The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.

abstract：:This study was undertaken to gain further insight into the severely impaired natural killer (NK) activity we and others have previously observed in patients with chronic lymphocytic leukemia (CLL). Normal individuals' NK cells are large granular lymphocytes (LGL) that (A) bind to and lyse NK-sensitive cells, including...

journal_title：Blood

authors： Kay NE,Zarling JM

更新日期：1984-02-01 00:00:00

abstract：:To determine if megakaryocytes are targeted by immune thrombocytopenic purpura (ITP) autoantibodies, as are platelets, we have studied the effects of ITP plasma on in vitro megakaryocytopoiesis. Umbilical cord blood mononuclear cells were incubated in the presence of thrombopoietin and 10% plasma from either ITP patie...

journal_title：Blood

authors： Chang M,Nakagawa PA,Williams SA,Schwartz MR,Imfeld KL,Buzby JS,Nugent DJ

更新日期：2003-08-01 00:00:00

abstract：:Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Platelet packaging and release concludes at the tips of each proplatelet. Essential in this process is the distribution of organelles and platelet-specific granules i...

journal_title：Blood

authors： Richardson JL,Shivdasani RA,Boers C,Hartwig JH,Italiano JE Jr

更新日期：2005-12-15 00:00:00

abstract：:The mutation status and usage of specific VH genes such as V3-21 and V1-69 are potentially independent pathogenic and prognostic factors in chronic lymphocytic leukemia (CLL). To investigate the role of antigenic stimulation, we analyzed the expression of genes involved in B-cell receptor (BCR) signaling/activation, c...

journal_title：Blood

authors： Kienle D,Benner A,Kröber A,Winkler D,Mertens D,Bühler A,Seiler T,Jäger U,Lichter P,Döhner H,Stilgenbauer S

更新日期：2006-03-01 00:00:00

abstract：:Aneuploidy and lg light chain restriction were used as separate, independent tumor specific markers to study 26 patients with multiple myeloma to determine whether bone marrow B cells, as defined by CD19 expression, are clonally related to myeloma plasma cells. Specimens were characterized using multidimensional flow ...

journal_title：Blood

authors： McSweeney PA,Wells DA,Shults KE,Nash RA,Bensinger WI,Buckner CD,Loken MR

更新日期：1996-07-15 00:00:00

abstract：:Alterations in the vascular system and the onset of angioproliferative lesions such as Kaposi's sarcoma (KS) are common traits of human immunodeficiency virus-1 (HIV-1)-infected patients. To investigate possible factors involved in acquired immunodeficiency syndrome (AIDS)-associated vasculopathy and vascular malfunct...

journal_title：Blood

authors： Ascherl G,Hohenadl C,Schatz O,Shumay E,Bogner J,Eckhart L,Tschachler E,Monini P,Ensoli B,Stürzl M

更新日期：1999-06-15 00:00:00

abstract：:The best initial therapy for elderly patients with chronic lymphocytic leukemia (CLL) has not yet been defined. We investigated the activity of lenalidomide as initial therapy for elderly patients with CLL. Sixty patients with CLL 65 years of age and older received treatment with lenalidomide orally 5 mg daily for 56 ...

journal_title：Blood

authors： Badoux XC,Keating MJ,Wen S,Lee BN,Sivina M,Reuben J,Wierda WG,O'Brien SM,Faderl S,Kornblau SM,Burger JA,Ferrajoli A

更新日期：2011-09-29 00:00:00

abstract：:Peripheral eosinophilia is almost invariably observed during the course of interleukin-2 (IL-2) therapy and is frequently accompanied by the development of a capillary leak syndrome characterized by edema, weight gain, and oliguria. We studied five patients with advanced malignancy treated with IL-2. Eosinophilia was ...

journal_title：Blood

authors： van Haelst Pisani C,Kovach JS,Kita H,Leiferman KM,Gleich GJ,Silver JE,Dennin R,Abrams JS

更新日期：1991-09-15 00:00:00

abstract：:The granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is a potential target for toxin-directed therapy, because it is overexpressed on many leukemias and solid tumors and apparently not on stem cells. To investigate the potential therapeutic use of GM-CSF toxins, we fused human GM-CSF to truncated fo...

journal_title：Blood

authors： Kreitman RJ,Pastan I

更新日期：1997-07-01 00:00:00

abstract：:Vascular endothelial-cadherin (VE-cadherin) is a calcium-dependent adhesive molecule, exclusively and constitutively expressed in endothelial cells. Analysis of the VE-cadherin promoter fused to a reporter gene in bovine aortic endothelial cells showed three major functional regions. The proximal region alone (-139, +...

journal_title：Blood

authors： Gory S,Vernet M,Laurent M,Dejana E,Dalmon J,Huber P

更新日期：1999-01-01 00:00:00

abstract：:Pulmonary complication in severe Plasmodium falciparum malaria is manifested as a prolonged impairment of gas transfer or the more severe acute respiratory distress syndrome (ARDS). In either clinical presentation, vascular permeability is a major component of the pathologic process. In this report, we examined the ef...

