Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists.

abstract：:Members of the 14-3-3 family of proteins function as adapters/modulators that recognize phosphoserine/phosphothreonine-based binding motifs in many intracellular proteins and play fundamental roles in signal transduction pathways of eukaryotic cells. In platelets, 14-3-3 plays a wide range of regulatory roles in phosp...

journal_title：Blood

authors： Chen Y,Ruggeri ZM,Du X

更新日期：2018-05-31 00:00:00

abstract：:An electroimmunoassay was applied to the quantitation of platelet-associated IgG (PAIgG). Protein solubilized by Triton X100 from washed platelets was electrophoresed at pH 5.0 in agarose gels containing carbamoylated rabbit anti-human IgG (pI approximately equal to 5.0). Because the rabbit antibody is immobilized und...

journal_title：Blood

authors： Kunicki TJ,Koenig MB,Kristopeit SM,Aster RH

更新日期：1982-07-01 00:00:00

abstract：:Managing vitamin K antagonist (VKA) therapy is challenging in children because of a narrow therapeutic range and wide inter- and intra-individual variability in dose response. Only a few small studies have investigated the effect of nongenetic and genetic factors on the dose response to VKAs in children. In a cohort s...

journal_title：Blood

authors： Moreau C,Bajolle F,Siguret V,Lasne D,Golmard JL,Elie C,Beaune P,Cheurfi R,Bonnet D,Loriot MA

更新日期：2012-01-19 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by antibody-mediated platelet destruction. Different mechanisms have been suggested to explain accelerated platelet clearance and impaired thrombopoiesis, but the pathophysiology of ITP has yet to be fully delineated. In this study, we tested...

journal_title：Blood

authors： Morodomi Y,Kanaji S,Won E,Ruggeri ZM,Kanaji T

更新日期：2020-06-18 00:00:00

abstract：:The expression of a number of blood coagulation factors (F) (FX, FIX, FVIII, FVII, alpha-, beta-, gamma-fibrinogen chains, protein C, and antithrombin III [AT III]) was analyzed at RNA and protein level in 5- to 10-week-old human embryos and fetuses. FX, FIX, and FVII were also analyzed at protein level. Total and pol...

journal_title：Blood

authors： Hassan HJ,Leonardi A,Chelucci C,Mattia G,Macioce G,Guerriero R,Russo G,Mannucci PM,Peschle C

更新日期：1990-09-15 00:00:00

abstract：:We used the polymerase chain reaction (PCR) to detect ALL1-AF4 rearrangements, the molecular hallmark of t(4;11) in a series of 46 pre-pre-B (CD19+, CD24+, CD10/CD20/cylgM/sIgM-) acute lymphoblastic leukemias (ALL). Eighteen patients (39%) exhibited fusion transcripts including 4 of 12 children and 14 of 34 adults. Th...

journal_title：Blood

authors： Janssen JW,Ludwig WD,Borkhardt A,Spadinger U,Rieder H,Fonatsch C,Hossfeld DK,Harbott J,Schulz AS,Repp R

更新日期：1994-12-01 00:00:00

abstract：:Venous limb gangrene (VLG) can occur in cancer patients, but the clinical picture and pathogenesis remain uncertain. We identified 10 patients with metastatic cancer (7 pathologically proven) who developed severe venous limb ischemia (phlegmasia/VLG) after initiating treatment of deep-vein thrombosis (DVT); in 8 patie...

journal_title：Blood

authors： Warkentin TE,Cook RJ,Sarode R,Sloane DA,Crowther MA

更新日期：2015-07-23 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia in which venous thrombosis is the most common cause of death. Here we address the risk factors for thrombosis and the role of warfarin prophylaxis in PNH. The median follow-up of 163 PNH patients was 6 years (range, 0.2-38 years). Of the patient...

journal_title：Blood

authors： Hall C,Richards S,Hillmen P

更新日期：2003-11-15 00:00:00

abstract：:CCR5 is a receptor for several beta chemokines and the entry coreceptor used by macrophage-tropic (R5) strains of HIV-1. In addition to supporting viral entry, CCR5 ligation by the HIV-1 envelope glycoprotein 120 (gp120) can activate intracellular signals in macrophages and trigger inflammatory mediator release. Using...

journal_title：Blood

authors： Tomkowicz B,Lee C,Ravyn V,Cheung R,Ptasznik A,Collman RG

更新日期：2006-08-15 00:00:00

abstract：:The prevalence, the prognostic effect, and interaction with other molecular markers of DNMT3A mutations was studied in 415 patients with acute myeloid leukemia (AML) younger than 60 years. We show mutations in DNMT3A in 96 of 415 patients with newly diagnosed AML (23.1%). Univariate Cox regression analysis showed that...

journal_title：Blood

authors： Ribeiro AF,Pratcorona M,Erpelinck-Verschueren C,Rockova V,Sanders M,Abbas S,Figueroa ME,Zeilemaker A,Melnick A,Löwenberg B,Valk PJ,Delwel R

