Abstract:
:CD8+CD25+ cells, which expressed high levels of Foxp3, glucocorticoid-induced tumor necrosis factor receptor (GITR), CCR8, tumor necrosis factor receptor 2 (TNFR2), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) mRNAs, were identified in the fibrous septa and medullary areas of human thymus. Activated CD8+CD25+ thymocytes did not produce cytokines, but most of them expressed surface CTLA-4 and transforming growth factor beta1 (TGF-beta1). Like CD4+CD25+, CD8+CD25+ thymocytes suppressed the proliferation of autologous CD25-T cells via a contact-dependent mechanism. The suppressive activity of CD8+CD25+ thymocytes was abrogated by a mixture of anti-CTLA-4 and anti-TGF-beta1 antibodies and it was mediated by their ability to inhibit the expression of the interleukin 2 receptor alpha chain on target T cells. These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells.
journal_name
Bloodjournal_title
Bloodauthors
Cosmi L,Liotta F,Lazzeri E,Francalanci M,Angeli R,Mazzinghi B,Santarlasci V,Manetti R,Vanini V,Romagnani P,Maggi E,Romagnani S,Annunziato Fdoi
10.1182/blood-2003-04-1320subject
Has Abstractpub_date
2003-12-01 00:00:00pages
4107-14issue
12eissn
0006-4971issn
1528-0020pii
2003-04-1320journal_volume
102pub_type
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