Abstract:
:Adoptive T-cell therapy in cancer or chronic viral infections is often impeded by the development of functional impairment of the transferred cells. To overcome this therapeutic limitation we combined adoptive transfer of naive, virus-specific CD8+ T cells with immunostimulative CpG oligodeoxynucleotides (ODNs) in mice chronically infected with the Friend retrovirus. The CpG-ODN co-injection prevented the T cells from developing functional defects in IFNgamma and granzyme production and degranulation of cytotoxic molecules. Thus, the transferred T cells were able to reduce chronic viral loads when combined with CpG-ODNs. This strategy provides a new approach for developing successful adoptive T-cell therapy against chronic infections.
journal_name
Bloodjournal_title
Bloodauthors
Kraft AR,Krux F,Schimmer S,Ohlen C,Greenberg PD,Dittmer Udoi
10.1182/blood-2006-06-022178subject
Has Abstractpub_date
2007-04-01 00:00:00pages
2982-4issue
7eissn
0006-4971issn
1528-0020pii
blood-2006-06-022178journal_volume
109pub_type
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