Serum CD44 in malignant lymphoma: an association with treatment response.

abstract：:Highly enriched, phenotypically defined hematopoietic stem, Thy-1loLin-Sca-1+, and progenitor cell populations from mouse bone marrow (BM) were tested at limiting dilution for their ability to reconstitute Dexter monolayers. Several classes of BM cells can reconstitute Dexter cultures, first forming discrete "cobblest...

journal_title：Blood

authors： Weilbaecher K,Weissman I,Blume K,Heimfeld S

更新日期：1991-08-15 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors (HDACis) have demonstrated activity in hematological and solid malignancies. Vorinostat, romidepsin, belinostat, and panobinostat are Food and Drug Administration-approved for hematological malignancies and inhibit class II and/or class I HDACs, including HDAC1, 2, 3, and 6. We co...

journal_title：Blood

authors： Matthews GM,Mehdipour P,Cluse LA,Falkenberg KJ,Wang E,Roth M,Santoro F,Vidacs E,Stanley K,House CM,Rusche JR,Vakoc CR,Zuber J,Minucci S,Johnstone RW

更新日期：2015-11-19 00:00:00

abstract：:Regulated migration of hematopoietic stem cells is fundamental for hematopoiesis. The molecular mechanisms underlying stem cell trafficking are poorly defined. Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX...

journal_title：Blood

authors： Thieme S,Gyárfás T,Richter C,Özhan G,Fu J,Alexopoulou D,Muders MH,Michalk I,Jakob C,Dahl A,Klink B,Bandola J,Bachmann M,Schröck E,Buchholz F,Stewart AF,Weidinger G,Anastassiadis K,Brenner S

更新日期：2013-03-28 00:00:00

abstract：:Autosomal recessive STAT1 deficiency is associated with impaired cellular responses to interferons and susceptibility to intracellular bacterial and viral infections. We report here a new form of partial STAT1 deficiency in 2 siblings presenting mycobacterial and viral diseases. Both carried a homozygous missense muta...

journal_title：Blood

authors： Kong XF,Ciancanelli M,Al-Hajjar S,Alsina L,Zumwalt T,Bustamante J,Feinberg J,Audry M,Prando C,Bryant V,Kreins A,Bogunovic D,Halwani R,Zhang XX,Abel L,Chaussabel D,Al-Muhsen S,Casanova JL,Boisson-Dupuis S

更新日期：2010-12-23 00:00:00

abstract：:Multinucleated giant cells (MGC) are a common feature of granulomas that develop during various inflammatory reactions. MGC originate from fusion of monocytes or macrophages, but the exact mechanism of their generation is still unclear. In the present study, we investigated the influence of monocyte to macrophage matu...

journal_title：Blood

authors： Möst J,Spötl L,Mayr G,Gasser A,Sarti A,Dierich MP

更新日期：1997-01-15 00:00:00

abstract：:NF-kappaB is a transcription factor that controls the expression of a number of genes important for mediating immune and inflammatory responses. In this study, we examined whether bortezomib and PS-1145, each of which inhibits NF-kappaB, could protect mice from lethal graft-versus-host disease (GVHD), which is charact...

journal_title：Blood

authors： Vodanovic-Jankovic S,Hari P,Jacobs P,Komorowski R,Drobyski WR

更新日期：2006-01-15 00:00:00

abstract：:In this report, we describe a modification of the assay for long-term culture-initiating cells (LTC-IC) that allows a subset of murine LTC-IC (designated as LTC-ICML) to express both their myeloid (M) and lymphoid (L) differentiative potentials in vitro. The modified assay involves culturing test cells at limiting dil...

journal_title：Blood

authors： Lemieux ME,Rebel VI,Lansdorp PM,Eaves CJ

更新日期：1995-08-15 00:00:00

abstract：:Epstein-Barr virus (EBV) infections may induce a diverse clinical picture, ranging from the well characterized infectious mononucleosis (IM) syndrome to the rare X-linked lymphoproliferative syndrome. We describe two unrelated children, a 21-mo-old white boy and a 15-mo-old black girl, who presented with the clinical ...

journal_title：Blood

authors： Herrod HG,Dow LW,Sullivan JL

更新日期：1983-06-01 00:00:00

abstract：:Previous results have demonstrated that anti-D therapy in children with chronic auto-immune thrombocytopenic purpura (AITP) induced a significant increase in several pro- and anti-inflammatory plasma cytokines within 2 hours of administration. To investigate the biologic basis of these early in vivo responses, we deve...

journal_title：Blood

authors： Coopamah MD,Freedman J,Semple JW

更新日期：2003-10-15 00:00:00

abstract：:Twenty consecutive patients with Hodgkin disease in continuous complete remission and off treatment for at least 5 yr (range 5-25 yr, median 9 yr) were studied with a battery of immunologic parameters. Skin test reactivity to four common antigens, sensitization to 2,4-dinitrochlorobenzene, absolute lymphocyte count, r...

