A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma.

abstract：:The D816V mutation of c-kit has been detected in patients with mastocytosis. This mutation leads to constitutive tyrosine kinase activation of Kit. Because stem cell factor (SCF), the ligand for Kit (CD117(+)), is a chemoattractant for CD117(+) cells and one feature of mastocytosis is an abnormal collection of mast ce...

journal_title：Blood

authors： Taylor ML,Dastych J,Sehgal D,Sundstrom M,Nilsson G,Akin C,Mage RG,Metcalfe DD

更新日期：2001-08-15 00:00:00

abstract：:Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, but few genetic risk factors have been associated with its development. Recently, it has been reported that some polymorphisms that affect clotting factors increase the risk for thrombosis. However, reports have analyzed the effect of...

journal_title：Blood

authors： Corral J,Iniesta JA,González-Conejero R,Villalón M,Vicente V

更新日期：2001-05-15 00:00:00

abstract：:Imatinib mesylate, a competitive inhibitor of Abl tyrosine kinase, is highly effective for the early stages of chronic myelogenous leukemia (CML), but remissions induced in advanced-phase CML and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia tend to be relatively short-lived. Therefore, the searc...

journal_title：Blood

authors： Kuroda J,Kimura S,Segawa H,Kobayashi Y,Yoshikawa T,Urasaki Y,Ueda T,Enjo F,Tokuda H,Ottmann OG,Maekawa T

更新日期：2003-09-15 00:00:00

abstract：:Nitric oxide (NO) exerts vasodilatatory, antiplatelet, antioxidant, and antiproliferative effects. Endothelium-derived NO has been shown to be of crucial importance in cardiovascular protection, whereas evidence that NO is synthesized by platelets and regulates platelet function is still controversial. By using a sens...

journal_title：Blood

authors： Cozzi MR,Guglielmini G,Battiston M,Momi S,Lombardi E,Miller EC,De Zanet D,Mazzucato M,Gresele P,De Marco L

更新日期：2015-01-22 00:00:00

abstract：:Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; man...

journal_title：Blood

authors： Brodsky RA,Sensenbrenner LL,Jones RJ

更新日期：1996-01-15 00:00:00

abstract：:Fas ligand (FasL) and perforin pathways not only are the major mechanisms of T cell-mediated cytotoxicity but also are involved in homeostatic regulation of these T cells. In the present study, we tested whether CD8+ donor T cells that are deficient in both perforin and FasL (cytotoxic double deficient [cdd]) could in...

journal_title：Blood

authors： Maeda Y,Levy RB,Reddy P,Liu C,Clouthier SG,Teshima T,Ferrara JL

更新日期：2005-03-01 00:00:00

abstract：:The development of peroxidase (PO) reaction in the nuclear envelope (NE) and endoplasmic reticulum (ER) of monocytes differentiating in vitro and its relationship with arachidonic acid metabolism were studied. The PO, as visualized by the diaminobenzidine (DAB) technique, appeared in the NE and ER of the majority of m...

journal_title：Blood

authors： Deimann W,Seitz M,Gemsa D,Fahimi HD

更新日期：1984-08-01 00:00:00

abstract：:The expression of Lewis fucosyltransferase (FT) mRNA was examined in gastric mucosa from two Lewis-positive [Le(+)] and two Lewis-negative [Le(-)] individuals. Northern blot analysis demonstrated that levels of mRNA were similar in both Le(+) and Le(-) gastric mucosa. We isolated the protein-coding region of the Lewis...

journal_title：Blood

authors： Koda Y,Kimura H,Mekada E

更新日期：1993-11-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is the major regulator of granulopoiesis and acts through binding to its specific receptor (G-CSF-R) on neutrophilic granulocytes. Previous studies of signaling from the 4 G-CSF-R cytoplasmic tyrosine residues used model cell lines that may have idiosyncratic, nonphysiolog...

journal_title：Blood

authors： Akbarzadeh S,Ward AC,McPhee DO,Alexander WS,Lieschke GJ,Layton JE

更新日期：2002-02-01 00:00:00

abstract：:Chromosome 11q deletions are frequently observed in chronic lymphocytic leukemia (CLL) in association with progressive disease and a poor prognosis. A minimal region of deletion has been assigned to 11q22-q23. Trinucleotide repeats have been associated with anticipation in disease, and evidence of anticipation has bee...

journal_title：Blood

authors： Auer RL,Jones C,Mullenbach RA,Syndercombe-Court D,Milligan DW,Fegan CD,Cotter FE

