SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia.

abstract：:Regulatory T (Treg) cells contribute to immune evasion by malignancies. To investigate their importance in non-Hodgkin lymphoma (NHL), we enumerated Treg cells in peripheral blood mononuclear cells (PBMCs) and involved tissues from 30 patients. CD25(+)FoxP3(+)CD127(low)CD4(+) Treg cells were increased markedly in PBMC...

journal_title：Blood

authors： Mittal S,Marshall NA,Duncan L,Culligan DJ,Barker RN,Vickers MA

更新日期：2008-06-01 00:00:00

abstract：:Intestinal mucosal mast cells (IMMC) express granule neutral proteases that are regulated by T-cell-derived cytokines, including interleukin-3 (IL-3) and IL-9, and by stem cell factor (SCF). The IMMC-specific chymase, mouse mast cell protease-1 (mMCP-1), is released in substantial quantities into the blood stream duri...

journal_title：Blood

authors： Miller HR,Wright SH,Knight PA,Thornton EM

更新日期：1999-05-15 00:00:00

abstract：:Using a cohort of C57BL/6 (B6) x (NZB x B6)F1 backcross male mice bearing the Yaa (Y-linked autoimmune acceleration) mutation, we mapped and characterized the NZB-derived susceptibility loci predisposing to the development of autoimmune hemolytic anemia (AHA). Our analysis identified 2 major loci on NZB chromosome 7 a...

journal_title：Blood

authors： Kikuchi S,Amano H,Amano E,Fossati-Jimack L,Santiago-Raber ML,Moll T,Ida A,Kotzin BL,Izui S

更新日期：2005-08-15 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a disease that affects not only red cells, but other blood cells as well. The common defect is supposed to be an acquired deficiency of glycosyl-phosphatidylinositol (GPI)-anchored membrane proteins, which may be present already at the hematopoietic stem cell level. Recentl...

journal_title：Blood

authors： van der Schoot CE,Huizinga TW,van 't Veer-Korthof ET,Wijmans R,Pinkster J,von dem Borne AE

更新日期：1990-11-01 00:00:00

abstract：:The Bcl-2 proto-oncogene was discovered at the t(14;18) breakpoint found in most follicular B-cell lymphomas and some diffuse large-cell lymphomas. Bcl-2 is unique among proto-oncogenes, being localized to mitochondria and extending cell survival by blocking programmed cell death. We examined Bcl-2 protein expression ...

journal_title：Blood

authors： Zutter M,Hockenbery D,Silverman GA,Korsmeyer SJ

更新日期：1991-08-15 00:00:00

abstract：:The intracellular Ca(2+) concentration of many nonexcitable cells is regulated by calcium store release and store-operated calcium entry (SOCE). In platelets, STIM1 was recently identified as the main calcium sensor expressed in the endoplasmic reticulum. To evaluate the role of the SOC channel moiety, Orai1, in plate...

journal_title：Blood

authors： Bergmeier W,Oh-Hora M,McCarl CA,Roden RC,Bray PF,Feske S

更新日期：2009-01-15 00:00:00

abstract：:Human invariant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogeneous and are capable of enacting diverse functions, and the composition of iNKT cell subsets can alter disease outcomes. In ...

journal_title：Blood

authors： Erkers T,Xie BJ,Kenyon LJ,Smith B,Rieck M,Jensen KP,Ji X,Basina M,Strober S,Negrin RS,Maecker HT,Meyer EH

更新日期：2020-03-12 00:00:00

abstract：:We have used a combination of hematopoietic growth factors to induce in vitro granulocytic maturation. A fraction of marrow cells enriched for hematopoietic progenitor cells (CD34+, HLA-DR+) was isolated from normal human bone marrow by monoclonal antibody staining and fluorescence-activated cell sorting. Cells were c...

journal_title：Blood

authors： Berliner N,Hsing A,Graubert T,Sigurdsson F,Zain M,Bruno E,Hoffman R

更新日期：1995-02-01 00:00:00

abstract：:There are many reports in the literature of blood test abnormalities occurring in patients with venous or arterial thrombosis. Most of these have not used acceptable criteria for establishing an association between thrombosis and blood tests and, therefore, their interpretation is questionable. Recently, sensitive and...

journal_title：Blood

authors： Hirsh J

更新日期：1981-01-01 00:00:00

abstract：:Pim kinases are involved in B-cell development and are overexpressed in B-cell chronic lymphocytic leukemia (CLL). We hypothesized that Pim kinase inhibition would affect B-cell survival. Identified from a screen of imidazo[1,2-b]pyridazine compounds, SGI-1776 inhibits Pim-1, Pim-2, and Pim-3. Treatment of CLL cells w...

