Synthesis of abnormal heavy chains in Bence-Jones plasma cell leukemia with intracellular IgG.

abstract：:The introduction of immunosuppressive therapy for treatment of aplastic anemia has led to a considerable improvement in the prognosis of this disease. However, long-term follow-up of these patients showed a high incidence of "late" hematologic complications such as myelodysplasia and paroxysmal nocturnal hemoglobinuri...

journal_title：Blood

authors： Schubert J,Vogt HG,Zielinska-Skowronek M,Freund M,Kaltwasser JP,Hoelzer D,Schmidt RE

更新日期：1994-04-15 00:00:00

abstract：:To study the role of different cytokine combinations on the proliferation and differentiation of highly purified primitive progenitor cells, a serum-free liquid culture system was used in combination with phenotypic and functional analysis of the cells produced in culture. CD34+ CD45RAlo CD71lo cells, purified from um...

journal_title：Blood

authors： Mayani H,Dragowska W,Lansdorp PM

更新日期：1993-06-15 00:00:00

abstract：:Skewed X-chromosome inactivation in peripheral blood granulocytes becomes more frequent with increasing age, affecting up to half of those over 75 years old. To investigate the mechanisms underlying this phenomenon, X-inactivation profiles in 33 monozygotic and 22 dizygotic elderly twin pairs were studied. Differentia...

journal_title：Blood

authors： Vickers MA,McLeod E,Spector TD,Wilson IJ

更新日期：2001-03-01 00:00:00

abstract：:Fibronectin (FN) plays a role in several adhesion mediated functions including the interaction of platelets with subendothelium. We investigated the role of plasma FN in platelet adhesion and platelet thrombus formation under flow conditions. We used two different perfusion models: the annular chamber with alpha-chymo...

journal_title：Blood

authors： Bastida E,Escolar G,Ordinas A,Sixma JJ

更新日期：1987-11-01 00:00:00

abstract：:The iron storage macrophage has been isolated from the marrow of Imferon-treated mice and studied in vitro by morphologic, histochemical, and functional tests and isotope labeling techniques. These macrophages on stained preparations are large, many times binucleate cells (up to 150 mu), and show Prussian blue reactiv...

journal_title：Blood

authors： Fedorko ME

更新日期：1975-03-01 00:00:00

abstract：:As a dendritic cell (DC) matures, it becomes more potent as an antigen-presenting cell. This functional change is accompanied by a change in DC immunophenotype. The signal transduction events underlying this process are poorly characterized. In this study, we have investigated the signal transduction pathways involved...

journal_title：Blood

authors： Ardeshna KM,Pizzey AR,Devereux S,Khwaja A

更新日期：2000-08-01 00:00:00

abstract：:Although sickle cell disease (SCD) has a variable clinical course, many patients develop end-organ complications that are associated with significant morbidity and early mortality. Myeloablative allogeneic HSCT (allo-HSCT) is curative but has been historically performed only in children younger than 16 years of age. M...

journal_title：Blood

authors： Hsieh MM,Fitzhugh CD,Tisdale JF

更新日期：2011-08-04 00:00:00

abstract：:To ascertain the genetic basis of a paroxysmal nocturnal hemoglobinuria (PNH) case without somatic mutations in PIGA, we performed deep next-generation sequencing on all exons of known genes of the glycosylphosphatidylinositol (GPI) anchor synthesis pathway. We identified a heterozygous germline splice site mutation i...

journal_title：Blood

authors： Krawitz PM,Höchsmann B,Murakami Y,Teubner B,Krüger U,Klopocki E,Neitzel H,Hoellein A,Schneider C,Parkhomchuk D,Hecht J,Robinson PN,Mundlos S,Kinoshita T,Schrezenmeier H

更新日期：2013-08-15 00:00:00

abstract：:Hematopoietic stem cells (HSC) transplanted in utero are in competition with endogenous HSC; thus, ultimately the graft constitutes a relatively small fraction of total HSC pool. To enhance the engraftment of donor cells in sheep fetuses, we preincubated these cells, ex vivo, for 16 hours at 37 degrees C with the cond...

journal_title：Blood

authors： Zanjani ED,Ascensao JL,Harrison MR,Tavassoli M

更新日期：1992-06-01 00:00:00

abstract：:In this issue of Blood, Goussetis et al identify autophagy as a new pathway for the degradation of the oncoprotein BCR-ABL. They show that the therapeutic drug arsenic trioxide (AS(2)O(3)) targets BCR-ABL for autophagic degradation via a p62/SQSTM1-dependent mechanism that is critical for the antileukemic effect of th...

journal_title：Blood

authors： Auberger P

更新日期：2012-10-25 00:00:00

abstract：:Hairy cell leukemia (HCL) is marked by near 100% mutational frequency of BRAFV600E mutations. Recurrent cooperating genetic events that may contribute to HCL pathogenesis or affect the clinical course of HCL are currently not described. Therefore, we performed whole exome sequencing to explore the mutational landscape...

