当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy.

Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy.

Abstract：

:Chronic myeloid leukemia (CML) with T315I mutation has been reported to have poor prognosis. We analyzed 27 patients with T315I, including 20 who developed T315I after imatinib failure (representing 11% of 186 patients with imatinib failure), and 7 of 23 who developed new mutations after second tyrosine kinase inhibitor (TKI). Median follow-up from mutation detection was 18 months. At the time of T315I detection, 10 were in chronic phase (CP), 9 in accelerated phase, and 8 in blast phase. Except for the lack of response to second TKIs (P = .002), there was no difference in patient characteristics and outcome between patients with T315I and those with other or no mutations. Patients in CP had a 2-year survival rate of 87%. Although the T315I mutation is resistant to currently available TKIs, survival of patients with T315I remains mostly dependent on the stage of the disease, with many CP patients having an indolent course.

journal_name

Blood

journal_title

Blood

authors

Jabbour E,Kantarjian H,Jones D,Breeden M,Garcia-Manero G,O'Brien S,Ravandi F,Borthakur G,Cortes J

doi

10.1182/blood-2007-11-123950

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

53-5

issue

1

eissn

0006-4971

issn

1528-0020

pii

blood-2007-11-123950

journal_volume

112

pub_type

杂志文章

相关文献

BLOOD文献大全
  • AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML.

    abstract：:The nonobese diabetic/severe combined immunodeficient (NOD/SCID) assay is the current model for assessment of human normal and leukemic stem cells. We explored why 51% of 59 acute myeloid leukemia (AML) patients were unable to initiate leukemia in NOD/SCID mice. Increasing the cell dose, using more permissive recipien...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-06-2325

    authors： Pearce DJ,Taussig D,Zibara K,Smith LL,Ridler CM,Preudhomme C,Young BD,Rohatiner AZ,Lister TA,Bonnet D

    更新日期：2006-02-01 00:00:00

  • An autoantibody directed against human thrombin anion-binding exosite in a patient with arterial thrombosis: effects on platelets, endothelial cells, and protein C activation.

    abstract：:An autoantibody, developed by a patient with severe and recurrent arterial thrombosis, was characterized to be directed against the anion-binding exosite of thrombin, and inhibited all thrombin interactions requiring this secondary binding site without interfering with the catalytic site. The effect of the antibody wa...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Arnaud E,Lafay M,Gaussem P,Picard V,Jandrot-Perrus M,Aiach M,Rendu F

    更新日期：1994-09-15 00:00:00

  • The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients.

    abstract：:Staining with CD14 and CD16 monoclonal antibodies will identify two monocyte subpopulations in human blood: a major population of regular monocytes, which strongly expresses the CD14 antigen (CD14++), and a minor population with weak expression of CD14 and expression of the CD16 antigen (CD14+/CD16+ cells). As shown h...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Fingerle G,Pforte A,Passlick B,Blumenstein M,Ströbel M,Ziegler-Heitbrock HW

    更新日期：1993-11-15 00:00:00

  • T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells.

    abstract：:In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils represents an independent prognostic factor. These cell subsets include monocytic and granulocytic myeloid-derived suppressor cells (M- and G-MDSCs) defined by their ability to suppress T-cell responses. MDSCs are a heterogen...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2015-08-662783

    authors： Azzaoui I,Uhel F,Rossille D,Pangault C,Dulong J,Le Priol J,Lamy T,Houot R,Le Gouill S,Cartron G,Godmer P,Bouabdallah K,Milpied N,Damaj G,Tarte K,Fest T,Roussel M

    更新日期：2016-08-25 00:00:00

  • The response of red cell hexose monophosphate shunt after sulfhydryl inhibition.

    abstract：:In this investigation, we studied the importance of cellular glutathione (GSH) in the hexose monophosphate shunt (HMPS) activity of unstimulated human erythrocytes and the mechanism by which pyruvate stimulates the HMPS. The rate of HMPS activity was measured by the production of radioactive CO2 from 14C-1-glucose or ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Sagone AL Jr,Balcerzak SP,Metz EN

    更新日期：1975-01-01 00:00:00

  • In vivo studies of the role of factor VII in hemostasis.

