Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53.

abstract：:Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating IgG antibodies that recognize platelet factor 4 (PF4) bound to heparin. Immunogenicity of heparins differs in that unfractionated heparin (UFH) induces more anti-PF4/heparin antibodies than low-molecular-weight heparin (LMWH) and UFH also causes m...

journal_title：Blood

authors： Warkentin TE,Cook RJ,Marder VJ,Sheppard JA,Moore JC,Eriksson BI,Greinacher A,Kelton JG

更新日期：2005-12-01 00:00:00

abstract：:Oxygen deprivation (hypoxia) is a consistent component of ischemia that induces an inflammatory and prothrombotic response in the endothelium. In this report, it is demonstrated that exposure of endothelial cells to hypoxia (1% O(2)) increases messenger RNA and protein levels of transforming growth factor-beta2 (TGF-b...

journal_title：Blood

authors： Akman HO,Zhang H,Siddiqui MA,Solomon W,Smith EL,Batuman OA

更新日期：2001-12-01 00:00:00

abstract：:Chromosomal rearrangements affecting RUNX1 and CBFB are common in acute leukemias. These mutations result in the expression of fusion proteins that act dominant-negatively to suppress the normal function of the Runt-related transcription factor 1 (RUNX)/core binding factor beta (CBFbeta) complexes. In addition, loss-o...

journal_title：Blood

authors： Kundu M,Compton S,Garrett-Beal L,Stacy T,Starost MF,Eckhaus M,Speck NA,Liu PP

更新日期：2005-11-15 00:00:00

abstract：:The study of the molecular bases of thrombophilia in a large family with 4 symptomatic members is reported. Three thrombophilic genetic components (FV R506Q, FV H1299R, and PT 20210G/A), all affecting the activity of the prothrombinase complex, were detected alone and in combination in various family members. In addit...

journal_title：Blood

authors： Castoldi E,Simioni P,Kalafatis M,Lunghi B,Tormene D,Girelli D,Girolami A,Bernardi F

更新日期：2000-08-15 00:00:00

abstract：:The Aalpha-fibrinogen Thr312Ala polymorphism, which occurs in a region involved in factor XIII (FXIII)-dependent cross-linking processes, is associated with poststroke mortality in subjects with atrial fibrillation, suggesting an influence either on intraatrial clot formation or embolization. We have determined the as...

journal_title：Blood

authors： Carter AM,Catto AJ,Kohler HP,Ariëns RA,Stickland MH,Grant PJ

更新日期：2000-08-01 00:00:00

abstract：:Approximately 4% to 5% of all bone marrow (BM) cells and 8% to 9% of low density BM cells from FVB/N and BALB/c mice (Ly-6a haplotype) show high to intermediate expression of Ly-6E.1 antigen, recognized by the Sca-1 antibody. Functional properties of enriched cells expressing Ly-6E.1-allelic form of Sca-1 antigen were...

journal_title：Blood

authors： Jurecic R,Van NT,Belmont JW

更新日期：1993-11-01 00:00:00

abstract：:While studying patient plasma containing an unusual pattern of von Willebrand factor (VWF) multimers, we discovered a previously unreported phenomenon: heavy predominance of dimeric VWF. Genomic analysis revealed a new congenital mutation (Tyr87Ser) that altered the final stages of VWF biosynthesis. This mutation in t...

journal_title：Blood

authors： Rosenberg JB,Haberichter SL,Jozwiak MA,Vokac EA,Kroner PA,Fahs SA,Kawai Y,Montgomery RR

更新日期：2002-09-01 00:00:00

abstract：:A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral bl...

journal_title：Blood

authors： Wiggans RG,Jacobson RJ,Fialkow PJ,Woolley PV 3rd,Macdonald JS,Schein PS

更新日期：1978-10-01 00:00:00

abstract：:Human K562 erythroleukemia cells were transfected with human band 3 (anion exchanger 1 [AE1]) cDNA, using the pBabe retroviral vector. Stable K562 clones expressing band 3 were isolated by flow cytometry, and surface expression was quantified by immunoblotting. The function of band 3 expressed at the cell surface was ...

journal_title：Blood

authors： Beckmann R,Smythe JS,Anstee DJ,Tanner MJ

更新日期：1998-12-01 00:00:00

abstract：:Stem cell proliferation induced by potent cytokines usually leads to a loss of primitive potential through differentiation. In this study, the ability of cytokines and murine MS5 stromal cells to independently regulate the proliferation and long-term culture-initiating cell (LTC-IC) activity of primitive CD34(+)CD38(l...

journal_title：Blood

authors： Bennaceur-Griscelli A,Pondarré C,Schiavon V,Vainchenker W,Coulombel L

更新日期：2001-01-15 00:00:00

abstract：:The molecular mechanisms that underlie T-cell quiescence are poorly understood. In the present study, we report a primary immunodeficiency phenotype associated with MST1 deficiency and primarily characterized by a progressive loss of naive T cells. The in vivo consequences include recurrent bacterial and viral infecti...

