Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes.

Abstract:

:CD8+CD25+ cells, which expressed high levels of Foxp3, glucocorticoid-induced tumor necrosis factor receptor (GITR), CCR8, tumor necrosis factor receptor 2 (TNFR2), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) mRNAs, were identified in the fibrous septa and medullary areas of human thymus. Activated CD8+CD25+ thymocytes did not produce cytokines, but most of them expressed surface CTLA-4 and transforming growth factor beta1 (TGF-beta1). Like CD4+CD25+, CD8+CD25+ thymocytes suppressed the proliferation of autologous CD25-T cells via a contact-dependent mechanism. The suppressive activity of CD8+CD25+ thymocytes was abrogated by a mixture of anti-CTLA-4 and anti-TGF-beta1 antibodies and it was mediated by their ability to inhibit the expression of the interleukin 2 receptor alpha chain on target T cells. These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells.

journal_name

Blood

journal_title

Blood

authors

Cosmi L,Liotta F,Lazzeri E,Francalanci M,Angeli R,Mazzinghi B,Santarlasci V,Manetti R,Vanini V,Romagnani P,Maggi E,Romagnani S,Annunziato F

doi

10.1182/blood-2003-04-1320

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

4107-14

issue

12

eissn

0006-4971

issn

1528-0020

pii

2003-04-1320

journal_volume

102

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens.

    abstract::The adoptive transfer of donor T cells that recognize recipient minor histocompatibility antigens (mHAgs) is a potential strategy for preventing or treating leukemic relapse after allogeneic hematopoietic cell transplantation (HCT). A total of 7 patients with recurrent leukemia after major histocompatibility complex (...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-10-248997

    authors: Warren EH,Fujii N,Akatsuka Y,Chaney CN,Mito JK,Loeb KR,Gooley TA,Brown ML,Koo KK,Rosinski KV,Ogawa S,Matsubara A,Appelbaum FR,Riddell SR

    更新日期:2010-05-13 00:00:00

  • SRF is required for neutrophil migration in response to inflammation.

    abstract::Serum response factor (SRF) is a ubiquitously expressed transcription factor and master regulator of the actin cytoskeleton. We have previously shown that SRF is essential for megakaryocyte maturation and platelet formation and function. Here we elucidate the role of SRF in neutrophils, the primary defense against inf...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-06-507582

    authors: Taylor A,Tang W,Bruscia EM,Zhang PX,Lin A,Gaines P,Wu D,Halene S

    更新日期:2014-05-08 00:00:00

  • Characterization of nuclear factors that bind to a critical positive regulatory element of the human granulocyte-macrophage colony-stimulating factor promoter.

    abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that stimulates the proliferation, maturation, and functional activity of myeloid cells in peripheral blood and bone marrow. Expression of GM-CSF is tightly regulated and is limited to cells stimulated directly (T cells, macroph...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Fraser JK,Tran S,Nimer SD,Gasson JC

    更新日期:1994-10-15 00:00:00

  • Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck.

    abstract::Dexamethasone (DM) is a synthetic member of the glucocorticoid (GC) class of hormones that possesses anti-inflammatory and immunosuppressant activity and is commonly used to treat chronic inflammatory disorders, severe allergies, and other disease states. Although GCs are known to mediate well-defined transcriptional ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-04-151803

    authors: Ghosh MC,Baatar D,Collins G,Carter A,Indig F,Biragyn A,Taub DD

    更新日期:2009-01-15 00:00:00

  • Beyond hairy cell: the activity of cladribine in other hematologic malignancies.

    abstract::Before the contemporary development of rationally designed antineoplastic therapies, cladribine was identified as a lymphocyte-specific agent. Its profound impact on the natural history of hairy cell leukemia, with responses approaching 100% and a median duration of response of nearly a decade after only a single 7-da...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2010-02-246140

    authors: Sigal DS,Miller HJ,Schram ED,Saven A

    更新日期:2010-10-21 00:00:00

  • The osmotic fragility of erythrocytes after prolonged liquid storage and after reinfusion.

    abstract::Although it is recognized that red cells lose membrane during storage, estimation of the osmotic fragility of erythrocytes has not previously proven to be a useful measurement of the storage lesion. Erythrocytes from blood stored in CPD-A2 were found to have a markedly increased osmotic fragility. A major portion of t...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Beutler E,Kuhl W,West C

    更新日期:1982-06-01 00:00:00

  • Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28.