    abstract：:The effect of both congenital and acquired factor VII deficiency on the cuticle bleeding time (CBT) was evaluated in dogs. The CBT has been previously documented to be a sensitive indicator of factor VIII:C deficiency in hemophilic dogs. Serial CBT determinations were made on normal dogs treated with high-dose warfari...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Giles AR,Tinlin S,Brosseau L,Hoogendoorn H

    更新日期：1985-05-01 00:00:00

  • Failure of W/Wv mouse-derived cultured mast cells to enter S phase upon contact with NIH/3T3 fibroblasts.

    abstract：:Although W/Wv mutant mice are profoundly deficient in tissue mast cells, these mice do have cells with similar features of mast cells that develop from their bone marrow cells as efficiently as those from congenic +/+ mice in pokeweed mitogen-stimulated spleen cell-conditioned medium (PWM-SCM). With cultured mast cell...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Fujita J,Nakayama H,Onoue H,Ebi Y,Kanakura Y,Kuriu A,Kitamura Y

    更新日期：1988-08-01 00:00:00

  • HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.

    abstract：:Human immunodeficiency virus type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry. It was recently demonstrated that HIV-1 glycoprotein 120 (gp120) elevated calcium and activated several ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v98.10.2909

    authors： Del Corno M,Liu QH,Schols D,de Clercq E,Gessani S,Freedman BD,Collman RG

    更新日期：2001-11-15 00:00:00

  • Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation.

    abstract：:Multinucleated giant cells (MGC) are a common feature of granulomas that develop during various inflammatory reactions. MGC originate from fusion of monocytes or macrophages, but the exact mechanism of their generation is still unclear. In the present study, we investigated the influence of monocyte to macrophage matu...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Möst J,Spötl L,Mayr G,Gasser A,Sarti A,Dierich MP

    更新日期：1997-01-15 00:00:00

  • Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells.

    abstract：:Internal tandem duplication of the Fms-like tyrosine kinase-3 receptor (FLT3) internal tandem duplication (ITD) is found in 30% of acute myeloid leukemia (AML) and is associated with a poor outcome. In addition to tyrosine kinase inhibitors, therapeutic strategies that modulate the expression of FLT3-ITD are also prom...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2015-05-646497

    authors： Larrue C,Saland E,Boutzen H,Vergez F,David M,Joffre C,Hospital MA,Tamburini J,Delabesse E,Manenti S,Sarry JE,Récher C

    更新日期：2016-02-18 00:00:00

  • Factors affecting duration of survival after onset of blastic transformation of chronic myeloid leukemia.

    abstract：:We analyzed factors having an impact on response to treatment and survival in 78 consecutive patients with chronic myeloid leukemia (CML) in blastic transformation (BT) referred to the Hammersmith Hospital from January 1995 to December 2000. BT was defined as the presence of at least 30% blasts in blood or marrow or e...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.7.2304

    authors： Wadhwa J,Szydlo RM,Apperley JF,Chase A,Bua M,Marin D,Olavarria E,Kanfer E,Goldman JM

    更新日期：2002-04-01 00:00:00

  • Distribution of complement receptor subtypes in non-Hodgkin's lymphomas of B-cell origin.

    abstract：:Surface receptors specific for either the C4b (CR1) or C3d (CR2) component of complement were examined on the neoplastic cells from 30 cases of non-Hodgkin's lymphoma of B-cell origin and on cells derived from 9 normal lymphoid tissues. Lymphocyte suspensions from non-neoplastic peripheral blood, tonsils, and lymph no...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Cossman J,Jaffe ES

    更新日期：1981-07-01 00:00:00

  • Hematopoietic cell transplantation and HIV cure: where we are and what next?

    abstract：:The report of the so-called Berlin patient cured of HIV with hematopoietic stem cell transplantation and a few other studies raised tremendous hope, excitement, and curiosity in the field. The National Heart, Lung and Blood Institute of the National Institutes of Health convened a Working Group to address emerging hea...

    journal_title：Blood

    pub_type：

    doi：10.1182/blood-2013-07-518316

    authors： Zou S,Glynn S,Kuritzkes D,Shah M,Cook N,Berliner N,NHLBI AIDS Blood Session Working Group.