journal_title：Blood

authors： Dietrich S,Hüllein J,Lee SC,Hutter B,Gonzalez D,Jayne S,Dyer MJ,Oleś M,Else M,Liu X,Słabicki M,Wu B,Troussard X,Dürig J,Andrulis M,Dearden C,von Kalle C,Granzow M,Jauch A,Fröhling S,Huber W,Meggendorfer M,Hafe

更新日期：2015-08-20 00:00:00

abstract：:Although infants with acute lymphoblastic leukemia (ALL) and a germline MLL gene have a better prognosis than comparable infants with a rearranged MLL gene, their optimal therapy is controversial. In 2 consecutive studies, conducted between 1996 and 2002, we treated 22 cases of infant ALL with germline MLL using chemo...

journal_title：Blood

authors： Nagayama J,Tomizawa D,Koh K,Nagatoshi Y,Hotta N,Kishimoto T,Takahashi Y,Kuno T,Sugita K,Sato T,Kato K,Ogawa A,Nakahata T,Mizutani S,Horibe K,Ishii E,Japan Infant Leukemia Study Group.

更新日期：2006-06-15 00:00:00

abstract：:Venomous snakes produce an array of toxic compounds, including procoagulants to defend themselves and incapacitate prey. The Australian snake Pseudonaja textilis has a venom-derived prothrombin activator homologous to coagulation factors V (FV) and Xa (FXa). Here we show that the FV component (pt-FV) has unique biolog...

journal_title：Blood

authors： Bos MH,Boltz M,St Pierre L,Masci PP,de Jersey J,Lavin MF,Camire RM

更新日期：2009-07-16 00:00:00

abstract：:Myelodysplastic syndromes (MDSs) are chronic and often progressive myeloid neoplasms associated with remarkable heterogeneity in the histomorphology and clinical course. Various somatic mutations are involved in the pathogenesis of MDS. Recently, mutations in a gene encoding a spliceosomal protein, SF3B1, were discove...

journal_title：Blood

authors： Makishima H,Visconte V,Sakaguchi H,Jankowska AM,Abu Kar S,Jerez A,Przychodzen B,Bupathi M,Guinta K,Afable MG,Sekeres MA,Padgett RA,Tiu RV,Maciejewski JP

更新日期：2012-04-05 00:00:00

abstract：:To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138(+) plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded to clusters desc...

journal_title：Blood

authors： Broyl A,Hose D,Lokhorst H,de Knegt Y,Peeters J,Jauch A,Bertsch U,Buijs A,Stevens-Kroef M,Beverloo HB,Vellenga E,Zweegman S,Kersten MJ,van der Holt B,el Jarari L,Mulligan G,Goldschmidt H,van Duin M,Sonneveld P

更新日期：2010-10-07 00:00:00

abstract：:The t(1;19)(q23;p13) chromosomal translocation is observed cytogenetically in 25% of children with pre-B-cell acute lymphoblastic leukemia (ALL) and is associated with an adverse treatment outcome. The t(1;19) juxtaposes the E2A gene from chromosome 19 with the PBX1 gene on chromosome 1, leading to the production of f...

journal_title：Blood

authors： Hunger SP,Galili N,Carroll AJ,Crist WM,Link MP,Cleary ML

更新日期：1991-02-15 00:00:00

abstract：:The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophilic erythroblast. Rema...

journal_title：Blood

authors： Yao H,Goldman DC,Nechiporuk T,Kawane S,McWeeney SK,Tyner JW,Fan G,Kerenyi MA,Orkin SH,Fleming WH,Mandel G

更新日期：2014-05-15 00:00:00

abstract：:CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally active adenovirus ve...

journal_title：Blood

authors： Tatsis N,Fitzgerald JC,Reyes-Sandoval A,Harris-McCoy KC,Hensley SE,Zhou D,Lin SW,Bian A,Xiang ZQ,Iparraguirre A,Lopez-Camacho C,Wherry EJ,Ertl HC

更新日期：2007-09-15 00:00:00

abstract：:The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds to decreases in tissue oxygenation with increased EPO production. Although studies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible factor 2 (Hif-2) plays a major role in the regulation ...

journal_title：Blood

authors： Kapitsinou PP,Liu Q,Unger TL,Rha J,Davidoff O,Keith B,Epstein JA,Moores SL,Erickson-Miller CL,Haase VH

更新日期：2010-10-21 00:00:00

abstract：:Sixteen patients treated by allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia (CML) were evaluated by the polymerase chain reaction (PCR) for bcr/abl-specific RNA transcripts at various time points after BMT. In reconstitution experiments, one CML cell per million normal mononuclear cells c...

