Molecular analysis of the structure and expression of the RH locus in individuals with D--, Dc-, and DCw- gene complexes.

Abstract:

:Rh blood group antigens of the D, C/c, and E/e series are carried by at least three red cell membrane polypeptides encoded by two highly related genes, RHD and RHCE. Homozygous individuals carrying the D--, Dc-, and DCw- gene complexes are characterized by a total or partial lack of expression of the RHCE-encoded antigens. Analysis of the molecular genetic basis of these rare conditions indicates that complete or partial expression defect of Cc/Ee antigens result from different alterations at the RH locus, but not from gross deletions. No rearrangement or mutation of the RHCE gene could be detected in donors homozygous for the D-- complex, suggesting that the lack of the Cc and Ee antigens might result from a reduced transcriptional activity of the RHCE gene. The Dc- and DCw- gene complexes, however, exhibited an important rearrangement of the RHCE gene. Instead of the normal RHCE gene, both variants carried a hybrid RHCE-D-CE gene in which exons 4 to 9 (Dc- complex) and 2 (or 3) to 9 (DCw- complex) of the RHCE gene, respectively, have been substituted by the equivalent region of the RHD gene. These gene conversion events provide an explanation for the well-described abnormal antigen profiles associated with the Dc- and DCw- complexes, like the increased expression of RhD, the reduced expression of RhC/c or RhCw, and the absence of RhE/e.

journal_name

Blood

journal_title

Blood

authors

Chérif-Zahar B,Raynal V,D'Ambrosio AM,Cartron JP,Colin Y

subject

Has Abstract

pub_date

1994-12-15 00:00:00

pages

4354-60

issue

12

eissn

0006-4971

issn

1528-0020

journal_volume

84

pub_type

杂志文章

相关文献

BLOOD文献大全
  • HLA associations with leukemia.

    abstract::Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Bortin MM,D'Amaro J,Bach FH,Rimm AA,van Rood JJ

    更新日期:1987-07-01 00:00:00

  • Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of interleukin-4.

    abstract::The stress-activated protein/c-Jun N-terminal kinases (SAPK/JNK) have been shown to be activated by pro-inflammatory cytokines, as well as physical and chemical stresses. We now show that a variety of hematopoietic growth factors, including Steel locus factor (SLF), granulocyte-macrophage colony-stimulating factor (GM...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Foltz IN,Schrader JW

    更新日期:1997-05-01 00:00:00

  • In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation.

    abstract::Expression of B7 family costimulatory molecules on B cells defines their capacity to function as antigen presenting cells (APCs). B cells that do not express B7 costimulatory molecules induce T-cell tolerance. Therefore, the expression of B7 costimulatory molecules on malignant B cells might be critical for their reco...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Dorfman DM,Schultze JL,Shahsafaei A,Michalak S,Gribben JG,Freeman GJ,Pinkus GS,Nadler LM

    更新日期:1997-12-01 00:00:00

  • Small noncleaved cell lymphoma and leukemia in adults. A retrospective study of 65 adults treated with the LMB pediatric protocols.

    abstract::In France, more than 80% of children with Burkitt's lymphoma or Burkitt's leukemia (ALL3) are now cured with the LMB (B-cell non-Hodgkin's lymphoma and B-ALL) protocols of the Société Française d'Oncologie Pédiatrique, but so far, poor results have been obtained in the few adult studies available. We have analyzed the...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Soussain C,Patte C,Ostronoff M,Delmer A,Rigal-Huguet F,Cambier N,Leprisé PY,François S,Cony-Makhoul P,Harousseau JL

    更新日期:1995-02-01 00:00:00

  • Treatment-related deaths and second cancer risk after autologous stem-cell transplantation for Hodgkin's disease.

    abstract::Autologous stem-cell transplantation has become a widely used therapy in Hodgkin's disease (HD). To appreciate the early and late risks associated with this procedure, its lethal toxicity and effects on the incidence of secondary cancers were studied. Data related to 467 French patients grafted from 1982 to 1995 for p...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: André M,Henry-Amar M,Blaise D,Colombat P,Fleury J,Milpied N,Cahn JY,Pico JL,Bastion Y,Kuentz M,Nedellec G,Attal M,Fermé C,Gisselbrecht C

    更新日期:1998-09-15 00:00:00

  • Interleukin-10 suppresses IP-10 gene transcription by inhibiting the production of class I interferon.

