Genetic inactivation of TRAF3 in canine and human B-cell lymphoma.

abstract：:Daratumumab, a monoclonal CD38 antibody, is approved in the treatment of myeloma, but its efficacy and safety in light-chain (AL) amyloidosis has not been formally studied. This prospective phase 2 trial of daratumumab monotherapy for the treatment of AL amyloidosis was designed to determine the safety, tolerability, ...

journal_title：Blood

authors： Sanchorawala V,Sarosiek S,Schulman A,Mistark M,Migre ME,Cruz R,Sloan JM,Brauneis D,Shelton AC

更新日期：2020-04-30 00:00:00

abstract：:Approximately 30% to 40% of patients with acute leukemia receiving repeated pooled random-donor platelet transfusions develop anti-HLA alloantibodies. Over time, however, serum anti-HLA concentrations decrease in approximately 50% of these patients, despite continued exposure to platelet and/or red blood cell transfus...

journal_title：Blood

authors： Atlas E,Freedman J,Blanchette V,Kazatchkine MD,Semple JW

更新日期：1993-01-15 00:00:00

abstract：:Enzymes of the glycolytic pathway as well as some ancillary enzymes were studied in normal red cells parasitized with Plasmodium falciparum in culture at varying parasitemias as well as in isolated parasites. The levels of all enzymes except diphosphoglycerate mutase, glucose-6-phosphate dehydrogenase, and adenylate k...

journal_title：Blood

authors： Roth EF Jr,Calvin MC,Max-Audit I,Rosa J,Rosa R

更新日期：1988-12-01 00:00:00

abstract：:An inherited fibrinogen variant, fibrinogen Bern I, was isolated from plasma of an asymptomatic woman. Routine coagulation studies showed prolonged thrombin and reptilase clotting times. Fibrinogen concentration was diminished when determined by a functional assay, but was normal by the heat precipitation method. The ...

journal_title：Blood

authors： Steinmann C,Reber P,Jungo M,Lämmle B,Heinemann G,Wermuth B,Furlan M

更新日期：1993-10-01 00:00:00

abstract：:The serine protease prolylcarboxypeptidase (PRCP), isolated from human umbilical vein endothelial cells (HUVECs), is a plasma prekallikrein (PK) activator. PRCP cDNA was cloned in pMT/BIP/V5-HIS-C, transfected into Schneider insect (S2) cells, and purified from serum-free media. Full-length recombinant PRCP (rPRCP) ac...

journal_title：Blood

authors： Shariat-Madar Z,Mahdi F,Schmaier AH

更新日期：2004-06-15 00:00:00

abstract：:2-Chlorodeoxyadenosine, a new lymphocyte-selective, anti-neoplastic drug was administered to 18 patients with advanced chronic lymphocytic leukemia of B-cell origin. All patients were resistant to conventional treatment. A total of 44 courses of 2-chlorodeoxyadenosine were completed with minimal toxicity. An overall r...

journal_title：Blood

authors： Piro LD,Carrera CJ,Beutler E,Carson DA

更新日期：1988-09-01 00:00:00

abstract：:Viral infections have been associated with reduced platelet counts, the biological significance of which has remained elusive. Here, we show that infection with encephalomyocarditis virus (EMCV) rapidly reduces platelet count, and this response is attributed to platelet Toll-like receptor 7 (TLR7). Platelet-TLR7 stimu...

journal_title：Blood

authors： Koupenova M,Vitseva O,MacKay CR,Beaulieu LM,Benjamin EJ,Mick E,Kurt-Jones EA,Ravid K,Freedman JE

更新日期：2014-07-31 00:00:00

abstract：:We have developed a new helper-dependent (HD) adenoviral vector FTC that contains 3 cis-acting sequences as stuffer DNA: a human fragment of alphoid repeat DNA, matrix-attachment regions (MARs), and the hepatocyte control region enhancer. To determine the most robust human coagulation factor IX (hFIX) expression casse...

journal_title：Blood

authors： Ehrhardt A,Kay MA

更新日期：2002-06-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm associated with somatic mutations in the genes involved in the RAF/MEK/extracellular signal-regulated kinase (ERK) signaling pathway. Recently, oncogenic mutations in NRAS/KRAS, upstream regulators of the RAF/MEK/ERK pathway, have been reported in pulm...

journal_title：Blood

authors： Kamata T,Giblett S,Pritchard C

更新日期：2017-07-27 00:00:00

abstract：:Crystallographic structures indicate that gamma-chain residue Asn308 participates in D:D interactions and indeed substitutions of gammaAsn308 with lysine or isoleucine have been identified in dysfibrinogens with impaired polymerization. To probe the role of Asn308 in polymerization, we synthesized 3 variant fibrinogen...