    abstract::TLRs expressed on dendritic cells (DCs) differentially activate DCs when activated alone or in combination, inducing distinct cytokines and costimulatory molecules that influence T-cell responses. Defining the requirements of DCs to program T cells during priming to become memory rather than effector cells could enhan...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-11-317966

    authors: Pufnock JS,Cigal M,Rolczynski LS,Andersen-Nissen E,Wolfl M,McElrath MJ,Greenberg PD

    更新日期:2011-06-16 00:00:00

  • Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes.

    abstract::The turnover rates of beta and gamma globin messenger RNAs and of beta and gamma globin protein synthesis in human reticulocytes have been measured. Our goal was to determine whether beta globin mRNA is significantly more stable than gamma globin mRNA during the final stages of erythroid cell maturation. Such a result...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Ross J,Sullivan TD

    更新日期:1985-11-01 00:00:00

  • Differential binding of plasminogen to crosslinked and noncrosslinked fibrins: its significance in hemostatic defect in factor XIII deficiency.

    abstract::In spontaneous fibrinolysis of an alpha 2-plasmin inhibitor-deficient plasma clot or tissue-type plasminogen activator-induced fibrinolysis in a purified system without alpha 2-plasmin inhibitor, the lysis was faster when factor XIII-mediated crosslinking of fibrin to fibrin did not occur. During the initial period, t...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Sakata Y,Mimuro J,Aoki N

    更新日期:1984-06-01 00:00:00

  • The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression.

    abstract::Apoptosis is an essential process in embryonic tissue remodeling and adult tissue homeostasis. Within the adult hematopoietic system, it allows for tight regulation of hematopoietic cell subsets. Previously, it was shown that B-cell leukemia 2 (Bcl-2) overexpression in the adult increases the viability and activity of...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-06-1827

    authors: Orelio C,Harvey KN,Miles C,Oostendorp RA,van der Horn K,Dzierzak E

    更新日期:2004-06-01 00:00:00

  • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties.

    abstract::Cytogenetics is considered one of the most valuable prognostic determinants in acute myeloid leukemia (AML). However, many studies on which this assertion is based were limited by relatively small sample sizes or varying treatment approach, leading to conflicting data regarding the prognostic implications of specific ...

    journal_title:Blood

    pub_type: 临床试验,杂志文章

    doi:

    authors: Grimwade D,Walker H,Oliver F,Wheatley K,Harrison C,Harrison G,Rees J,Hann I,Stevens R,Burnett A,Goldstone A

    更新日期:1998-10-01 00:00:00

  • Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function.

    abstract::The PI3K/Akt/mTOR pathway has emerged as a critical regulator of dendritic cell (DC) development and function. The kinase mTOR is found in 2 distinct complexes, mTORC1 and mTORC2. In this study, we show that mTORC1 but not mTORC2 is required for epidermal Langerhans cell (LC) homeostasis. Although the initial seeding ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-06-439786

    authors: Kellersch B,Brocker T

    更新日期:2013-01-10 00:00:00

  • Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas.

    abstract::Escape from immune detection favors both tumor survival and progression, and new approaches to circumvent this are essential to combat cancers. Nonvirulent, tumor-tropic bacteria, such as Salmonella typhimurium, can unmask a tumor by transforming it into a site of inflammation; however, the nonspecific invasiveness of...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-12-474098

    authors: Massa PE,Paniccia A,Monegal A,de Marco A,Rescigno M

    更新日期:2013-08-01 00:00:00

  • Comparison of in vitro growth characteristics of blast cell progenitors (CFU-L) in patients with myelodysplastic syndromes and acute myeloid leukemia.

    abstract::Current knowledge is inadequate to explain the different patterns of blast cell accumulation in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We compared the growth patterns of blast cell progenitors (CFU-L) in 23 patients with advanced MDS and 32 patients with de novo AML. Circulating blast progen...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Aul C,Gattermann N,Schneider W

    更新日期:1992-08-01 00:00:00

  • Identification of T lymphocytes in human mixed hemopoietic colonies.

    abstract::The addition of a T-cell growth-promoting medium (PHA-TCM) to culture conditions that support growth of multi-lineage hemopoietic colonies enhances the proliferation of cells with lymphoid morphology within these colonies. These cells were identified as T lymphocytes by their ability to form rosettes with SRBC and the...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Messner HA,Izaquirre CA,Jamal N

