A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation.

abstract：:Filamin A (FLNa), a dimeric actin cross-linking and scaffold protein with numerous intracellular binding partners, anchors the platelet adhesion glycoprotein (GP) Ib-IX-V receptor to actin cytoskeleton. We mapped the GPIbalpha binding site to a single domain of FLNa and resolved the structure of this domain and its in...

journal_title：Blood

authors： Nakamura F,Pudas R,Heikkinen O,Permi P,Kilpeläinen I,Munday AD,Hartwig JH,Stossel TP,Ylänne J

更新日期：2006-03-01 00:00:00

abstract：:The molecular mechanisms that underlie T-cell quiescence are poorly understood. In the present study, we report a primary immunodeficiency phenotype associated with MST1 deficiency and primarily characterized by a progressive loss of naive T cells. The in vivo consequences include recurrent bacterial and viral infecti...

journal_title：Blood

authors： Nehme NT,Schmid JP,Debeurme F,André-Schmutz I,Lim A,Nitschke P,Rieux-Laucat F,Lutz P,Picard C,Mahlaoui N,Fischer A,de Saint Basile G

更新日期：2012-04-12 00:00:00

abstract：:A qualitative defect of antithrombin III (AT III) has been demonstrated over three generations in eight members of an Italian family by the discrepancy between a normal amount of antigen and decreased antithrombin and anti-Xa activity in the presence or in the absence of heparin. By two-dimensional immunoelectrophores...

journal_title：Blood

authors： Wolf M,Boyer C,Tripodi A,Meyer D,Larrieu MJ,Mannucci PM

更新日期：1985-02-01 00:00:00

abstract：:Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by thrombotic microangiopathy leading to end-organ damage. The standard of care (SOC) treatment is therapeutic plasma exchange (TPE) alongside immunomodulation with steroids, with increasing use of rituximab +/- other immuno...

journal_title：Blood

authors： Goshua G,Sinha P,Hendrickson JE,Tormey CA,Bendapudi P,Lee AI

更新日期：2020-12-06 00:00:00

abstract：:Early B-cell factor 1 (Ebf1) is a transcription factor with documented dose-dependent functions in normal and malignant B-lymphocyte development. To understand more about the roles of Ebf1 in malignant transformation, we investigated the impact of reduced functional Ebf1 dosage on mouse B-cell progenitors. Gene expres...

journal_title：Blood

authors： Prasad MA,Ungerbäck J,Åhsberg J,Somasundaram R,Strid T,Larsson M,Månsson R,De Paepe A,Lilljebjörn H,Fioretos T,Hagman J,Sigvardsson M

更新日期：2015-06-25 00:00:00

abstract：:Previous studies suggested a role for prostaglandins or thromboxane A2, or both in the exposure of fibrinogen receptors on normal platelets in response to several aggregating agents. Platelets from diabetics are known to be more sensitive to aggregating agents and to produce more prostaglandins and thromboxane than pl...

journal_title：Blood

authors： DiMinno G,Silver MJ,Cerbone AM,Riccardi G,Rivellese A,Mancini M,Thiagarajan P

更新日期：1985-01-01 00:00:00

abstract：:During innate immune responses, the inflammatory CC chemokine receptors CCR1, CCR2, and CCR5 mediate the recruitment of blood monocytes to infected tissues by promoting cell migration in response to chemokines CCL2-5. Toll-like receptors also play an essential role, allowing pathogen recognition by the recruited monoc...

journal_title：Blood

authors： Fox JM,Letellier E,Oliphant CJ,Signoret N

更新日期：2011-02-10 00:00:00

abstract：:The replating capability of human umbilical cord blood (CB) multipotential (CFU-GEMM) progenitors was assessed in vitro as an estimate of self-renewal using erythropoietin (Epo), steel factor (SLF), and either fetal bovine serum (FBS) or CB plasma. This study found a much higher replating efficiency for CB CFU-GEMM th...

journal_title：Blood

authors： Carow CE,Hangoc G,Broxmeyer HE

更新日期：1993-02-15 00:00:00

abstract：:CXCL4 and CXCL4L1 are 2 closely related CXC chemokines that exhibit potent antiangiogenic activity. Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B. We further demo...

journal_title：Blood

authors： Dubrac A,Quemener C,Lacazette E,Lopez F,Zanibellato C,Wu WG,Bikfalvi A,Prats H

更新日期：2010-11-25 00:00:00

abstract：:Lipoprotein (a) [Lp(a)] has been associated with both anti-fibrinolytic and atherogenic effects. However, no direct link currently exists between this atherogenic lipoprotein and intravascular coagulation. The current study examined the binding and functional effects of Lp(a), its lipoprotein constituents, apoliprotei...