journal_title：Blood

authors： Case DC Jr,Hansen JA,Corrales E,Young CW,Dupont B,Pinsky CM,Good RA

更新日期：1977-05-01 00:00:00

abstract：:Chronic graft-versus-host disease (GVHD) requires long-term immunosuppressive therapy after hematopoietic cell transplantation. We retrospectively analyzed a cohort of 751 patients with chronic GVHD to identify characteristics associated with the duration of immunosuppressive treatment. Among the 274 patients who disc...

journal_title：Blood

authors： Stewart BL,Storer B,Storek J,Deeg HJ,Storb R,Hansen JA,Appelbaum FR,Carpenter PA,Sanders JE,Kiem HP,Nash RA,Petersdorf EW,Moravec C,Morton AJ,Anasetti C,Flowers ME,Martin PJ

更新日期：2004-12-01 00:00:00

abstract：:Angiotensin I-converting enzyme (ACE) inhibitors can affect hematopoiesis by several mechanisms including inhibition of angiotensin II formation and increasing plasma concentrations of AcSDKP (acetyl-N-Ser-Asp-Lys-Pro), an ACE substrate and a negative regulator of hematopoiesis. We tested whether ACE inhibition could ...

journal_title：Blood

authors： Charrier S,Michaud A,Badaoui S,Giroux S,Ezan E,Sainteny F,Corvol P,Vainchenker W

更新日期：2004-08-15 00:00:00

abstract：:Acquired factor XIII (FXIII) deficiency due to autoantibody against FXIII is a very rare severe hemorrhagic diathesis. Antibodies directed against the A subunit of FXIII, which interfere with different functions of FXIII, have been described. Here, for the first time, we report an autoantibody against the B subunit of...

journal_title：Blood

authors： Ajzner E,Schlammadinger A,Kerényi A,Bereczky Z,Katona E,Haramura G,Boda Z,Muszbek L

更新日期：2009-01-15 00:00:00

abstract：:To define the efficacy of venetoclax with extended follow-up and identify clinical or biological treatment effect modifiers, updated data for previously treated patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) enrolled in 4 early-phase trials were pooled. Rates of response, complete...

journal_title：Blood

authors： Roberts AW,Ma S,Kipps TJ,Coutre SE,Davids MS,Eichhorst B,Hallek M,Byrd JC,Humphrey K,Zhou L,Chyla B,Nielsen J,Potluri J,Kim SY,Verdugo M,Stilgenbauer S,Wierda WG,Seymour JF

更新日期：2019-07-11 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...

journal_title：Blood

authors： Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

更新日期：2008-11-01 00:00:00

abstract：:LIRs are immunoglobulinlike receptors that have activating and inhibitory functions in leukocytes. Here we report the identification of the first LIR family member, LIR9, expressed as a membrane-bound receptor and as a secreted molecule. We identified 4 different forms of LIR9, 2 of which encode transmembrane molecule...

journal_title：Blood

authors： Borges L,Kubin M,Kuhlman T

更新日期：2003-02-15 00:00:00

abstract：:Polycythemia vera (PV) treatment with interferon α (IFNα) is frequently limited by dose-related toxicity. PV CD34(+) cells are characterized by overexpression of Bcl-xL, which can be antagonized by ABT-737 leading to apoptosis. We explored the effects of ABT-737 and IFNα on PV hematopoiesis. Both IFNα and ABT-737 alon...

journal_title：Blood

authors： Lu M,Wang J,Li Y,Berenzon D,Wang X,Mascarenhas J,Xu M,Hoffman R

更新日期：2010-11-18 00:00:00

abstract：:The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance or homing of MM cells into new sites of the BM. Hypoxia in solid tumors was shown to promote metastasis through activation of proteins involved in the epithelial-mesenchymal transition (EMT) process. We hypothesized...

journal_title：Blood

authors： Azab AK,Hu J,Quang P,Azab F,Pitsillides C,Awwad R,Thompson B,Maiso P,Sun JD,Hart CP,Roccaro AM,Sacco A,Ngo HT,Lin CP,Kung AL,Carrasco RD,Vanderkerken K,Ghobrial IM

更新日期：2012-06-14 00:00:00

abstract：:Donor alloreactive CD4(+) T cells are important to the pathogenesis of chronic graft-versus-host disease (cGVHD), but specific subsets of CD4(+) T cells responsible for GVHD have not been defined. We hypothesized that cGVHD might be associated with a preponderance of CD4(+) effector memory cells (CCR7(-)/CD62L(low), C...

