,Metcalf D,Scott CL,Cory S

更新日期：2010-10-28 00:00:00

abstract：:In the past 5 years we have witnessed significant advances in both the diagnostic process and optimal therapy for patients with essential thrombocythemia (ET). Insights into the underlying molecular mechanisms have been accompanied by the development of new diagnostic tests and by an improved understanding of the rela...

journal_title：Blood

authors： Beer PA,Erber WN,Campbell PJ,Green AR

更新日期：2011-02-03 00:00:00

abstract：:Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro-generated DCs are representative o...

journal_title：Blood

authors： Maraskovsky E,Daro E,Roux E,Teepe M,Maliszewski CR,Hoek J,Caron D,Lebsack ME,McKenna HJ

更新日期：2000-08-01 00:00:00

abstract：:Several transgenic murine models for sickle cell anemia have been developed that closely reproduce the biochemical and physiological disorders in the human disease. A comprehensive characterization is described of hematologic parameters of mature red blood cells, reticulocytes, and red cell precursors in the bone marr...

journal_title：Blood

authors： de Jong K,Emerson RK,Butler J,Bastacky J,Mohandas N,Kuypers FA

更新日期：2001-09-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is composed of large, frequently bizarre, cells of T- or null-cell phenotype that show a preferential sinusoidal growth pattern and consistent CD30 positivity. Whether these tumors represent a single entity or several, and what the exact cell origin, is controversial. Recently, gr...

journal_title：Blood

authors： Krenacs L,Wellmann A,Sorbara L,Himmelmann AW,Bagdi E,Jaffe ES,Raffeld M

更新日期：1997-02-01 00:00:00

abstract：:To know the role and initiation mechanism of the interaction of glycoprotein (GP) Ib with surface-immobilized von Willebrand factor (vWF), we examined the effect of shear stress levels on platelet binding to vWF-coated plates using a cone-and-plate type viscometer capable of loading various levels of shear stress. The...

journal_title：Blood

authors： Tsuji S,Sugimoto M,Kuwahara M,Nishio K,Takahashi Y,Fujimura Y,Ikeda Y,Yoshioka A

更新日期：1996-11-15 00:00:00

abstract：:Serine proteinase inhibitors (serpins) play a vital regulatory role in a wide range of biological processes, and serpins from viruses have been implicated in pathogen evasion of the host defence system. For the first time, we report a functional serpin gene from nematodes that may function in this manner. This gene, n...

journal_title：Blood

authors： Zang X,Yazdanbakhsh M,Jiang H,Kanost MR,Maizels RM

更新日期：1999-08-15 00:00:00

abstract：:During an 8-year period, 3,638 children from institutions of the Pediatric Oncology Group (POG) were diagnosed with acute lymphoblastic leukemia (ALL). Fifty-seven patients had Philadelphia chromosome-positive (Ph1) ALL. Blast cells obtained at diagnosis from 13 of these 57 cases (23%) were also found to have partial ...

journal_title：Blood

authors： Russo C,Carroll A,Kohler S,Borowitz M,Amylon M,Homans A,Kedar A,Shuster J,Land V,Crist W

更新日期：1991-03-01 00:00:00

abstract：:Protein disulfide isomerase (PDI) derived from intravascular cells is required for thrombus formation. However, it remains unclear whether platelet PDI contributes to the process. Using platelet-specific PDI-deficient mice, we demonstrate that PDI-null platelets have defects in aggregation and adenosine triphosphate s...

journal_title：Blood

authors： Kim K,Hahm E,Li J,Holbrook LM,Sasikumar P,Stanley RG,Ushio-Fukai M,Gibbins JM,Cho J

更新日期：2013-08-08 00:00:00

abstract：:Recent studies with long-term mouse marrow cultures have indicated the importance of the adherent layer as a primary reservoir of the most primitive stem cells, from which derivative stem cells and more differentiated progenitors are continuously generated. We have now examined the role of the adherent cell layer in l...

journal_title：Blood

authors： Coulombel L,Eaves AC,Eaves CJ

更新日期：1983-08-01 00:00:00

abstract：:Inhibitors of bromodomain and extraterminal motif proteins (BETs) are being evaluated for the treatment of cancer and other diseases, yet much remains to be learned about how BET proteins function during normal physiology. We used genomic and genetic approaches to examine BET function in a hematopoietic maturation sys...