更新日期：2001-01-15 00:00:00

abstract：:Red blood cell (RBC) and platelet transfusion requirements in patients given nonmyeloablative versus conventional peripheral blood stem cell (PBSC) transplants from HLA-matched siblings were compared. Between December 1997 and March 2000, 40 patients, aged 21 to 67 years (median 51), with hematologic malignancies unde...

journal_title：Blood

authors： Weissinger F,Sandmaier BM,Maloney DG,Bensinger WI,Gooley T,Storb R

更新日期：2001-12-15 00:00:00

abstract：:High-dose melphalan followed by stem cell transplantation (HDM-SCT) has become the treatment of choice for patients with immunoglobulin light chain amyloidosis (AL). Unfortunately, treatment mortality can be excessive in certain subpopulations. We have noted that patients who gained more than 2% body weight during mob...

journal_title：Blood

authors： Leung N,Leung TR,Cha SS,Dispenzieri A,Lacy MQ,Gertz MA

更新日期：2005-11-15 00:00:00

abstract：:Proteolytic fragments of fibronectin (Fn) can possess properties not inherent to intact Fn. Previously, only mixtures of low molecular weight Fn fragments, and the 120-Kd fibroblastic cell-binding segment, but not intact Fn, were shown to be selectively chemotactic for human monocytes (MOs). In order to determine if o...

journal_title：Blood

authors： Lohr KM,Kurth CA,Xie DL,Seyer JM,Homandberg GA

更新日期：1990-11-15 00:00:00

abstract：:Reprogramming of somatic cells to desired cell types holds great promise in regenerative medicine. However, production of transplantable hematopoietic stem cells (HSCs) in vitro by defined factors has not yet been achieved. Therefore, it is critical to fully understand the molecular mechanisms of HSC development in vi...

journal_title：Blood

authors： Wang L,Liu T,Xu L,Gao Y,Wei Y,Duan C,Chen GQ,Lin S,Patient R,Zhang B,Hong D,Liu F

更新日期：2013-07-18 00:00:00

abstract：:The mi locus of mice encodes a member of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Cultured mast cells of mi/mi genotype (mi/mi CMCs) did not normally respond to stem cell factor (SCF), a ligand for the c-kit receptor tyrosine kinase. The poor...

journal_title：Blood

authors： Tsujimura T,Morii E,Nozaki M,Hashimoto K,Moriyama Y,Takebayashi K,Kondo T,Kanakura Y,Kitamura Y

更新日期：1996-08-15 00:00:00

abstract：:Human parvovirus B19 (B19V) infection shows a strong erythroid tropism and drastically destroys erythroid progenitor cells, thus leading to most of the disease outcomes associated with B19V infection. In this study, we systematically examined the 3 B19V nonstructural proteins, 7.5 kDa, 11 kDa, and NS1, for their funct...

journal_title：Blood

authors： Chen AY,Zhang EY,Guan W,Cheng F,Kleiboeker S,Yankee TM,Qiu J

更新日期：2010-02-04 00:00:00

abstract：:The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely impairs the development and function of B cells but not T cells. Here w...

journal_title：Blood

authors： Deane JA,Kharas MG,Oak JS,Stiles LN,Luo J,Moore TI,Ji H,Rommel C,Cantley LC,Lane TE,Fruman DA

更新日期：2007-04-01 00:00:00

abstract：:In ischemic stroke, treatment options are limited. Therapeutic thrombolysis is restricted to the first few hours after stroke, and the utility of current platelet aggregation inhibitors, including GPIIb/IIIa receptor antagonists, and anticoagulants is counterbalanced by the risk of intracerebral bleeding complications...

journal_title：Blood

authors： Stoll G,Kleinschnitz C,Nieswandt B

更新日期：2008-11-01 00:00:00

abstract：:The bcl-2 gene is translocated into the Ig loci in about 80% of human follicular lymphomas and in 10% of B-type chronic lymphocytic leukemias (B-CLL), resulting in a high level of expression. We have compared the expression of bcl-2 transcripts and protein in B-CLL cells in their normal equivalent CD5+ B cells and in ...

journal_title：Blood

authors： Schena M,Larsson LG,Gottardi D,Gaidano G,Carlsson M,Nilsson K,Caligaris-Cappio F

更新日期：1992-06-01 00:00:00

abstract：:Primary diffuse large B-cell lymphomas (DLBCLs) are aggressive tumors accounting for approximately 40% of B-cell malignancies. The immunoglobulin (Ig) variable region genes have undergone rearrangement and are commonly somatically mutated. The majority show intraclonal variation which indicates that somatic mutation h...

