TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release.

abstract：:A prominent feature of most if not all cancers is a striking genetic instability, leading to ongoing accrual of mutational changes, some of which underlie tumor progression, including acquisition of invasiveness, drug resistance, and metastasis. Thus, the molecular basis for the generation of this genetic diversity in...

journal_title：Blood

authors： Shammas MA,Shmookler Reis RJ,Koley H,Batchu RB,Li C,Munshi NC

更新日期：2009-03-05 00:00:00

abstract：:Mice deficient for the transcription factor, interferon consensus sequence binding protein (ICSBP), are immunodeficient and develop disease symptoms similar to human chronic myeloid leukemia (CML). To elucidate the hematopoietic disorder of ICSBP(-/-) mice, we investigated the growth, differentiation, and leukemogenic...

journal_title：Blood

authors： Scheller M,Foerster J,Heyworth CM,Waring JF,Löhler J,Gilmore GL,Shadduck RK,Dexter TM,Horak I

更新日期：1999-12-01 00:00:00

abstract：:A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be the main cause of cancer. These mutational events include activation of oncogenes and inactivation of tumor suppressor genes. The elucidation of human cancer at t...

journal_title：Blood

authors： Reuter CW,Morgan MA,Bergmann L

更新日期：2000-09-01 00:00:00

abstract：:In subjects mismatched in the HLA alleles C*03:03/C*03:04 no allogeneic cytotoxic T-lymphocyte responses are detected in vitro. Hematopoietic stem cell transplantation (HSCT) with unrelated donors (UDs) showed no association between the HLA-C allele mismatches (CAMMs) and adverse outcomes; antigen mismatches at this a...

journal_title：Blood

authors： Fernandez-Viña MA,Wang T,Lee SJ,Haagenson M,Aljurf M,Askar M,Battiwalla M,Baxter-Lowe LA,Gajewski J,Jakubowski AA,Marino S,Oudshoorn M,Marsh SG,Petersdorf EW,Schultz K,Turner EV,Waller EK,Woolfrey A,Umejiego J,Spell

更新日期：2014-02-20 00:00:00

abstract：:Human parvovirus B19 (B19V) infection shows a strong erythroid tropism and drastically destroys erythroid progenitor cells, thus leading to most of the disease outcomes associated with B19V infection. In this study, we systematically examined the 3 B19V nonstructural proteins, 7.5 kDa, 11 kDa, and NS1, for their funct...

journal_title：Blood

authors： Chen AY,Zhang EY,Guan W,Cheng F,Kleiboeker S,Yankee TM,Qiu J

更新日期：2010-02-04 00:00:00

abstract：:Self-renewal is a feature of cancer and can be assessed by cell transplantation into immune-compromised or immune-matched animals. However, studies in zebrafish have been severely limited by lack of these reagents. Here, Myc-induced T-cell acute lymphoblastic leukemias (T-ALLs) have been made in syngeneic, clonal zebr...

journal_title：Blood

authors： Smith AC,Raimondi AR,Salthouse CD,Ignatius MS,Blackburn JS,Mizgirev IV,Storer NY,de Jong JL,Chen AT,Zhou Y,Revskoy S,Zon LI,Langenau DM

更新日期：2010-04-22 00:00:00

abstract：:Electrolyte disturbances in leukemia can be the result of the disease process or drug therapy. One group of electrolyte abnormalities is related to the stage of the leukemic process. Included in this group are newly diagnosed patients who may show elevated serum potassium, phosphorus, and magnesium--a result of their ...

journal_title：Blood

authors： O'Regan S,Carson S,Chesney RW,Drummond KN

更新日期：1977-03-01 00:00:00

abstract：:Erythropoietin (Epo) and dimethyl sulfoxide (DMSO) are believed to induce the differentiation of transformed erythroid cells by different signal transduction pathways. We have now obtained evidence for the interaction of these pathways. We used a Rauscher murine erythroleukemia cell line with a relatively low (8% to 1...

journal_title：Blood

authors： Chern Y,Yonekura S,Sytkowski AJ

更新日期：1990-12-01 00:00:00

abstract：:To identify genes linked to normal plasma cell (PC) differentiation and to classify multiple myeloma (MM) with respect to the expression patterns of these genes, we analyzed global mRNA expression in CD19-enriched B cells (BCs) from 7 tonsils, CD138-enriched PCs from 11 tonsils, 31 normal bone marrow samples, and 74 M...