    abstract::Interleukin-10 (IL-10) selectively inhibited lipopolysaccharide (LPS)-induced chemoattractant cytokine gene expression: levels of IP-10 mRNA were markedly suppressed in IL-10-treated mouse peritoneal macrophages, whereas the expression of the RANTES mRNA was only modestly reduced. IL-10 inhibited IP-10 mRNA accumulati...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Tebo JM,Kim HS,Gao J,Armstrong DA,Hamilton TA

    更新日期:1998-12-15 00:00:00

  • The effect of PGI2 and theophylline on the response of platelets subjected to shear stress.

    abstract::A specially designed rotational viscometer was used to investigate the effects of the antiplatelet agent PGI2 in combination with theophylline on the response of human platelets subjected to shear stress. Samples of citrated platelet-rich plasma (PRP) were exposed to shear stress in the viscometer for a period of 5 mi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Hardwick RA,Hellums JD,Peterson DM,Moake JL,Olson JD

    更新日期:1981-10-01 00:00:00

  • Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes.

    abstract::The turnover rates of beta and gamma globin messenger RNAs and of beta and gamma globin protein synthesis in human reticulocytes have been measured. Our goal was to determine whether beta globin mRNA is significantly more stable than gamma globin mRNA during the final stages of erythroid cell maturation. Such a result...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Ross J,Sullivan TD

    更新日期:1985-11-01 00:00:00

  • In situ immunologic characterization of cellular constituents in lymph nodes and spleens involved by Hodgkin's disease.

    abstract::The cellular constituents in lymph nodes and spleens of patients with Hodgkin's disease were studied with a series of monoclonal antibodies directed against human thymocyte, peripheral T-cell, and la antigens. Utilizing both an immunoperoxidase technique on frozen tissue sections and indirect immunofluorescence on cel...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Poppema S,Bhan AK,Reinherz EL,Posner MR,Schlossman SF

    更新日期:1982-02-01 00:00:00

  • Transplacentally acquired maternal T lymphocytes in severe combined immunodeficiency: a study of 121 patients.

    abstract::A study in 121 infants with severe combined immunodeficiency (SCID) was performed to determine the prevalence of an engraftment by transplacentally acquired maternal T cells and to explore clinical and immunological findings related to this abnormality. Each newly diagnosed patient with SCID presenting with circulatin...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v98.6.1847

    authors: Müller SM,Ege M,Pottharst A,Schulz AS,Schwarz K,Friedrich W

    更新日期:2001-09-15 00:00:00

  • Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies.

    abstract::Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a powerful karyotyping tool in numerous translational cancer studies. SNP-A complements traditional metaphase cytogenetics with the unique ability to delineate a previously hidden chromosomal defect, copy neutral loss of heterozygosity ...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2009-10-201848

    authors: O'Keefe C,McDevitt MA,Maciejewski JP

    更新日期:2010-04-08 00:00:00

  • Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML.

    abstract::Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to de...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2016-07-728873

    authors: Warfvinge R,Geironson L,Sommarin MNE,Lang S,Karlsson C,Roschupkina T,Stenke L,Stentoft J,Olsson-Strömberg U,Hjorth-Hansen H,Mustjoki S,Soneji S,Richter J,Karlsson G

    更新日期:2017-04-27 00:00:00

  • Demonstration and mode of action of an inhibitor for activated Hageman factor (factor XIIa) of the intrinsic blood coagulation pathway from Schistosoma mansoni.

    abstract::An anticoagulant activity from adult Schistosoma mansoni whole worm homogenate is described. The inhibitor appears to be specific for the contact activation step of the intrinsic pathway. Experiments with both human and mouse plasmas have defined the specificity of the inhibitor as follows: (1) It lengthens the partia...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Tsang VC,Damian RT

    更新日期:1977-04-01 00:00:00

  • Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID.

    abstract::We assessed primary cutaneous large B-cell lymphoma, leg type (PCLBCL, leg type; n = 13), and primary cutaneous follicle center lymphoma (PCFCL; n = 19) for somatic hypermutation (SHM) of BCL6, and aberrant SHM of MYC, RhoH/TTF, and PAX5. We demonstrate SHM of BCL6 in 8 PCLBCLs (62%), leg type, and 7 PCFCL patients (3...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-08-3443

    authors: Dijkman R,Tensen CP,Buettner M,Niedobitek G,Willemze R,Vermeer MH

    更新日期:2006-06-15 00:00:00

  • Identification of the c-kit ligand: end of the road for understanding aplastic anemia in steel mutant mice?