journal_title：Blood

authors： Okumura N,Gorkun OV,Terasawa F,Lord ST

更新日期：2004-06-01 00:00:00

abstract：:It was found in a long-term bromodeoxyuridine (BrdU) infusion study that two or more different subpopulations of bone marrow stem cells exist in mice. One of these subpopulations appears to be noncycling and forms approximately 10% of eight-day CFU-S. Another one, a subpopulation of slowly cycling bone marrow cells, i...

journal_title：Blood

authors： Pietrzyk ME,Priestley GV,Wolf NS

更新日期：1985-12-01 00:00:00

abstract：:Adhesion to extracellular ligands through integrins regulates cell shape, migration, growth, and survival. How integrins transmit signals in the outside-to-in direction remains unknown. Whereas in resting integrins the alpha and beta subunit transmembrane domains are associated, ligand binding promotes dissociation an...

journal_title：Blood

authors： Zhu J,Carman CV,Kim M,Shimaoka M,Springer TA,Luo BH

更新日期：2007-10-01 00:00:00

abstract：:Bortezomib (PS-341), a selective inhibitor of proteasomes, induces apoptosis in multiple myeloma (MM) cells; however, prolonged drug exposure may result in cumulative toxicity and the development of chemoresistance. Here we show that combining PK-11195 (PK), an antagonist to mitochondrial peripheral benzodiazepine rec...

journal_title：Blood

authors： Chauhan D,Li G,Podar K,Hideshima T,Mitsiades C,Schlossman R,Munshi N,Richardson P,Cotter FE,Anderson KC

更新日期：2004-10-15 00:00:00

abstract：:Peripheral blood leukemia cells from patients with acute monoblastic leukemia (AMoL) were tested for killer cell activity against target cells that detected natural killer cell-mediated or monocyte-mediated spontaneous cytotoxicity. The fibrosarcoma cell line Wehi 164, pretreated with actinomycin D to induce susceptib...

journal_title：Blood

authors： Ziegler-Heitbrock HW,Munker R,Thiel E,Krebs I,Riethmüller G

更新日期：1985-01-01 00:00:00

abstract：:The mi locus of mice encodes a member of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Because the expression of the mouse mast cell protease 6 (MMCP-6) gene is remarkably reduced in mast cells of mi/mi mutant mice, we investigated the effect of M...

journal_title：Blood

authors： Morii E,Tsujimura T,Jippo T,Hashimoto K,Takebayashi K,Tsujino K,Nomura S,Yamamoto M,Kitamura Y

更新日期：1996-10-01 00:00:00

abstract：:Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have alre...

journal_title：Blood

authors： Holtan SG,Pasquini M,Weisdorf DJ

更新日期：2014-07-17 00:00:00

abstract：:This phase 2 study evaluated whether substituting bortezomib for vincristine in frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy could improve efficacy in non-germinal center B-cell-like diffuse large B-cell lymphoma (non-GCB DLBCL), centrally confirmed by immunohist...

journal_title：Blood

authors： Offner F,Samoilova O,Osmanov E,Eom HS,Topp MS,Raposo J,Pavlov V,Ricci D,Chaturvedi S,Zhu E,van de Velde H,Enny C,Rizo A,Ferhanoglu B

更新日期：2015-10-15 00:00:00

abstract：:Severe factor V (FV) deficiency is a rare bleeding disorder, whose genetic bases have been characterized only in a limited number of cases. We investigated 6 unrelated patients with extremely reduced plasma FV levels, associated with a bleeding tendency ranging from moderately severe to severe. Clinical manifestations...

journal_title：Blood

authors： Montefusco MC,Duga S,Asselta R,Malcovati M,Peyvandi F,Santagostino E,Mannucci PM,Tenchini ML

更新日期：2003-11-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors (HDACis) have demonstrated activity in hematological and solid malignancies. Vorinostat, romidepsin, belinostat, and panobinostat are Food and Drug Administration-approved for hematological malignancies and inhibit class II and/or class I HDACs, including HDAC1, 2, 3, and 6. We co...

journal_title：Blood

authors： Matthews GM,Mehdipour P,Cluse LA,Falkenberg KJ,Wang E,Roth M,Santoro F,Vidacs E,Stanley K,House CM,Rusche JR,Vakoc CR,Zuber J,Minucci S,Johnstone RW

