Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia.

abstract：:Platelets stored as concentrates (PC) for 72 h at 22 degrees C develop a functional defect. Alterations in adenine nucleotides of platelets have been shown to affect platelet function. Adenine nucleotide content of platelets was measured before and after storage and a decrease of 27.1 /+- 1.7% (mean /+- SE) in ATP and...

journal_title：Blood

authors： Rao AK,Niewiarowski S,Murphy S

更新日期：1981-02-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are agonists of the endothelial differentiation gene (Edg) family of G-protein-coupled receptors. LPA and S1P are generated by platelet activation during blood coagulation. Both lipids induce assembly of exogenous fibronectin (FN) by fibroblasts. This study...

journal_title：Blood

authors： Olorundare OE,Peyruchaud O,Albrecht RM,Mosher DF

更新日期：2001-07-01 00:00:00

abstract：:Rapid exclusion of heparin-induced thrombocytopenia (HIT) is needed to determine which patients can continue to receive heparin. In this prospective management study, 526 participants had a 4Ts score, rapid particle gel immunoassay (platelet factor 4/heparin [PF4/H]-PaGIA), and serotonin-release assay (SRA) performed....

journal_title：Blood

authors： Linkins LA,Bates SM,Lee AY,Heddle NM,Wang G,Warkentin TE

更新日期：2015-07-30 00:00:00

abstract：:While investigating 2592 patients enrolled in multicenter myeloma trials, we found light chain-only (LCO) patients had worse median survival times (1.9 years) than patients with IgA and IgG paraproteins (2.3 and 2.5 years, respectively) (P < .001). However, IgA and IgG patients with levels of LC excretion similar to t...

journal_title：Blood

authors： Drayson M,Begum G,Basu S,Makkuni S,Dunn J,Barth N,Child JA

更新日期：2006-09-15 00:00:00

abstract：:To characterize and clarify the function of CD34 antigen experimentally, we isolated two types of CD34 mRNA from a cDNA library of murine stromal cell line, PA-6 stimulated with lipopolysaccharide (LPS) and 12-o-tetra-decanoylphorbol 13-acetate (TPA) using a human CD34 probe. In addition to the clone (open reading fra...

journal_title：Blood

authors： Suda J,Sudo T,Ito M,Ohno N,Yamaguchi Y,Suda T

更新日期：1992-05-01 00:00:00

abstract：:Recent studies have reported that the pharmacokinetics of high-dose busulfan in bone marrow transplantation (BMT) are age-dependent: with the usual dosage of 16 mg/kg over 4 days, systemic exposure is two to four times lower in children than in adults. Data suggested that the dose of busulfan should rather be calculat...

journal_title：Blood

authors： Vassal G,Deroussent A,Challine D,Hartmann O,Koscielny S,Valteau-Couanet D,Lemerle J,Gouyette A

更新日期：1992-05-01 00:00:00

abstract：:The p21-activated kinases (Paks) are serine/threonine kinases that are major effectors of the Rho guanosine 5'\x{2011}triphosphatase, Rac, and Cdc42. Rac and Cdc42 are known regulators of hematopoietic stem and progenitor cell (HSPC) function, however, a direct role for Paks in HSPCs has yet to be elucidated. Lin(-)Sc...

journal_title：Blood

authors： Dorrance AM,De Vita S,Radu M,Reddy PN,McGuinness MK,Harris CE,Mathieu R,Lane SW,Kosoff R,Milsom MD,Chernoff J,Williams DA

更新日期：2013-03-28 00:00:00

abstract：:To examine the relationship between dietary iron exposure through the consumption of traditional beer and the presence of iron overload in black Africans not related by birth, we studied 28 husband and wife pairs from a rural Zimbabwean community. Lifetime traditional beer consumption was estimated by questioning subj...

journal_title：Blood

authors： Moyo VM,Gangaidzo IT,Gomo ZA,Khumalo H,Saungweme T,Kiire CF,Rouault T,Gordeuk VR

更新日期：1997-03-15 00:00:00

abstract：:Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduced in plasma in the absence of factor XII or its substrate of the int...

journal_title：Blood

authors： Nickel KF,Ronquist G,Langer F,Labberton L,Fuchs TA,Bokemeyer C,Sauter G,Graefen M,Mackman N,Stavrou EX,Ronquist G,Renné T

更新日期：2015-09-10 00:00:00

abstract：:A 13-yr-old Japanese female with acute lymphoblastic leukemia (ALL) that was associated with a Philadelphia chromosome (Ph1) as well as a 14q+ chromosome abnormality is reported. The cell surface phenotype of leukemic cells was determined to be non-T, non-B ALL on the basis of positive Ia-like antigen, terminal deoxyn...