    abstract::We here report the initiation of hematopoietic recovery in congenitally hypoplastic S1/S1d mice by the cytotoxic ablation of cells bearing the natural killer (NK) phenotype (NK 1.1+). The most striking finding was the early several-fold increase in the cycling fraction of stem and progenitor cells (with the exception ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Pantel K,Boertman J,Nakeff A

    更新日期:1991-09-15 00:00:00

  • Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.

    abstract::In multiple myeloma (MM), both vascular endothelial (VEGF) and basic fibroblast growth factor (bFGF) promote tumor growth and survival. We have used the novel indolinone BIBF 1000 to study effects of simultaneous inhibition of VEGF, FGF and transforming growth factor-beta on MM cells and their interactions with bone m...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-11-4250

    authors: Bisping G,Kropff M,Wenning D,Dreyer B,Bessonov S,Hilberg F,Roth GJ,Munzert G,Stefanic M,Stelljes M,Scheffold C,Müller-Tidow C,Liebisch P,Lang N,Tchinda J,Serve HL,Mesters RM,Berdel WE,Kienast J

    更新日期:2006-03-01 00:00:00

  • A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28.

    abstract::We have characterized a splice variant (isoform) of the human CD28 T cell costimulatory receptor. The nucleotide sequence of this CD28 isoform was identical to that of CD28 in the signal peptide, the transmembrane domain, and the cytoplasmic tail, but it was missing a large segment of the extracellular ligand-binding ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v99.6.2138

    authors: Hanawa H,Ma Y,Mikolajczak SA,Charles ML,Yoshida T,Yoshida R,Strathdee CA,Litchfield DW,Ochi A

    更新日期:2002-03-15 00:00:00

  • Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs.

    abstract::Hematopoietic stem cell (HSC)-based gene therapy holds promise for the cure of many diseases. The field is now moving toward the use of lentiviral vectors (LVs) as evidenced by 4 successful clinical trials. These trials used vesicular-stomatitis-virus-G protein (VSV-G)-LVs at high doses combined with strong cytokine-c...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2014-02-558163

    authors: Girard-Gagnepain A,Amirache F,Costa C,Lévy C,Frecha C,Fusil F,Nègre D,Lavillette D,Cosset FL,Verhoeyen E

    更新日期:2014-08-21 00:00:00

  • Stem cell factor contributes to intestinal mucosal mast cell hyperplasia in rats infected with Nippostrongylus brasiliensis or Trichinella spiralis, but anti-stem cell factor treatment decreases parasite egg production during N brasiliensis infection.

    abstract::We assessed the effects of the c-kit ligand, stem cell factor (SCF), in the jejunal mucosal mast cell hyperplasia that occurs during infection with the intestinal nematodes, Nippostrongylus brasiliensis or Trichinella spiralis in rats. Compared with vehicle-treated rats, rats treated with SCF (25 micrograms/kg/d, intr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Newlands GF,Miller HR,MacKellar A,Galli SJ

    更新日期:1995-09-01 00:00:00

  • An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era.

    abstract::The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with aggressive non-Hodgkin lymphoma (NHL) for the past 20 years. Using raw clinical data from the National Comprehensive Cancer Network (NCCN) database collected during the rituximab era, we built an enhanced IPI with th...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究

    doi:10.1182/blood-2013-09-524108

    authors: Zhou Z,Sehn LH,Rademaker AW,Gordon LI,Lacasce AS,Crosby-Thompson A,Vanderplas A,Zelenetz AD,Abel GA,Rodriguez MA,Nademanee A,Kaminski MS,Czuczman MS,Millenson M,Niland J,Gascoyne RD,Connors JM,Friedberg JW,Winter JN

    更新日期:2014-02-06 00:00:00

  • Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy.

    abstract::Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic system, specialized in antigen capture, processing, and presentation. The different DC subsets act as sentinels throughout the body and perform a key role in the induction of immunogenic as well as tolerogenic immune responses. Bec...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2011-11-370130

    authors: van de Laar L,Coffer PJ,Woltman AM

    更新日期:2012-04-12 00:00:00

  • The proportion of mitoses in different cell lineages changes during short-term culture of normal human bone marrow.