journal_title：Blood

authors： Zhan F,Tian E,Bumm K,Smith R,Barlogie B,Shaughnessy J Jr

更新日期：2003-02-01 00:00:00

abstract：:Retrospective studies of patients with thrombotic microangiopathies (TMAs) have shown that a deficient activity of von Willebrand factor (vWF)-cleaving protease is involved in thrombotic thrombocytopenic purpura (TTP) but not in the hemolytic-uremic syndrome (HUS). To further analyze the relevance of this enzymatic ac...

journal_title：Blood

authors： Veyradier A,Obert B,Houllier A,Meyer D,Girma JP

更新日期：2001-09-15 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) is an important growth and survival factor in multiple myeloma (MM). Here, we demonstrate that IGF-1 induces significant down-regulation of the proapoptotic BH3-only protein Bim in MM cells. Reduced Bim levels by RNA interference (RNAi) protected cells from drug-induced cell death....

journal_title：Blood

authors： De Bruyne E,Bos TJ,Schuit F,Van Valckenborgh E,Menu E,Thorrez L,Atadja P,Jernberg-Wiklund H,Vanderkerken K

更新日期：2010-03-25 00:00:00

abstract：:Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro-generated DCs are representative o...

journal_title：Blood

authors： Maraskovsky E,Daro E,Roux E,Teepe M,Maliszewski CR,Hoek J,Caron D,Lebsack ME,McKenna HJ

更新日期：2000-08-01 00:00:00

abstract：:Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in ...

journal_title：Blood

authors： Lindemann A,Ludwig WD,Oster W,Mertelsmann R,Herrmann F

更新日期：1989-03-01 00:00:00

abstract：:Recent studies have identified nonredundant roles for basophils in immune responses including allergy and protective immunity. It is well known that activated basophils release granule contents such as histamine and proteases as do mast cells. However, the functional significance of basophil-derived proteases remains ...

journal_title：Blood

authors： Iki M,Tanaka K,Deki H,Fujimaki M,Sato S,Yoshikawa S,Yamanishi Y,Karasuyama H

更新日期：2016-12-22 00:00:00

abstract：:Immune-mediated platelet destruction is most frequently caused by allo- or autoantibodies via Fcγ receptor-dependent phagocytosis. Disease severity can be predicted neither by antibody isotype nor by titer, indicating that other factors play a role. Here we show that the acute phase protein C-reactive protein (CRP), a...

journal_title：Blood

authors： Kapur R,Heitink-Pollé KM,Porcelijn L,Bentlage AE,Bruin MC,Visser R,Roos D,Schasfoort RB,de Haas M,van der Schoot CE,Vidarsson G

更新日期：2015-03-12 00:00:00

abstract：:Although recent advances have enabled hematopoietic stem cells (HSCs) to be enriched to near purity, more information about their characteristics will improve our understanding of their development and stage-related functions. Here, using microarray technology, we identified endothelial cell-selective adhesion molecul...

journal_title：Blood

authors： Yokota T,Oritani K,Butz S,Kokame K,Kincade PW,Miyata T,Vestweber D,Kanakura Y

更新日期：2009-03-26 00:00:00

abstract：:The human leukemic cell lines K562 and HL-60 were cocultured with normal bone marrow (BM) cells. Coculture with 10(4) K562 or HL-60 cells results in 50% inhibition of normal CFU-E and BFU-E colony formation. However, when the same number of K562 and HL-60 cells is first treated for two to five days with agents that in...

journal_title：Blood

authors： Steinberg HN,Tsiftsoglou AS,Robinson SH

更新日期：1985-01-01 00:00:00

abstract：:A 27-year-old male patient with ataxia telangiectasia (AT) developed atypical chronic lymphocytic leukemia with increasing bone marrow infiltration in the absence of organomegaly. One-third of the leukemia cells expressed a mature suppressor/cytotoxic T cell phenotype (T3+ T4- T6- T8+ T10-), two-thirds demonstrated ad...

journal_title：Blood

authors： Dührsen U,Uppenkamp M,Uppenkamp I,Becher R,Engelhard M,König E,Meusers P,Meuer S,Brittinger G

更新日期：1986-08-01 00:00:00

abstract：:1-deamino-8-d-arginine vasopressin (desmopressin [DDAVP]) is clinically efficacious in patients with mild platelet function disorders but it is not known which mechanisms mediate this effect. Our aim was to evaluate the impact of in vivo DDAVP administration in these patients. We assessed von Willebrand factor (VWF), ...

journal_title：Blood

authors： Colucci G,Stutz M,Rochat S,Conte T,Pavicic M,Reusser M,Giabbani E,Huynh A,Thürlemann C,Keller P,Alberio L

更新日期：2014-03-20 00:00:00

abstract：:To assess the relationship between venous thrombosis and plasma glucosylceramide (GlcCer) or phosphatidylethanolamine (PE), plasma levels of GlcCer and PE were determined for 70 venous thrombosis patients referred for evaluation and 70 healthy blood donors. The mean GlcCer level, but not the PE level, was lower in pat...

