CML patients with deep molecular responses to TKI have restored immune effectors and decreased PD-1 and immune suppressors.

abstract：:MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote sel...

journal_title：Blood

authors： Argiropoulos B,Yung E,Xiang P,Lo CY,Kuchenbauer F,Palmqvist L,Reindl C,Heuser M,Sekulovic S,Rosten P,Muranyi A,Goh SL,Featherstone M,Humphries RK

更新日期：2010-05-20 00:00:00

abstract：:Human immunodeficiency virus-1 subtypes A and C differ in the highly conserved Gag-TL9 epitope at a single amino acid position. Similarly, the TL9 presenting human leukocyte antigen (HLA) class I molecules B42 and B81 differ only at 6 amino acid positions. Here, we addressed the influence of such minor viral and host ...

journal_title：Blood

authors： Geldmacher C,Metzler IS,Tovanabutra S,Asher TE,Gostick E,Ambrozak DR,Petrovas C,Schuetz A,Ngwenyama N,Kijak G,Maboko L,Hoelscher M,McCutchan F,Price DA,Douek DC,Koup RA

更新日期：2009-08-20 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in recipients of allogeneic bone marrow transplants through yet to be defined mechanisms. Here, we demonstrate in mice that MHC-mismatched donor T cells home into the thymus of unconditioned recipients. There, activated donor T cells ...

journal_title：Blood

authors： Hauri-Hohl MM,Keller MP,Gill J,Hafen K,Pachlatko E,Boulay T,Peter A,Holländer GA,Krenger W

更新日期：2007-05-01 00:00:00

abstract：:WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is an immune deficiency linked in many cases to heterozygous mutations causing truncations in the cytoplasmic tail of CXC chemokine receptor 4 (CXCR4). Leukocytes expressing truncated CXCR4 display enhanced responses to the receptor ligand CXC...

journal_title：Blood

authors： Lagane B,Chow KY,Balabanian K,Levoye A,Harriague J,Planchenault T,Baleux F,Gunera-Saad N,Arenzana-Seisdedos F,Bachelerie F

更新日期：2008-07-01 00:00:00

abstract：:Mutations leading to the alteration of cell-cycle checkpoint functions are a common feature of most cancers. Because of the highly regulated nature of the cell cycle, it seems likely that variation in gene dosage of key components due to functional regulatory polymorphisms could play an important role in cancer develo...

journal_title：Blood

authors： Healy J,Bélanger H,Beaulieu P,Larivière M,Labuda D,Sinnett D

更新日期：2007-01-15 00:00:00

abstract：:The structural basis of the interaction between single-chain urokinase-type plasminogen activator (scuPA) and its receptor (uPAR) is incompletely defined. Several observations indicated the kringle facilitates the binding of uPA to uPAR. A scuPA variant lacking the kringle (Delta K-scuPA) bound to soluble uPAR (suPAR)...

journal_title：Blood

authors： Bdeir K,Kuo A,Sachais BS,Rux AH,Bdeir Y,Mazar A,Higazi AA,Cines DB

更新日期：2003-11-15 00:00:00

abstract：:The tetraspanin family member CD151 forms complexes with integrins and regulates cell adhesion and migration. While CD151 is highly expressed in megakaryocytes and to a lesser extent in platelets, its physiologic role in platelets is unclear. In this study, we investigate the physical and functional importance of CD15...

journal_title：Blood

authors： Lau LM,Wee JL,Wright MD,Moseley GW,Hogarth PM,Ashman LK,Jackson DE

更新日期：2004-10-15 00:00:00

abstract：:In this issue of Blood, Bachanova et al describe how modulation of the inhibitory tumor environment may enhance natural killer (NK) cell clinical activity and produce encouraging results in the treatment of refractory acute myeloid leukemia (AML). NK cells are highly proliferative, early responders of the innate immun...

journal_title：Blood

authors： Rooney CM

更新日期：2014-06-19 00:00:00

abstract：:Recent demonstration that Cromer-related human blood group antigens reside on decay-accelerating factor (DAF) has led to identification of an apparent null phenotype (Inab) for erythrocyte DAF. This study examined expression of other phosphatidylinositol (PI)-anchored proteins by Inab erythrocytes and showed that the ...

journal_title：Blood

authors： Telen MJ,Green AM

更新日期：1989-07-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMNLs) exposed to influenza A virus (IAV) undergo activation of the respiratory burst followed by depression of cell function when subsequently exposed to particulate or soluble stimuli. The effect of IAV on PMNLs is likely to be mediated through the attachment of IAV to one or more speci...

journal_title：Blood

authors： Abramson JS,Hudnor HR

更新日期：1995-03-15 00:00:00

abstract：:During the course of multiple myeloma (MM), new monoclonal proteins of an isotype distinct from the original clone, referred to as secondary monoclonal gammopathy of undetermined significance (MGUS), have been described. We report on the frequency, characteristics, and outcome of secondary MGUS. Of the 1942 patients w...

journal_title：Blood

authors： Wadhera RK,Kyle RA,Larson DR,Dispenzieri A,Kumar S,Lazarus HM,Rajkumar SV

