当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation.

Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation.

Abstract：

:In mouse mid-gestational embryos, definitive hematopoietic stem progenitor cells are derived directly from a very small proportion of the arterial endothelium. However, the physiological mechanisms restraining excessive endothelial-hematopoietic transition remain elusive. We show here that genetic deletion of Smad4 from the endothelium stage (using Tie2-Cre), but not from embryonic hematopoietic cells (using Vav-Cre), leads to a strikingly augmented emergence of intra-arterial hematopoietic clusters and an enhanced in vitro generation of hematopoietic progenitors, with no increase in the proliferation and survival of hematopoietic cluster cells. This finding indicates a temporally restricted negative effect of Smad4 on the endothelial to hematopoietic progenitor transition. Furthermore, the absence of endothelial Smad4 causes an increased expression of subaortic bone morphogenetic protein 4 and an activation of aortic extracellular signal-regulated kinase, thereby resulting in the excessive generation of blood cells. Collectively, our data for the first time identify a physiological suppressor that functions specifically during the transition of endothelial cells to hematopoietic progenitors and further suggest that endothelial Smad4 is a crucial modulator of the subaortic microenvironment that controls the hematopoietic fate of the aortic endothelium.

journal_name

Blood

journal_title

Blood

authors

Lan Y,He W,Li Z,Wang Y,Wang J,Gao J,Wang W,Cheng T,Liu B,Yang X

doi

10.1182/blood-2013-09-526053

subject

Has Abstract

pub_date

2014-04-03 00:00:00

pages

2161-71

issue

14

eissn

0006-4971

issn

1528-0020

pii

blood-2013-09-526053

journal_volume

123

pub_type

杂志文章

相关文献

BLOOD文献大全
  • B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging.

    abstract：:Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells....

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-09-307983

    authors： Keren Z,Naor S,Nussbaum S,Golan K,Itkin T,Sasaki Y,Schmidt-Supprian M,Lapidot T,Melamed D

    更新日期：2011-03-17 00:00:00

  • Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow support.

    abstract：:Endogenous cytokines are thought to mediate numerous biologic processes and may account for some adverse effects experienced following the administration of recombinant proteins. This study describes the pattern of endogenous cytokine exposure following high-dose chemotherapy. Blood concentrations of interleukin-6 (IL...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：

    authors： Rabinowitz J,Petros WP,Stuart AR,Peters WP

    更新日期：1993-05-01 00:00:00

  • The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model.

    abstract：:Current treatment strategies for chronic lymphocytic leukemia (CLL) involve a combination of conventional chemotherapeutics, monoclonal antibodies, and targeted signaling inhibitors. However, CLL remains largely incurable, with drug resistance and treatment relapse a common occurrence, leading to the search for novel ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-11-610329

    authors： Blunt MD,Carter MJ,Larrayoz M,Smith LD,Aguilar-Hernandez M,Cox KL,Tipton T,Reynolds M,Murphy S,Lemm E,Dias S,Duncombe A,Strefford JC,Johnson PW,Forconi F,Stevenson FK,Packham G,Cragg MS,Steele AJ

    更新日期：2015-06-25 00:00:00

  • Posttranslational processing of a human myeloid lysosomal protein, myeloperoxidase.

    abstract：:Myeloperoxidase (MPO) is a lysosomal enzyme present in the azurophilic granules of human neutrophils and monocytes and is important for optimal oxygen-dependent killing of microorganisms. The native molecule is a heterodimer composed of a pair of heavy-light protomers, each containing a 59-kDa and 13.5-kDa subunit. Th...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Nauseef WM

    更新日期：1987-10-01 00:00:00

  • Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies.

    abstract：:Toxicity-reduced conditioning is being used for allogeneic stem cell transplantation in older and/or comorbid patients. We report on the treatment of 133 patients (median age: 55.6 years [23-73 years]) with acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS; n = 81), myeloproliferative syndromes (MPS; n = 20),...

    journal_title：Blood

    pub_type： 杂志文章,多中心研究

    doi：10.1182/blood-2007-08-104745

    authors： Marks R,Potthoff K,Hahn J,Ihorst G,Bertz H,Spyridonidis A,Holler E,Finke JM

    更新日期：2008-07-15 00:00:00

  • Dangerous small B-cell clones.