journal_title：Blood

authors： Deguchi H,Fernández JA,Pabinger I,Heit JA,Griffin JH

更新日期：2001-04-01 00:00:00

abstract：:The regulation of megakaryocytopoiesis and thrombopoiesis appears to be under the control of an array of hematopoietic growth factors. To determine the relationship of endogenous thrombopoietic cytokine levels and circulating platelet (PLT) counts, we measured the levels of thrombo-poietin (TPO), interleukin-11 (IL-11...

journal_title：Blood

authors： Chang M,Suen Y,Meng G,Buzby JS,Bussel J,Shen V,van de Ven C,Cairo MS

更新日期：1996-11-01 00:00:00

abstract：:Activation of Fas antigen, a cell surface receptor molecule, by its ligand results in transduction of a signal for cell death. The Fas system has been implicated in target cell recognition, clonal development of immune effector cells, and termination of the cellular immune response. Fas antigen expression on lymphocyt...

journal_title：Blood

authors： Maciejewski J,Selleri C,Anderson S,Young NS

更新日期：1995-06-01 00:00:00

abstract：:Glucose is a major source of energy for living organisms, and its transport in vertebrates is a universally conserved property. Of all cell lineages, human erythrocytes express the highest level of the Glut1 glucose transporter with more than 200,000 molecules per cell. However, we recently reported that erythrocyte G...

journal_title：Blood

authors： Montel-Hagen A,Blanc L,Boyer-Clavel M,Jacquet C,Vidal M,Sitbon M,Taylor N

更新日期：2008-12-01 00:00:00

abstract：:A major limitation to the widespread use of hematopoietic stem cells (HSC) is the relatively crude level of our knowledge of how to maintain these cells in vitro without loss of the long-term multilineage growth and differentiation properties required for their clinical utility. An experimental and theoretical framewo...

journal_title：Blood

authors： Zandstra PW,Lauffenburger DA,Eaves CJ

更新日期：2000-08-15 00:00:00

abstract：:Neutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into account. In the INSIGHT study,...

journal_title：Blood

authors： Eckhardt CL,van Velzen AS,Peters M,Astermark J,Brons PP,Castaman G,Cnossen MH,Dors N,Escuriola-Ettingshausen C,Hamulyak K,Hart DP,Hay CR,Haya S,van Heerde WL,Hermans C,Holmström M,Jimenez-Yuste V,Keenan RD,Klamroth R

更新日期：2013-09-12 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) can kill target cells by the granule/exocytosis pathway or the Fas-mediated apoptosis pathway. The sensitivity of chronic lymphocytic leukemia (CLL) B cells to CTL-mediated apoptosis before and after CD40 activation was examined. Resting or CD40-activated CLL cells were found to be equal...

journal_title：Blood

authors： Chu P,Wierda WG,Kipps TJ

更新日期：2000-06-15 00:00:00

abstract：:Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor immunity. However, the underlying reasons for this impaired NK cell function remain to be uncovered. We found that NK cells in aggressive B-cell lymphoma underwen...

journal_title：Blood

authors： Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

更新日期：2020-12-24 00:00:00

abstract：:Nasal natural killer (NK) cell lymphoma is rare, so that its optimal therapy, long-term outcome, and prognostic factors are unclear. Data on 52 men and 15 women with well-characterized nasal NK cell lymphomas were analyzed retrospectively to define the impact of primary therapy on remission and long-term outcome and t...

journal_title：Blood

authors： Chim CS,Ma SY,Au WY,Choy C,Lie AK,Liang R,Yau CC,Kwong YL

更新日期：2004-01-01 00:00:00

abstract：:All-trans retinoic acid (RA) induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL). Nevertheless, most of these patients develop RA resistance and relapse. The mechanisms of RA resistance by APL cells are still unclear. To understand the characteristics of human leukemia, ...

journal_title：Blood

authors： Kizaki M,Matsushita H,Takayama N,Muto A,Ueno H,Awaya N,Kawai Y,Asou H,Kamada N,Ikeda Y

更新日期：1996-09-01 00:00:00

abstract：:The FAS receptor-FAS ligand system is a key apoptotic pathway for cells of the immune system. Ligation of the FAS-receptor (CD95) induces apoptosis by activation of pro-caspase-8 followed by downstream events, including an increase in reactive oxygen species (ROS) and the release of proapoptotic factors from the mitoc...

journal_title：Blood

authors： Perez-Cruz I,Carcamo JM,Golde DW

更新日期：2003-07-01 00:00:00