Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function.

abstract：:Renal disease has not been considered a major late complication of bone marrow transplantation. Of 31 evaluable pediatric patients undergoing allogeneic or autologous bone marrow transplantation for neuroblastoma or acute lymphoblastic leukemia, 14 developed a hemolytic anemia, microscopic hematuria, and renal insuffi...

journal_title：Blood

authors： Guinan EC,Tarbell NJ,Niemeyer CM,Sallan SE,Weinstein HJ

更新日期：1988-08-01 00:00:00

abstract：:Viral infections are common and are potentially life-threatening in patients with moderate to severe primary immunodeficiency disorders. Because T-cell immunity contributes to the control of many viral pathogens, adoptive immunotherapy with virus-specific T cells (VSTs) has been a logical and effective way of combatin...

journal_title：Blood

authors： Keller MD,Bollard CM

更新日期：2020-02-27 00:00:00

abstract：:The non-Hodgkin's lymphoma (NHL) subset commonly referred to as large cell lymphoma (LCL) has historically been characterized by it's marked cytological, immunological, and clinical heterogeneity. One potential defining feature of these lymphomas, the t(2;5)(p23;q35), occurs in 25% to 30% of anaplastic LCLs and is als...

journal_title：Blood

authors： Mathew P,Sanger WG,Weisenburger DD,Valentine M,Valentine V,Pickering D,Higgins C,Hess M,Cui X,Srivastava DK,Morris SW

更新日期：1997-03-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory disease. Inherited forms of HLH are caused by biallelic mutations in several effectors of granule-dependent lymphocyte-mediated cytotoxicity. A small proportion of patients with a so-called "secondary" form of HLH, which develops in the a...

journal_title：Blood

authors： Sepulveda FE,Garrigue A,Maschalidi S,Garfa-Traore M,Ménasché G,Fischer A,de Saint Basile G

更新日期：2016-04-28 00:00:00

abstract：:The number of CD34+ cells in the peripheral blood of cancer patients is known to be increased following the administration of high dose chemotherapy and hematopoietic growth factors. These so-called peripheral blood stem cell grafts are now frequently used for autologous transplantation of patients with malignancies. ...

journal_title：Blood

authors： Murray L,Chen B,Galy A,Chen S,Tushinski R,Uchida N,Negrin R,Tricot G,Jagannath S,Vesole D

更新日期：1995-01-15 00:00:00

abstract：:Current monoclonal antibody therapies for multiple myeloma have had limited success, perhaps due to narrow target specificity. We have previously described the ability of polyclonal rabbit antithymocyte globulin (rATG) to induce caspase- and cathepsin-mediated apoptosis in human B and plasma cells. We now extend this ...

journal_title：Blood

authors： Zand MS,Vo T,Pellegrin T,Felgar R,Liesveld JL,Ifthikharuddin JJ,Abboud CN,Sanz I,Huggins J

更新日期：2006-04-01 00:00:00

abstract：:The kidney is involved in 70% of patients with immunoglobulin light-chain (AL) amyloidosis, but little is known on progression or reversibility of renal involvement, and criteria for renal response have never been validated. Newly diagnosed patients from the Pavia (n = 461, testing cohort) and Heidelberg (n = 271, val...

journal_title：Blood

authors： Palladini G,Hegenbart U,Milani P,Kimmich C,Foli A,Ho AD,Vidus Rosin M,Albertini R,Moratti R,Merlini G,Schönland S

更新日期：2014-10-09 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV (AIDS-related PCNSL). These cases are poorly characteri...

journal_title：Blood

authors： Gandhi MK,Hoang T,Law SC,Brosda S,O'Rourke K,Tobin JWD,Vari F,Murigneux V,Fink JL,Gunawardana J,Gould CM,Oey H,Bednarska K,Delecluse S,Trappe RU,de Long LM,Sabdia MB,Bhagat G,Hapgood G,Blyth E,Clancy LE,Wight J

更新日期：2020-11-17 00:00:00

abstract：:von Willebrand's antigen II (vW AgII), a plasma and platelet antigen immunologically and biochemically distinct from factor-VIII-related antigen (VIIIR:Ag), is decreased in von Willebrand's disease. vW AgII is released from platelets during aggregation and clotting. The release of platelet vW AgII was studied in washe...

journal_title：Blood

authors： Scott JP,Montgomery RR

更新日期：1981-12-01 00:00:00

abstract：:DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display highly dysregulated DNA methylation profiles, characterized by global hypomethylation in conjunction with hypermethylation of promoter CpG is...