更新日期：2011-09-15 00:00:00

abstract：:Coagulation factor XIII (FXIII) is the main stabilizer of the fibrin clot. It circulates in plasma as a tetramer of two A-subunits and two B-subunits. Under physiological conditions, FXIII-A exists as a dimer (FXIII-A2). The interactions between the FXIII-A-subunits that stabilize the FXIII-A2 dimer are not fully unde...

journal_title：Blood

authors： Li B,Kohler HP,Schroeder V

更新日期：2020-01-09 00:00:00

abstract：:The RUNX1/AML1 gene is the most frequently mutated gene in human leukemia. Conditional deletion of Runx1 in adult mice results in an increase of hematopoietic stem cells (HSCs), which serve as target cells for leukemia; however, Runx1(-/-) mice do not develop spontaneous leukemia. Here we show that maintenance of Runx...

journal_title：Blood

authors： Jacob B,Osato M,Yamashita N,Wang CQ,Taniuchi I,Littman DR,Asou N,Ito Y

更新日期：2010-02-25 00:00:00

abstract：:The mechanisms responsible for the low factor VIII (fVIII) activity in the plasma of patients with mild/moderate hemophilia A are poorly understood. In such patients, we have identified a series of fVIII mutations (Ile2098Ser, Ser2119Tyr, Asn2129Ser, Arg2150His, and Pro2153Gln) clustered in the C1 domain and associate...

journal_title：Blood

authors： Jacquemin M,Lavend'homme R,Benhida A,Vanzieleghem B,d'Oiron R,Lavergne JM,Brackmann HH,Schwaab R,VandenDriessche T,Chuah MK,Hoylaerts M,Gilles JG,Peerlinck K,Vermylen J,Saint-Remy JM

更新日期：2000-08-01 00:00:00

abstract：:In this issue of Blood, Baychelier et al identify a ligand for a major natural killer (NK) cell receptor that mediates natural cytotoxicity toward tumor cells, thus ending a search that lasted well over a decade. ...

journal_title：Blood

authors： Rajagopalan S,Long EO

更新日期：2013-10-24 00:00:00

abstract：:B19 parvovirus is the etiologic agent of fifth disease and transient aplastic crisis. In natural infections, B19 antigen and DNA have been detected in sera early in the course of aplastic crisis and only rarely in fifth disease. We have found B19 DNA in circulating cells of infected patients by DNA dot blot with a vir...

journal_title：Blood

authors： Kurtzman GJ,Gascon P,Caras M,Cohen B,Young NS

更新日期：1988-05-01 00:00:00

abstract：:Although it is recognized that red cells lose membrane during storage, estimation of the osmotic fragility of erythrocytes has not previously proven to be a useful measurement of the storage lesion. Erythrocytes from blood stored in CPD-A2 were found to have a markedly increased osmotic fragility. A major portion of t...

journal_title：Blood

authors： Beutler E,Kuhl W,West C

更新日期：1982-06-01 00:00:00

abstract：:Bone marrow CD34(+) cell apoptosis (annexin V), proliferation (Ki-67), and Bcl-2-related protein expression was evaluated by flow cytometry in 102 patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia secondary to MDS (MDS-AML) and in 30 normal donors (NBM). Apoptosis was significantly increased in r...

journal_title：Blood

authors： Parker JE,Mufti GJ,Rasool F,Mijovic A,Devereux S,Pagliuca A

更新日期：2000-12-01 00:00:00

abstract：:Patients with the B-cell malignancy hairy cell leukemia (HCL) exhibit a skewed T-cell repertoire with oligoclonal expression or absence of many members of the T-cell receptor (TCR) BV gene families. To evaluate whether interferon-alpha (IFN-alpha) therapy would not only restore normal hematopoiesis, but also the abnor...

journal_title：Blood

authors： Kluin-Nelemans HC,Kester MG,van deCorput L,Boor PP,Landegent JE,van Dongen JJ,Willemze R,Falkenburg JH

更新日期：1998-06-01 00:00:00

abstract：:Sickle cell anemia (SCA) is an inherited disorder of beta-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is associated with an 8% to 10% mortality rate, primarily from complications ...

journal_title：Blood

authors： Iannone R,Luznik L,Engstrom LW,Tennessee SL,Askin FB,Casella JF,Kickler TS,Goodman SN,Hawkins AL,Griffin CA,Noffsinger L,Fuchs EJ

更新日期：2001-06-15 00:00:00

abstract：:The monoclonal antibodies Tab and AP3 are directed, respectively, against GPIIb and GPIIIa, the subunits of the platelet fibrinogen receptor. When added together to platelets, these antibodies prevent adenosine diphosphate (ADP)-induced platelet aggregation, despite normal fibrinogen binding (Newman et al, Blood 69:66...

