The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells.

abstract：:Little is known about the ontogeny of naturally occurring CD4(+)CD25(+) regulatory/suppressor T cells that play a major role in maintaining self-tolerance in mice and humans. In rodents, thymectomy on day 3 of life leads to multiple organ-specific autoimmune diseases that can be prevented by adoptive transfer of regul...

journal_title：Blood

authors： Darrasse-Jèze G,Marodon G,Salomon BL,Catala M,Klatzmann D

更新日期：2005-06-15 00:00:00

abstract：:Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of VCAN proteolysis re...

journal_title：Blood

authors： Hope C,Foulcer S,Jagodinsky J,Chen SX,Jensen JL,Patel S,Leith C,Maroulakou I,Callander N,Miyamoto S,Hematti P,Apte SS,Asimakopoulos F

更新日期：2016-08-04 00:00:00

abstract：:A technique has been developed for handling human bone marrow cells intended for the examination of DNA repair synthesis. DNA-repair synthesis, induced by melphalan and nitrogen mustard, was measured as the incorporation of 3H-thymidine, registered by autoradiography as unscheduled DNA synthesis (UDS). Comparison of v...

journal_title：Blood

authors： Lewensohn R,Ringborg U

更新日期：1979-12-01 00:00:00

abstract：:Protein Z is a vitamin K-dependent glycoprotein that plays a role in the regulation of coagulation. A nucleotide substitution of G by C in exon II of the protein Z gene, resulting in the replacement of Glu-30 with Gln (E30Q), and a G to A transition at the 79th nucleotide in intron F (IntF79G/A) were heterozygously id...

journal_title：Blood

authors： Souri M,Koseki-Kuno S,Iwata H,Kemkes-Matthes B,Ichinose A

更新日期：2005-04-15 00:00:00

abstract：:Even if neoplastic cells express tumor associated antigens they still may fail to function as antigen presenting cells (APC) if they lack expression of one or more molecules critical for the induction of productive immunity. These cellular defects can be repaired by physiologic activation, transfection, or fusion of t...

journal_title：Blood

authors： Cardoso AA,Schultze JL,Boussiotis VA,Freeman GJ,Seamon MJ,Laszlo S,Billet A,Sallan SE,Gribben JG,Nadler LM

更新日期：1996-07-01 00:00:00

abstract：:The present studies were initiated to define the coding region of a 34 kilodalton (kd) protein (p34) frequently observed with antibodies from HTLV-III/LAV-infected people by immunoblotting and radioimmunoprecipitation (RIP) techniques. We have directly mapped this viral protein to the pol gene of HTLV-III/LAV by radio...

journal_title：Blood

authors： Allan JS,Coligan JE,Lee TH,Barin F,Kanki PJ,M'Boup S,McLane MF,Groopman JE,Essex M

更新日期：1987-01-01 00:00:00

abstract：:FTY720 is an immunosuppressant developed to prevent organ transplant rejection. Recent studies indicate an additional role for FTY720 in inducing cell apoptosis. We demonstrate here that FTY720 mediates toxic effects in cell lines representing different B-cell malignancies and primary B cells from patients with chroni...

journal_title：Blood

authors： Liu Q,Zhao X,Frissora F,Ma Y,Santhanam R,Jarjoura D,Lehman A,Perrotti D,Chen CS,Dalton JT,Muthusamy N,Byrd JC

更新日期：2008-01-01 00:00:00

abstract：:In The Netherlands from July 1988 to October 1991, children (0 to 16 years of age) with de novo acute lymphoblastic leukemia (ALL) were treated according to protocol ALL-7 of the Dutch Childhood Leukemia Study Group (DCLSG). In this protocol, chemotherapy and treatment stratification were identical to the ALL-BFM-86 p...

journal_title：Blood

authors： Kamps WA,Bökkerink JP,Hählen K,Hermans J,Riehm H,Gadner H,Schrappe M,Slater R,van den Berg-de Ruiter E,Smets LA,de Vaan GA,Weening RS,van Weerden JF,van Wering ER,den der Does-van den Berg A

更新日期：1999-08-15 00:00:00

abstract：:Lymphoepithelioid lymphoma (Lennert's lymphoma) was first described as a special variant of Hodgkin's disease. This lesion is characterized by a high percentage of epithelioid and T cells and rarely contains the classical Hodgkin's/Reed-Sternberg cells. Cytogenetic abnormalities indicate that Lennert's lymphoma is of ...

journal_title：Blood

authors： Feller AC,Griesser GH,Mak TW,Lennert K

更新日期：1986-09-01 00:00:00

abstract：:In this issue of Blood, Usmani et al provide important information on second primary malignancies in patients treated with thalidomide and lenalidomide in the Arkansas total therapy trials. ...

