Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.

abstract：:T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MT...

journal_title：Blood

authors： Madani A,Choukroun V,Soulier J,Cacheux V,Claisse JF,Valensi F,Daliphard S,Cazin B,Levy V,Leblond V,Daniel MT,Sigaux F,Stern MH

更新日期：1996-03-01 00:00:00

abstract：:Rh blood group antigens of the D, C/c, and E/e series are carried by at least three red cell membrane polypeptides encoded by two highly related genes, RHD and RHCE. Homozygous individuals carrying the D--, Dc-, and DCw- gene complexes are characterized by a total or partial lack of expression of the RHCE-encoded anti...

journal_title：Blood

authors： Chérif-Zahar B,Raynal V,D'Ambrosio AM,Cartron JP,Colin Y

更新日期：1994-12-15 00:00:00

abstract：:Erythroid cell iron and transferrin uptake and release was studied in the anemia of the Belgrade laboratory rat (gene symbol, b), an autosomal recessive trait characterized by hypochromia and hyperferrinemia. When reticulocyte-rich red cells were incubated in vitro with doubly (59Fe, 125I) labeled transferrin, b/b cel...

journal_title：Blood

authors： Edwards JA,Sullivan AL,Hoke JE

更新日期：1980-04-01 00:00:00

abstract：:Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth factor-beta superfamily and has been identified in different contexts as a hypoxia-inducible gene product and as a molecule involved in hepcidin regulation. The biology of iron and oxygen is closely related, and known regulatory ...

journal_title：Blood

authors： Lakhal S,Talbot NP,Crosby A,Stoepker C,Townsend AR,Robbins PA,Pugh CW,Ratcliffe PJ,Mole DR

更新日期：2009-02-12 00:00:00

abstract：:A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibl...

journal_title：Blood

authors： Ramsay NK,Kim T,Nesbit ME,Krivit W,Coccia PF,Levitt SH,Woods WG,Kersey JH

更新日期：1980-02-01 00:00:00

abstract：:Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor immunity. However, the underlying reasons for this impaired NK cell function remain to be uncovered. We found that NK cells in aggressive B-cell lymphoma underwen...

journal_title：Blood

authors： Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

更新日期：2020-12-24 00:00:00

abstract：:B-lymphoid kinase (Blk) is exclusively expressed in B cells and thymocytes. Interestingly, transgenic expression of a constitutively active form of Blk in the T-cell lineage of mice results in the development of T-lymphoid lymphomas. Here, we demonstrate nuclear factor-kappa B (NF-kappaB)-mediated ectopic expression o...

journal_title：Blood

authors： Krejsgaard T,Vetter-Kauczok CS,Woetmann A,Kneitz H,Eriksen KW,Lovato P,Zhang Q,Wasik MA,Geisler C,Ralfkiaer E,Becker JC,Ødum N

更新日期：2009-06-04 00:00:00

abstract：:The development of peroxidase (PO) reaction in the nuclear envelope (NE) and endoplasmic reticulum (ER) of monocytes differentiating in vitro and its relationship with arachidonic acid metabolism were studied. The PO, as visualized by the diaminobenzidine (DAB) technique, appeared in the NE and ER of the majority of m...

journal_title：Blood

authors： Deimann W,Seitz M,Gemsa D,Fahimi HD

更新日期：1984-08-01 00:00:00

abstract：:Human T-cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells both in vivo and in vitro. However, the long latency period between infection and development of ATL, as well as the small fraction of the infected population that actually develops this disease, su...

journal_title：Blood

authors： Mori N,Kashanchi F,Prager D

更新日期：1997-12-15 00:00:00

abstract：:Fetal hemoglobin (HbF, α2γ2) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that UNC0638, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces γ-globin expression. EHMT1/2 catalyze mono- and dimethylation of lysine 9 on hi...

journal_title：Blood

authors： Renneville A,Van Galen P,Canver MC,McConkey M,Krill-Burger JM,Dorfman DM,Holson EB,Bernstein BE,Orkin SH,Bauer DE,Ebert BL

更新日期：2015-10-15 00:00:00

abstract：:Survival in infants younger than 1 year who have acute lymphoblastic leukemia (ALL) is inferior whether MLL is rearranged (R) or germline (G). MLL translocations confer chemotherapy resistance, and infants experience excess complications. We characterized in vitro sensitivity to the pan-antiapoptotic BCL-2 family inhi...

journal_title：Blood

authors： Urtishak KA,Edwards AY,Wang LS,Hudome A,Robinson BW,Barrett JS,Cao K,Cory L,Moore JS,Bantly AD,Yu QC,Chen IM,Atlas SR,Willman CL,Kundu M,Carroll AJ,Heerema NA,Devidas M,Hilden JM,Dreyer ZE,Hunger SP,Reaman GH,