    abstract：:The detection of a monoclonal immunoglobulin in serum or urine usually raises concerns about the size of the underlying B-cell-derived clone and possible systemic effects caused by its expansion. However, a small clone can synthesize a very toxic protein, producing devastating systemic damage and protean clinical pres...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2006-03-001164

    authors： Merlini G,Stone MJ

    更新日期：2006-10-15 00:00:00

  • Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications.

    abstract：:Recurrence of multiple myeloma (MM) after therapy suggests the presence of tumor-initiating subpopulations. In our study, we performed flow cytometry-based Hoechst 33342 staining to evaluate the existence of a MM population with stem-like features known as side population (SP) cells. SP cells exhibit substantial heter...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-02-267344

    authors： Jakubikova J,Adamia S,Kost-Alimova M,Klippel S,Cervi D,Daley JF,Cholujova D,Kong SY,Leiba M,Blotta S,Ooi M,Delmore J,Laubach J,Richardson PG,Sedlak J,Anderson KC,Mitsiades CS

    更新日期：2011-04-28 00:00:00

  • Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies.

    abstract：:CD20 is a nonglycosylated 33 to 37 kD phosphoprotein involved in B-cell signaling that subserves important functions in the regulation of B-cell proliferation and differentiation. In addition, this B-cell surface antigen has been shown recently to be an effective target for immunotherapy of B-cell malignancies using c...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Shan D,Ledbetter JA,Press OW

    更新日期：1998-03-01 00:00:00

  • Chlorambucil therapy in hairy cell leukemia: effects on lipid composition and lymphocyte subpopulations.

    abstract：:Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholester...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Krigel R,Liebes LF,Pelle E,Silber R

    更新日期：1982-07-01 00:00:00

  • Repression of transcription from the human T-cell leukemia virus type I long terminal repeat and cellular gene promoters by wild-type p53.

    abstract：:Human T-cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells both in vivo and in vitro. However, the long latency period between infection and development of ATL, as well as the small fraction of the infected population that actually develops this disease, su...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Mori N,Kashanchi F,Prager D

    更新日期：1997-12-15 00:00:00

  • Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas.

    abstract：:Chimeric antigen receptor (CAR) T cells have emerged as a novel form of treatment of patients with B-cell malignancies. In particular, anti-CD19 CAR T-cell therapy has effected impressive clinical responses in B-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma. However, not all patients respond, and...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2018-04-842708

    authors： Scarfò I,Ormhøj M,Frigault MJ,Castano AP,Lorrey S,Bouffard AA,van Scoyk A,Rodig SJ,Shay AJ,Aster JC,Preffer FI,Weinstock DM,Maus MV

    更新日期：2018-10-04 00:00:00

  • Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice.

    abstract：:Oxygen-induced retinopathy (OIR) is a well-characterized model for retinopathy of prematurity, a disorder that results from rapid microvascular proliferation after exposure of the retina to high oxygen levels. Here, we report that the proliferative phase of OIR requires transcriptional induction of the annexin A2 (A2)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-03-341214

    authors： Huang B,Deora AB,He KL,Chen K,Sui G,Jacovina AT,Almeida D,Hong P,Burgman P,Hajjar KA

    更新日期：2011-09-08 00:00:00

  • Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.

    abstract：:Pathologic blood clotting is a leading cause of morbidity and mortality in the developed world, underlying deep vein thrombosis, myocardial infarction, and stroke. Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modifying factors remai...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-03-561027

    authors： Liu Y,Kretz CA,Maeder ML,Richter CE,Tsao P,Vo AH,Huarng MC,Rode T,Hu Z,Mehra R,Olson ST,Joung JK,Shavit JA

    更新日期：2014-07-03 00:00:00

  • Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

    abstract：:Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2013-03-487942

    authors： Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

    更新日期：2013-10-31 00:00:00

  • Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma.

    abstract：:Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target nonplasma cells tha...

    journal_title：Blood

    pub_type： 杂志文章,多中心研究

    doi：10.1182/blood-2015-12-687749

    authors： Krejcik J,Casneuf T,Nijhof IS,Verbist B,Bald J,Plesner T,Syed K,Liu K,van de Donk NW,Weiss BM,Ahmadi T,Lokhorst HM,Mutis T,Sasser AK

    更新日期：2016-07-21 00:00:00

  • Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults.

