FLT3/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units.

abstract：:Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct subgroup of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) that has a dismal outcome when treated with standard therapy. For improved diagnosis and risk stratification, the initiating genetic events need to be elucidated. To...

journal_title：Blood

authors： Rand V,Parker H,Russell LJ,Schwab C,Ensor H,Irving J,Jones L,Masic D,Minto L,Morrison H,Ryan S,Robinson H,Sinclair P,Moorman AV,Strefford JC,Harrison CJ

更新日期：2011-06-23 00:00:00

abstract：:Binding of platelets to fibrinogen via integrin alphaIIbbeta3 stimulates cytoskeletal reorganization and spreading. These responses depend on tyrosine phosphorylation of multiple proteins by Src family members and Syk. Among Src substrates in platelets is adhesion- and degranulation-promoting adapter protein (ADAP), a...

journal_title：Blood

authors： Kasirer-Friede A,Ruggeri ZM,Shattil SJ

更新日期：2010-03-18 00:00:00

abstract：:We investigated the effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and recombinant human granulocyte colony-stimulating factor (rhG-CSF) therapy on the natural killer (NK) cell lineage in patients with aplastic anemia and myelodysplastic syndrome. Selected bone marrow (BM) cel...

journal_title：Blood

authors： Shibuya A,Taguchi K,Kojima H,Abe T

更新日期：1991-12-15 00:00:00

abstract：:Affinity purified anticardiolipin antibodies (ACLA) raised in rabbits showed cross-reactivities with various negatively charged phospholipids as shown by both the solid phase enzyme-linked immunosorbent assay (ELISA) and inhibition studies. In ELISA, ACLA showed strong cross-reactivity to both sphingomyelin (SM) and p...

journal_title：Blood

authors： Lin YL,Wang CT

更新日期：1992-12-15 00:00:00

abstract：:Families with 3 different syndromes characterized by autosomal dominant inheritance of low platelet count and giant platelets were studied. Fechtner syndrome is an autosomal-dominant variant of Alport syndrome manifested by nephritis, sensorineural hearing loss, and cataract formation in addition to macrothrombocytope...

journal_title：Blood

authors： Toren A,Rozenfeld-Granot G,Rocca B,Epstein CJ,Amariglio N,Laghi F,Landolfi R,Brok-Simoni F,Carlsson LE,Rechavi G,Greinacher A

更新日期：2000-11-15 00:00:00

abstract：:Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. In recent years, important progress has been made in the knowledge of the molecular biology and the prognostic assessment of MF. Convention...

journal_title：Blood

authors： Cervantes F

更新日期：2014-10-23 00:00:00

abstract：:Recently, our laboratory showed that platelets, like leukocytes, roll on activated endothelium expressing P-selectin, thus suggesting a role for P-selectin in hemostasis (Frenette et at, Proc Natl Acad Sci USA 92:7450, 1995). We report here that the P-selectin--deficient mice show a 40% prolongation of the bleeding ti...

journal_title：Blood

authors： Subramaniam M,Frenette PS,Saffaripour S,Johnson RC,Hynes RO,Wagner DD

更新日期：1996-02-15 00:00:00

abstract：:In order to evaluate the role of the stromal bone marrow microenvironment in regulating granulopoiesis, we have examined the capacity of adult human proximal hemopoietic (PH) and distal nonhemopoietic (DNH) long bone to produce colony-stimulating activity (CSA), characterized the cellular sources of CSA, and quantitat...

journal_title：Blood

authors： Schwartz RS,Greenberg PL

更新日期：1981-04-01 00:00:00

abstract：:A strategy to phenotype rare populations of hematopoietic cells expressing the cell-surface marker CD34 was studied. The antigenic phenotype of umbilical core blood (CB) CD34+ cells was investigated using flow cytometry and compared with the mRNA-phenotype determined by cDNA-polymerase chain reaction (cDNA-PCR) analys...

journal_title：Blood

authors： Thoma SJ,Lamping CP,Ziegler BL

更新日期：1994-04-15 00:00:00

abstract：:The extracellular presence of endotoxin-free heat shock protein 70 (HSP70) enhances the rate and capacity of macrophage-mediated phagocytosis at 6 times the basal rate. It is protein-specific, dose- and time-dependent and involves the internalization of inert microspheres, Gram-positive and -negative bacteria and fung...

journal_title：Blood

authors： Wang R,Kovalchin JT,Muhlenkamp P,Chandawarkar RY

更新日期：2006-02-15 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV) is detected in approximately 80% of Merkel cell carcinomas (MCC). Yet, clonal integration and truncating mutations of the large T antigen (LTAg) of MCPyV are restricted to MCC. We tested the presence and mutations of MCPyV in highly purified leukemic cells of 70 chronic lymphocytic leu...