journal_title：Blood

authors： Lio CJ,Yuita H,Rao A

更新日期：2019-10-31 00:00:00

abstract：:In children with acute lymphoblastic leukemia (ALL), the level of minimal residual disease (MRD) at the end of induction strongly predicts outcome, presumably because it measures both drug sensitivity and the number of leukemic cells requiring elimination. Children with high levels (> 10(-3) leukemic cells per marrow ...

journal_title：Blood

authors： Brisco J,Hughes E,Neoh SH,Sykes PJ,Bradstock K,Enno A,Szer J,McCaul K,Morley AA

更新日期：1996-06-15 00:00:00

abstract：:The differentiation of human peripheral blood monocytes into resident macrophages is driven by colony-stimulating factor-1 (CSF-1), which upon interaction with CSF-1 receptor (CSF-1R) induces within minutes the phosphorylation of its cytoplasmic tyrosine residues and the activation of multiple signaling complexes. Cas...

journal_title：Blood

authors： Jacquel A,Benikhlef N,Paggetti J,Lalaoui N,Guery L,Dufour EK,Ciudad M,Racoeur C,Micheau O,Delva L,Droin N,Solary E

更新日期：2009-10-22 00:00:00

abstract：:Megakaryopoiesis is the hierarchical differentiation of hematopoietic stem cells into megakaryocytes. Differentiating megakaryocytes undergo maturation characterized by endomitosis and produce numerous platelets through proplatelet formation. C-type lectin-like receptor 2 (CLEC-2) is a podoplanin (PDPN) receptor mainl...

journal_title：Blood

authors： Tamura S,Suzuki-Inoue K,Tsukiji N,Shirai T,Sasaki T,Osada M,Satoh K,Ozaki Y

更新日期：2016-03-31 00:00:00

abstract：:Interleukin-1 (IL-1) has been shown to ameliorate the hematopoietic toxicities of antitumor chemotherapeutic agents in both mice and humans. However, IL-1 toxicity in humans is considerable and is similar to the systemic inflammatory toxicities induced by IL-3, IL-6, and other cytokines with pleiotropic biologic activ...

journal_title：Blood

authors： Rinehart J,Delamater EW,Keville L,Measel J

更新日期：1994-09-01 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) in children is sometimes characterized by a severe course, requiring prolonged administration of immunosuppressive therapy. Rituximab is able to cause selective in vivo destruction of B lymphocytes, with abrogation of antibody production. In a prospective study, we have evaluated the...

journal_title：Blood

authors： Zecca M,Nobili B,Ramenghi U,Perrotta S,Amendola G,Rosito P,Jankovic M,Pierani P,De Stefano P,Bonora MR,Locatelli F

更新日期：2003-05-15 00:00:00

abstract：:Congenital deficiency in coagulation factor XIII is a rare autosomal recessive bleeding disorder. Although the defect was characterized over 30 years ago, little is known about the molecular basis of the disorder. Here, we show two novel point mutations in the gene of the A-subunit of factor XIII in the genetically is...

journal_title：Blood

authors： Mikkola H,Syrjälä M,Rasi V,Vahtera E,Hämäläinen E,Peltonen L,Palotie A

更新日期：1994-07-15 00:00:00

abstract：:The subcellular localization of the platelet membrane receptors glycoproteins (GP) Ib and IIb/IIIa [corrected] has been studied within resting platelets by a combination of biochemical and cytochemical techniques. While both GPIb and GPIIb/IIIa are localized within the plasma membrane and surface-connected canalicular...

journal_title：Blood

authors： Cramer EM,Lu H,Caen JP,Soria C,Berndt MC,Tenza D

更新日期：1991-02-15 00:00:00

abstract：:6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) is a novel compound that represents the prototype of a new class of synthetic retinoids with apoptogenic properties in acute promyelocytic leukemia (APL) and other types of leukemia. In this article, using SCID mice xenografted with APL-derived NB4 ...

journal_title：Blood

authors： Ponzanelli I,Giannì M,Giavazzi R,Garofalo A,Nicoletti I,Reichert U,Erba E,Rambaldi A,Terao M,Garattini E

更新日期：2000-04-15 00:00:00

abstract：:Sickle cell anemia (SCA) is an inherited disorder of beta-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is associated with an 8% to 10% mortality rate, primarily from complications ...

journal_title：Blood

authors： Iannone R,Luznik L,Engstrom LW,Tennessee SL,Askin FB,Casella JF,Kickler TS,Goodman SN,Hawkins AL,Griffin CA,Noffsinger L,Fuchs EJ

更新日期：2001-06-15 00:00:00

abstract：:Mice homozygous for Hertwig's anemia, an/an, have a mild macrocytic anemia and are refractory to the potentially curative action of exogenously administered erythropoietin (EP). Both red and white blood cell numbers are decreased. One possible explanation is that a precursor stem cell population is in short supply. We...