journal_title：Blood

authors： Caplice NM,Panetta C,Peterson TE,Kleppe LS,Mueske CS,Kostner GM,Broze GJ Jr,Simari RD

更新日期：2001-11-15 00:00:00

abstract：:Surprisingly, the role(s) of eosinophils in health and disease is often summarized by clinicians and basic research scientists as a pervasive consensus opinion first learned in medical/graduate school. Eosinophils are rare white blood cells whose activities are primarily destructive and are only relevant in parasitic ...

journal_title：Blood

authors： Jacobsen EA,Helmers RA,Lee JJ,Lee NA

更新日期：2012-11-08 00:00:00

abstract：:Platelet von Willebrand factor (vWF) has been suggested to play an important role in the hemostatic process. Clinical and experimental data indicate that bleeding time (BT) and platelet-vessel wall interaction cannot be normalized unless the defect of platelet vWF is also corrected. We have examined the effect of norm...

journal_title：Blood

authors： Castillo R,Monteagudo J,Escolar G,Ordinas A,Magallón M,Martín Villar J

更新日期：1991-05-01 00:00:00

abstract：:The rapid transformation of human blood platelets from inert discoid cells to spheroechinocytes that is induced by adenosine diphosphate (ADP) has been followed by right-angle light scattering intensity measurements using a laser light source and a sensitive photomultiplier. Two steps have been observed, and their rat...

journal_title：Blood

authors： Hantgan RR

更新日期：1984-10-01 00:00:00

abstract：:Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma). Although there is some knowledge about molecular mechanisms that induce IFN-gamma in NK cells, considerably less is known about the mechanisms that reduce its expression. Here, w...

journal_title：Blood

authors： Becknell B,Hughes TL,Freud AG,Blaser BW,Yu J,Trotta R,Mao HC,Caligiuri de Jesús ML,Alghothani M,Benson DM Jr,Lehman A,Jarjoura D,Perrotti D,Bates MD,Caligiuri MA

更新日期：2007-03-15 00:00:00

abstract：:Polycythemia vera (PV) treatment with interferon α (IFNα) is frequently limited by dose-related toxicity. PV CD34(+) cells are characterized by overexpression of Bcl-xL, which can be antagonized by ABT-737 leading to apoptosis. We explored the effects of ABT-737 and IFNα on PV hematopoiesis. Both IFNα and ABT-737 alon...

journal_title：Blood

authors： Lu M,Wang J,Li Y,Berenzon D,Wang X,Mascarenhas J,Xu M,Hoffman R

更新日期：2010-11-18 00:00:00

abstract：:We investigated treatment with gemtuzumab ozogamicin (GO) in 51 patients aged 65 years or older with newly diagnosed acute myeloid leukemia (AML), refectory anemia (RA) with excess of blasts in transformation, or RA with excess blasts. GO was given in doses of 9 mg/m(2) of body-surface area on days 1 and 8 or, therape...

journal_title：Blood

authors： Estey EH,Thall PF,Giles FJ,Wang XM,Cortes JE,Beran M,Pierce SA,Thomas DA,Kantarjian HM

更新日期：2002-06-15 00:00:00

abstract：:A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive im...

journal_title：Blood

authors： Shimazu T,Iida R,Zhang Q,Welner RS,Medina KL,Alberola-Lla J,Kincade PW

更新日期：2012-05-24 00:00:00

abstract：:Interleukin-3 (IL-3) is a hematopoietic growth factor that regulates the differentiation of multilineage and committed progenitor cells and the functions of some mature blood cells. The expression of human IL-3 appears to be restricted to stimulated T lymphocytes. We have investigated the kinetics and mechanisms invol...

journal_title：Blood

authors： Ryan GR,Milton SE,Lopez AF,Bardy PG,Vadas MA,Shannon MF

更新日期：1991-03-15 00:00:00

abstract：:Pathologic blood clotting is a leading cause of morbidity and mortality in the developed world, underlying deep vein thrombosis, myocardial infarction, and stroke. Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modifying factors remai...

journal_title：Blood

authors： Liu Y,Kretz CA,Maeder ML,Richter CE,Tsao P,Vo AH,Huarng MC,Rode T,Hu Z,Mehra R,Olson ST,Joung JK,Shavit JA

更新日期：2014-07-03 00:00:00

abstract：:Ionophore A23187-induced 14C-serotonin secretion and thromboxane B2(TxB2) formation were found to be absent in citrated platelet-rich plasma (PRP) from thrombasthenic subjects and in normal PRP treated with glycoprotein (GP) IIb-IIIa complex-specific monoclonal antibodies. Both responses were restored to normal levels...