journal_title：Blood

authors： Pantulu ND,Pallasch CP,Kurz AK,Kassem A,Frenzel L,Sodenkamp S,Kvasnicka HM,Wendtner CM,Zur Hausen A

更新日期：2010-12-09 00:00:00

abstract：:Aberrant regulation of endogenous survival pathways plays a major role in progression of chronic lymphocytic leukemia (CLL). Signaling via conjugation of surface receptors within the tumor environmental niche activates survival and proliferation pathways in CLL. Of these, the phosphoinositide 3-kinase (PI3K)/protein k...

journal_title：Blood

authors： Liu TM,Ling Y,Woyach JA,Beckwith K,Yeh YY,Hertlein E,Zhang X,Lehman A,Awan F,Jones JA,Andritsos LA,Maddocks K,MacMurray J,Salunke SB,Chen CS,Phelps MA,Byrd JC,Johnson AJ

更新日期：2015-01-08 00:00:00

abstract：:Platelet-von Willebrand factor (VWF) interactions must be tightly regulated in order to promote effective hemostasis and prevent occlusive thrombus formation. However, it is unclear what role the inherent properties of the bond formed between the platelet receptor glycoprotein Ibα and the A1 domain of VWF play in thes...

journal_title：Blood

authors： Chen J,Zhou H,Diacovo A,Zheng XL,Emsley J,Diacovo TG

更新日期：2014-12-11 00:00:00

abstract：:Previous in vitro findings suggest a critical role for the polymorphonuclear leukocyte (PMN) membrane glycoprotein complex CD18 in PMN adherence and chemotaxis. We examined the effect of the murine monoclonal antibody (MoAb) 60.3, recognizing CD18, on induced PMN accumulation in vivo. Rabbits were pretreated with MoAb...

journal_title：Blood

authors： Arfors KE,Lundberg C,Lindbom L,Lundberg K,Beatty PG,Harlan JM

更新日期：1987-01-01 00:00:00

abstract：:A substantial body of published data suggests activation of lineage-specific genes in multipotential hemopoietic cells before their unilineage commitment. Because the behavior and plasticity of cells isolated in vitro away from microenvironmental constraints exercised in vivo may be altered, one wonders whether simila...

journal_title：Blood

authors： Papayannopoulou T,Priestley GV,Rohde A,Peterson KR,Nakamoto B

更新日期：2000-02-15 00:00:00

abstract：:The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML). We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a. Here, we confirm miR-30c as a novel...

journal_title：Blood

authors： Katzerke C,Madan V,Gerloff D,Bräuer-Hartmann D,Hartmann JU,Wurm AA,Müller-Tidow C,Schnittger S,Tenen DG,Niederwieser D,Behre G

更新日期：2013-10-03 00:00:00

abstract：:Acute myeloid leukemia (AML) cases with 11q23 abnormalities involving the MLL gene comprise one category of recurring genetic abnormalities in the WHO classification. In an unselected series of 1897 AML cases, 54 patients with an 11q23/MLL rearrangement were identified, resulting in an incidence of 2.8%. The incidence...

journal_title：Blood

authors： Schoch C,Schnittger S,Klaus M,Kern W,Hiddemann W,Haferlach T

更新日期：2003-10-01 00:00:00

abstract：:For many years, human hemoglobin (Hb) isolated from erythrocytes has been investigated as a potential oxygen delivery therapeutic. Advantages with respect to the need for blood typing were balanced with various undesirable properties of cell-free Hb, including cost, overall oxygen affinity, alterations in cooperativit...

journal_title：Blood

authors： Sanders KE,Lo J,Sligar SG

更新日期：2002-07-01 00:00:00

abstract：:Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restrict...

journal_title：Blood

authors： Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E

更新日期：2010-07-15 00:00:00

abstract：:The intercellular crosstalk between hematological malignancies and the tumor microenvironment is mediated by cell-to-cell interactions and soluble factors. One component of the secretome that is gaining increasing attention is the extracellular vesicles and, in particular, the exosomes. Apart from the role as vectors ...

journal_title：Blood

authors： Vardaki I,Sanchez C,Fonseca P,Olsson M,Chioureas D,Rassidakis G,Ullén A,Zhivotovsky B,Björkholm M,Panaretakis T

更新日期：2016-12-08 00:00:00

abstract：:An inactivating polymorphism at position 609 in the NAD(P)H:quinone oxidoreductase 1 gene (NQO1 C609T) is associated with an increased risk of adult leukemia. A small British study suggested that NQO1 C609T was associated with an increased risk of infant leukemias with MLL translocations, especially infant acute lymph...