journal_title：Blood

authors： Chen LS,Redkar S,Bearss D,Wierda WG,Gandhi V

更新日期：2009-11-05 00:00:00

abstract：:Fibrin is essential for hemostasis; however, abnormal fibrin formation is hypothesized to increase thrombotic risk. We previously showed that in situ thrombin generation on a cell's surface modulates the 3-dimensional structure and stability of the fibrin network. Currently, we compared the abilities of extravascular ...

journal_title：Blood

authors： Campbell RA,Overmyer KA,Selzman CH,Sheridan BC,Wolberg AS

更新日期：2009-11-26 00:00:00

abstract：:Studies on purified blood dendritic cells (DCs) are hampered by poor viability in tissue culture. We, therefore, attempted to study some of the interactions/relationships between DCs and other blood cells by culturing unseparated peripheral blood mononuclear cell (PBMC) preparations in vitro. Flow cytometric technique...

journal_title：Blood

authors： Ho CS,Munster D,Pyke CM,Hart DN,López JA

更新日期：2002-04-15 00:00:00

abstract：:The presence of multiple VHDJH joinings in upwards of 30% of acute lymphoblastic leukemias (ALL) suggests a relative instability of the rearranged immunoglobulin heavy chain (IgH) gene, but the mechanisms involved are not completely understood. An investigation of the structure of the VHDJH joinings using complementar...

journal_title：Blood

authors： Wasserman R,Yamada M,Ito Y,Finger LR,Reichard BA,Shane S,Lange B,Rovera G

更新日期：1992-01-01 00:00:00

abstract：:The inv(16)(p13q22) and t(16;16)(p13;q22) cytogenetic abnormalities occur commonly in acute myeloid leukemia (AML), typically associated with French-American-British (FAB) AML-M4Eo subtype. Reverse transcriptase-polymerase chain reaction (RT-PCR) techniques have been recently developed to detect the presence of severa...

journal_title：Blood

authors： Viswanatha DS,Chen I,Liu PP,Slovak ML,Rankin C,Head DR,Willman CL

更新日期：1998-03-15 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) have previously been reported to mediate phagocytosis of anti-CD20-opsonized B cells from patients with chronic lymphocytic leukemia (CLL). However, recent data have suggested that PMNs, like macrophages, can also mediate trogocytosis. We have performed experiments to more precisel...

journal_title：Blood

authors： Valgardsdottir R,Cattaneo I,Klein C,Introna M,Figliuzzi M,Golay J

更新日期：2017-05-11 00:00:00

abstract：:Managing vitamin K antagonist (VKA) therapy is challenging in children because of a narrow therapeutic range and wide inter- and intra-individual variability in dose response. Only a few small studies have investigated the effect of nongenetic and genetic factors on the dose response to VKAs in children. In a cohort s...

journal_title：Blood

authors： Moreau C,Bajolle F,Siguret V,Lasne D,Golmard JL,Elie C,Beaune P,Cheurfi R,Bonnet D,Loriot MA

更新日期：2012-01-19 00:00:00

abstract：:3-Hydroxypropyl flufenamide (Flu-HPA) is one of a series of flufenamic acid derivatives that enhances blood clot lysis in vitro. Studies of possible mechanisms of action of Flu-HPA were undertaken. The profibrinolytic activity of Flu-HPA in clot lysis assays was found to be dependent on plasminogen. The influence of F...

journal_title：Blood

authors： Miles LA,Burnier JP,Verlander MS,Goodman M,Kleiss AJ,Griffin JH

更新日期：1981-06-01 00:00:00

abstract：:The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate gamma-globin expression via a p38 mitogen-activating protein kinase (MAPK)-dependent mechanism. We hypothesized that down-stream effectors of p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP response element (CRE...

journal_title：Blood

authors： Sangerman J,Lee MS,Yao X,Oteng E,Hsiao CH,Li W,Zein S,Ofori-Acquah SF,Pace BS

更新日期：2006-11-15 00:00:00

abstract：:The hematopoietically expressed homeobox gene, Hhex, is a transcription factor that is important for development of definitive hematopoietic stem cells (HSCs) and B cells, and that causes T-cell leukemia when overexpressed. Here, we have used an Hhex inducible knockout mouse model to study the role of Hhex in adult he...

journal_title：Blood

authors： Jackson JT,Nasa C,Shi W,Huntington ND,Bogue CW,Alexander WS,McCormack MP

更新日期：2015-01-29 00:00:00

abstract：:Multiple lines of evidence indicate that thrombopoietin (TPO) substantially impacts the number of hematopoietic stem cells and progenitors of all myeloid lineages. Nevertheless, tpo knock-out mice (T(-)) display thrombocytopenia only; blood erythroid and neutrophil levels are normal despite 60% to 85% reductions in st...