更新日期：2015-11-19 00:00:00

abstract：:Pneumonia induced by Gram-negative bacteria is a common and serious disease associated with high morbidity and mortality. Elimination of bacterial pathogens relies on the recruitment and functions of neutrophils. The adhesion molecule L-selectin has recently been implicated in integrin activation in neutrophils (insid...

journal_title：Blood

authors： Cappenberg A,Margraf A,Thomas K,Bardel B,McCreedy DA,Van Marck V,Mellmann A,Lowell CA,Zarbock A

更新日期：2019-10-24 00:00:00

abstract：:Filamin A (FLNa), a dimeric actin cross-linking and scaffold protein with numerous intracellular binding partners, anchors the platelet adhesion glycoprotein (GP) Ib-IX-V receptor to actin cytoskeleton. We mapped the GPIbalpha binding site to a single domain of FLNa and resolved the structure of this domain and its in...

journal_title：Blood

authors： Nakamura F,Pudas R,Heikkinen O,Permi P,Kilpeläinen I,Munday AD,Hartwig JH,Stossel TP,Ylänne J

更新日期：2006-03-01 00:00:00

abstract：:We conducted a double-blind, randomized multicenter trial to determine whether the addition of mycophenolate mofetil (MMF) improves the efficacy of initial systemic treatment of chronic graft-versus-host disease (GVHD). The primary endpoint was resolution of chronic GVHD and withdrawal of all systemic treatment within...

journal_title：Blood

authors： Martin PJ,Storer BE,Rowley SD,Flowers ME,Lee SJ,Carpenter PA,Wingard JR,Shaughnessy PJ,DeVetten MP,Jagasia M,Fay JW,van Besien K,Gupta V,Kitko C,Johnston LJ,Maziarz RT,Arora M,Jacobson PA,Weisdorf D

更新日期：2009-05-21 00:00:00

abstract：:It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries. As these countries go through an epidemiologic transition, with a reduction in childhood and infant mortality due to ...

journal_title：Blood

authors： Weatherall DJ

更新日期：2010-06-03 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, a bicistronic retroviral vector encoding GATA-2 and the green fluorescent protein (GFP) was used to maintain the high levels of...

journal_title：Blood

authors： Persons DA,Allay JA,Allay ER,Ashmun RA,Orlic D,Jane SM,Cunningham JM,Nienhuis AW

更新日期：1999-01-15 00:00:00

abstract：:In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdivide the CD34(+)CD38(-) compartment in the bone marrow of acute myeloid leukemia (AML) patients. They identify a unique population with intermediate ALDH activity (ALDH(int)) that contains leukemia stem cells (LSCs). Moreove...

journal_title：Blood

authors： Fleischman AG

更新日期：2012-04-12 00:00:00

abstract：:To know the role and initiation mechanism of the interaction of glycoprotein (GP) Ib with surface-immobilized von Willebrand factor (vWF), we examined the effect of shear stress levels on platelet binding to vWF-coated plates using a cone-and-plate type viscometer capable of loading various levels of shear stress. The...

journal_title：Blood

authors： Tsuji S,Sugimoto M,Kuwahara M,Nishio K,Takahashi Y,Fujimura Y,Ikeda Y,Yoshioka A

更新日期：1996-11-15 00:00:00

abstract：:We have previously shown that coculture of human embryonic stem cells (hESCs) for 14 days with immortalized fetal hepatocytes yields CD34(+) cells that can be expanded in serum-free liquid culture into large numbers of megaloblastic nucleated erythroblasts resembling yolk sac-derived cells. We show here that these pri...

journal_title：Blood

authors： Qiu C,Olivier EN,Velho M,Bouhassira EE

更新日期：2008-02-15 00:00:00

abstract：:Polycythemia vera (PV) treatment with interferon α (IFNα) is frequently limited by dose-related toxicity. PV CD34(+) cells are characterized by overexpression of Bcl-xL, which can be antagonized by ABT-737 leading to apoptosis. We explored the effects of ABT-737 and IFNα on PV hematopoiesis. Both IFNα and ABT-737 alon...

journal_title：Blood

authors： Lu M,Wang J,Li Y,Berenzon D,Wang X,Mascarenhas J,Xu M,Hoffman R

更新日期：2010-11-18 00:00:00

abstract：:To assess the relationship between venous thrombosis and plasma glucosylceramide (GlcCer) or phosphatidylethanolamine (PE), plasma levels of GlcCer and PE were determined for 70 venous thrombosis patients referred for evaluation and 70 healthy blood donors. The mean GlcCer level, but not the PE level, was lower in pat...

journal_title：Blood

authors： Deguchi H,Fernández JA,Pabinger I,Heit JA,Griffin JH

更新日期：2001-04-01 00:00:00