    更新日期:1981-08-01 00:00:00

  • Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature.

    abstract::Human polymorphonuclear leukocytes adhesion to endothelial cells during the early stage of inflammation leads to cell surface externalization of Annexin A1 (AnxA1), an effector of endogenous anti-inflammation. The antiadhesive properties of AnxA1 become operative to finely tune polymorphonuclear leukocytes transmigrat...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-02-270520

    authors: Pederzoli-Ribeil M,Maione F,Cooper D,Al-Kashi A,Dalli J,Perretti M,D'Acquisto F

    更新日期:2010-11-18 00:00:00

  • Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.

    abstract::Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in ∼12% of patients with acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2-hydroxyglutarate resulting in DNA and histone hypermethylation, which leads to blocked cellular differentiation. Enasidenib (AG-221/CC-90007) is a firs...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2017-04-779405

    authors: Stein EM,DiNardo CD,Pollyea DA,Fathi AT,Roboz GJ,Altman JK,Stone RM,DeAngelo DJ,Levine RL,Flinn IW,Kantarjian HM,Collins R,Patel MR,Frankel AE,Stein A,Sekeres MA,Swords RT,Medeiros BC,Willekens C,Vyas P,Tosolini A

    更新日期:2017-08-10 00:00:00

  • Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia.

    abstract::To characterize genetic contributions toward aberrant splicing of the hyaluronan synthase 1 (HAS1) gene in multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), we sequenced 3616 bp in HAS1 exons and introns involved in aberrant splicing, from 17 patients. We identified a total of 197 HAS1 genetic variations (...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-02-141770

    authors: Adamia S,Reichert AA,Kuppusamy H,Kriangkum J,Ghosh A,Hodges JJ,Pilarski PM,Treon SP,Mant MJ,Reiman T,Belch AR,Pilarski LM

    更新日期:2008-12-15 00:00:00

  • Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis.

    abstract::Congenital hypothyroidism (CH) is one of the most prevalent endocrine diseases, for which the underlying mechanisms remain unknown; it is often accompanied by anemia and immunodeficiency in patients. Here, we created a severe CH model together with anemia and T lymphopenia to mimic the clinical features of hypothyroid...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2017-05-783043

    authors: Zhang Y,Xue Y,Cao C,Huang J,Hong Q,Hai T,Jia Q,Wang X,Qin G,Yao J,Wang X,Zheng Q,Zhang R,Li Y,Luo A,Zhang N,Shi G,Wang Y,Ying H,Liu Z,Wang H,Meng A,Zhou Q,Wei H,Liu F,Zhao J

    更新日期:2017-11-16 00:00:00

  • Interleukin-4 induces secretion of CSF for granulocytes and CSF for macrophages by peripheral blood monocytes.

    abstract::T cells are known to interact cooperatively with monocytes to produce Colony-Stimulating Factors (CSF), although T cell-mediated signals leading to CSF secretion by monocytes are not completely understood. We have made use of Northern blot hybridization and specific bioassays to study the effects of the T cell product...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Wieser M,Bonifer R,Oster W,Lindemann A,Mertelsmann R,Herrmann F

    更新日期:1989-04-01 00:00:00

  • Two cases of carcinoma of the lung characterized by a bone marrow agar culture pattern resembling acute myeloid leukemia.

    abstract::In vitro agar culture patterns of bone marrow cells in acute myeloid leukemia may show several growth patterns, including cultures where no colonies or clusters develop, cultures with varying numbers of clusters and no colonies, or colony and cluster formation with an extremely high ratio of clusters to colonies. Twel...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: McCarthy JH,Sullivan JR,Ungar B,Metcalf D

    更新日期:1979-08-01 00:00:00

  • Analysis of leukocyte differentiation antigens in blood and bone marrow from preleukemia (refractory anemia) patients using monoclonal antibodies.

    abstract::Peripheral blood and bone marrow mononuclear cells from patients with refractory anemia (RA) or RA with sideroblasts (defined according to the revised French-American-British classification with less than 5% blast cells in the bone marrow) were analyzed using a panel of monoclonal antibodies directed against leukocyte...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Hokland P,Kerndrup G,Griffin JD,Ellegaard J

    更新日期:1986-04-01 00:00:00

  • Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia.