journal_title：Blood

authors： Gillrie MR,Krishnegowda G,Lee K,Buret AG,Robbins SM,Looareesuwan S,Gowda DC,Ho M

更新日期：2007-11-01 00:00:00

abstract：:The structural basis of the interaction between single-chain urokinase-type plasminogen activator (scuPA) and its receptor (uPAR) is incompletely defined. Several observations indicated the kringle facilitates the binding of uPA to uPAR. A scuPA variant lacking the kringle (Delta K-scuPA) bound to soluble uPAR (suPAR)...

journal_title：Blood

authors： Bdeir K,Kuo A,Sachais BS,Rux AH,Bdeir Y,Mazar A,Higazi AA,Cines DB

更新日期：2003-11-15 00:00:00

abstract：:Aurora-A kinase (Aur-A) is a member of the serine/threonine kinase family that regulates the cell division process, and has recently been implicated in tumorigenesis. In this study, we identified an antigenic 9-amino-acid epitope (Aur-A(207-215): YLILEYAPL) derived from Aur-A capable of generating leukemia-reactive cy...

journal_title：Blood

authors： Ochi T,Fujiwara H,Suemori K,Azuma T,Yakushijin Y,Hato T,Kuzushima K,Yasukawa M

更新日期：2009-01-01 00:00:00

abstract：:With the aim of establishing whether the HR2 haplotype in factor V affects the risk of venous thromboembolism, a retrospective multicenter cohort study was performed in 810 family members identified through 174 probands who suffered from at least 1 episode of deep vein thrombosis and/or pulmonary embolism and had an i...

journal_title：Blood

authors： Faioni EM,Franchi F,Bucciarelli P,Margaglione M,De Stefano V,Castaman G,Finazzi G,Mannucci PM

更新日期：1999-11-01 00:00:00

abstract：:We conducted a double-blind, randomized multicenter trial to determine whether the addition of mycophenolate mofetil (MMF) improves the efficacy of initial systemic treatment of chronic graft-versus-host disease (GVHD). The primary endpoint was resolution of chronic GVHD and withdrawal of all systemic treatment within...

journal_title：Blood

authors： Martin PJ,Storer BE,Rowley SD,Flowers ME,Lee SJ,Carpenter PA,Wingard JR,Shaughnessy PJ,DeVetten MP,Jagasia M,Fay JW,van Besien K,Gupta V,Kitko C,Johnston LJ,Maziarz RT,Arora M,Jacobson PA,Weisdorf D

更新日期：2009-05-21 00:00:00

abstract：:Cord plasma contains colony-stimulating activity (CSA) which stimulates the in vitro clonal growth of neutrophils, eosinophils, macrophages, erythrocytes, and persisting mast cells in semisolid cultures. Analysis of day 35 colonies in agar cultures was found to be a suitable means of demonstrating this activity and di...

journal_title：Blood

authors： Brown RD,Yuen E,Kronenberg H,Rickard KA

更新日期：1986-07-01 00:00:00

abstract：:p38 MAP kinase in human platelets is activated by platelet agonists including thrombin, thromboxane A2 (TxA2), ADP, and others. However, both upstream mechanisms of p38 MAP kinase activation, and their downstream sequelae, are presently controversial and essentially unclear. Certain studies report sequential activatio...

journal_title：Blood

authors： Begonja AJ,Geiger J,Rukoyatkina N,Rauchfuss S,Gambaryan S,Walter U

更新日期：2007-01-15 00:00:00

abstract：:We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet generation were recor...

journal_title：Blood

authors： Di Buduo CA,Wray LS,Tozzi L,Malara A,Chen Y,Ghezzi CE,Smoot D,Sfara C,Antonelli A,Spedden E,Bruni G,Staii C,De Marco L,Magnani M,Kaplan DL,Balduini A

更新日期：2015-04-02 00:00:00

abstract：:Nasal natural killer (NK) cell lymphoma is rare, so that its optimal therapy, long-term outcome, and prognostic factors are unclear. Data on 52 men and 15 women with well-characterized nasal NK cell lymphomas were analyzed retrospectively to define the impact of primary therapy on remission and long-term outcome and t...

journal_title：Blood

authors： Chim CS,Ma SY,Au WY,Choy C,Lie AK,Liang R,Yau CC,Kwong YL

更新日期：2004-01-01 00:00:00

abstract：:Dendritic cell (DC) development is efficiently supported by Flt3-ligand or GM-CSF in vitro, and lymphoid-organ DC maintenance in vivo is critically dependent on Flt3-ligand. However, the relevance of GM-CSF for lymphoid-tissue DC maintenance and the importance of both cytokines for nonlymphoid organ DC homeostasis are...

