Abstract:
:Hematopoietic stem cell (HSC) transplantation is a lifesaving therapy for malignant and nonmalignant hematologic diseases and metabolic disorders. Although successful, hematopoietic transplantation can be hindered by inadequate stem cell number or poor engrafting efficiency. To overcome these deficits, we and others have previously reported the HSC-enhancing ability of a short-term exposure of prostaglandin E2 (PGE2); this strategy has now progressed to phase 1 clinical trials in double cord blood transplantation. To further analyze the short- and long-term effects of HSC exposure to PGE2, we followed the repopulation kinetics of PGE2-treated hematopoietic grafts through 5 serial transplantations and compared inherent long-term competitiveness in a HSC head-to-head secondary transplantation model. Treatment with PGE2 did not result in a long-term increase in HSC competitiveness, lineage bias, or enhanced proliferative potential, demonstrating that pulse exposure to PGE2 results in transient increases in HSC homing and engraftment potential.
journal_name
Bloodjournal_title
Bloodauthors
Hoggatt J,Mohammad KS,Singh P,Pelus LMdoi
10.1182/blood-2013-07-515288subject
Has Abstractpub_date
2013-10-24 00:00:00pages
2997-3000issue
17eissn
0006-4971issn
1528-0020pii
blood-2013-07-515288journal_volume
122pub_type
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