    abstract::Thrombopoietin (TPO), the major growth factor for cells of the megakaryocytic lineage, is removed from circulation by binding to c-mpl receptors present on platelets and megakaryocytes. We studied patients with acute lymphoblastic leukemia (ALL) or acute myeloblastic leukemia (AML) and used TPO-induced c-fos protein u...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-06-2552

    authors: Corazza F,Hermans C,D'Hondt S,Ferster A,Kentos A,Benoît Y,Sariban E

    更新日期:2006-03-15 00:00:00

  • Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1.

    abstract::The production of interleukin-1beta (IL-1beta), a powerful mediator of inflammation, is tightly regulated at several levels. However, in some pathologic conditions, a pharmacologic treatment is required to control the toxicity of excessive extracellular IL-1beta. Because of the heavy side effects of most therapies use...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Hamon Y,Luciani MF,Becq F,Verrier B,Rubartelli A,Chimini G

    更新日期:1997-10-15 00:00:00

  • Release of iron from phagocytosed Escherichia coli and uptake by neutrophil lactoferrin.

    abstract::Escherichia coli were labeled with 59Fe and then either treated with myeloperoxidase, H2O2, and chloride or opsonized and mixed with human neutrophils. The myeloperoxidase system at pH 7.4 caused release of most of the bacterial 59Fe. A similar result has been obtained by Rosen and Klebanoff (J Biol Chem 257:13731, 19...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Molloy AL,Winterbourn CC

    更新日期:1990-02-15 00:00:00

  • Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

    abstract::Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene therapy is severely limited by intrinsic HSC resistance to modification with lentiviral vectors (LVs), thus requiring high doses or repe...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2019000040

    authors: Ozog S,Timberlake ND,Hermann K,Garijo O,Haworth KG,Shi G,Glinkerman CM,Schefter LE,D'Souza S,Simpson E,Sghia-Hughes G,Carillo RR,Boger DL,Kiem HP,Slukvin I,Ryu BY,Sorrentino BP,Adair JE,Snyder SA,Compton AA,Torbet

    更新日期:2019-10-17 00:00:00

  • Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease.

    abstract::The incidence and severity of acute graft-versus-host disease (GVHD) after allogeneic transplantation using peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor (G-CSF) appear to be no worse than those after bone marrow transplantation, despite the presence of large numbers of T cells i...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Pan L,Delmonte J Jr,Jalonen CK,Ferrara JL

    更新日期:1995-12-15 00:00:00

  • Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis.

    abstract::Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a 20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of acquisition of leukemia-associated mutations were investigated using next-generation deep-sequencing in 31 CN patients who developed leukemia or MDS....

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-11-538025

    authors: Skokowa J,Steinemann D,Katsman-Kuipers JE,Zeidler C,Klimenkova O,Klimiankou M,Unalan M,Kandabarau S,Makaryan V,Beekman R,Behrens K,Stocking C,Obenauer J,Schnittger S,Kohlmann A,Valkhof MG,Hoogenboezem R,Göhring G,Rein

    更新日期:2014-04-03 00:00:00

  • IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma.

    abstract::Anaplastic large cell lymphoma (ALCL) is a T-cell malignancy predominantly driven by a hyperactive anaplastic lymphoma kinase (ALK) fusion protein. ALK inhibitors, such as crizotinib, provide alternatives to standard chemotherapy with reduced toxicity and side effects. Children with lymphomas driven by nucleophosmin 1...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2019003793

    authors: Prokoph N,Probst NA,Lee LC,Monahan JM,Matthews JD,Liang HC,Bahnsen K,Montes-Mojarro IA,Karaca-Atabay E,Sharma GG,Malik V,Larose H,Forde SD,Ducray SP,Lobello C,Wang Q,Luan SL,Pospíšilová Š,Gambacorti-Passerini C,Burk

    更新日期:2020-10-01 00:00:00

  • A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation.

    abstract::Idiopathic pneumonia syndrome (IPS) is a major complication after allogeneic bone marrow transplantation (allo-BMT) and involves the infiltration of donor leukocytes and the secretion of inflammatory cytokines. We hypothesized that leukocyte recruitment during IPS is dependent in part upon interactions between chemoki...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-08-2708

    authors: Hildebrandt GC,Duffner UA,Olkiewicz KM,Corrion LA,Willmarth NE,Williams DL,Clouthier SG,Hogaboam CM,Reddy PR,Moore BB,Kuziel WA,Liu C,Yanik G,Cooke KR

    更新日期:2004-03-15 00:00:00