    abstract：:Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults. Patients with newly diagnosed B-cell ALL (B-ALL) who received frontline chemotherapy at MD Anderson Cancer Center underwent...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2016-07-726588

    authors： Jain N,Roberts KG,Jabbour E,Patel K,Eterovic AK,Chen K,Zweidler-McKay P,Lu X,Fawcett G,Wang SA,Konoplev S,Harvey RC,Chen IM,Payne-Turner D,Valentine M,Thomas D,Garcia-Manero G,Ravandi F,Cortes J,Kornblau S,O'Brien

    更新日期：2017-02-02 00:00:00

  • The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element.

    abstract：:Cellular interleukin 6 (IL-6) is an important growth factor for Kaposi sarcoma- associated herpesvirus (KSHV)-associated neoplasms, which include human immunodeficiency virus (HIV)-related and -unrelated cases of Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Increased ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.2.649

    authors： An J,Lichtenstein AK,Brent G,Rettig MB

    更新日期：2002-01-15 00:00:00

  • How I treat monoclonal gammopathy of renal significance (MGRS).

    abstract：:Recently, the term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney disease from those that are benign. By definition, patients with MGRS have B-cell clones that do not meet the definition of multiple myeloma or lymphoma. ...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2013-05-495929

    authors： Fermand JP,Bridoux F,Kyle RA,Kastritis E,Weiss BM,Cook MA,Drayson MT,Dispenzieri A,Leung N,International Kidney and Monoclonal Gammopathy Research Group.

    更新日期：2013-11-21 00:00:00

  • Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis.

    abstract：:The alternatively spliced and highly conserved EIIIA domain of fibronectin (FN) is included in most FN of the extracellular matrix in embryos. In adults, both extracellular matrix and plasma FN essentially lack EIIIA. In diverse inflammatory situations however, EIIIA is specifically included by regulated RNA splicing....

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-09-3363

    authors： Tan MH,Sun Z,Opitz SL,Schmidt TE,Peters JH,George EL

    更新日期：2004-07-01 00:00:00

  • Treatment of hairy cell leukemia with recombinant alpha interferon: II. In vivo down-regulation of alpha interferon receptors on tumor cells.

    abstract：:Interferons (IFNs) initiate their effects by interacting with specific high-affinity cell surface receptors, but little is known about the physiology of IFN receptor interaction in vivo. Treatment of patients suffering from hairy cell leukemia (HCL) with human recombinant alpha IFN results in significant tumor regress...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Billard C,Sigaux F,Castaigne S,Valensi F,Flandrin G,Degos L,Falcoff E,Aguet M

    更新日期：1986-03-01 00:00:00

  • Interleukin-15 (IL-15) induces NF-kappaB activation and IL-8 production in human neutrophils.

    abstract：:Interleukin-2 (IL-2) and IL-15 exert similar biological actions, which largely reflect the fact that their receptors share common beta and gamma subunits; in contrast, distinct subunits are required for high-affinity binding of either cytokine to a heterotrimeric receptor complex. Human neutrophils are known to expres...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： McDonald PP,Russo MP,Ferrini S,Cassatella MA

    更新日期：1998-12-15 00:00:00

  • Inhibitory effect of granulocyte-macrophage colony-stimulating factor therapy on the generation of natural killer cells.

    abstract：:We investigated the effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and recombinant human granulocyte colony-stimulating factor (rhG-CSF) therapy on the natural killer (NK) cell lineage in patients with aplastic anemia and myelodysplastic syndrome. Selected bone marrow (BM) cel...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Shibuya A,Taguchi K,Kojima H,Abe T

    更新日期：1991-12-15 00:00:00

  • Monitoring of tumor cell purging after highly efficient immunomagnetic selection of CD34 cells from leukapheresis products in breast cancer patients: comparison of immunocytochemical tumor cell staining and reverse transcriptase-polymerase chain reaction.

    abstract：:We studied the efficiency of indirect tumor cell purging via enrichment of CD34+ hematopoietic progenitor cells from leukapheresis products (LP) in breast cancer patients based on immunomagnetic selection of CD34+ cells. Detection of tumor cells was made by immunocytochemical staining. In addition, we evaluated the ca...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Mapara MY,Körner IJ,Hildebrandt M,Bargou R,Krahl D,Reichardt P,Dörken B

