Abstract:
:With the introduction of genomic technologies, more hereditary cancer syndromes with hematologic malignancies are being described. Up to 10% of hematologic malignancies in children and adults may be the result of an underlying inherited genetic risk. Managing these patients with hereditary hematologic malignancies, including familial leukemia, remains a clinical challenge because there is little information about these relatively rare disorders. This article covers some of the issues related to the diagnosis and interpretation of variants associated with hereditary hematologic malignancies, including the importance of an accurate family history in interpreting genetic variants associated with disease. The challenges of screening other family members and offering the most appropriate early malignancy detection is also discussed. We now have a good opportunity to better define hereditary cancer syndromes with associated hematologic malignancies and contribute to clinically effective guidelines.
journal_name
Bloodjournal_title
Bloodauthors
Kohlmann W,Schiffman JDdoi
10.1182/blood-2016-06-716704subject
Has Abstractpub_date
2016-11-24 00:00:00pages
2497-2503issue
21eissn
0006-4971issn
1528-0020pii
blood-2016-06-716704journal_volume
128pub_type
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