Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting.

abstract：:Proteins exported from Plasmodium falciparum parasites into red blood cells (RBCs) interact with the membrane skeleton and contribute to the pathogenesis of malaria. Specifically, exported proteins increase RBC membrane rigidity, decrease deformability, and increase adhesiveness, culminating in intravascular sequestra...

journal_title：Blood

authors： Glenister FK,Fernandez KM,Kats LM,Hanssen E,Mohandas N,Coppel RL,Cooke BM

更新日期：2009-01-22 00:00:00

abstract：:The majority of mouse Vα14 invariant natural killer T (Vα14i NKT) cells produce several cytokines, including IFNγ and IL-4, very rapidly after activation. A subset of these cells, known as NKT17 cells, however, differentiates in the thymus to preferentially produce IL-17. Here, we show that the transcription factor-kn...

journal_title：Blood

authors： Engel I,Zhao M,Kappes D,Taniuchi I,Kronenberg M

更新日期：2012-11-29 00:00:00

abstract：:The aim of this study was to investigate whether interleukin (IL)-6 induces the production of IL-1 and tumor necrosis factor (TNF) antagonists. Serial plasma samples were obtained from cancer patients participating in phase I and II trials of recombinant IL-6 administered as a 120-hour continuous intravenous (IV) infu...

journal_title：Blood

authors： Tilg H,Trehu E,Atkins MB,Dinarello CA,Mier JW

更新日期：1994-01-01 00:00:00

abstract：:The pathogenesis of thrombotic thrombocytopenic purpura (TTP) is obscure. It is manifested classically by platelet thrombi and localized microvascular endothelial cell (EC) proliferation, in the absence of an inflammatory response. It is statistically associated with human retroviral disease, but pathological studies ...

journal_title：Blood

authors： Laurence J,Mitra D,Steiner M,Staiano-Coico L,Jaffe E

更新日期：1996-04-15 00:00:00

abstract：:Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers. All 50 household contac...

journal_title：Blood

authors： Lawrence DN,Jason JM,Bouhasin JD,McDougal JS,Knutsen AP,Evatt BL,Joist JH

更新日期：1985-09-01 00:00:00

abstract：:Combination cytokine therapy continues to be evaluated in an effort to stimulate multilineage hematopoietic reconstitution after bone marrow myelosuppression. This study evaluated the efficacy of combination therapy with the synthetic interleukin-3 receptor agonist, Synthokine-SC55494, and recombinant methionyl human ...

journal_title：Blood

authors： MacVittie TJ,Farese AM,Herodin F,Grab LB,Baum CM,McKearn JP

更新日期：1996-05-15 00:00:00

abstract：:Although preclinical work with rapalogs suggests potential in treatment of multiple myeloma (MM), they have been less successful clinically. These drugs allostearically inhibit the mammalian target of rapamycin kinase primarily curtailing activity of the target of rapamycin complex (TORC)1. To assess if the mammalian ...

journal_title：Blood

authors： Hoang B,Frost P,Shi Y,Belanger E,Benavides A,Pezeshkpour G,Cappia S,Guglielmelli T,Gera J,Lichtenstein A

更新日期：2010-11-25 00:00:00

abstract：:NF-kappaB is a transcription factor that controls the expression of a number of genes important for mediating immune and inflammatory responses. In this study, we examined whether bortezomib and PS-1145, each of which inhibits NF-kappaB, could protect mice from lethal graft-versus-host disease (GVHD), which is charact...

journal_title：Blood

authors： Vodanovic-Jankovic S,Hari P,Jacobs P,Komorowski R,Drobyski WR

更新日期：2006-01-15 00:00:00

abstract：:Recombinant rat stem cell factor (rrSCF) administered to rats as a single intravenous injection causes a dose-dependent neutrophilia and lymphocytosis as well as the appearance of immature myeloid cells and occasional blast cells in the circulation. Neutrophilia begins at 2 hours, peaks at 4 to 6 hours, and subsides b...

journal_title：Blood

authors： Ulich TR,del Castillo J,Yi ES,Yin S,McNiece I,Yung YP,Zsebo KM

更新日期：1991-08-01 00:00:00

abstract：:A myeloma cell-reactive monoclonal antibody (MoAb), MM4, was generated from BALB/c mice immunized with alternate injections of cells from two human multiple myeloma (MM) cell lines. Screening by the enzyme-linked immunosorbent assay (ELISA) technique showed that MM4 reacted with human MM cell lines (7 of 7 positive), ...