journal_title：Blood

authors： Kingston D,Schmid MA,Onai N,Obata-Onai A,Baumjohann D,Manz MG

更新日期：2009-07-23 00:00:00

abstract：:To examine the role of the fibrinogen gamma chain in the assembly and secretion of this multichain protein, we synthesized a series of fibrinogen variants with truncated gamma chains, terminating between residues gamma379 and the C-terminus, gamma411. The variant fibrinogens were synthesized from altered gamma-chain c...

journal_title：Blood

authors： Okumura N,Terasawa F,Tanaka H,Hirota M,Ota H,Kitano K,Kiyosawa K,Lord ST

更新日期：2002-05-15 00:00:00

abstract：:Important predictors of adverse outcomes of thrombosis in children, including postthrombotic syndrome (PTS), have recently been identified. Given this knowledge and the encouraging preliminary pediatric experience with systemic thrombolysis, we sought to retrospectively analyze our institutional experience with a thro...

journal_title：Blood

authors： Goldenberg NA,Durham JD,Knapp-Clevenger R,Manco-Johnson MJ

更新日期：2007-07-01 00:00:00

abstract：:Patients who are chronically infected with hepatitis C virus (HCV) often develop mixed cryoglobulinemia (MC), a B-cell proliferative disorder with polyclonal activation and autoantibody production. We investigated if MC is associated with a deficit of CD4(+)CD25(+) immunoregulatory T (Treg) cells, which have been show...

journal_title：Blood

authors： Boyer O,Saadoun D,Abriol J,Dodille M,Piette JC,Cacoub P,Klatzmann D

更新日期：2004-05-01 00:00:00

abstract：:CCR5 is a receptor for several beta chemokines and the entry coreceptor used by macrophage-tropic (R5) strains of HIV-1. In addition to supporting viral entry, CCR5 ligation by the HIV-1 envelope glycoprotein 120 (gp120) can activate intracellular signals in macrophages and trigger inflammatory mediator release. Using...

journal_title：Blood

authors： Tomkowicz B,Lee C,Ravyn V,Cheung R,Ptasznik A,Collman RG

更新日期：2006-08-15 00:00:00

abstract：:Clonality studies of hematopoietic reconstitution after remission were performed in 24 female patients (pts) with leukemias characterized by specific molecular markers. At diagnosis, 13 pts had promyelocytic leukemia (PML) retinoic acid receptor-alpha (RAR-alpha)-rearranged acute promyelocytic leukemia (APL), 8 Philad...

journal_title：Blood

authors： Lo Coco F,Pelicci PG,D'Adamo F,Diverio D,Alimena G,Montefusco E,Arcese W,Avvisati G,De Felice L,Meloni G

更新日期：1993-07-15 00:00:00

abstract：:Congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of inherited anemias that affect the normal differentiation-proliferation pathways of the erythroid lineage. They belong to the wide group of ineffective erythropoiesis conditions that mainly result in monolinear cytopenia. CDAs are classified into ...

journal_title：Blood

authors： Iolascon A,Andolfo I,Russo R

更新日期：2020-09-10 00:00:00

abstract：:P-selectin (CD62P) is a member of the selectin family of adhesion molecules involved in the regulation of leukocyte traffic. P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin-like molecule that is thought to be a primary ligand for P-selectin. The interaction of P-selectin with PSGL-1 results in leukocyte rolling a...

journal_title：Blood

authors： Snapp KR,Wagers AJ,Craig R,Stoolman LM,Kansas GS

更新日期：1997-02-01 00:00:00

abstract：:Several signaling cascades are engaged by expression of the p210 bcr-abl tyrosine kinase, and evidence suggests that these signals drive leukemogenesis. In this report, signaling pathways were examined and compared between cells derived from leukemic patients and cells expressing a bcr-abl construct (MBA). The effects...

journal_title：Blood

authors： Donato NJ,Wu JY,Zhang L,Kantarjian H,Talpaz M

更新日期：2001-05-01 00:00:00

abstract：:The mechanism of platelet release has been studied in mouse bone marrow, using scanning and transmission electron microscopy. Cytoplasmic processes extended into sinusoids by megakaryocytes were found to undergo attenuation, and at the distal end develop constrictions between segments of platelet size. Rupture at site...

journal_title：Blood

authors： Radley JM,Scurfield G

更新日期：1980-12-01 00:00:00

abstract：:Peripheral blood progenitor cells (PBPCs) are increasingly being used to replace bone marrow cells (BMCs) as a source of hematopoietic stem cells also in the field of allogeneic transplantation. Whereas it is well known that PBPC grafts and BM differ significantly in progenitor cell content and lymphocyte dose, the cl...

journal_title：Blood

authors： Glass B,Uharek L,Zeis M,Dreger P,Löffler H,Steinmann J,Schmitz N

更新日期：1997-08-15 00:00:00