journal_title：Blood

authors： Kaushansky K,Fox N,Lin NL,Liles WC

更新日期：2002-05-15 00:00:00

abstract：:Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). We investigated the feasibility of intensified preemptive immunotherapy in children receiving allo-SCT for AML. Eighty-four...

journal_title：Blood

authors： Rettinger E,Willasch AM,Kreyenberg H,Borkhardt A,Holter W,Kremens B,Strahm B,Woessmann W,Mauz-Koerholz C,Gruhn B,Burdach S,Albert MH,Schlegel PG,Klingebiel T,Bader P

更新日期：2011-11-17 00:00:00

abstract：:Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cel...

journal_title：Blood

authors： Nilsson L,Edén P,Olsson E,Månsson R,Astrand-Grundström I,Strömbeck B,Theilgaard-Mönch K,Anderson K,Hast R,Hellström-Lindberg E,Samuelsson J,Bergh G,Nerlov C,Johansson B,Sigvardsson M,Borg A,Jacobsen SE

更新日期：2007-10-15 00:00:00

abstract：:Using Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) as a model, our aim has been to develop a molecular cytogenetic method of high resolution analysis for monitoring the frequency of cells with nonrandom chromosome rearrangements in the bone marrow of patients receiving treatment for hemato...

journal_title：Blood

authors： Seong DC,Kantarjian HM,Ro JY,Talpaz M,Xu J,Robinson JR,Deisseroth AB,Champlin RE,Siciliano MJ

更新日期：1995-09-15 00:00:00

abstract：:Biologic responses to cytokines are mediated by intracellular pathways involving induction of signaling and metabolic cascades. Interferon (IFN) regulatory factor-1 (IRF-1) is a major transcription factor induced not only by IFN-gamma but also by other cytokines including tumor necrosis factor-alpha (TNF-alpha). Possi...

journal_title：Blood

authors： Sato T,Selleri C,Young NS,Maciejewski JP

更新日期：1995-11-01 00:00:00

abstract：:This study describes a simple and relatively rapid method of purifying Reed-Sternberg (R-S) cells and their morphologic variants from the lymph nodes of patients affected by Hodgkin's disease. Our initial studies defined the optimal procedure for a quantitative disaggregation of Hodgkin's lymph nodes and the densities...

journal_title：Blood

authors： Sitar G,Brusamolino E,Bernasconi C,Ascari E

更新日期：1989-01-01 00:00:00

abstract：:A large English pedigree in which heterocellular hereditary persistence of fetal hemoglobin (HPFH) segregates is described. beta-globin cluster deletions and gamma gene promoter mutations associated with HPFH have been excluded. Of particular importance in this pedigree is the absence of any cosegregating hemoglobinop...

journal_title：Blood

authors： Craig JE,Rochette J,Sampietro M,Wilkie AO,Barnetson R,Hatton CS,Demenais F,Thein SL

更新日期：1997-07-01 00:00:00

abstract：:The combined blockade of the IL-6R/STAT3 and the MAPK signaling pathways has been shown to inhibit bone marrow microenvironment (BMM)-mediated survival of multiple myeloma (MM) cells. Here, we identify the molecular chaperones heat shock proteins (Hsp) 90alpha and beta as target genes of both pathways. The siRNA-media...

journal_title：Blood

authors： Chatterjee M,Jain S,Stühmer T,Andrulis M,Ungethüm U,Kuban RJ,Lorentz H,Bommert K,Topp M,Krämer D,Müller-Hermelink HK,Einsele H,Greiner A,Bargou RC

更新日期：2007-01-15 00:00:00

abstract：:In this issue of Blood, Neufeld and colleagues present promising results on the safety and efficacy of a novel iron chelator for the treatment of transfusional iron overload. ...

journal_title：Blood

authors： Taher AT,Musallam KM

更新日期：2012-04-05 00:00:00

abstract：:In this issue of Blood, Rowley et al report that noncoding RNAs precisely regulate the messenger RNA (mRNA) profile in platelets. Interfering in this process using genetically engineered mice affects hemostatic and thrombotic functions of platelets. ...

journal_title：Blood

authors： Boilard E,Belleannée C

更新日期：2016-04-07 00:00:00

abstract：:The endothelium, as the interface between blood and all tissues, plays a critical role in inflammation. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid, highly abundant in plasma, that potently regulates endothelial responses through interaction with its receptors (S1PRs). Here, we studied the role of S1PR2 ...

journal_title：Blood

authors： Zhang G,Yang L,Kim GS,Ryan K,Lu S,O'Donnell RK,Spokes K,Shapiro N,Aird WC,Kluk MJ,Yano K,Sanchez T

更新日期：2013-07-18 00:00:00