更新日期：2012-06-14 00:00:00

abstract：:Plasmodium vivax merozoites only invade reticulocytes, a minor though heterogeneous population of red blood cell precursors that can be graded by levels of transferrin receptor (CD71) expression. The development of a protocol that allows sorting reticulocytes into defined developmental stages and a robust ex vivo P vi...

journal_title：Blood

authors： Malleret B,Li A,Zhang R,Tan KS,Suwanarusk R,Claser C,Cho JS,Koh EG,Chu CS,Pukrittayakamee S,Ng ML,Ginhoux F,Ng LG,Lim CT,Nosten F,Snounou G,Rénia L,Russell B

更新日期：2015-02-19 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center (GC) formation and immunoglobulin deposition are required for multiorgan system cGVHD and associated bronchiolitis obliterans syndrome (BOS...

journal_title：Blood

authors： Flynn R,Du J,Veenstra RG,Reichenbach DK,Panoskaltsis-Mortari A,Taylor PA,Freeman GJ,Serody JS,Murphy WJ,Munn DH,Sarantopoulos S,Luznik L,Maillard I,Koreth J,Cutler C,Soiffer RJ,Antin JH,Ritz J,Dubovsky JA,Byrd JC,

更新日期：2014-06-19 00:00:00

abstract：:Immune deficiency viruses such as SIV in macaques or HIV-1 in human beings have evolved mechanisms to defeat host immunity that also impact the efficacy of vaccines. A key factor for vaccine protection is whether immune responses elicited by prior immunization remain at levels sufficient to limit disease progression o...

journal_title：Blood

authors： Poonia B,Salvato MS,Yagita H,Maeda T,Okumura K,Pauza CD

更新日期：2009-08-06 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is considered the gold standard in the frontline therapy of younger patients with multiple myeloma because it results in higher complete remission (CR) rates and longer event-free survival than conventional chemotherapy. The greatest benefit from ASCT is obtained in patients...

journal_title：Blood

authors： Bladé J,Rosiñol L,Cibeira MT,Rovira M,Carreras E

更新日期：2010-05-06 00:00:00

abstract：:In this study, we analyzed tyrosine phosphorylation of guanosine triphosphatase (GTPase) activating protein in human B cells stimulated through surface IgG, using Western blot and immunoprecipitation. Stimulation through surface IgG induced the tyrosine phosphorylation of GTPase-activating protein (GAP) and two associ...

journal_title：Blood

authors： Yagura H,Oyaizu N,Pahwa S

更新日期：1993-03-15 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a malignant disease of the hematopoietic stem cell characterized by abnormal circulation and proliferation of malignant progenitors. In contrast to their normal counterparts, CML progenitors adhere poorly to bone marrow stroma or fibronectin (FN). Aside from anchoring progenitors ...

journal_title：Blood

authors： Lundell BI,McCarthy JB,Kovach NL,Verfaillie CM

更新日期：1996-03-15 00:00:00

abstract：:Many current experimental results show the necessity of new conceptual approaches to understand hematopoietic stem cell organization. Recently, we proposed a novel theoretical concept and a corresponding quantitative model based on microenvironment-dependent stem cell plasticity. The objective of our present work is t...

journal_title：Blood

authors： Roeder I,Kamminga LM,Braesel K,Dontje B,de Haan G,Loeffler M

更新日期：2005-01-15 00:00:00

abstract：:Regulated migration of hematopoietic stem cells is fundamental for hematopoiesis. The molecular mechanisms underlying stem cell trafficking are poorly defined. Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX...

journal_title：Blood

authors： Thieme S,Gyárfás T,Richter C,Özhan G,Fu J,Alexopoulou D,Muders MH,Michalk I,Jakob C,Dahl A,Klink B,Bandola J,Bachmann M,Schröck E,Buchholz F,Stewart AF,Weidinger G,Anastassiadis K,Brenner S

更新日期：2013-03-28 00:00:00

abstract：:Escape from immune detection favors both tumor survival and progression, and new approaches to circumvent this are essential to combat cancers. Nonvirulent, tumor-tropic bacteria, such as Salmonella typhimurium, can unmask a tumor by transforming it into a site of inflammation; however, the nonspecific invasiveness of...

journal_title：Blood

authors： Massa PE,Paniccia A,Monegal A,de Marco A,Rescigno M

更新日期：2013-08-01 00:00:00

abstract：:In the 2005-01 trial, we have demonstrated that bortezomib-dexamethasone as induction therapy before autologous stem cell transplantation was superior to vincristine-adriamycin-dexamethasone. We conducted a post-hoc analysis to assess the prognostic impact of initial characteristics as well as response to therapy in p...

journal_title：Blood

authors： Moreau P,Attal M,Pégourié B,Planche L,Hulin C,Facon T,Stoppa AM,Fuzibet JG,Grosbois B,Doyen C,Ketterer N,Sebban C,Kolb B,Chaleteix C,Dib M,Voillat L,Fontan J,Garderet L,Jaubert J,Mathiot C,Esseltine D,Avet-Loise