journal_title：Blood

authors： Isenberg WM,Bainton DF,Newman PJ

更新日期：1990-10-15 00:00:00

abstract：:Human natural killer (NK) cells express Toll-like receptor 9 (TLR9) transcript and, upon exposure to microbial CpG oligodeoxynucleotide (ODN), release cytokines and kill target cells. Here we show that NK cell treatment with CpG ODN results in down-modulation of KIR3DL2 inhibitory receptor from the cell surface and in...

journal_title：Blood

authors： Sivori S,Falco M,Carlomagno S,Romeo E,Soldani C,Bensussan A,Viola A,Moretta L,Moretta A

更新日期：2010-09-09 00:00:00

abstract：:JAK3 is a tyrosine kinase that associates with the common γ chain of cytokine receptors and is recurrently mutated in T-cell acute lymphoblastic leukemia (T-ALL). We tested the transforming properties of JAK3 pseudokinase and kinase domain mutants using in vitro and in vivo assays. Most, but not all, JAK3 mutants tran...

journal_title：Blood

authors： Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J

更新日期：2014-11-13 00:00:00

abstract：:Interleukin-10 (IL-10) selectively inhibited lipopolysaccharide (LPS)-induced chemoattractant cytokine gene expression: levels of IP-10 mRNA were markedly suppressed in IL-10-treated mouse peritoneal macrophages, whereas the expression of the RANTES mRNA was only modestly reduced. IL-10 inhibited IP-10 mRNA accumulati...

journal_title：Blood

authors： Tebo JM,Kim HS,Gao J,Armstrong DA,Hamilton TA

更新日期：1998-12-15 00:00:00

abstract：:Long-term survival is now an expected outcome after hematopoietic cell transplantation (HCT). However, the burden of morbidity long-term after HCT remains unknown. We examined the magnitude of risk of chronic health conditions reported by 1022 HCT survivors and their siblings (n = 309). A severity score (grades 1 [mil...

journal_title：Blood

authors： Sun CL,Francisco L,Kawashima T,Leisenring W,Robison LL,Baker KS,Weisdorf DJ,Forman SJ,Bhatia S

更新日期：2010-10-28 00:00:00

abstract：:Acquired hemophilia is a rare bleeding disorder characterized by the spontaneous occurrence of inhibitory antibodies against endogenous factor VIII (FVIII). IgG from some patients with acquired hemophilia hydrolyze FVIII. Because of the complex etiology of the disease, no clinical parameter, including the presence of ...

journal_title：Blood

authors： Wootla B,Christophe OD,Mahendra A,Dimitrov JD,Repessé Y,Ollivier V,Friboulet A,Borel-Derlon A,Levesque H,Borg JY,Andre S,Bayry J,Calvez T,Kaveri SV,Lacroix-Desmazes S

更新日期：2011-02-17 00:00:00

abstract：:Chronic lymphocytic leukemia is characterized by relapse after treatment and chemotherapy resistance. Similarly, in other malignancies leukemia cells accumulate mutations during growth, forming heterogeneous cell populations that are subject to Darwinian selection and may respond differentially to treatment. There is ...

journal_title：Blood

authors： Schuh A,Becq J,Humphray S,Alexa A,Burns A,Clifford R,Feller SM,Grocock R,Henderson S,Khrebtukova I,Kingsbury Z,Luo S,McBride D,Murray L,Menju T,Timbs A,Ross M,Taylor J,Bentley D

更新日期：2012-11-15 00:00:00

abstract：:X-linked severe combined immunodeficiency (XSCID) is characterized by absent or profoundly reduced numbers of T cells and normal numbers of B cells in the circulation. Affected patients have mutations of the interleukin-2 (IL-2) receptor gamma chain gene. Using Epstein-Barr virus-transformed B-lymphoblastoid cell line...

journal_title：Blood

authors： Kumaki S,Ochs HD,Timour M,Schooley K,Ahdieh M,Hill H,Sugamura K,Anderson D,Zhu Q,Cosman D

更新日期：1995-08-15 00:00:00

abstract：:Previous studies have suggested that, in patients with AL amyloidosis treated with high-dose melphalan and autologous stem-cell transplantation (HDM/SCT), the greatest benefit is seen in those patients achieving a hematologic complete response (CR). We analyzed a series of 421 consecutive patients treated with HDM/SCT...

journal_title：Blood

authors： Cibeira MT,Sanchorawala V,Seldin DC,Quillen K,Berk JL,Dember LM,Segal A,Ruberg F,Meier-Ewert H,Andrea NT,Sloan JM,Finn KT,Doros G,Blade J,Skinner M

更新日期：2011-10-20 00:00:00

abstract：:Recently, Dawson et al identified a previously unrecognized nuclear role of JAK2 in the phosphorylation of histone H3 in hematopoietic cell lines. We searched nuclear JAK2 in total bone marrow (BM) cells and in 4 sorted BM cell populations (CD34(+), CD15(+), CD41(+), and CD71(+)) of 10 myeloproliferative neoplasia (MP...

journal_title：Blood

authors： Rinaldi CR,Rinaldi P,Alagia A,Gemei M,Esposito N,Formiggini F,Martinelli V,Senyuk V,Nucifora G,Pane F

更新日期：2010-12-23 00:00:00