更新日期：2013-04-04 00:00:00

abstract：:The Bcl-2 proto-oncogene was discovered at the t(14;18) breakpoint found in most follicular B-cell lymphomas and some diffuse large-cell lymphomas. Bcl-2 is unique among proto-oncogenes, being localized to mitochondria and extending cell survival by blocking programmed cell death. We examined Bcl-2 protein expression ...

journal_title：Blood

authors： Zutter M,Hockenbery D,Silverman GA,Korsmeyer SJ

更新日期：1991-08-15 00:00:00

abstract：:Recurrence of the underlying malignancy remains a major cause of treatment failure after autologous bone marrow transplantation (BMT) for patients with lymphoma. In this regard, we have developed an immunotherapeutic approach designed to induce resistance against residual tumor cells persisting after BMT. Previous stu...

journal_title：Blood

authors： Kwak LW,Campbell MJ,Zelenetz AD,Levy R

更新日期：1990-12-01 00:00:00

abstract：:The effect of donor/recipient histocompatibility on relapse in patients receiving T-cell-depleted (TCD) grafts for chronic myelogenous leukemia (CML) was evaluated. Specifically, we sought to determine whether TCD results in an attenuation of the graft-versus-leukemia (GVL) effect on recipients of unrelated marrow gra...

journal_title：Blood

authors： Hessner MJ,Endean DJ,Casper JT,Horowitz MM,Keever-Taylor CA,Roth M,Flomenberg N,Drobyski WR

更新日期：1995-11-15 00:00:00

abstract：:Hypoxia is a strong stimulus for the transcription of a set of genes, including erythropoietin and vascular endothelial growth factor. Here we report on the cloning, functional significance, and expression of a complementary DNA (cDNA) that is involved in hypoxia-mediated expression of these 2 genes. The full-length c...

journal_title：Blood

authors： Gupta M,Mungai PT,Goldwasser E

更新日期：2000-07-15 00:00:00

abstract：:The International Immune Tolerance Study was a multicenter, prospective, randomized comparison of high-dose (HD; 200 IU/kg/d) and low-dose (LD; 50 IU/kg 3 times/week) factor VIII regimens in 115 "good-risk," severe high-titer inhibitor hemophilia A subjects. Sixty-six of 115 subjects reached the defined study end poin...

journal_title：Blood

authors： Hay CR,DiMichele DM,International Immune Tolerance Study.

更新日期：2012-02-09 00:00:00

abstract：:The multimeric size and the function of circulating von Willebrand factor are modulated via its proteolytic cleavage by the plasma metalloproteinase, ADAMTS13. It is unclear how ADAMTS13 activity is regulated within the vascular system. In the absence of a regulatory mechanism, ADAMTS13 activity might compromise plate...

journal_title：Blood

authors： Crawley JT,Lam JK,Rance JB,Mollica LR,O'Donnell JS,Lane DA

更新日期：2005-02-01 00:00:00

abstract：:Similar to endothelial cells (ECs), vascular endothelial growth factor (VEGF) induces Bcl-2 expression on VEGF receptor-positive (VEGFR(+)) primary leukemias and cell lines, promoting survival. We investigated the molecular pathways activated by VEGF on such leukemias, by performing a gene expression analysis of VEGF-...

journal_title：Blood

authors： Dias S,Shmelkov SV,Lam G,Rafii S

更新日期：2002-04-01 00:00:00

abstract：:Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant so...

journal_title：Blood

authors： Hao Z,Guo C,Jiang X,Krueger S,Pietri T,Dufour S,Cone RE,O'Rourke J

更新日期：2006-07-01 00:00:00

abstract：:The peripheral blood lymphocytes from 42 patients with multiple myeloma (MM) and 13 patients with monoclonal gammopathy of undetermined significance (MGUS) were studied by three-color immunofluorescence (IF) using antibodies directed to a broad range of B-cell markers (CD19, CD20, CD21, CD24), CALLA (CD10), PCA-1 (a p...

journal_title：Blood

authors： Jensen GS,Mant MJ,Belch AJ,Berenson JR,Ruether BA,Pilarski LM

更新日期：1991-08-01 00:00:00

abstract：:Development of inhibitory antibodies is a serious complication of treatment with repeated factor IX infusions in a minority of patients with hemophilia B. Such antibodies detected in 8 patients have been characterized. Typing studies revealed that patients' immune response toward factor IX is highly heterogeneous and ...