journal_title：Blood

authors： Ottensmeier CH,Stevenson FK

更新日期：2000-10-01 00:00:00

abstract：:This prospective multicenter study examined whether simultaneous administration of granulocyte colony-stimulating factor (G-CSF; Filgrastim) and induction chemotherapy for adult acute lymphoblastic leukemia (ALL) could prevent treatment-related neutropenia, infections, and resulting treatment delays. Seventy-six patie...

journal_title：Blood

authors： Ottmann OG,Hoelzer D,Gracien E,Ganser A,Kelly K,Reutzel R,Lipp T,Busch FW,Schwonzen M,Heil G

更新日期：1995-07-15 00:00:00

abstract：:Discoveries during the past decade have revolutionized our understanding of idiopathic thrombotic thrombocytopenic purpura (TTP). Most cases in adults are caused by acquired autoantibodies that inhibit ADAMTS13, a metalloprotease that cleaves von Willebrand factor within nascent platelet-rich thrombi to prevent hemoly...

journal_title：Blood

authors： Sadler JE

更新日期：2008-07-01 00:00:00

abstract：:Monocytes are thought to play a role in host resistance to tumor cell growth in animals and humans. In addition, platelets are known to be involved in tumor metastases. To investigate the interaction of these two cell types and their effect on tumor cells, human monocytes and platelets were examined using an in vitro ...

journal_title：Blood

authors： Ibele GM,Kay NE,Johnson GJ,Jacob HS

更新日期：1985-05-01 00:00:00

abstract：:B12 deficiency is the leading cause of megaloblastic anemia, and although more common in the elderly, can occur at any age. Clinical disease caused by B12 deficiency usually connotes severe deficiency, resulting from a failure of the gastric or ileal phase of physiological B12 absorption, best exemplified by the autoi...

journal_title：Blood

authors： Green R

更新日期：2017-05-11 00:00:00

abstract：:Although sickle cell disease (SCD) has a variable clinical course, many patients develop end-organ complications that are associated with significant morbidity and early mortality. Myeloablative allogeneic HSCT (allo-HSCT) is curative but has been historically performed only in children younger than 16 years of age. M...

journal_title：Blood

authors： Hsieh MM,Fitzhugh CD,Tisdale JF

更新日期：2011-08-04 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT). When GVHD is controlled by T-cell-depleted grafts or immunosuppressants, BM transplant recipients often suffer from an increased rate of leukemic relapse and impaired reconstitution of immunity. Using a mouse BMT ...

journal_title：Blood

authors： Imado T,Iwasaki T,Kataoka Y,Kuroiwa T,Hara H,Fujimoto J,Sano H

更新日期：2004-09-01 00:00:00

abstract：:A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be the main cause of cancer. These mutational events include activation of oncogenes and inactivation of tumor suppressor genes. The elucidation of human cancer at t...

journal_title：Blood

authors： Reuter CW,Morgan MA,Bergmann L

更新日期：2000-09-01 00:00:00

abstract：:Soluble thrombomodulin plasma concentrations are elevated in steroid-resistant graft-versus-host disease (GVHD), implying endothelial hypofunctioning for thrombomodulin-dependent generation of activated protein C's (APC) anticoagulant, anti-inflammatory, and antiapoptotic functions. Recombinant thrombomodulin or APC a...

journal_title：Blood

authors： Sinha RK,Flynn R,Zaiken M,Paz K,Gavin AL,Nemazee D,Fernández JA,Xu X,Griffin JH,Blazar BR

更新日期：2019-08-29 00:00:00

abstract：:Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants wi...

journal_title：Blood

authors： Huffman JE,de Vries PS,Morrison AC,Sabater-Lleal M,Kacprowski T,Auer PL,Brody JA,Chasman DI,Chen MH,Guo X,Lin LA,Marioni RE,Müller-Nurasyid M,Yanek LR,Pankratz N,Grove ML,de Maat MP,Cushman M,Wiggins KL,Qi L,Sennb

更新日期：2015-09-10 00:00:00

abstract：:We have identified an intergenic transcriptional activity that is located between the human HOXA1 and HOXA2 genes, shows myeloid-specific expression, and is up-regulated during granulocytic differentiation. The novel gene, termed HOTAIRM1 (HOX antisense intergenic RNA myeloid 1), is transcribed antisense to the HOXA g...

journal_title：Blood

authors： Zhang X,Lian Z,Padden C,Gerstein MB,Rozowsky J,Snyder M,Gingeras TR,Kapranov P,Weissman SM,Newburger PE

更新日期：2009-03-12 00:00:00