A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells.

Abstract:

:Various virus infections cause dysfunctional hemostasis and in some instances lead to the development of viral hemorrhagic fever syndrome. How do diverse viruses induce the expression of tissue factor on vascular cells? We hypothesize that a direct stimulation of pattern recognition receptors (PRR) by viral nucleic acids may be the key. Double-stranded RNA (dsRNA) is produced by many viruses and is recognized by various PRR, including Toll-like receptor-3 (TLR3). We have investigated whether poly I:C, a model for viral dsRNA, can influence cellular hemostasis. Poly I:C could up-regulate tissue factor and down-regulate thrombomodulin expression on endothelial cells but not on monocytes. The response to poly I:C was diminished upon small interfering RNA (siRNA)-mediated inhibition of TLR3, but not other PRR. In vivo, application of poly I:C induced similar changes in the aortic endothelium of mice as determined by enface microscopy. D-dimer, a circulating marker for enhanced coagulation and fibrinolysis, and tissue fibrin deposition was elevated. All the hemostasis-related responses to poly I:C, but not cytokine secretion, were blunted in TLR3(-/-) mice. Hence, the activation of TLR3 can induce the procoagulant state in the endothelium, and this could be relevant for understanding the mechanisms of viral stimulation of hemostasis.

journal_name

Blood

journal_title

Blood

authors

Shibamiya A,Hersemeyer K,Schmidt Wöll T,Sedding D,Daniel JM,Bauer S,Koyama T,Preissner KT,Kanse SM

doi

10.1182/blood-2008-02-137901

subject

Has Abstract

pub_date

2009-01-15 00:00:00

pages

714-22

issue

3

eissn

0006-4971

issn

1528-0020

pii

blood-2008-02-137901

journal_volume

113

pub_type

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