journal_title：Blood

authors： Lages B,Weiss HJ

更新日期：1994-05-01 00:00:00

abstract：:Hairy cell leukemia variant (HCLv) presents with high disease burden, lack of typical antigens like CD25, and poor response to standard treatments like cladribine. Occasionally, patients with classic HCL respond poorly. Clinical and molecular features of HCL and HCLv has not been compared. Rearrangements expressing im...

journal_title：Blood

authors： Arons E,Suntum T,Stetler-Stevenson M,Kreitman RJ

更新日期：2009-11-19 00:00:00

abstract：:In this issue of Blood, Sun and colleagues from the Bone Marrow Transplant Survivors Study report the chronic health outcomes of more than 1000 survivors of stem cell transplantation. Their results demonstrate a significant burden of chronic conditions among survivors. ...

journal_title：Blood

authors： Cutler C

更新日期：2010-10-28 00:00:00

abstract：:Natural killer (NK) cells have held great promise for the immunotherapy of cancer for more than 3 decades. However, to date only modest clinical success has been achieved manipulating the NK cell compartment in patients with malignant disease. Progress in the field of NK cell receptors has revolutionized our concept o...

journal_title：Blood

authors： Farag SS,Fehniger TA,Ruggeri L,Velardi A,Caligiuri MA

更新日期：2002-09-15 00:00:00

abstract：:Natural killer (NK) cells participate in host defense by surveying for and ultimately killing virally infected or malignant target cells. NK cell cytotoxicity is a tightly regulated process that proceeds stepwise from adhesion and activation to the secretion of preformed lytic granule contents onto a diseased or stres...

journal_title：Blood

authors： James AM,Hsu HT,Dongre P,Uzel G,Mace EM,Banerjee PP,Orange JS

更新日期：2013-04-04 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a malignant disease of the hematopoietic stem cell characterized by abnormal circulation and proliferation of malignant progenitors. In contrast to their normal counterparts, CML progenitors adhere poorly to bone marrow stroma or fibronectin (FN). Aside from anchoring progenitors ...

journal_title：Blood

authors： Lundell BI,McCarthy JB,Kovach NL,Verfaillie CM

更新日期：1996-03-15 00:00:00

abstract：:Follicular lymphoma (FL) grades 1 and 2 are regarded as a distinct disease entity, whereas data suggest that FL grade 3 might be an inhomogeneous tumor category. To define the biologic spectrum of FL, 89 follicular lymphomas were studied for their cytologic composition, antigen expression, mitotic and proliferation in...

journal_title：Blood

authors： Ott G,Katzenberger T,Lohr A,Kindelberger S,Rüdiger T,Wilhelm M,Kalla J,Rosenwald A,Müller JG,Ott MM,Müller-Hermelink HK

更新日期：2002-05-15 00:00:00

abstract：:Since the introduction of replacement therapy in the early 1960s by the infusion of plasma-derived factor VIII and IX preparations, important changes have occurred for hemophilia patients. We studied the medical and social developments over 30 years of hemophilia treatment. Since 1972, 5 cross-sectional national posta...

journal_title：Blood

authors： Plug I,van der Bom JG,Peters M,Mauser-Bunschoten EP,de Goede-Bolder A,Heijnen L,Smit C,Zwart-van Rijkom JE,Willemse J,Rosendaal FR

更新日期：2004-12-01 00:00:00

abstract：:Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases...

journal_title：Blood

authors： Tobin G,Thunberg U,Johnson A,Thörn I,Söderberg O,Hultdin M,Botling J,Enblad G,Sällström J,Sundström C,Roos G,Rosenquist R

更新日期：2002-03-15 00:00:00

abstract：:Gemtuzumab ozogamicin (GO) contains an anti-CD33 antibody to facilitate uptake of a toxic calicheamicin-gamma(1) derivative. While recent in vitro data demonstrated a quantitative relationship between CD33 expression and GO cytotoxicity, previous correlative studies failed to identify a significant association between...

journal_title：Blood

authors： Walter RB,Gooley TA,van der Velden VH,Loken MR,van Dongen JJ,Flowers DA,Bernstein ID,Appelbaum FR

更新日期：2007-05-15 00:00:00

abstract：:Antithymocyte globulin (ATG) has recently been popularized as an effective treatment in myelodysplastic syndrome (MDS). We treated 8 anemic MDS patients (refractory anemia [RA] and refractory anemia with excess blasts [RAEB-1]) with ATG (40 mg/kg/d for 4 days) and prednisone in a phase 2 trial. The study was stopped e...

journal_title：Blood

authors： Steensma DP,Dispenzieri A,Moore SB,Schroeder G,Tefferi A

更新日期：2003-03-15 00:00:00