journal_title：Blood

authors： Maekawa T,Sonoda Y,Taniwaki M,Misawa S,Abe T,Takino T

更新日期：1984-02-01 00:00:00

abstract：:The microbiota is known to influence the generation of hematopoietic progenitors, although the pathways underlying this process are still poorly understood. NOD1 and NOD2 are intracellular sensors for both Gram-positive and Gram-negative bacteria, but their role in steady-state hematopoiesis has never been characteriz...

journal_title：Blood

authors： Iwamura C,Bouladoux N,Belkaid Y,Sher A,Jankovic D

更新日期：2017-01-12 00:00:00

abstract：:Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performed whole-exome sequencing of 23 highly purified FL cases and 1 transfo...

journal_title：Blood

authors： Yildiz M,Li H,Bernard D,Amin NA,Ouillette P,Jones S,Saiya-Cork K,Parkin B,Jacobi K,Shedden K,Wang S,Chang AE,Kaminski MS,Malek SN

更新日期：2015-01-22 00:00:00

abstract：:Analysis of a growing number of chromosomal translocations in human tumors have shown that they frequently result in gene fusions encoding chimeric proteins. We have characterized the recurrent t(12;21)(p12;q22) translocation present in human B-lineage acute leukemias. This translocation fused two genes, tel and AML1,...

journal_title：Blood

authors： Romana SP,Mauchauffé M,Le Coniat M,Chumakov I,Le Paslier D,Berger R,Bernard OA

更新日期：1995-06-15 00:00:00

abstract：:The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing signals, Ikaros(-/-) (I...

journal_title：Blood

authors： Rao KN,Smuda C,Gregory GD,Min B,Brown MA

更新日期：2013-10-10 00:00:00

abstract：:The combination of high levels of beta2-microglobulin (beta2-m) and chromosome 13 deletion allows identification of a high-risk subgroup of patients with de novo multiple myeloma (MM). In this population of patients, we have evaluated the impact of a murine anti-interleukin 6 (anti-IL-6) monoclonal antibody (BE-8) as ...

journal_title：Blood

authors： Moreau P,Hullin C,Garban F,Yakoub-Agha I,Benboubker L,Attal M,Marit G,Fuzibet JG,Doyen C,Voillat L,Berthou C,Ketterer N,Casassus P,Monconduit M,Michallet M,Najman A,Sotto JJ,Bataille R,Harousseau JL,Intergroupe Fran

更新日期：2006-01-01 00:00:00

abstract：:Most bone marrow (BM) malignancies develop in association with an angiogenic phenotype and increased numbers of endothelial cells. The molecular mechanisms involved in the modulation and recruitment of BM endothelium are largely unknown and may provide novel therapeutic targets for neoplastic diseases. We observed tha...

journal_title：Blood

authors： Costa LF,Balcells M,Edelman ER,Nadler LM,Cardoso AA

更新日期：2006-01-01 00:00:00

abstract：:Delivery of biologically active peptides into human polymorphonuclear neutrophils (PMNs) has implications for studying cellular functions and may be therapeutically relevant. The transcription factor nuclear factor-kappaB (NF-kappaB) regulates the expression of multiple genes controlling inflammation, proliferation, a...

journal_title：Blood

authors： Choi M,Rolle S,Wellner M,Cardoso MC,Scheidereit C,Luft FC,Kettritz R

更新日期：2003-09-15 00:00:00

abstract：:Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA). For both fluoride ...

journal_title：Blood

authors： English D,Roloff JS,Lukens JN

更新日期：1981-07-01 00:00:00

abstract：:Donor lymphocyte infusions have been effective in patients with chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation, but their use is associated with the risk of graft-versus-host disease. We investigated the effects of prophylactic infusion of in vitro-generated donor T cells reactive ...

journal_title：Blood

authors： Bornhäuser M,Thiede C,Platzbecker U,Kiani A,Oelschlaegel U,Babatz J,Lehmann D,Hölig K,Radke J,Tuve S,Wermke M,Wehner R,Jähnisch H,Bachmann MP,Rieber EP,Schetelig J,Ehninger G,Schmitz M

更新日期：2011-06-30 00:00:00

abstract：:Keratinocyte growth factor (KGF) is important in tissue repair and wound healing and its administration can abrogate chemical- and radiation-induced tissue damage in rodents. We investigated KGF as a therapeutic agent for the prevention of graft-versus-host disease (GVHD)-induced tissue damage, morbidity, and mortalit...