journal_title：Blood

authors： Roth MS,Antin JH,Bingham EL,Ginsburg D

更新日期：1989-08-01 00:00:00

abstract：:In children with acute lymphoblastic leukemia (ALL), the level of minimal residual disease (MRD) at the end of induction strongly predicts outcome, presumably because it measures both drug sensitivity and the number of leukemic cells requiring elimination. Children with high levels (> 10(-3) leukemic cells per marrow ...

journal_title：Blood

authors： Brisco J,Hughes E,Neoh SH,Sykes PJ,Bradstock K,Enno A,Szer J,McCaul K,Morley AA

更新日期：1996-06-15 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p21WAF1/Cip1 and Survivin enhance granulocyte macrophage colony-forming unit (CFU-GM) cell cycle and proliferation and have been implicated as antiapoptotic proteins. We investigated the relationships between p21 and Survivin in primary CFU-GM and c-kit+, lineage-negative (Lin-) c...

journal_title：Blood

authors： Fukuda S,Mantel CR,Pelus LM

更新日期：2004-01-01 00:00:00

abstract：:Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invasive telemetric moni...

journal_title：Blood

authors： Adams GN,LaRusch GA,Stavrou E,Zhou Y,Nieman MT,Jacobs GH,Cui Y,Lu Y,Jain MK,Mahdi F,Shariat-Madar Z,Okada Y,D'Alecy LG,Schmaier AH

更新日期：2011-04-07 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) kill target cells through the polarized release of lytic molecules from secretory lysosomes. Loss of munc13-4 function inhibits this process and causes familial hemophagocytic lymphohistiocytosis type 3 (FHL3). munc13-4 binds rab27a, but the necessity of the complex remains enigmatic, be...

journal_title：Blood

authors： Elstak ED,Neeft M,Nehme NT,Voortman J,Cheung M,Goodarzifard M,Gerritsen HC,van Bergen En Henegouwen PM,Callebaut I,de Saint Basile G,van der Sluijs P

更新日期：2011-08-11 00:00:00

abstract：:Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs). We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarc...

journal_title：Blood

authors： Massa M,Rosti V,Ferrario M,Campanelli R,Ramajoli I,Rosso R,De Ferrari GM,Ferlini M,Goffredo L,Bertoletti A,Klersy C,Pecci A,Moratti R,Tavazzi L

更新日期：2005-01-01 00:00:00

abstract：:Sickle cell disease is a common hemolytic disorder with a broad range of complications, including vaso-occlusive episodes, acute chest syndrome (ACS), pain, and stroke. Heme oxygenase-1 (gene HMOX1; protein HO-1) is the inducible, rate-limiting enzyme in the catabolism of heme and might attenuate the severity of outco...

journal_title：Blood

authors： Bean CJ,Boulet SL,Ellingsen D,Pyle ME,Barron-Casella EA,Casella JF,Payne AB,Driggers J,Trau HA,Yang G,Jones K,Ofori-Acquah SF,Hooper WC,DeBaun MR

更新日期：2012-11-01 00:00:00

abstract：:Conventional chemotherapy has failed to substantially prolong survival for patients with advanced follicular lymphoma. To improve outcomes, the German Low-Grade Lymphoma Study Group (GLSG) initiated a randomized trial to compare the effect of potentially curative myeloablative radiochemotherapy followed by autologous ...

journal_title：Blood

authors： Lenz G,Dreyling M,Schiegnitz E,Forstpointner R,Wandt H,Freund M,Hess G,Truemper L,Diehl V,Kropff M,Kneba M,Schmitz N,Metzner B,Pfirrmann M,Unterhalt M,Hiddemann W,German Low-Grade Lymphoma Study Group.

更新日期：2004-11-01 00:00:00

abstract：:Initial molecular events leading to natural killer lymphocyte (NK) and dendritic cell (DC) interactions are largely unknown. Here, the role of CX3CL1 (fractalkine), a chemokine expressed on mature dendritic cells (mDCs) has been investigated. We show that CX3CL1 promotes NK activation by mDCs. After blocking of CX3CL1...

journal_title：Blood

authors： Pallandre JR,Krzewski K,Bedel R,Ryffel B,Caignard A,Rohrlich PS,Pivot X,Tiberghien P,Zitvogel L,Strominger JL,Borg C

更新日期：2008-12-01 00:00:00

abstract：:CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of nonhematopoietic origin. CD38 is a transmembrane glycoprotein with ectoenzymatic activity, and also functions as a receptor and adhesion molecule. Altogether,...

journal_title：Blood

authors： van de Donk NWCJ,Richardson PG,Malavasi F

更新日期：2018-01-04 00:00:00

abstract：:The detection of a monoclonal immunoglobulin in serum or urine usually raises concerns about the size of the underlying B-cell-derived clone and possible systemic effects caused by its expansion. However, a small clone can synthesize a very toxic protein, producing devastating systemic damage and protean clinical pres...

journal_title：Blood

authors： Merlini G,Stone MJ

更新日期：2006-10-15 00:00:00