journal_title：Blood

authors： Yamashita K,Choi U,Woltz PC,Foster SF,Sneller MC,Hakim FT,Fowler DH,Bishop MR,Pavletic SZ,Tamari M,Castro K,Barrett AJ,Childs RW,Illei GG,Leitman SF,Malech HL,Horwitz ME

更新日期：2004-05-15 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) confers significant survival potential in a variety of tumors. Several established or novel anti-multiple myeloma (anti-MM) agents, such as dexamethasone, thalidomide, and proteasome inhibitors (PS-341), inhibit NF-kappaB activity as part of their diverse acti...

journal_title：Blood

authors： Mitsiades N,Mitsiades CS,Poulaki V,Chauhan D,Richardson PG,Hideshima T,Munshi N,Treon SP,Anderson KC

更新日期：2002-06-01 00:00:00

abstract：:The TEL/PDGFbetaR fusion protein is expressed as the consequence of a recurring t(5;12) translocation associated with chronic myelomonocytic leukemia (CMML). Unlike other activated protein tyrosine kinases associated with hematopoietic malignancies, TEL/PDGFbetaR is invariably associated with a myeloid leukemia phenot...

journal_title：Blood

authors： Tomasson MH,Williams IR,Hasserjian R,Udomsakdi C,McGrath SM,Schwaller J,Druker B,Gilliland DG

更新日期：1999-03-01 00:00:00

abstract：:The onset of hematopoiesis in the mouse embryo and in the embryonic stem (ES) cell differentiation model is defined by the emergence of the hemangioblast, a progenitor with both hematopoietic and vascular potential. While there is evidence for the existence of a hemangioblast in the mouse, it is unclear if this progen...

journal_title：Blood

authors： Kennedy M,D'Souza SL,Lynch-Kattman M,Schwantz S,Keller G

更新日期：2007-04-01 00:00:00

abstract：:Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose p...

journal_title：Blood

authors： Bachireddy P,Hainz U,Rooney M,Pozdnyakova O,Aldridge J,Zhang W,Liao X,Hodi FS,O'Connell K,Haining WN,Goldstein NR,Canning CM,Soiffer RJ,Ritz J,Hacohen N,Alyea EP 3rd,Kim HT,Wu CJ

更新日期：2014-02-27 00:00:00

abstract：:In vitro agar culture patterns of bone marrow cells in acute myeloid leukemia may show several growth patterns, including cultures where no colonies or clusters develop, cultures with varying numbers of clusters and no colonies, or colony and cluster formation with an extremely high ratio of clusters to colonies. Twel...

journal_title：Blood

authors： McCarthy JH,Sullivan JR,Ungar B,Metcalf D

更新日期：1979-08-01 00:00:00

abstract：:The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in a special niche. We...

journal_title：Blood

authors： Mamani-Matsuda M,Cosma A,Weller S,Faili A,Staib C,Garçon L,Hermine O,Beyne-Rauzy O,Fieschi C,Pers JO,Arakelyan N,Varet B,Sauvanet A,Berger A,Paye F,Andrieu JM,Michel M,Godeau B,Buffet P,Reynaud CA,Weill JC

更新日期：2008-05-01 00:00:00

abstract：:Recent reports have shown that leukocyte-leukocyte adhesion is dependent on L-selectin and that leukocyte recognition of L-selectin may be mediated by P-selectin glycoprotein ligand-1 (PSGL-1). We show that the specific attachment and rolling of human neutrophils and the leukemia cell lines HL-60 and U937 on immobiliz...

journal_title：Blood

authors： Ramos CL,Smith MJ,Snapp KR,Kansas GS,Stickney GW,Ley K,Lawrence MB

更新日期：1998-02-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive malignancy derived from precursors of plasmacytoid dendritic cells. We analyzed 21 cases with array-based comparative genomic hybridization (aCGH). Complete or partial chromosomal losses largely outnumbered the gains, with common deleted reg...

journal_title：Blood

authors： Lucioni M,Novara F,Fiandrino G,Riboni R,Fanoni D,Arra M,Venegoni L,Nicola M,Dallera E,Arcaini L,Onida F,Vezzoli P,Travaglino E,Boveri E,Zuffardi O,Paulli M,Berti E

更新日期：2011-10-27 00:00:00

abstract：:The mevalonate pathway produces many critical substances in cells, including sterols essential for membrane structure and isoprenoids vital to the function of many membrane proteins. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a rate-limiting enzyme in the mevalonate pathway. Because cholesterol is a ...

journal_title：Blood

authors： Li HY,Appelbaum FR,Willman CL,Zager RA,Banker DE

更新日期：2003-05-01 00:00:00

abstract：:Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitous...

journal_title：Blood

authors： Gilchrist M,McCauley SD,Befus AD

更新日期：2004-07-15 00:00:00

abstract：:ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative stat...

journal_title：Blood

authors： Neubauer A,Shannon K,Liu E

更新日期：1991-02-01 00:00:00