    更新日期：1997-01-01 00:00:00

  • Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disorders.

    abstract：:Immunosuppression resulting in impaired Epstein-Barr virus (EBV)-specific T-cell immunity is involved in the pathogenesis of EBV-positive post-transplantation lymphoproliferative disorder (EBV(+) PTLD). Restoration of EBV-specific T-cell immunity by adoptive immunotherapy can induce remission. EBV-nuclear antigen-1 (E...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-03-274076

    authors： Jones K,Nourse JP,Morrison L,Nguyen-Van D,Moss DJ,Burrows SR,Gandhi MK

    更新日期：2010-09-30 00:00:00

  • Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia.

    abstract：:Chronic myelomonocytic leukemia (CMML) is a hematological malignancy characterized by uncontrolled proliferation of dysplastic myelomonocytes and frequent progression to acute myeloid leukemia (AML). We identified mutations in the Cbl gene, which encodes a negative regulator of cytokine signaling, in a subset of CMML ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2016-06-724658

    authors： Nakata Y,Ueda T,Nagamachi A,Yamasaki N,Ikeda KI,Sera Y,Takubo K,Kanai A,Oda H,Sanada M,Ogawa S,Tsuji K,Ebihara Y,Wolff L,Honda ZI,Suda T,Inaba T,Honda H

    更新日期：2017-04-13 00:00:00

  • Incidence of therapy-related myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine: long-term follow-up of US Intergroup Study E2997.

    abstract：:Chemotherapy-related myeloid neoplasia (t-MN) is a significant late toxicity concern after cancer therapy. In the randomized intergroup phase 3 E2997 trial, initial therapy of chronic lymphocytic leukemia with fludarabine plus cyclophosphamide (FC) compared with fludarabine alone yielded higher complete and overall re...

    journal_title：Blood

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1182/blood-2011-03-342485

    authors： Smith MR,Neuberg D,Flinn IW,Grever MR,Lazarus HM,Rowe JM,Dewald G,Bennett JM,Paietta EM,Byrd JC,Hussein MA,Appelbaum FR,Larson RA,Litzow MR,Tallman MS

    更新日期：2011-09-29 00:00:00

  • Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia.

    abstract：:Enforced BCL-2 gene expression in leukemic cell lines suppresses apoptosis and confers resistance to anticancer drugs, but the clinical significance of increased BCL-2 protein levels in acute lymphoblastic leukemia (ALL) is unknown. Among 52 children with newly diagnosed ALL, BCL-2 expression in leukemic lymphoblasts ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Coustan-Smith E,Kitanaka A,Pui CH,McNinch L,Evans WE,Raimondi SC,Behm FG,Aricò M,Campana D

    更新日期：1996-02-01 00:00:00

  • Speaking a common language in MDS/MPNs.

    abstract：:In this issue of Blood, Savona and an international consortium of clinical investigators propose uniform response criteria for treatment trials enrolling adult patients with myelodysplastic/myeloproliferative neoplasms (MDS/MPNs). Such a proposal is needed because new drugs are finally being tested in these rare “over...

    journal_title：Blood

    pub_type： 评论,杂志文章

    doi：10.1182/blood-2015-02-626473

    authors： Steensma DP

    更新日期：2015-03-19 00:00:00

  • Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders.

    abstract：:Red blood cell (RBC) transfusion is unique as a common large-scale intravenous introduction of foreign tissue and provides a valuable opportunity to study human immunologic response to intravenous foreign antigen. Patients receiving RBC transfusions are at risk of forming alloantibodies against donor RBC antigens, and...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-03-146415

    authors： Higgins JM,Sloan SR

    更新日期：2008-09-15 00:00:00

  • The exon 46-encoded sequence is essential for stability of human erythroid alpha-spectrin and heterodimer formation.

    abstract：:Human erythroid alpha-spectrin alleles responsible for hereditary elliptocytosis (alphaHE alleles) undergo increased incorporation into red blood cell membranes when the polymorphism alphaLELY (LELY: Low Expression LYon) occurs in trans. The alphaLELY polymorphism is characterized by a mutation in exon 40 at codon 185...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Wilmotte R,Harper SL,Ursitti JA,Maréchal J,Delaunay J,Speicher DW

    更新日期：1997-11-15 00:00:00