Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations.

abstract：:Chronic infection with Schistosoma mansoni induces in humans and mice a Th2-dominant immune response in which eosinophils and IgE are conspicuously elevated. Human eosinophils express IgE receptors that participate in an IgE-dependent eosinophil-mediated ADCC reaction against Schistosomula larvae in vitro. To investig...

journal_title：Blood

authors： de Andres B,Rakasz E,Hagen M,McCormik ML,Mueller AL,Elliot D,Metwali A,Sandor M,Britigan BE,Weinstock JV,Lynch RG

更新日期：1997-05-15 00:00:00

abstract：:We investigated whether atorvastatin (AT) was capable of protecting animals from acute graft-versus-host disease (aGVHD) across major histocompatibility complex (MHC) mismatch barriers. AT treatment of the donor induced a Th-2 cytokine profile in the adoptively transferred T cells and reduced their in vivo expansion, ...

journal_title：Blood

authors： Zeiser R,Youssef S,Baker J,Kambham N,Steinman L,Negrin RS

更新日期：2007-12-15 00:00:00

abstract：:Impaired immune reconstitution has moved to the forefront of clinical problems limiting progress in allogeneic bone marrow transplantation (BMT). The identification of therapies that can enhance immune reconstitution by increasing thymopoiesis is critical to solving this problem. Interleukin 7 (IL-7) is the most poten...

journal_title：Blood

authors： Sinha ML,Fry TJ,Fowler DH,Miller G,Mackall CL

更新日期：2002-10-01 00:00:00

abstract：:Redox biology is fundamental to both normal cellular homeostasis and pathological states associated with excessive oxidative stress. Reactive oxygen species function not only as signaling molecules but also as redox regulators of protein function. In the vascular system, redox reactions help regulate key physiologic r...

journal_title：Blood

authors： Gu SX,Stevens JW,Lentz SR

更新日期：2015-06-18 00:00:00

abstract：:The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In T- and pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor. We found the KLF4 promoter methylated in B-cell lymphoma cell lines and in primary cases of B-cell lymphomas, namely, follicular lymph...

journal_title：Blood

authors： Guan H,Xie L,Leithäuser F,Flossbach L,Möller P,Wirth T,Ushmorov A

更新日期：2010-09-02 00:00:00

abstract：:Intravenous immunoglobulin (IVIgG) causes an acute rise in the platelet count in the majority of patients with chronic immune thrombocytopenic purpura (ITP) but the mechanism(s) of action is still unknown. We evaluated the ability of three different IVIgG preparations to inhibit the in vitro binding of autoantibody to...

journal_title：Blood

authors： Berchtold P,Dale GL,Tani P,McMillan R

更新日期：1989-11-15 00:00:00

abstract：:Cells derived from human cord blood were recently used instead of bone marrow (BM) for transplantation. However, several questions concerning the potential of these cells to reconstitute the hematopoietic and immunologic system of the recipient and to induce a graft-versus-host disease (GVHD) remain unanswered. Here w...

journal_title：Blood

authors： de La Selle V,Gluckman E,Bruley-Rosset M

更新日期：1996-05-01 00:00:00

abstract：:Airway dendritic cells (DCs) are held responsible for inducing sensitization to inhaled antigen, leading to eosinophilic airway inflammation, typical of asthma. However, less information is available about the role of these cells in ongoing inflammation. In a mouse model of asthma, sensitization to ovalbumin (OVA) was...

journal_title：Blood

authors： van Rijt LS,Prins JB,Leenen PJ,Thielemans K,de Vries VC,Hoogsteden HC,Lambrecht BN

更新日期：2002-11-15 00:00:00

abstract：:Heme is an essential cofactor for numerous cellular functions, but release of free heme during hemolysis results in oxidative tissue damage, vascular dysfunction, and inflammation. Macrophages play a key protective role in heme clearance; however, the mechanisms that regulate metabolic adaptations that are required fo...

journal_title：Blood

authors： Bories GFP,Yeudall S,Serbulea V,Fox TE,Isakson BE,Leitinger N

更新日期：2020-09-24 00:00:00

abstract：:In a patient with nonspherocytic hemolytic anemia, a hexokinase deficiency was detected in the red cells (residual activity about 25% of normal) and in blood platelets (20%-35% of normal activity). Although the total hexokinase activity in lymphocytes was normal, the amount of hexokinase type I was decreased to about ...

journal_title：Blood

authors： Rijksen G,Akkerman JW,van den Wall Bake AW,Hofstede DP,Staal GE

更新日期：1983-01-01 00:00:00

abstract：:The evolutionarily conserved immune system of the zebrafish (Danio rerio), in combination with its genetic tractability, position it as an excellent model system in which to elucidate the origin and function of vertebrate immune cells. We recently reported the existence of antigen-presenting mononuclear phagocytes in ...

