Plasmodium vivax: restricted tropism and rapid remodeling of CD71-positive reticulocytes.

abstract：:The effect of FLT3/FLK2 ligand (FL) on the growth of primitive hematopoietic cells was investigated using ThyloSca1+ stem cells. FL was observed to interact with a variety of factors to initiate colony formation by stem cells. When stem cells were stimulated in liquid culture with FL plus interleukin (IL)-3, IL-6, gra...

journal_title：Blood

authors： Hudak S,Hunte B,Culpepper J,Menon S,Hannum C,Thompson-Snipes L,Rennick D

更新日期：1995-05-15 00:00:00

abstract：:Secondary chromosomal aberrations were surveyed in non-Hodgkin's lymphomas (NHL) reported in the literature with one of the following, presently recognized, primary abnormalities: t(2;5), +3, t(3;14), del(6q), +X, and -Y. Of 2,175 NHLs with clonal karyotypic changes, 908 (42%) had one of the 13 selected primary chromo...

journal_title：Blood

authors： Johansson B,Mertens F,Mitelman F

更新日期：1995-11-15 00:00:00

abstract：:We report here 7 new mutations in the ADAMTS13 gene responsible for Upshaw-Schulman syndrome (USS), a catastrophic phenotype of congenital thrombotic thrombocytopenic purpura, by analyzing 5 Japanese families. There were 3 mutations that occurred at exon-intron boundaries: 414+1G>A at intron 4, 686+1G>A at intron 6, a...

journal_title：Blood

authors： Matsumoto M,Kokame K,Soejima K,Miura M,Hayashi S,Fujii Y,Iwai A,Ito E,Tsuji Y,Takeda-Shitaka M,Iwadate M,Umeyama H,Yagi H,Ishizashi H,Banno F,Nakagaki T,Miyata T,Fujimura Y

更新日期：2004-02-15 00:00:00

abstract：:Relapse following remission induction chemotherapy remains a barrier to survival in approximately 20% of children suffering from acute lymphoblastic leukemia (ALL). To investigate the mechanism of relapse, 27 matched diagnosis and relapse ALL samples were analyzed for clonal populations using polymerase chain reaction...

journal_title：Blood

authors： Choi S,Henderson MJ,Kwan E,Beesley AH,Sutton R,Bahar AY,Giles J,Venn NC,Pozza LD,Baker DL,Marshall GM,Kees UR,Haber M,Norris MD

更新日期：2007-07-15 00:00:00

abstract：:Artemisinin resistance threatens worldwide malaria control and elimination. Elevation of phosphatidylinositol-3-phosphate (PI3P) can induce resistance in blood stages of Plasmodium falciparum The parasite unfolded protein response (UPR) has also been implicated as a proteostatic mechanism that may diminish artemisinin...

journal_title：Blood

authors： Bhattacharjee S,Coppens I,Mbengue A,Suresh N,Ghorbal M,Slouka Z,Safeukui I,Tang HY,Speicher DW,Stahelin RV,Mohandas N,Haldar K

更新日期：2018-03-15 00:00:00

abstract：:The interaction of thrombin with plasminogen activator inhibitor 1 (PAI-1) is shown to result in the simultaneous formation of both cleaved PAI-1 and a sodium dodecyl sulfate-stable thrombin-PAI-1 complex. The kinetics of this reaction can be described by a "suicide substrate" mechanism that includes a branched reacti...

journal_title：Blood

authors： van Meijer M,Smilde A,Tans G,Nesheim ME,Pannekoek H,Horrevoets AJ

更新日期：1997-09-01 00:00:00

abstract：:Factor V (FV) deficiency is a rare bleeding disorder whose genetic basis has been described in a relatively small number of cases. Among a total of 12 genetic defects reported in severely or moderately severe deficient patients, 3 were missense mutations and in no case was the mechanism underlying the deficiency explo...

journal_title：Blood

authors： Duga S,Montefusco MC,Asselta R,Malcovati M,Peyvandi F,Santagostino E,Mannucci PM,Tenchini ML

更新日期：2003-01-01 00:00:00

abstract：:As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. In the present study, we report that NSC606985, a rarely studied camptothecin analog, induces apoptosis in acute myeloid leukemia (AML) cells NB4 and U937 and inhib...

journal_title：Blood

authors： Song MG,Gao SM,Du KM,Xu M,Yu Y,Zhou YH,Wang Q,Chen Z,Zhu YS,Chen GQ

更新日期：2005-05-01 00:00:00

abstract：:Human subjects maintain long-term immunologic memory against infective organisms but the mechanism is unclear. CD4+ T-helper memory (Thmem) cells are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of protective immunity. To prob...

journal_title：Blood

authors： Di Genova G,Roddick J,McNicholl F,Stevenson FK

更新日期：2006-04-01 00:00:00

abstract：:The calcium ionophore A23187 promotes histamine synthesis in murine bone marrow cells by increasing the expression of mRNA encoding histidine decarboxylase (HDC), the histamine-forming enzyme. The cells responsible for this biological activity copurify with hematopoietic progenitors in terms of density, light scatter ...