journal_title：Blood

authors： Smith MT,Wang Y,Skibola CF,Slater DJ,Lo Nigro L,Nowell PC,Lange BJ,Felix CA

更新日期：2002-12-15 00:00:00

abstract：:Proteins exported from Plasmodium falciparum parasites into red blood cells (RBCs) interact with the membrane skeleton and contribute to the pathogenesis of malaria. Specifically, exported proteins increase RBC membrane rigidity, decrease deformability, and increase adhesiveness, culminating in intravascular sequestra...

journal_title：Blood

authors： Glenister FK,Fernandez KM,Kats LM,Hanssen E,Mohandas N,Coppel RL,Cooke BM

更新日期：2009-01-22 00:00:00

abstract：:Interleukin-25 (IL-25) is a recently described T helper 2 (T(H)2) cell-derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non-T-cell population. Here, we show that mast cells are also potent IL-25-producing cells. When bone marrow-derived mast cel...

journal_title：Blood

authors： Ikeda K,Nakajima H,Suzuki K,Kagami S,Hirose K,Suto A,Saito Y,Iwamoto I

更新日期：2003-05-01 00:00:00

abstract：:An abnormality of platelet aggregation has been detected in six family members with mild bleeding tendencies. In citrated platelet-rich plasma, primary aggregation induced by ADP or epinephrine and agglutination in response to ristocetin were present but second wave aggregation and aggregation in response to collagen ...

journal_title：Blood

authors： Ingerman CM,Smith JB,Shapiro S,Sedar A,Silver MJ

更新日期：1978-08-01 00:00:00

abstract：:Fanconi anemia (FA) is the most frequent inherited cause of bone marrow failure (BMF). Most FA patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the frequent emergence in their teens or young adulthood of...

journal_title：Blood

authors： Peffault de Latour R,Soulier J

更新日期：2016-06-16 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) caused by impaired FAS-mediated apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased risk of invasive bacterial infection, notably following splenectomy. We surveyed a cohort of 100 ALPS patients (including 33 splenectomize...

journal_title：Blood

authors： Neven B,Bruneau J,Stolzenberg MC,Meyts I,Magerus-Chatinet A,Moens L,Lanzarotti N,Weller S,Amiranoff D,Florkin B,Bader-Meunier B,Leverger G,Ferster A,Chantrain C,Blanche S,Picard C,Molina TJ,Brousse N,Durandy A,Rizzi

更新日期：2014-09-04 00:00:00

abstract：:Targeted disruption of the Friend leukemia integration 1 (Fli-1) proto-oncogene results in severe dysmegakaryopoiesis and embryonic lethality. We used morula-stage aggregation as a strategy to further clarify the hematopoietic defects of the Fli-1 gene-targeted mice. Analyses of lineage expression of Fli-1(+/-) and Fl...

journal_title：Blood

authors： Masuya M,Moussa O,Abe T,Deguchi T,Higuchi T,Ebihara Y,Spyropoulos DD,Watson DK,Ogawa M

更新日期：2005-01-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cells in a human leukocyte antigen (HLA)-dependent manner. KIR/HLA mismatched hematopoietic stem cell transplants induce alloreactive NK cells, which prevent leukemia relapse. Certain KIR/HLA combinations protect against HIV-1 infection, but the ...

journal_title：Blood

authors： Jennes W,Verheyden S,Mertens JW,Camara M,Seydi M,Dieye TN,Mboup S,Demanet C,Kestens L

更新日期：2013-02-14 00:00:00

abstract：:Three cases of T-lymphoblastic lymphomas (T-LL) expressing the T cell antigen receptor gamma delta (TCR gamma delta) are reported. All of them were CD3+/beta F1-/TCR delta 1+. Moreover, neoplastic cells reacted with the delta TCS1 monoclonal antibody (MoAb) which binds to the non-disulfide-linked form of the TCR gamma...

journal_title：Blood

authors： Falini B,Flenghi L,Fagioli M,Martelli MF,Pileri S,Grignani F,Beltrami A,Novero D,Pelicci PG

更新日期：1989-11-15 00:00:00

abstract：:NOTCH1 is mutated in 10% of chronic lymphocytic leukemia (CLL) patients and is associated with poor outcome. However, NOTCH1 activation is identified in approximately one-half of CLL cases even in the absence of NOTCH1 mutations. Hence, there appear to be additional factors responsible for the impairment of NOTCH1 deg...

journal_title：Blood

authors： Close V,Close W,Kugler SJ,Reichenzeller M,Yosifov DY,Bloehdorn J,Pan L,Tausch E,Westhoff MA,Döhner H,Stilgenbauer S,Oswald F,Mertens D

更新日期：2019-02-21 00:00:00