    abstract::To determine the hematopoietic cell lineage of mitotic cells in human bone marrow on direct examination and after 24-hour culture, marrow mitoses from four healthy individuals were studied, using a new technique that allows analysis of karyotypes in cells whose cell membrane and cytoplasm have been preserved. Mitoses ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Keinänen M,Knuutila S,Bloomfield CD,Elonen E,de la Chapelle A

    更新日期:1986-05-01 00:00:00

  • Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets.

    abstract::Human blood contains 2 populations of dendritic cells (DCs): plasmacytoid and myeloid (mDC). mDCs are subdivided into 3 subsets using the surface markers CD16, CD1c, and BDCA-3. Their role as pathogen sentinels and adjuvant targets was tested by phenotypic and functional analysis. We show that mDC subsets are immature...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2006-08-038422

    authors: Piccioli D,Tavarini S,Borgogni E,Steri V,Nuti S,Sammicheli C,Bardelli M,Montagna D,Locatelli F,Wack A

    更新日期:2007-06-15 00:00:00

  • SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.

    abstract::Tumors have several mechanisms to escape from the immune system. One of these involves expression of intracellular anticytotoxic proteins that modulate the execution of cell death. Previously, we have shown that the serine protease inhibitor (serpin) SPI-6, which inactivates the cytotoxic protease granzyme B (GrB), is...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-03-0791

    authors: Bots M,Kolfschoten IG,Bres SA,Rademaker MT,de Roo GM,Krüse M,Franken KL,Hahne M,Froelich CJ,Melief CJ,Offringa R,Medema JP

    更新日期:2005-02-01 00:00:00

  • Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice.

    abstract::Stem cell homing into the bone microenvironment is the first step in the initiation of marrow-derived blood cells. It is reported that human severe combined immunodeficient (SCID) repopulating cells home and accumulate rapidly, within a few hours, in the bone marrow and spleen of immunodeficient mice previously condit...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v97.10.3283

    authors: Kollet O,Spiegel A,Peled A,Petit I,Byk T,Hershkoviz R,Guetta E,Barkai G,Nagler A,Lapidot T

    更新日期:2001-05-15 00:00:00

  • Identification of four novel delta-globin gene mutations in Greek Cypriots using polymerase chain reaction and automated fluorescence-based DNA sequence analysis.

    abstract::The molecular basis of most beta-thalassemia syndromes has been defined, while the spectrum of mutations causing delta-thalassemia is not well characterized. In an attempt to identify such mutations, the region encompassing the delta-globin gene from three Greek Cypriot families suspected of having delta-thalassemia w...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Trifillis P,Ioannou P,Schwartz E,Surrey S

    更新日期:1991-12-15 00:00:00

  • Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies.

    abstract::The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but responses are usually partial and short-li...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-04-346601

    authors: Gupta M,Hendrickson AE,Yun SS,Han JJ,Schneider PA,Koh BD,Stenson MJ,Wellik LE,Shing JC,Peterson KL,Flatten KS,Hess AD,Smith BD,Karp JE,Barr S,Witzig TE,Kaufmann SH

    更新日期:2012-01-12 00:00:00

  • T gamma-lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular, and functional characteristics.

    abstract::T gamma lymphocytes are those lymphocytes that express receptors for both the Fc portion of IgG and sheep erythrocytes. A very high proportion of normal T gamma lymphocytes are large granular lymphocytes (LGL), the cell responsible for most, if not all, natural killer (NK) and antibody-dependent cell-mediated cytotoxi...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:

    authors: Reynolds CW,Foon KA

    更新日期:1984-12-01 00:00:00

  • Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis.

    abstract::Cytomegalovirus (CMV) has been a major cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). The importance of the recipient's serologic status is paramount. However, the importance of the donor's serologic status in CMV-seropositive recipients is controversial. We analyzed the influence o...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-10-3263

    authors: Ljungman P,Brand R,Einsele H,Frassoni F,Niederwieser D,Cordonnier C

    更新日期:2003-12-15 00:00:00

  • Lack of dominant-negative effects of a truncated gamma(c) on retroviral-mediated gene correction of immunodeficient mice.

    abstract::A recent clinical trial of gene therapy for X-linked severe combined immunodeficiency (XSCID) has shown that retroviral-mediated gene correction of bone marrow stem cells can lead to the development of normal immune function. These exciting results have been preceded by successful immune reconstitution in several XSCI...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v97.6.1618

    authors: Otsu M,Sugamura K,Candotti F

    更新日期:2001-03-15 00:00:00