journal_title：Blood

authors： Christophe OD,Lenting PJ,Cherel G,Boon-Spijker M,Lavergne JM,Boertjes R,Briquel ME,de Goede-Bolder A,Goudemand J,Gaillard S,d'Oiron R,Meyer D,Mertens K

更新日期：2001-09-01 00:00:00

abstract：:A simple and reliable cytogenetic test for Fanconi's anemia (FA) that is based on the hypersensitivity of FA cells to mitomycin C (MC) is described. Equal volumes of whole blood from a patient in whom the diagnosis of FA is suspected and from a normal person of the opposite sex are co-cultured in phytohemagglutinin-co...

journal_title：Blood

authors： German J,Schonberg S,Caskie S,Warburton D,Falk C,Ray JH

更新日期：1987-06-01 00:00:00

abstract：:Recombinant human macrophage colony-stimulating factor (rhM-CSF) was given to cynomolgus monkeys by continuous intravenous infusion or subcutaneous injection, at a dose of 50 to 100 micrograms/kg/d in repetitive 14-day cycles. Starting within 24 to 48 hours of initiation of rhM-CSF, there was a progressive increase in...

journal_title：Blood

authors： Munn DH,Garnick MB,Cheung NK

更新日期：1990-05-15 00:00:00

abstract：:Dendritic cells are the most potent antigen-presenting cells of the immune system. Although dendritic cells are likely to secrete selective cytokines that facilitate antigen presentation, the difficulty in isolating pure dendritic cells in sufficient numbers has made assessment of this function imprecise. In this stud...

journal_title：Blood

authors： Zhou LJ,Tedder TF

更新日期：1995-11-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in recipients of allogeneic bone marrow transplants through yet to be defined mechanisms. Here, we demonstrate in mice that MHC-mismatched donor T cells home into the thymus of unconditioned recipients. There, activated donor T cells ...

journal_title：Blood

authors： Hauri-Hohl MM,Keller MP,Gill J,Hafen K,Pachlatko E,Boulay T,Peter A,Holländer GA,Krenger W

更新日期：2007-05-01 00:00:00

abstract：:Pharmaceutical preparations of normal human immunoglobulin (IgG) are known to contain high-avidity and neutralizing antibodies (Ab) to the cytokines interleukin (IL)-1alpha, IL-6, and interferon (IFN)alpha. To test for other cytokine Ab, 23 batches of IgG were tested for saturable binding to eight 125I-labeled recombi...

journal_title：Blood

authors： Svenson M,Hansen MB,Ross C,Diamant M,Rieneck K,Nielsen H,Bendtzen K

更新日期：1998-03-15 00:00:00

abstract：:Endothelial cells play an important role in the regulation of fibrinolysis by the production of several key regulatory proteins. The cytokines tumor necrosis factor (TNF), lymphotoxin, and interleukin-1 (IL-1), but not interleukin-6, increase the production of plasminogen activator inhibitor-1 (PAI-1) by endothelial c...

journal_title：Blood

authors： van Hinsbergh VW,van den Berg EA,Fiers W,Dooijewaard G

更新日期：1990-05-15 00:00:00

abstract：:The replating capability of human multipotential (colony-forming unit-granulocyte-erythrocyte-macrophage-megakaryocyte [CFU-GEMM]) and erythroid (burst-forming unit-erythroid [BFU-E]) progenitors was assessed in vitro as a potential measure of self-renewal using purified, recombinant (r) human (hu) or murine (mu) mast...

journal_title：Blood

authors： Carow CE,Hangoc G,Cooper SH,Williams DE,Broxmeyer HE

更新日期：1991-11-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a potent adjuvant in cancer vaccination; however, the specific role of endogenous GM-CSF remains unknown. We performed cell-based vaccination in 2 tumor models. First, we vaccinated C57BL/6 mice lacking either GM-CSF, IL-5, or beta-common chain (betac), a re...

journal_title：Blood

authors： Zarei S,Schwenter F,Luy P,Aurrand-Lions M,Morel P,Kopf M,Dranoff G,Mach N

更新日期：2009-06-25 00:00:00

abstract：:Treatment outcomes for older patients with acute myeloid leukemia (AML) have remained dismal. This randomized, phase 2 trial in AML patients not considered suitable for intensive induction therapy compared low-dose cytarabine (LDAC) with or without volasertib, a highly potent and selective inhibitor of polo-like kinas...

journal_title：Blood

authors： Döhner H,Lübbert M,Fiedler W,Fouillard L,Haaland A,Brandwein JM,Lepretre S,Reman O,Turlure P,Ottmann OG,Müller-Tidow C,Krämer A,Raffoux E,Döhner K,Schlenk RF,Voss F,Taube T,Fritsch H,Maertens J

更新日期：2014-08-28 00:00:00