journal_title：Blood

authors： Rajkumar SV

更新日期：2012-08-23 00:00:00

abstract：:The PAX-5 gene codes for the transcription factor BSAP, which is expressed throughout B-cell development. Although loss-of-function mutation in the mouse showed an essential role for Pax-5 in early B lymphopoiesis, gain-of-function mutations have implicated the human PAX-5 gene in the control of late B-cell differenti...

journal_title：Blood

authors： Morrison AM,Jäger U,Chott A,Schebesta M,Haas OA,Busslinger M

更新日期：1998-11-15 00:00:00

abstract：:Genetic analysis of hemochromatosis has led to the discovery of a number of genes whose mutations disrupt iron homeostasis and lead to iron overload. The introduction of molecular tests into clinical practice has provided a tool for early diagnosis of these conditions. It has become clear that hemochromatosis includes...

journal_title：Blood

authors： Camaschella C

更新日期：2005-12-01 00:00:00

abstract：:The technique described in the preceding paper was applied to 12 abnormal sera selected for their increase in one or more B12-binding proteins. Even in the presence of large amounts of R-type binder, the ammonium sulfate technique gave a reliable separation of R binding proteins from TC II. Measurement of the TC II in...

journal_title：Blood

authors： Begley JA,Hall CA

更新日期：1975-02-01 00:00:00

abstract：:Activated protein C (APC) is inhibited by two major plasma inhibitors (PCIs). To find evidence for in vivo complexation of APC, immunoblotting studies were performed on plasmas of 85 patients with suspected disseminated intravascular coagulation (DIC). Samples from 62 of these patients contained 5% to 35% of protein C...

journal_title：Blood

authors： Heeb MJ,Mosher D,Griffin JH

更新日期：1989-02-01 00:00:00

abstract：:We report results from a study exploring the combination of romidepsin, bortezomib, and dexamethasone for the treatment of patients with multiple myeloma (MM) previously treated with > 1 prior therapy. The primary objective was to determine the maximum tolerated dose (MTD) of the combination using a novel accelerated ...

journal_title：Blood

authors： Harrison SJ,Quach H,Link E,Seymour JF,Ritchie DS,Ruell S,Dean J,Januszewicz H,Johnstone R,Neeson P,Dickinson M,Nichols J,Prince HM

更新日期：2011-12-08 00:00:00

abstract：:The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation...

journal_title：Blood

authors： Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F

更新日期：2012-05-03 00:00:00

abstract：:We studied the cell kill induced by granulocyte-macrophage colony-stimulating factor (GM-CSF ) fused to Diphtheria Toxin (DT-GM-CSF ) in acute myeloid leukemia (AML) samples and in populations of normal primitive hemopoietic progenitor cells. AML samples from three patients were incubated in vitro with 100 ng/mL DT-GM...

journal_title：Blood

authors： Terpstra W,Rozemuller H,Breems DA,Rombouts EJ,Prins A,FitzGerald DJ,Kreitman RJ,Wielenga JJ,Ploemacher RE,Löwenberg B,Hagenbeek A,Martens AC

更新日期：1997-11-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) is a potentially immunosuppressive agent that has been suggested to act as a cofactor in the progression of HIV disease. Exposure of human macrophages to HHV-6A or HHV-6B profoundly impaired their ability to produce interleukin 12 (IL-12) upon stimulation with interferon-gamma (IFN-gamma) a...

journal_title：Blood

authors： Smith A,Santoro F,Di Lullo G,Dagna L,Verani A,Lusso P

更新日期：2003-10-15 00:00:00

abstract：:The molecular basis for the hereditary persistence of fetal hemoglobin (HPFH) phenotype was studied in a Chinese individual who was heterozygous for a nondeletion form of A gamma-HPFH. Both allelic A gamma-globin genes were isolated by molecular cloning and subjected to nucleotide sequence analysis. One A gamma gene p...

journal_title：Blood

authors： Gelinas R,Bender M,Lotshaw C,Waber P,Kazazian H Jr,Stamatoyannopoulos G

更新日期：1986-06-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cases with 11q23 abnormalities involving the MLL gene comprise one category of recurring genetic abnormalities in the WHO classification. In an unselected series of 1897 AML cases, 54 patients with an 11q23/MLL rearrangement were identified, resulting in an incidence of 2.8%. The incidence...

journal_title：Blood

authors： Schoch C,Schnittger S,Klaus M,Kern W,Hiddemann W,Haferlach T

更新日期：2003-10-01 00:00:00

abstract：:Regulated migration of hematopoietic stem cells is fundamental for hematopoiesis. The molecular mechanisms underlying stem cell trafficking are poorly defined. Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX...