journal_title：Blood

authors： Nehme NT,Schmid JP,Debeurme F,André-Schmutz I,Lim A,Nitschke P,Rieux-Laucat F,Lutz P,Picard C,Mahlaoui N,Fischer A,de Saint Basile G

更新日期：2012-04-12 00:00:00

abstract：:Interleukin 2 (IL-2) rescued human natural killer (NK) KHYG-1 cells from apoptosis along with a reduction of ceramide. Conversely, an increase of ceramide inhibited IL-2-rescued survival. IL-2 deprivation-induced activation of acid sphingomyelinase (SMase) and inhibition of glucosylceramide synthase (GCS) and sphingom...

journal_title：Blood

authors： Taguchi Y,Kondo T,Watanabe M,Miyaji M,Umehara H,Kozutsumi Y,Okazaki T

更新日期：2004-11-15 00:00:00

abstract：:A method is described that allows for the routine long-term (greater than 3 mo) growth of normal, immature human myeloid cells in liquid suspension culture. The techniques employ cell separation, utilization of special growth conditions (RPMI with hydrocortisone and vitamin D), and cord blood as the source of leukocyt...

journal_title：Blood

authors： Salahuddin SZ,Markham PD,Ruscetti FW,Gallo RC

更新日期：1981-11-01 00:00:00

abstract：:To assess the relationship between venous thrombosis and plasma glucosylceramide (GlcCer) or phosphatidylethanolamine (PE), plasma levels of GlcCer and PE were determined for 70 venous thrombosis patients referred for evaluation and 70 healthy blood donors. The mean GlcCer level, but not the PE level, was lower in pat...

journal_title：Blood

authors： Deguchi H,Fernández JA,Pabinger I,Heit JA,Griffin JH

更新日期：2001-04-01 00:00:00

abstract：:MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote sel...

journal_title：Blood

authors： Argiropoulos B,Yung E,Xiang P,Lo CY,Kuchenbauer F,Palmqvist L,Reindl C,Heuser M,Sekulovic S,Rosten P,Muranyi A,Goh SL,Featherstone M,Humphries RK

更新日期：2010-05-20 00:00:00

abstract：:IgM-secreting plasma cell tumors are rare variants of typical isotype-switched multiple myeloma with a similar disease outcome. To probe the origin and clonal history of these tumors, we have analyzed V(H) gene sequences in 6 cases. Potentially functional tumor-derived V(H) genes were all derived from V(H)3, with the ...

journal_title：Blood

authors： Sahota SS,Garand R,Mahroof R,Smith A,Juge-Morineau N,Stevenson FK,Bataille R

更新日期：1999-08-01 00:00:00

abstract：:Human natural killer (NK) cells comprise 2 main subsets, CD56(bright) and CD56(dim) cells, that differ in function, phenotype, and tissue localization. To further dissect the heterogeneity of CD56(dim) cells, we have performed transcriptome analysis and functional ex vivo characterization of human NK-cell subsets acco...

journal_title：Blood

authors： Juelke K,Killig M,Luetke-Eversloh M,Parente E,Gruen J,Morandi B,Ferlazzo G,Thiel A,Schmitt-Knosalla I,Romagnani C

更新日期：2010-08-26 00:00:00

abstract：:Chronic myeloid leukemia (CML) patients with the BCR-ABL T315I mutation do not benefit from therapy with currently approved tyrosine kinase inhibitors. Omacetaxine mepesuccinate is a protein synthesis inhibitor that has demonstrated activity in cells harboring the T315I mutation. This phase 2 trial assessed the effica...

journal_title：Blood

authors： Cortes J,Lipton JH,Rea D,Digumarti R,Chuah C,Nanda N,Benichou AC,Craig AR,Michallet M,Nicolini FE,Kantarjian H,Omacetaxine 202 Study Group.

更新日期：2012-09-27 00:00:00

abstract：:The family of core-binding factors includes the DNA-binding subunits Runx1-3 and their common non-DNA-binding partner CBFbeta. We examined the collective role of core-binding factors in hematopoiesis with a hypomorphic Cbfb allelic series. Reducing CBFbeta levels by 3- or 6-fold caused abnormalities in bone developmen...

journal_title：Blood

authors： Talebian L,Li Z,Guo Y,Gaudet J,Speck ME,Sugiyama D,Kaur P,Pear WS,Maillard I,Speck NA

更新日期：2007-01-01 00:00:00

abstract：:Understanding the molecular pathogenesis of lymphoma has led to paradigm-changing treatment opportunities. One example involves tailoring specific agents based on the cell of origin in aggressive lymphomas. Germinal center (GC)-derived diffuse large B-cell lymphoma (DLBCL) is known to be driven by an addiction to Bcl6...

journal_title：Blood

authors： Amengual JE,Clark-Garvey S,Kalac M,Scotto L,Marchi E,Neylon E,Johannet P,Wei Y,Zain J,O'Connor OA