journal_title：Blood

authors： Dy M,Arnould A,Lemoine FM,Machavoine F,Ziltener H,Schneider E

更新日期：1996-04-15 00:00:00

abstract：:Fas (CD95/Apo-1) mutations were previously reported as the genetic defect responsible for human lymphoproliferative syndrome associated with autoimmune manifestations (also known as autoimmune lymphoproliferative syndrome or Canale-Smith syndrome). We have identified 14 new heterozygous Fas mutations. Analysis of pati...

journal_title：Blood

authors： Rieux-Laucat F,Blachère S,Danielan S,De Villartay JP,Oleastro M,Solary E,Bader-Meunier B,Arkwright P,Pondaré C,Bernaudin F,Chapel H,Nielsen S,Berrah M,Fischer A,Le Deist F

更新日期：1999-10-15 00:00:00

abstract：:Hematopoietic stem cells differentiate in the thymus to T cells along precisely defined intermediates. This process is thymic epithelium dependent and involves cytokines and cell-cell interactions between thymic stroma and T-cell precursors. Here we report that highly purified human CD34++ fetal liver stem cells diffe...

journal_title：Blood

authors： Plum J,De Smedt M,Defresne MP,Leclercq G,Vandekerckhove B

更新日期：1994-09-01 00:00:00

abstract：:Incubation of human platelets, human neutrophils, or highly metastatic mouse lymphoma cells with sulfate-labeled extracellular matrix (ECM) results in heparanase-mediated release of labeled heparan sulfate cleavage fragments (0.5 less than Kav less than 0.85 on Sepharose 6B). This degradation was inhibited by native h...

journal_title：Blood

authors： Bar-Ner M,Eldor A,Wasserman L,Matzner Y,Cohen IR,Fuks Z,Vlodavsky I

更新日期：1987-08-01 00:00:00

abstract：:The EVI1 gene encodes a zinc-finger, DNA-binding protein originally described as the transforming gene associated with a common ecotropic viral insertion site in myeloid leukemias. Previous studies demonstrated EVI1 expression in human leukemias in cases with 3q26 translocations, but not in normal blood or bone marrow...

journal_title：Blood

authors： Russell M,List A,Greenberg P,Woodward S,Glinsmann B,Parganas E,Ihle J,Taetle R

更新日期：1994-08-15 00:00:00

abstract：:The primary objective was to describe the prevalence and characteristics of microbiologically defined infections and infection-related mortality (IRM) in 492 children with acute myeloid leukemia enrolled on CCG 2961. Secondary objectives were to determine the relationship between demographic, disease-related, and ther...

journal_title：Blood

authors： Sung L,Lange BJ,Gerbing RB,Alonzo TA,Feusner J

更新日期：2007-11-15 00:00:00

abstract：:A major limitation to the widespread use of hematopoietic stem cells (HSC) is the relatively crude level of our knowledge of how to maintain these cells in vitro without loss of the long-term multilineage growth and differentiation properties required for their clinical utility. An experimental and theoretical framewo...

journal_title：Blood

authors： Zandstra PW,Lauffenburger DA,Eaves CJ

更新日期：2000-08-15 00:00:00

abstract：:Surface marker and gene rearrangement data have supported various hypotheses about the origin of the malignant cell in Hodgkin's disease. Cytogenetic data about this disorder, however, are very scanty. To determine if any chromosomal abnormalities that could add further information to this controversial point are pres...

journal_title：Blood

authors： Cabanillas F,Pathak S,Trujillo J,Grant G,Cork A,Hagemeister FB,Velasquez WS,McLaughlin P,Redman J,Katz R

更新日期：1988-06-01 00:00:00

abstract：:Rituximab, a monoclonal antibody that targets CD20 on B cells, is now central to the treatment of a variety of malignant and autoimmune disorders. Despite this success, a substantial proportion of B-cell lymphomas are unresponsive or develop resistance, hence more potent anti-CD20 monoclonal antibodies (mAbs) are cont...

journal_title：Blood

authors： Beers SA,French RR,Chan HT,Lim SH,Jarrett TC,Vidal RM,Wijayaweera SS,Dixon SV,Kim H,Cox KL,Kerr JP,Johnston DA,Johnson PW,Verbeek JS,Glennie MJ,Cragg MS

更新日期：2010-06-24 00:00:00

abstract：:A 14-year-old boy with hemoglobin SC disease and alpha-thalassemia-2 experienced five episodes of acute splenic sequestration crisis (ASSC), while two of his siblings with identical globin genotypes (SC and -alpha/alpha alpha) had no such experience. To determine if an additional red blood cell (RBC) defect was respon...