journal_title：Blood

authors： Thieme S,Gyárfás T,Richter C,Özhan G,Fu J,Alexopoulou D,Muders MH,Michalk I,Jakob C,Dahl A,Klink B,Bandola J,Bachmann M,Schröck E,Buchholz F,Stewart AF,Weidinger G,Anastassiadis K,Brenner S

更新日期：2013-03-28 00:00:00

abstract：:Regulatory T (Treg) cells contribute to immune evasion by malignancies. To investigate their importance in non-Hodgkin lymphoma (NHL), we enumerated Treg cells in peripheral blood mononuclear cells (PBMCs) and involved tissues from 30 patients. CD25(+)FoxP3(+)CD127(low)CD4(+) Treg cells were increased markedly in PBMC...

journal_title：Blood

authors： Mittal S,Marshall NA,Duncan L,Culligan DJ,Barker RN,Vickers MA

更新日期：2008-06-01 00:00:00

abstract：:We previously reported that sphingosine 1-phosphate (S1P) regulates peritoneal B-cell trafficking and subsequent intestinal IgA production, but the underlying mechanisms remain obscure. We demonstrate here that nuclear factor kappaB-inducing kinase (NIK) is involved in the regulation of S1P-mediated trafficking of per...

journal_title：Blood

authors： Kunisawa J,Gohda M,Kurashima Y,Ishikawa I,Higuchi M,Kiyono H

更新日期：2008-05-01 00:00:00

abstract：:Using urea-solubilized human fibrin monomer as an immunogen, we raised in mice a battery of monoclonal antibodies that reacted with the immunogen but not with urea-treated or native fibrinogen. Although they all failed to react with acid-solubilized fibrin monomer (acid-FM) alone, an antibody designated as IF-43 was f...

journal_title：Blood

authors： Soe G,Kohno I,Inuzuka K,Itoh Y,Matsuda M

更新日期：1996-09-15 00:00:00

abstract：:Meis1 is a homeodomain transcription factor coexpressed with Hoxa9 in most human acute myeloid leukemias (AMLs). In mouse models of leukemia produced by Hoxa9, Meis1 accelerates leukemogenesis. Because Hoxa9 immortalizes myeloid progenitors in the absence of Meis1 expression, the contribution of Meis1 toward leukemia ...

journal_title：Blood

authors： Wang GG,Pasillas MP,Kamps MP

更新日期：2005-07-01 00:00:00

abstract：:We used in vitro DNA amplification by the polymerase chain reaction and nonradioactive probes for prenatal diagnosis of beta thalassemia in Chinese from the Guangdong province. Exact molecular diagnoses were made in all 20 fetuses studied over a 6-month period. We conclude that this method of prenatal diagnosis for be...

journal_title：Blood

authors： Cai SP,Chang CA,Zhang JZ,Saiki RK,Erlich HA,Kan YW

更新日期：1989-02-01 00:00:00

abstract：:We demonstrate here that EL4-6.1 cells, a mouse thymoma that expresses high levels of membrane interleukin (IL)-1 receptors, produce IL-1 beta as an autocrine regulatory factor. Endogenous IL-1 beta sustains both proliferation and apoptosis: during the exponential phase, it mainly promotes proliferation, while during ...

journal_title：Blood

authors： Fratelli M,Gagliardini V,Galli G,Gnocchi P,Ghiara P,Ghezzi P

更新日期：1995-06-15 00:00:00

abstract：:Plasma hyperviscosity is a rare complication of both monoclonal and polyclonal disorders associated with elevation of immunoglobulins. Asymptomatic patients with an elevation in the serum viscosity do not require plasma exchange, and the majority will have other indications for therapeutic intervention. For patients w...

journal_title：Blood

authors： Gertz MA

更新日期：2018-09-27 00:00:00

abstract：:Chromosomal rearrangements affecting RUNX1 and CBFB are common in acute leukemias. These mutations result in the expression of fusion proteins that act dominant-negatively to suppress the normal function of the Runt-related transcription factor 1 (RUNX)/core binding factor beta (CBFbeta) complexes. In addition, loss-o...

journal_title：Blood

authors： Kundu M,Compton S,Garrett-Beal L,Stacy T,Starost MF,Eckhaus M,Speck NA,Liu PP

更新日期：2005-11-15 00:00:00

abstract：:Mutations of the type III receptor tyrosine kinase FLT3 occur in approximately 30% of acute myeloid leukemia patients and lead to constitutive activation. This has made FLT3-activating mutations an attractive drug target because they are probable driver mutations of this disease. As more potent FLT3 inhibitors are dev...

journal_title：Blood

authors： Galanis A,Ma H,Rajkhowa T,Ramachandran A,Small D,Cortes J,Levis M

更新日期：2014-01-02 00:00:00