journal_title：Blood

authors： Barker JE,Bernstein SE

更新日期：1983-04-01 00:00:00

abstract：:Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor immunity. However, the underlying reasons for this impaired NK cell function remain to be uncovered. We found that NK cells in aggressive B-cell lymphoma underwen...

journal_title：Blood

authors： Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

更新日期：2020-12-24 00:00:00

abstract：:Folylpoly-gamma-gluatamate synthetase (FPGS) catalyzes the polyglutamylation and thus intracellular retention of folates and antifolates (eg, methotrexate; MTX) through the addition of multiple glutamate equivalents to their gamma-carboxyl residue. Since polyglutamylation of antifolates is crucial for their pharmacolo...

journal_title：Blood

authors： Stark M,Wichman C,Avivi I,Assaraf YG

更新日期：2009-04-30 00:00:00

abstract：:Imatinib mesylate, a competitive inhibitor of Abl tyrosine kinase, is highly effective for the early stages of chronic myelogenous leukemia (CML), but remissions induced in advanced-phase CML and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia tend to be relatively short-lived. Therefore, the searc...

journal_title：Blood

authors： Kuroda J,Kimura S,Segawa H,Kobayashi Y,Yoshikawa T,Urasaki Y,Ueda T,Enjo F,Tokuda H,Ottmann OG,Maekawa T

更新日期：2003-09-15 00:00:00

abstract：:Low-dose interferon-alpha (IFN-alpha) therapy is consistently effective in the treatment of hairy cell leukemia (HCL). In two cases of resistance to IFN-alpha administration, we diagnosed variant HCL, a form of HCL with intermediate features between typical HCL and B cell prolymphocytic leukemia. We tried to distingui...

journal_title：Blood

authors： Lehn P,Sigaux F,Grausz D,Loiseau P,Castaigne S,Degos L,Flandrin G,Dautry F

更新日期：1986-10-01 00:00:00

abstract：:The cells of hematopoietic and vascular endothelial cell lineages are believed to share a common precursor, termed hemangioblast. However, the existence of a growth factor acting relatively specifically on hemangioblasts remains unclear. Here we report the identification of hemangiopoietin (HAPO), a novel growth facto...

journal_title：Blood

authors： Liu YJ,Lu SH,Xu B,Yang RC,Ren Q,Liu B,Li B,Lu M,Yan FY,Han ZB,Han ZC

更新日期：2004-06-15 00:00:00

abstract：:Identification of human hematopoietic stem cells and analysis of molecular mechanisms regulating their function require biological assays that permit differentiation in all hematopoietic lineages simultaneously. In this study, we established conditions that permit the joint expression of the B-lymphoid and myeloid pot...

journal_title：Blood

authors： Berardi AC,Meffre E,Pflumio F,Katz A,Vainchenker W,Schiff C,Coulombel L

更新日期：1997-05-15 00:00:00

abstract：:The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a major role in shaping the human genome, and this methylation damage remains the primary source of somatic mutations that accumulate with age. How 5mC deamination contributes to cancer risk in different tissues remains unclear. Genomic ...

journal_title：Blood

authors： Sanders MA,Chew E,Flensburg C,Zeilemaker A,Miller SE,Al Hinai AS,Bajel A,Luiken B,Rijken M,Mclennan T,Hoogenboezem RM,Kavelaars FG,Fröhling S,Blewitt ME,Bindels EM,Alexander WS,Löwenberg B,Roberts AW,Valk PJM,Majews

更新日期：2018-10-04 00:00:00

abstract：:Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants wi...

journal_title：Blood

authors： Huffman JE,de Vries PS,Morrison AC,Sabater-Lleal M,Kacprowski T,Auer PL,Brody JA,Chasman DI,Chen MH,Guo X,Lin LA,Marioni RE,Müller-Nurasyid M,Yanek LR,Pankratz N,Grove ML,de Maat MP,Cushman M,Wiggins KL,Qi L,Sennb

更新日期：2015-09-10 00:00:00

abstract：:Although the genes for four hematopoietic colony-stimulating factors (CSFs) have been cloned, neither the mechanism of the regulation of their production nor their cellular origins have been established with certainty. Monocytes are known to produce colony-stimulating and burst-promoting activities, as well as several...

journal_title：Blood

authors： Sieff CA,Niemeyer CM,Mentzer SJ,Faller DV

更新日期：1988-10-01 00:00:00

abstract：:Leukocyte recruitment to inflammation sites depends on interactions between integrins and extracellular matrix (ECM). In this report we show that mice lacking the ECM protein mindin exhibit severely impaired recruitment of neutrophils and macrophages in 4 different inflammation models. Furthermore, neutrophils directl...

journal_title：Blood

authors： Jia W,Li H,He YW

更新日期：2005-12-01 00:00:00