    更新日期：2013-10-31 00:00:00

  • Use of unrelated marrow grafts compensates for reduced graft-versus-leukemia reactivity after T-cell-depleted allogeneic marrow transplantation for chronic myelogenous leukemia.

    abstract：:The effect of donor/recipient histocompatibility on relapse in patients receiving T-cell-depleted (TCD) grafts for chronic myelogenous leukemia (CML) was evaluated. Specifically, we sought to determine whether TCD results in an attenuation of the graft-versus-leukemia (GVL) effect on recipients of unrelated marrow gra...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Hessner MJ,Endean DJ,Casper JT,Horowitz MM,Keever-Taylor CA,Roth M,Flomenberg N,Drobyski WR

    更新日期：1995-11-15 00:00:00

  • TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Resear

    abstract：:Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-10-054601

    authors： Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

    更新日期：2007-07-15 00:00:00

  • Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia.

    abstract：:The best initial therapy for elderly patients with chronic lymphocytic leukemia (CLL) has not yet been defined. We investigated the activity of lenalidomide as initial therapy for elderly patients with CLL. Sixty patients with CLL 65 years of age and older received treatment with lenalidomide orally 5 mg daily for 56 ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-03-339077

    authors： Badoux XC,Keating MJ,Wen S,Lee BN,Sivina M,Reuben J,Wierda WG,O'Brien SM,Faderl S,Kornblau SM,Burger JA,Ferrajoli A

    更新日期：2011-09-29 00:00:00

  • In situ immunologic characterization of cellular constituents in lymph nodes and spleens involved by Hodgkin's disease.

    abstract：:The cellular constituents in lymph nodes and spleens of patients with Hodgkin's disease were studied with a series of monoclonal antibodies directed against human thymocyte, peripheral T-cell, and la antigens. Utilizing both an immunoperoxidase technique on frozen tissue sections and indirect immunofluorescence on cel...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Poppema S,Bhan AK,Reinherz EL,Posner MR,Schlossman SF

    更新日期：1982-02-01 00:00:00

  • MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma.

    abstract：:Oncogenic EZH2 is overexpressed and extensively involved in the pathophysiology of different cancers including extranodal natural killer/T-cell lymphoma (NKTL). However, the mechanisms regarding EZH2 upregulation is poorly understood, and it still remains untargetable in NKTL. In this study, we examine EZH2 protein tu...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019000381

    authors： Li B,Yan J,Phyu T,Fan S,Chung TH,Mustafa N,Lin B,Wang L,Eichhorn PJA,Goh BC,Ng SB,Kappei D,Chng WJ

    更新日期：2019-12-05 00:00:00

  • IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo.

    abstract：:Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gammadelta T cells limit CD8 T-cell expansion but not the initial proliferation after transfer into lymphopenic recipients. Int...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-12-192997

    authors： Do JS,Min B

    更新日期：2009-06-18 00:00:00

  • Parsaclisib, a potent and highly selective PI3Kδ inhibitor, in patients with relapsed or refractory B-cell malignancies.

    abstract：:This phase 1/2 study assessed parsaclisib (INCB050465), a next-generation, potent, and highly selective phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor, in patients with relapsed or refractory B-cell malignancies, alone or in combination with a Janus kinase 1 inhibitor (itacitinib) or chemotherapy (rituximab, ifosfa...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2018-08-867499

    authors： Forero-Torres A,Ramchandren R,Yacoub A,Wertheim MS,Edenfield WJ,Caimi P,Gutierrez M,Akard L,Escobar C,Call J,Persky D,Iyer S,DeMarini DJ,Zhou L,Chen X,Dawkins F,Phillips TJ

    更新日期：2019-04-18 00:00:00

  • Loss of circulating CD27+ memory B cells and CCR4+ T cells occurring in association with elevated EBV loads in XLP patients surviving primary EBV infection.

    abstract：:Detailed longitudinal studies of patients with X-linked lymphoproliferative disease (XLP) may increase our understanding of the immunologic defects that contribute to the development of lymphoma and hypogammaglobulinemia in XLP. We describe progressive changes observed in immunoglobulin concentrations, lymphocyte subs...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-07-2525

    authors： Malbran A,Belmonte L,Ruibal-Ares B,Baré P,Massud I,Parodi C,Felippo M,Hodinka R,Haines K,Nichols KE,de Bracco MM