journal_title：Blood

authors： Warkentin TE,Barr RD,Ali MA,Mohandas N

更新日期：1990-01-01 00:00:00

abstract：:A novel deletion in the human beta-globin gene cluster associated with increased levels of fetal hemoglobin (HbF) in adult life was molecularly characterized in a member of a family of Eastern European descent. The phenotype of the deletion, documented in five members of the family, shows mild hypochromia and microcyt...

journal_title：Blood

authors： Palena A,Blau A,Stamatoyannopoulos G,Anagnou NP

更新日期：1994-06-15 00:00:00

abstract：:Previous results, presented in abstract form, indicate that replacement of thromboplastin with a mixture of phospholipid and truncated soluble tissue factor apoprotein results in a coagulation assay that can directly measure plasma factor VIIa levels without interference from zymogen factor VII (Atherosclerosis Thromb...

journal_title：Blood

authors： Wildgoose P,Nemerson Y,Hansen LL,Nielsen FE,Glazer S,Hedner U

更新日期：1992-07-01 00:00:00

abstract：:The formation and functioning of the factor X activating complex on the surface of cultured human venous endothelial cells (HVEC) were investigated. To the HVEC monolayer human factors IXa, VIII, X, CaCl2, and S-2222 were added, and a gradually increasing activation of factor X was observed. The maximum activity of 88...

journal_title：Blood

authors： Váradi K,Elödi S

更新日期：1987-02-01 00:00:00

abstract：:Cytokine gene-modified tumor cells have increased immunogenicity and retain the antigenic repertoire of a particular neoplasia. However, practical concerns have led to an increased interest in allogeneic gene-transduced bystander cells as a broader source of cytokines for autologous tumor cell-based vaccines. Here, we...

journal_title：Blood

authors： Curti A,Parenza M,Colombo MP

更新日期：2003-01-15 00:00:00

abstract：:Dosing of enzyme replacement therapy (ERT) for Gaucher disease type 1 is still a subject of debate and varies from 15 to 130 U/kg/mo, making a huge economic difference of 70,000 US dollars to 380,000 US dollars(euro55,000-300,000) per patient per year. To investigate whether this difference in dosing ultimately transl...

journal_title：Blood

authors： de Fost M,Hollak CE,Groener JE,Aerts JM,Maas M,Poll LW,Wiersma MG,Häussinger D,Brett S,Brill N,vom Dahl S

更新日期：2006-08-01 00:00:00

abstract：:The expression of early and mature B cell markers, surface beta 2-microglobulin (B2M) and cytoplasmic immunoglobulin (clg) by aneuploid tumor cells in bone marrow aspirates from 44 patients with multiple myeloma was evaluated by correlated DNA immunofluorescence flow cytometry. Myeloma tumor cells of almost 90% of the...

journal_title：Blood

authors： Epstein J,Barlogie B,Katzmann J,Alexanian R

更新日期：1988-04-01 00:00:00

abstract：:The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration, and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, labor...

journal_title：Blood

authors： Hargrave DR,Wade A,Evans JP,Hewes DK,Kirkham FJ

更新日期：2003-02-01 00:00:00

abstract：:The number of CD34+ cells in the peripheral blood of cancer patients is known to be increased following the administration of high dose chemotherapy and hematopoietic growth factors. These so-called peripheral blood stem cell grafts are now frequently used for autologous transplantation of patients with malignancies. ...

journal_title：Blood

authors： Murray L,Chen B,Galy A,Chen S,Tushinski R,Uchida N,Negrin R,Tricot G,Jagannath S,Vesole D

更新日期：1995-01-15 00:00:00

abstract：:The process of dendritic cell (DC) maturation, critical for effective DC-based immunotherapy, also alters the proteasome such that peptides presented in the context of HLA class I are generated not by the constitutive proteasome, but by the immunoproteasome. Cytotoxic T lymphocytes (CTLs) induced by such DCs might not...

journal_title：Blood

authors： Dannull J,Lesher DT,Holzknecht R,Qi W,Hanna G,Seigler H,Tyler DS,Pruitt SK

更新日期：2007-12-15 00:00:00

abstract：:Crystallographic and electron microscopy studies revealed genuflexed (bent) integrins in both unliganded (inactive) and physiologic ligandbound (active) states, suggesting that local conformational changes are sufficient for activation. Herein we have explored the role of local changes in the contact region between th...

journal_title：Blood

authors： Gupta V,Gylling A,Alonso JL,Sugimori T,Ianakiev P,Xiong JP,Arnaout MA

更新日期：2007-04-15 00:00:00

abstract：:The more distal enhancers of the immunoglobulin heavy-chain 3' regulatory region, hs3b and hs4, were recently demonstrated as master control elements of germline transcription and class switch recombination to most immunoglobulin constant genes. In addition, they were shown to enhance the accumulation of somatic mutat...

journal_title：Blood

authors： Morvan CL,Pinaud E,Decourt C,Cuvillier A,Cogné M

更新日期：2003-08-15 00:00:00