journal_title：Blood

authors： Tong AW,Lee JC,Stone MJ

更新日期：1987-01-01 00:00:00

abstract：:Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitous...

journal_title：Blood

authors： Gilchrist M,McCauley SD,Befus AD

更新日期：2004-07-15 00:00:00

abstract：:The proapoptotic function of p53 is thought to underlie most anticancer modalities and is also activated in response to oncogenic insults, such as overexpression of the Myc oncoprotein. Here we generated tractable B lymphomas using retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in al...

journal_title：Blood

authors： Yu D,Carroll M,Thomas-Tikhonenko A

更新日期：2007-06-01 00:00:00

abstract：:Using a specific enzyme-linked immunosorbent assay, plasminogen activator inhibitor-2 (PAI-2) was quantitated in cultures of human monocytes. Lipopolysaccharide (LPS) increased both extracellular and cell-associated PAI-2 levels, as well as PAI-2 mRNA measured by Northern analysis. Both the lymphokine, interleukin-4 (...

journal_title：Blood

authors： Hamilton JA,Whitty GA,Last K,Royston AK,Hart PH,Burgess DR

更新日期：1992-07-01 00:00:00

abstract：:Sickle cell disease (SCD) is characterized by recurring episodes of vascular occlusion in which neutrophil activation plays a major role. The disease is associated with chronic hemolysis with elevated cell-free hemoglobin and heme. The ensuing depletion of heme scavenger proteins leads to nonspecific heme uptake and h...

journal_title：Blood

authors： Chen G,Zhang D,Fuchs TA,Manwani D,Wagner DD,Frenette PS

更新日期：2014-06-12 00:00:00

abstract：:The present study focuses on a large family with an X-linked immunodeficiency in which there are variable clinical and laboratory phenotypes, including recurrent viral and bacterial infections, hypogammaglobulinemia, Epstein-Barr virus-driven lymphoproliferation, splenomegaly, colitis, and liver disease. Molecular and...

journal_title：Blood

authors： Rigaud S,Lopez-Granados E,Sibéril S,Gloire G,Lambert N,Lenoir C,Synaeve C,Stacey M,Fugger L,Stephan JL,Fischer A,Picard C,Durandy A,Chapel H,Latour S

更新日期：2011-07-14 00:00:00

abstract：:We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet generation were recor...

journal_title：Blood

authors： Di Buduo CA,Wray LS,Tozzi L,Malara A,Chen Y,Ghezzi CE,Smoot D,Sfara C,Antonelli A,Spedden E,Bruni G,Staii C,De Marco L,Magnani M,Kaplan DL,Balduini A

更新日期：2015-04-02 00:00:00

abstract：:Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been invaluable for identification of new molecular targets. Because of low sample sizes and hetero...

journal_title：Blood

authors： Baaten CCFMJ,Meacham S,de Witt SM,Feijge MAH,Adams DJ,Akkerman JN,Cosemans JMEM,Grassi L,Jupe S,Kostadima M,Mattheij NJA,Prins MH,Ramirez-Solis R,Soehnlein O,Swieringa F,Weber C,White JK,Ouwehand WH,Heemskerk JWM

更新日期：2018-12-13 00:00:00

abstract：:The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, the available data fully justify critical reassessment of CML management. The panel therefore reviewed treatment of CML sinc...

journal_title：Blood

authors： Baccarani M,Saglio G,Goldman J,Hochhaus A,Simonsson B,Appelbaum F,Apperley J,Cervantes F,Cortes J,Deininger M,Gratwohl A,Guilhot F,Horowitz M,Hughes T,Kantarjian H,Larson R,Niederwieser D,Silver R,Hehlmann R,Europea

更新日期：2006-09-15 00:00:00

abstract：:A genetic mutation in mice (W/Wv) causes an autosomal recessive disease characterized by hypoplastic anemia which lasts throughout life. Double-dominant W/Wv anemic mice were sublethally irradiated to facilitate repopulation of marrow with transplanted cells and were injected intravenously with suspensions of 5-10 mil...

journal_title：Blood

authors： Dancis J,Jansen V,Brown GF,Gorstein F,Balis ME

更新日期：1977-10-01 00:00:00

abstract：:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, acti...

journal_title：Blood

authors： Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

更新日期：2015-10-29 00:00:00

abstract：:Immune reconstitution of autologous hematopoietic stem-cell transplant recipients with the progeny of mature T cells in the graft leads to profound changes in the emerging functional T-cell repertoire. In the steady state, the host is frequently tolerant to tumor antigens, reflecting dominant suppression of naive and ...