journal_title：Blood

authors： Wittamer V,Bertrand JY,Gutschow PW,Traver D

更新日期：2011-06-30 00:00:00

abstract：:We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia (AML) in the context of the current World Health Organization (WHO) classification and to evaluate the outcome of MK(+) patients after allogeneic HSCT. Of 1058 patients with abnormal cytogenetics, 319 (30%) were MK MK(+)....

journal_title：Blood

authors： Kayser S,Zucknick M,Döhner K,Krauter J,Köhne CH,Horst HA,Held G,von Lilienfeld-Toal M,Wilhelm S,Rummel M,Germing U,Götze K,Nachbaur D,Schlegelberger B,Göhring G,Späth D,Morlok C,Teleanu V,Ganser A,Döhner H,Schlenk

更新日期：2012-01-12 00:00:00

abstract：:Although the chromosomal localization (9q34) of the gene encoding the human form of ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13) and its exclusive expression in the liver have been established, the cells that produce this enzyme are yet to be determined. We investigated the ...

journal_title：Blood

authors： Uemura M,Tatsumi K,Matsumoto M,Fujimoto M,Matsuyama T,Ishikawa M,Iwamoto TA,Mori T,Wanaka A,Fukui H,Fujimura Y

更新日期：2005-08-01 00:00:00

abstract：:Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for much of the biologic activity of HO-1, including anti-inflammatory, antiapo-ptotic, antiproliferative, and antioxidant effects. We have identified an additional cytoprote...

journal_title：Blood

authors： Kinderlerer AR,Pombo Gregoire I,Hamdulay SS,Ali F,Steinberg R,Silva G,Ali N,Wang B,Haskard DO,Soares MP,Mason JC

更新日期：2009-02-12 00:00:00

abstract：:CD99 is a crucial regulator of the transmigration (diapedesis) of leukocytes through the blood vessel wall. Here, we report that CD99 acts at 2 different steps in the extravasation process. In agreement with previous antibody-blocking experiments, we found that CD99 gene inactivation caused neutrophil accumulation bet...

journal_title：Blood

authors： Goswami D,März S,Li YT,Artz A,Schäfer K,Seelige R,Pacheco-Blanco M,Jing D,Bixel MG,Araki M,Araki K,Yamamura KI,Vestweber D

更新日期：2017-03-30 00:00:00

abstract：:To investigate the tropism of the T-lymphotropic human herpesvirus 7 (HHV-7) for hematopoietic progenitors, cord blood CD34(+) cells were inoculated in vitro with HHV-7 and then induced to differentiate along the granulocytic and erythroid lineages by the addition of appropriate cytokine cocktails. In semisolid assays...

journal_title：Blood

authors： Mirandola P,Secchiero P,Pierpaoli S,Visani G,Zamai L,Vitale M,Capitani S,Zauli G

更新日期：2000-07-01 00:00:00

abstract：:During the early period following bone marrow transplantation before the immune system has reached full functional maturity, unprimed, nonspecific lytic systems may play a critical role as antiviral or antitumor effectors. The reconstitution of cells with this potential is of particular importance in recipients of bon...

journal_title：Blood

authors： Keever CA,Welte K,Small T,Levick J,Sullivan M,Hauch M,Evans RL,O'Reilly RJ

更新日期：1987-12-01 00:00:00

abstract：:Adoptive T-cell therapy using CD3/CD28 co-stimulation likely requires in vivo generation of antigen specificity. Because CD28 promotes TH1/TC1 (T1) or TH2/TC2 (T2) differentiation, costimulation may generate donor T1 or T2 cells capable of differentially mediating allogeneic graft-versus-tumor (GVT) effects and graft-...

journal_title：Blood

authors： Jung U,Foley JE,Erdmann AA,Eckhaus MA,Fowler DH

更新日期：2003-11-01 00:00:00

abstract：:In attempting to identify antigens that are differentially expressed on tumor cells following transformation from follicular small cleaved cell lymphoma (FSC) to immunoblastic lymphoma (IL), we identified a unique epitope of the transferrin receptor (TfR). The epitope is available for binding in aggressive lymphomas b...

journal_title：Blood

authors： Esserman L,Takahashi S,Rojas V,Warnke R,Levy R

更新日期：1989-12-01 00:00:00

abstract：:In the present study, we investigated disease characteristics and clinical outcome in young patients (< 40 years) with World Health Organization (WHO)-defined essential thrombocythemia (ET) compared with early/prefibrotic primary myelofibrosis (PMF) with presenting thrombocythemia. We recruited 213 young patients (med...

journal_title：Blood

authors： Barbui T,Thiele J,Carobbio A,Passamonti F,Rumi E,Randi ML,Bertozzi I,Vannucchi AM,Gisslinger H,Gisslinger B,Finazzi G,Ruggeri M,Rodeghiero F,Rambaldi A,Gangat N,Tefferi A