更新日期：2013-09-19 00:00:00

abstract：:The tumorigenicity of most cases of ALK-positive anaplastic large-cell lymphoma (ALK+ ALCL) is driven by the oncogenic fusion protein NPM-ALK in a STAT3-dependent manner. Because it has been shown that STAT3 can be inhibited by STAT1 in some experimental models, we hypothesized that the STAT1 signaling pathway is defe...

journal_title：Blood

authors： Wu C,Molavi O,Zhang H,Gupta N,Alshareef A,Bone KM,Gopal K,Wu F,Lewis JT,Douglas DN,Kneteman NM,Lai R

更新日期：2015-07-16 00:00:00

abstract：:The stage of progenitor maturation and factors that determine the fate and clonal acquisition of human natural killer (NK) cell receptors during development are unknown. To study human NK cell receptor ontogeny, umbilical cord blood CD34(+)/Lin(-)/CD38(-) cells were cultured with a murine fetal liver line (AFT024) and...

journal_title：Blood

authors： Miller JS,McCullar V

更新日期：2001-08-01 00:00:00

abstract：:Administration of hematopoietic growth factors is being used increasingly to obtain populations of blood progenitor/stem cells (PBPC) for clinical transplantation. Here we examined the effect of combining stem cell factor (SCF ) and granulocyte colony-stimulating factor (G-CSF ) versus G-CSF alone in a randomized clin...

journal_title：Blood

authors： Begley CG,Basser R,Mansfield R,Thomson B,Parker WR,Layton J,To B,Cebon J,Sheridan WP,Fox RM,Green MD

更新日期：1997-11-01 00:00:00

abstract：:Erdheim-Chester disease (ECD) pathophysiology remains largely unknown. Its treatment is not codified and usually disappointing. Interferon (IFN)-α therapy lacks efficacy for some life-threatening manifestations and has a poor tolerance profile. Because interleukin (IL)-1Ra synthesis is naturally induced after stimulat...

journal_title：Blood

authors： Aouba A,Georgin-Lavialle S,Pagnoux C,Martin Silva N,Renand A,Galateau-Salle F,Le Toquin S,Bensadoun H,Larousserie F,Silvera S,Provost N,Candon S,Seror R,de Menthon M,Hermine O,Guillevin L,Bienvenu B

更新日期：2010-11-18 00:00:00

abstract：:Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4+ T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not supp...

journal_title：Blood

authors： Barchet W,Price JD,Cella M,Colonna M,MacMillan SK,Cobb JP,Thompson PA,Murphy KM,Atkinson JP,Kemper C

更新日期：2006-02-15 00:00:00

abstract：:Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cel...

journal_title：Blood

authors： Nilsson L,Edén P,Olsson E,Månsson R,Astrand-Grundström I,Strömbeck B,Theilgaard-Mönch K,Anderson K,Hast R,Hellström-Lindberg E,Samuelsson J,Bergh G,Nerlov C,Johansson B,Sigvardsson M,Borg A,Jacobsen SE

更新日期：2007-10-15 00:00:00

abstract：:During mouse cytomegalovirus (CMV) infection, a population of Ly49H(+) natural killer (NK) cells expands and is responsible for disease clearance through the induction of a "memory NK-cell response." Whether similar events occur in human CMV infection is unknown. In the present study, we characterized the kinetics of ...

journal_title：Blood

authors： Foley B,Cooley S,Verneris MR,Pitt M,Curtsinger J,Luo X,Lopez-Vergès S,Lanier LL,Weisdorf D,Miller JS

更新日期：2012-03-15 00:00:00

abstract：:Indolent systemic mastocytosis (SM) patients have a varied clinical presentation, ranging from predominantly cutaneous symptoms to recurrent systemic symptoms (eg, flushing, palpitations, dyspepsia, diarrhea, bone pain) that can be severe and potentially life threatening (anaphylaxis). Mastocytosis patients without sk...

journal_title：Blood

authors： Pardanani A

更新日期：2013-04-18 00:00:00

abstract：:The Eastern Cooperative Oncology Group (ECOG) conducted a randomized trial in patients less than or equal to 65 years old (median, 44 years) to determine whether increasing the intensity of postremission therapy in acute myeloid leukemia (AML) would improve the outcome. After uniform induction therapy, patients in com...

journal_title：Blood

authors： Cassileth PA,Lynch E,Hines JD,Oken MM,Mazza JJ,Bennett JM,McGlave PB,Edelstein M,Harrington DP,O'Connell MJ

更新日期：1992-04-15 00:00:00

abstract：:The past 40 years have witnessed major advances in defining the cytogenetic aberrations, mutational landscape, epigenetic profiles, and expression changes underlying hematological malignancies. Although it has become apparent that acute myeloid leukemia (AML) is highly heterogeneous at the molecular level, the standar...

journal_title：Blood

authors： Grimwade D,Freeman SD

更新日期：2014-11-27 00:00:00