    更新日期：2004-03-01 00:00:00

  • Alloantibodies in von Willebrand disease.

    abstract：:The development of alloantibodies against von Willebrand factor (VWF) represents a rare but serious complication of treatment of von Willebrand disease (VWD), occurring in ~5% to 10% of type 3 VWD patients. Affected patients can present with a range of symptoms, including lack or loss of hemostatic response to infused...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2012-10-462085

    authors： James PD,Lillicrap D,Mannucci PM

    更新日期：2013-08-01 00:00:00

  • Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells.

    abstract：:CXC ligand 12 (CXCL12; also known as stromal cell-derived factor 1alpha/SDF-1alpha) chemoattracts hematopoietic stem and progenitor cells (HSCs/HPCs) and is thought to play a crucial role in the mobilization of HSCs/HPCs from the bone marrow. CD26 (dipeptidylpeptidase IV [DPPIV]) is a membrane-bound extracellular pept...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-12-3893

    authors： Christopherson KW 2nd,Cooper S,Broxmeyer HE

    更新日期：2003-06-15 00:00:00

  • Polyclonal long-term repopulating stem cell clones in a primate model.

    abstract：:Hematopoietic bone marrow stem cells generate differentiated blood cells and, when transplanted, may contribute to other organs, such as the brain, heart, and liver. An understanding of in vivo clonal behavior of stem cells will have important implications for cellular and gene therapy. For the first time, we have dir...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-02-0407

    authors： Schmidt M,Zickler P,Hoffmann G,Haas S,Wissler M,Muessig A,Tisdale JF,Kuramoto K,Andrews RG,Wu T,Kiem HP,Dunbar CE,von Kalle C

    更新日期：2002-10-15 00:00:00

  • -245 bp of 5'-flanking region from the human platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo.

    abstract：:Platelet factor 4 (PF4) serves as a lineage-specific marker of megakaryocyte development. We previously identified two positively acting sequences in the human platelet factor 4 (hPF4) gene promoter that synergized to drive high-level luciferase reporter gene expression in vitro. Using portions of the hPF4 5'-flanking...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Cui Z,Reilly MP,Surrey S,Schwartz E,McKenzie SE

    更新日期：1998-04-01 00:00:00

  • Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoiesis.

    abstract：:Lactoferrin is a major constituent of polymorphonuclear leukocyte granules and is present in mature neutrophils but not in blasts or promyelocytes. We have isolated a cDNA probe for lactoferrin and used it to study the synthesis of lactoferrin mRNA by normal and leukemic granulocyte precursors. The probe pHL-41 has be...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Rado TA,Wei XP,Benz EJ Jr

    更新日期：1987-10-01 00:00:00

  • T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

    abstract：:The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely impairs the development and function of B cells but not T cells. Here w...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-07-038620

    authors： Deane JA,Kharas MG,Oak JS,Stiles LN,Luo J,Moore TI,Ji H,Rommel C,Cantley LC,Lane TE,Fruman DA

    更新日期：2007-04-01 00:00:00

  • The human Kell blood group gene maps to chromosome 7q33 and its expression is restricted to erythroid cells.

    abstract：:The Kell blood group is one of the major antigenic systems in human red blood cells. To determine the location of the Kell gene on human chromosomes, panels containing genomic DNA of human-hamster somatic cell hybrids were hybridized with radiolabeled cDNA probe specific for the Kell locus. Only the samples containing...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Lee S,Zambas ED,Marsh WL,Redman CM

    更新日期：1993-05-15 00:00:00

  • AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model.

    abstract：:As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to comb...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2012-10-464677

    authors： Wunderlich M,Mizukawa B,Chou FS,Sexton C,Shrestha M,Saunthararajah Y,Mulloy JC

    更新日期：2013-03-21 00:00:00

  • Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells.

    abstract：:Thioredoxin (Trx) is a ubiquitous protein disulfide oxidoreductase with antioxidant, cytokine, and chemotactic properties. Previously, we showed that Trx, in synergy with interleukin 1 (IL-1), IL-2, IL-4, tumor necrosis factor alpha (TNF-alpha), and CD40-ligation induced S-phase entry and mitosis in normal B cells and...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Nilsson J,Söderberg O,Nilsson K,Rosén A

    更新日期：2000-02-15 00:00:00