更新日期：2012-07-19 00:00:00

abstract：:Eosinophil accumulation has been associated with the pathogenesis of numerous allergic inflammatory disorders. Despite the great interest in this response, many aspects of eosinophil accumulation remain unknown. This is particularly true with respect to tissue-specific mechanisms that may regulate the accumulation of ...

journal_title：Blood

authors： Larbi KY,Allen AR,Tam FW,Haskard DO,Lobb RR,Silva PM,Nourshargh S

更新日期：2000-11-15 00:00:00

abstract：:Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by thrombotic microangiopathy leading to end-organ damage. The standard of care (SOC) treatment is therapeutic plasma exchange (TPE) alongside immunomodulation with steroids, with increasing use of rituximab +/- other immuno...

journal_title：Blood

authors： Goshua G,Sinha P,Hendrickson JE,Tormey CA,Bendapudi P,Lee AI

更新日期：2020-12-06 00:00:00

abstract：:von Willebrand's antigen II (vW AgII), a plasma and platelet antigen immunologically and biochemically distinct from factor-VIII-related antigen (VIIIR:Ag), is decreased in von Willebrand's disease. vW AgII is released from platelets during aggregation and clotting. The release of platelet vW AgII was studied in washe...

journal_title：Blood

authors： Scott JP,Montgomery RR

更新日期：1981-12-01 00:00:00

abstract：:We have examined the effect of graft-versus-host disease (GVHD) on the reconstitution of donor hematopoiesis in a murine bone marrow transplant (BMT) model of GVHD to minor histocompatibility antigens. GVHD had no effect on peripheral blood counts, which normalized by 1 month after BMT, and did not affect numbers of h...

journal_title：Blood

authors： van Dijken PJ,Wimperis J,Crawford JM,Ferrara JL

更新日期：1991-11-15 00:00:00

abstract：:The translocation t(15;17)(q22;q21) is seen exclusively in patients with acute promyelocytic leukemia (APL) and in the promyelocytic blast crisis of chronic myeloid leukemia (CML). This translocation juxta-poses the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor-alpha (RARA) gene on ...

journal_title：Blood

authors： Hiorns LR,Min T,Swansbury GJ,Zelent A,Dyer MJ,Catovsky D

更新日期：1994-05-15 00:00:00

abstract：:In the past 5 years we have witnessed significant advances in both the diagnostic process and optimal therapy for patients with essential thrombocythemia (ET). Insights into the underlying molecular mechanisms have been accompanied by the development of new diagnostic tests and by an improved understanding of the rela...

journal_title：Blood

authors： Beer PA,Erber WN,Campbell PJ,Green AR

更新日期：2011-02-03 00:00:00

abstract：:Acute promyelocytic leukemias (APLs) are characterized by a translocation that involves chromosomes 15 and 17. The translocation breakpoints have recently been identified and shown to involve the RAR-alpha gene on 17 and myl on 15. Here we report Southern blotting analysis of 26 APLs, including cases with normal karyo...

journal_title：Blood

authors： Biondi A,Rambaldi A,Alcalay M,Pandolfi PP,Lo Coco F,Diverio D,Rossi V,Mencarelli A,Longo L,Zangrilli D

更新日期：1991-04-01 00:00:00

abstract：:The variability of laboratory findings in von Willebrand's disease (vWd) was evaluated by performing serial studies of bleeding time (BT), factor VIII coagulant activity (VIII:C), factor-VIII-related antigen (VIIIR:Ag) and ristocetin cofactor (VIIIR:Rcof) in 50 individuals from 25 families with this disorder. The type...

journal_title：Blood

authors： Abildgaard CF,Suzuki Z,Harrison J,Jefcoat K,Zimmerman TS

更新日期：1980-10-01 00:00:00

abstract：:Myeloid leukemias in AKXD23 mice contain proviral insertions at Evi1, resulting in transcriptional activation. Although Evi1 is clearly involved in leukemia, gene transfer studies in mice with Evi1 fail to cause leukemia, arguing that cooperating events are necessary. We reanalyzed AKXD-23 tumors for cooperating provi...

journal_title：Blood

authors： Boyd KE,Xiao YY,Fan K,Poholek A,Copeland NG,Jenkins NA,Perkins AS

更新日期：2006-01-15 00:00:00

abstract：:Plasmin cleaves fibrin at or near sites involved in platelet recognition and may modulate platelet adhesion and spreading. Using an in vitro system, we have characterized the effects of limited plasmic degradation of polymerized fibrin on platelet adhesion and spreading. As shown by scanning electron microscopy, expos...

journal_title：Blood

authors： Hamaguchi M,Bunce LA,Sporn LA,Francis CW

更新日期：1994-08-15 00:00:00