journal_title：Blood

authors： Panoskaltsis-Mortari A,Lacey DL,Vallera DA,Blazar BR

更新日期：1998-11-15 00:00:00

abstract：:The American Board of Internal Medicine (ABIM) has called on directors of hematology training programs to establish systems to evaluate, document, and substantiate those components of overall clinical competence considered essential for certification in the subspecialty. Many of these can be assessed only by repeated ...

journal_title：Blood

authors： Schrier SL,Benson JA Jr

更新日期：1988-10-01 00:00:00

abstract：:In this issue of Blood, Kurtz et al report the potential clinical utility of immunoglobulin high-throughput sequencing as a tool for disease monitoring and surveillance in aggressive B-cell lymphoma. ...

journal_title：Blood

authors： Sweetenham JW

更新日期：2015-06-11 00:00:00

abstract：:NKG2D is an activation receptor that allows natural killer (NK) cells to detect diseased host cells. The engagement of NKG2D with corresponding ligand results in surface modulation of the receptor and reduced function upon subsequent receptor engagement. However, it is not clear whether in addition to modulation the N...

journal_title：Blood

authors： Coudert JD,Zimmer J,Tomasello E,Cebecauer M,Colonna M,Vivier E,Held W

更新日期：2005-09-01 00:00:00

abstract：:Lipoprotein (a) [Lp(a)] has been associated with both anti-fibrinolytic and atherogenic effects. However, no direct link currently exists between this atherogenic lipoprotein and intravascular coagulation. The current study examined the binding and functional effects of Lp(a), its lipoprotein constituents, apoliprotei...

journal_title：Blood

authors： Caplice NM,Panetta C,Peterson TE,Kleppe LS,Mueske CS,Kostner GM,Broze GJ Jr,Simari RD

更新日期：2001-11-15 00:00:00

abstract：:Sardinian beta-thalassemia patients all are homozygotes for the same null allele in the beta-globin gene, but the clinical manifestations are extremely variable in severity. Previous studies have shown that the coinheritance of alpha-thalassemia or the presence of genetic variants that sustain fetal hemoglobin product...

journal_title：Blood

authors： Galanello R,Sanna S,Perseu L,Sollaino MC,Satta S,Lai ME,Barella S,Uda M,Usala G,Abecasis GR,Cao A

更新日期：2009-10-29 00:00:00

abstract：:Non-Hodgkin lymphoma (NHL) incidence is greatly increased after kidney transplantation. NHL risk was investigated in a nationwide cohort of 8164 kidney transplant recipients registered on the Australia and New Zealand Dialysis and Transplant Registry. NHL diagnoses were ascertained using linkage with national cancer r...

journal_title：Blood

authors： van Leeuwen MT,Grulich AE,Webster AC,McCredie MR,Stewart JH,McDonald SP,Amin J,Kaldor JM,Chapman JR,Vajdic CM

更新日期：2009-07-16 00:00:00

abstract：:Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear entry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high titer. Experiments to evaluate HIV-derived lentiviral vectors ...

journal_title：Blood

authors： Trobridge GD,Beard BC,Gooch C,Wohlfahrt M,Olsen P,Fletcher J,Malik P,Kiem HP

更新日期：2008-06-15 00:00:00

abstract：:Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future etiologic investigations. We therefore conducted a comprehensive assessment of 114,548 lymphoid neoplasms diagnosed during 1992-2001 in 12 Surveillance, Epidemiology, ...

journal_title：Blood

authors： Morton LM,Wang SS,Devesa SS,Hartge P,Weisenburger DD,Linet MS

更新日期：2006-01-01 00:00:00

abstract：:Endotoxin-free purified recombinant human erythroid-potentiating activity (EPA) was administered to normal and bled mice. In anemic ICR mice EPA treatment led to a significant increase in the number of reticulocytes in the peripheral blood and erythroid precursors in the spleen. Stimulation of CFU-E and BFU-E in the s...

journal_title：Blood

authors： Niskanen E,Gasson JC,Teates CD,Golde DW

更新日期：1988-08-01 00:00:00

abstract：:Serum cobalamin (vitamin B12) and unsaturated B12 binding capacity (UBBC) have been measured in 24 cases of hypereosinophilia: 16 were cases of hypereosinophilic syndrome (HES) and 8 of secondary eosinophilia. The two groups were similar with respect to absolute eosinophil counts. Serum cobalamin and UBBC were found t...

journal_title：Blood

authors： Zittoun J,Farcet JP,Marquet J,Sultan C,Zittoun R

更新日期：1984-04-01 00:00:00