更新日期：2011-03-17 00:00:00

abstract：:Circulating endothelial progenitor cells (EPCs) are thought to contribute to angiogenesis following vascular injury, stimulating interest in their ability to mediate therapeutic angiogenesis. However, the number of EPCs in the blood is low, limiting endogenous repair, and a method to rapidly mobilize EPCs has not been...

journal_title：Blood

authors： Shepherd RM,Capoccia BJ,Devine SM,Dipersio J,Trinkaus KM,Ingram D,Link DC

更新日期：2006-12-01 00:00:00

abstract：:Thrombopoietin (TPO) is a recently cloned cytokine that binds to its receptor, Mpl, and promotes hematopoietic expansion and maturation, primarily of the megakaryocyte lineage. The signaling pathways responsible for these events are thought to involve the Janus family of nonreceptor tyrosine kinases (JAKs) and the sig...

journal_title：Blood

authors： Drachman JG,Sabath DF,Fox NE,Kaushansky K

更新日期：1997-01-15 00:00:00

abstract：:The NADPH:O2 oxidoreductase catalyzing the respiratory burst in activated phagocytes from healthy individuals is not operative in phagocytes from patients with chronic granulomatous disease (CGD). In a microscopic slide test using the dye nitroblue tetrazolium (NBT), carriers of X-linked CGD can be recognized by a mos...

journal_title：Blood

authors： Verhoeven AJ,van Schaik ML,Roos D,Weening RS

更新日期：1988-02-01 00:00:00

abstract：:Heme is an essential cofactor for numerous cellular functions, but release of free heme during hemolysis results in oxidative tissue damage, vascular dysfunction, and inflammation. Macrophages play a key protective role in heme clearance; however, the mechanisms that regulate metabolic adaptations that are required fo...

journal_title：Blood

authors： Bories GFP,Yeudall S,Serbulea V,Fox TE,Isakson BE,Leitinger N

更新日期：2020-09-24 00:00:00

abstract：:Twenty-two molecular diagnostic laboratories from 14 countries participated in a consortium study to estimate the impact of Factor VIII gene inversions in severe hemophilia A. A total of 2,093 patients with severe hemophilia A were studied; of those, 740 (35%) had a type 1 (distal) factor VIII inversion, and 140 (7%) ...

journal_title：Blood

authors： Antonarakis SE,Rossiter JP,Young M,Horst J,de Moerloose P,Sommer SS,Ketterling RP,Kazazian HH Jr,Négrier C,Vinciguerra C,Gitschier J,Goossens M,Girodon E,Ghanem N,Plassa F,Lavergne JM,Vidaud M,Costa JM,Laurian Y,Lin

更新日期：1995-09-15 00:00:00

abstract：:Intravenous immunoglobulin (IVIgG) causes an acute rise in the platelet count in the majority of patients with chronic immune thrombocytopenic purpura (ITP) but the mechanism(s) of action is still unknown. We evaluated the ability of three different IVIgG preparations to inhibit the in vitro binding of autoantibody to...

journal_title：Blood

authors： Berchtold P,Dale GL,Tani P,McMillan R

更新日期：1989-11-15 00:00:00

abstract：:The prognostic implications of t(9;22)(q34;q11) were assessed at a median follow-up of 3.5 years in 434 children receiving intensive treatment for acute lymphoblastic leukemia (ALL). Four-year event-free and overall survivals were 81% and 88%, respectively, in 419 children lacking t(9;22), but were 0% and 20%, respect...

journal_title：Blood

authors： Fletcher JA,Lynch EA,Kimball VM,Donnelly M,Tantravahi R,Sallan SE

更新日期：1991-02-01 00:00:00

abstract：:An increasing number of reports document instances in which individual leukemic cells coexpress markers normally believed to be restricted to a single lineage. This has been interpreted by McCulloch and colleagues as aberrant programming or lineage infidelity and contrasts with earlier suggestions that lineage fidelit...

journal_title：Blood

authors： Greaves MF,Chan LC,Furley AJ,Watt SM,Molgaard HV

更新日期：1986-01-01 00:00:00

abstract：:The promising activity of BET protein inhibitors (BETi's) is compromised by adaptive or innate resistance in acute myeloid leukemia (AML). Here, modeling of BETi-persister/resistance (BETi-P/R) in human postmyeloproliferative neoplasm (post-MPN) secondary AML (sAML) cells demonstrated accessible and active chromatin i...

journal_title：Blood

authors： Saenz DT,Fiskus W,Mill CP,Perera D,Manshouri T,Lara BH,Karkhanis V,Sharma S,Horrigan SK,Bose P,Kadia TM,Masarova L,DiNardo CD,Borthakur G,Khoury JD,Takahashi K,Bhaskara S,Lin CY,Green MR,Coarfa C,Crews CM,Versto

更新日期：2020-04-09 00:00:00

abstract：:Monocytes are thought to play a role in host resistance to tumor cell growth in animals and humans. In addition, platelets are known to be involved in tumor metastases. To investigate the interaction of these two cell types and their effect on tumor cells, human monocytes and platelets were examined using an in vitro ...

journal_title：Blood

authors： Ibele GM,Kay NE,Johnson GJ,Jacob HS

更新日期：1985-05-01 00:00:00