journal_title：Blood

authors： Stonestrom AJ,Hsu SC,Jahn KS,Huang P,Keller CA,Giardine BM,Kadauke S,Campbell AE,Evans P,Hardison RC,Blobel GA

更新日期：2015-04-30 00:00:00

abstract：:The hereditary stomatocytoses are a series of dominantly inherited hemolytic anemias in which the permeability of the erythrocyte membrane to monovalent cations is pathologically increased. The causative mutations for some forms of hereditary stomatocytosis have been found in the transporter protein genes, RHAG and SL...

journal_title：Blood

authors： Flatt JF,Guizouarn H,Burton NM,Borgese F,Tomlinson RJ,Forsyth RJ,Baldwin SA,Levinson BE,Quittet P,Aguilar-Martinez P,Delaunay J,Stewart GW,Bruce LJ

更新日期：2011-11-10 00:00:00

abstract：:Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a powerful karyotyping tool in numerous translational cancer studies. SNP-A complements traditional metaphase cytogenetics with the unique ability to delineate a previously hidden chromosomal defect, copy neutral loss of heterozygosity ...

journal_title：Blood

authors： O'Keefe C,McDevitt MA,Maciejewski JP

更新日期：2010-04-08 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial dysfunction and vascular remodeling. Recently, bone marrow progenitor cells have been localized to PAH lungs, raising the question of their role in disease progression. Independently, serotonin (5-HT) and its receptors hav...

journal_title：Blood

authors： Launay JM,Hervé P,Callebert J,Mallat Z,Collet C,Doly S,Belmer A,Diaz SL,Hatia S,Côté F,Humbert M,Maroteaux L

更新日期：2012-02-16 00:00:00

abstract：:Immunizing bone marrow donors prior to bone marrow transplant (BMT) has the potential for adoptively transferring specific immunity against opportunistic pathogens. Studies have shown that long-term antibody production occurs in the bone marrow and that specific humoral immunity may be transferred from donor to recipi...

journal_title：Blood

authors： Slifka MK,Whitmire JK,Ahmed R

更新日期：1997-09-01 00:00:00

abstract：:Dendritic cells (DCs) process and present bacterial and endogenous lipid antigens in complex with CD1 molecules to T cells and invariant natural killer T (NKT) cells. However, different types of DCs, such as blood myeloid DCs and skin Langerhans cells, exhibit distinct patterns of CD1a, CD1b, CD1c, and CD1d expression...

journal_title：Blood

authors： Smed-Sörensen A,Moll M,Cheng TY,Loré K,Norlin AC,Perbeck L,Moody DB,Spetz AL,Sandberg JK

更新日期：2008-05-15 00:00:00

abstract：:Bone marrow suppression is an adverse effect associated with many antibiotics, especially when administered for prolonged treatment courses. Recent advances in our understanding of steady-state hematopoiesis have allowed us to explore the effects of antibiotics on hematopoietic progenitors in detail using a murine mod...

journal_title：Blood

authors： Josefsdottir KS,Baldridge MT,Kadmon CS,King KY

更新日期：2017-02-09 00:00:00

abstract：:Chronic granulomatous disease (CGD) is characterized by the absence of a respiratory burst in activated phagocytes. Defects in at least four different genes lead to CGD. Patients with the X-linked form of CGD have mutations in the gene for the beta-subunit of cytochrome b558 (gp91-phox). We studied the molecular defec...

journal_title：Blood

authors： de Boer M,Bolscher BG,Dinauer MC,Orkin SH,Smith CI,Ahlin A,Weening RS,Roos D

更新日期：1992-09-15 00:00:00

abstract：:Human T cells were studied with regard to the regulation of interleukin-4 (IL-4) and IL-3 gene expression. IL-4 and IL-3 mRNA were undetectable in unstimulated T cells. On activation with the lectin concanavalin A (Con A), both IL-4 and IL-3 mRNA were expressed. Accumulation of IL-4 mRNA peaked after 6 to 12 hours, wh...

journal_title：Blood

authors： Dokter WH,Esselink MT,Sierdsema SJ,Halie MR,Vellenga E

更新日期：1993-01-01 00:00:00