journal_title：Blood

authors： Mirmonsef P,Tan G,Zhou G,Morino T,Noonan K,Borrello I,Levitsky HI

更新日期：2008-02-15 00:00:00

abstract：:Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)-infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in T cells of HIV-1-i...

journal_title：Blood

authors： Bäumler CB,Böhler T,Herr I,Benner A,Krammer PH,Debatin KM

更新日期：1996-09-01 00:00:00

abstract：:Ravulizumab (ALXN1210), a new complement C5 inhibitor, provides immediate, complete, and sustained C5 inhibition. This phase 3, open-label study assessed the noninferiority of ravulizumab to eculizumab in complement inhibitor-naive adults with paroxysmal nocturnal hemoglobinuria (PNH). Patients with lactate dehydrogen...

journal_title：Blood

authors： Lee JW,Sicre de Fontbrune F,Wong Lee Lee L,Pessoa V,Gualandro S,Füreder W,Ptushkin V,Rottinghaus ST,Volles L,Shafner L,Aguzzi R,Pradhan R,Schrezenmeier H,Hill A

更新日期：2019-02-07 00:00:00

abstract：:Genetic variation in the PEAR1 locus is linked to platelet reactivity and cardiovascular disease. The major G allele of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG-SNP), is associated with higher PEAR1 expression in platelets and endothelial cells than the minor A allele. ...

journal_title：Blood

authors： Izzi B,Pistoni M,Cludts K,Akkor P,Lambrechts D,Verfaillie C,Verhamme P,Freson K,Hoylaerts MF

更新日期：2016-08-18 00:00:00

abstract：:Graft-versus-host disease (GVHD), a life-threatening complication after allogeneic hematopoietic stem cell transplantation, is caused by alloreactive donor T cells that trigger host tissue damage. The inflammatory environment inside recipients is critical for GVHD pathogenesis, but the underpinning mechanisms remain e...

journal_title：Blood

authors： Zhao F,Zhang Y,Wang H,Jin M,He S,Shi Y,Guo Y,Zhang Y

更新日期：2011-02-03 00:00:00

abstract：:We report a patient with a disease characterized by proliferation of T cells with Fc receptors for IgG (TG). However, unlike lymphoid cells from normal individuals or from patients with other lymphoid malignancies, the patient's lymphocytes spontaneously produced gamma interferon (IFN-gamma) in vitro. The peripheral l...

journal_title：Blood

authors： Hooks JJ,Haynes BF,Detrick-Hooks B,Diehl LF,Gerrard TL,Fauci AS

更新日期：1982-01-01 00:00:00

abstract：:Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to nitrosourea-induced cytotoxicity and the development of secondary leukemia after nitrosourea treatment. Isolated CD34+ myeloid progenitors were also found to have l...

journal_title：Blood

authors： Gerson SL,Phillips W,Kastan M,Dumenco LL,Donovan C

更新日期：1996-09-01 00:00:00

abstract：:All-trans retinoic acid (RA) induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL). Nevertheless, most of these patients develop RA resistance and relapse. The mechanisms of RA resistance by APL cells are still unclear. To understand the characteristics of human leukemia, ...

journal_title：Blood

authors： Kizaki M,Matsushita H,Takayama N,Muto A,Ueno H,Awaya N,Kawai Y,Asou H,Kamada N,Ikeda Y

更新日期：1996-09-01 00:00:00

abstract：:In a series of 153 children with T-cell malignancies enrolled in 2 consecutive European Organization for Research and Treatment of Cancer (EORTC) trials, we assessed the HOX11L2 expression and/or the presence of a t(5;14)(q35;q32). Additionally, in 138 of these patients, HOX11 expression and SIL-TAL rearrangement were...

journal_title：Blood

authors： Cavé H,Suciu S,Preudhomme C,Poppe B,Robert A,Uyttebroeck A,Malet M,Boutard P,Benoit Y,Mauvieux L,Lutz P,Méchinaud F,Grardel N,Mazingue F,Dupont M,Margueritte G,Pages MP,Bertrand Y,Plouvier E,Brunie G,Bastard C,P

更新日期：2004-01-15 00:00:00

abstract：:The signals that mediate T-cell infiltration during T-cell autoimmune diseases are poorly understood. The chemokine CCL21 (originally isolated by us and others as Exodus-2/6Ckine/SLC/TCA4) is highly potent and highly specific for stimulating T-cell migration. However, it is thought to be expressed only in secondary ly...

journal_title：Blood

authors： Christopherson KW 2nd,Hood AF,Travers JB,Ramsey H,Hromas RA

更新日期：2003-02-01 00:00:00