Abstract：
:Leukocyte recruitment to inflammation sites depends on interactions between integrins and extracellular matrix (ECM). In this report we show that mice lacking the ECM protein mindin exhibit severely impaired recruitment of neutrophils and macrophages in 4 different inflammation models. Furthermore, neutrophils directly bind to immobilized mindin, and mindin matrix mediates neutrophil migration in vitro. The adhesion of neutrophils to mindin is blocked by anti-integrin alpha4, anti-integrin alpha(M), and anti-integrin beta2 antibodies. We also show that HEK-293 cells transfected with cDNA encoding these integrins exhibit enhanced binding to immobilized mindin matrix and the increased binding can be blocked by anti-integrin antibodies. Our results suggest that mindin serves as a novel ligand for integrins and mindin-integrin interactions are critical for inflammatory cell recruitment in vivo.
journal_name
Bloodjournal_title
Bloodauthors
Jia W,Li H,He YWdoi
10.1182/blood-2005-04-1658subject
Has Abstractpub_date
2005-12-01 00:00:00pages
3854-9issue
12eissn
0006-4971issn
1528-0020pii
2005-04-1658journal_volume
106pub_type
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