Elevated serum levels of IL-2R, IL-1RA, and CXCL9 are associated with a poor prognosis in follicular lymphoma.

abstract：:We report in this paper that a novel small molecule, JTZ-132, induced growth and differentiation of megakaryocytic progenitor cells and improved thrombocytopenia in myelosuppressed mice. JTZ-132 stimulated proliferation of UT-7/TPO cells, a cell line highly sensitive to thrombopoietin (TPO), and exhibited full efficac...

journal_title：Blood

authors： Inagaki K,Oda T,Naka Y,Shinkai H,Komatsu N,Iwamura H

更新日期：2004-07-01 00:00:00

abstract：:Sickle erythrocyte (RBC) membranes were previously shown to manifest increased Fenton activity (iron-dependent, peroxide-driven formation of hydroxyl radical [.OH]) compared with normal RBC membranes, but the nature of the catalytic iron was not defined. We now find that sickle membranes exposed to superoxide (.O2-) a...

journal_title：Blood

authors： Repka T,Hebbel RP

更新日期：1991-11-15 00:00:00

abstract：:Intracellular protein transport in endothelial cells is selectively inhibited by homocysteine, a thiol amino acid associated with both thrombosis and atherosclerosis. In a previous study, homocysteine decreased cell surface expression of the surface transmembrane glycoprotein thrombomodulin without decreasing secretio...

journal_title：Blood

authors： Lentz SR,Sadler JE

更新日期：1993-02-01 00:00:00

abstract：:Anacardic acid (6-pentadecylsalicylic acid) is derived from traditional medicinal plants, such as cashew nuts, and has been linked to anticancer, anti-inflammatory, and radiosensitization activities through a mechanism that is not yet fully understood. Because of the role of nuclear factor-kappaB (NF-kappaB) activatio...

journal_title：Blood

authors： Sung B,Pandey MK,Ahn KS,Yi T,Chaturvedi MM,Liu M,Aggarwal BB

更新日期：2008-05-15 00:00:00

abstract：:Congenital erythropoietic porphyria (Günther's disease) is a rare disorder of heme biosynthesis inherited in an autosomal recessive fashion. The molecular abnormality responsible for the characteristic defect in uroporphyrinogen III synthase activity was investigated in two patients. For the first patient, complementa...

journal_title：Blood

authors： Deybach JC,de Verneuil H,Boulechfar S,Grandchamp B,Nordmann Y

更新日期：1990-05-01 00:00:00

abstract：:Interleukin-2 (IL-2) induces differential secretion of lymphokines by IL-2 receptor (IL-2R)-positive and IL-2R-negative T cells. We studied T cell IL-2R-specific modulation of adult bone marrow erythropoiesis by recombinant IL-2 (rIL-2). I3-2R were induced by CD3 T cell surface determinant-triggering and analyzed by c...

journal_title：Blood

authors： Burdach SE,Levitt LJ

更新日期：1987-05-01 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) results in a progressive depletion of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the marked loss of CD4+ T lymphocytes are incompletely understood. However, several lines of evidence indicate that direct cytopathology mediated ...

journal_title：Blood

authors： Cantin R,Fortin JF,Lamontagne G,Tremblay M

更新日期：1997-08-01 00:00:00

abstract：:Reticulocytes release small membrane vesicles termed exosomes during their maturation into erythrocytes. It has been suggested that reticulocytes remodel the plasma membrane of the immature red cell during erythropoiesis by specifically eliminating various proteins. We report here that exosome release is associated wi...

journal_title：Blood

authors： Blanc L,Barres C,Bette-Bobillo P,Vidal M

更新日期：2007-11-01 00:00:00

abstract：:To further evaluate the role of sialic acid in the dysfibrinogenemia associated with liver disease, we studied the effect of removal of excess sialic acid residues from the fibrinogen of five patients with liver disease on the thrombin time and fibrin monomer aggregation. Patient fibrinogens containing 1.4-3.4 residue...

journal_title：Blood

authors： Martinez J,MacDonald KA,Palascak JE

更新日期：1983-06-01 00:00:00

abstract：:Adenosine deaminase (ADA) deficiency is a disorder of the purine metabolism leading to combined immunodeficiency and systemic alterations, including skeletal abnormalities. We report that ADA deficiency in mice causes a specific bone phenotype characterized by alterations of structural properties and impaired mechanic...

journal_title：Blood

authors： Sauer AV,Mrak E,Hernandez RJ,Zacchi E,Cavani F,Casiraghi M,Grunebaum E,Roifman CM,Cervi MC,Ambrosi A,Carlucci F,Roncarolo MG,Villa A,Rubinacci A,Aiuti A

更新日期：2009-10-08 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are specialized DCs that produce high levels of type I IFN upon viral infection. Despite their key immunoregulatory role, little is known about pDC ontogeny or how developmental events regulate their function. We show that mice expressing low levels of the transcription factor Ikaro...

journal_title：Blood

authors： Allman D,Dalod M,Asselin-Paturel C,Delale T,Robbins SH,Trinchieri G,Biron CA,Kastner P,Chan S

更新日期：2006-12-15 00:00:00

abstract：:A hairy cell leukemia population was used as a clonal model for studying the direct immunomodulatory effects of recombinant interferon-alpha A (rIFN-alpha A) and rIFN-gamma on human B-cell proliferation. The leukemic cell population KON was notably quiescent when incubated in medium alone but was induced to significan...

journal_title：Blood

authors： Mongini P,Seremetis S,Blessinger C,Rudich S,Winchester R,Brunda M

更新日期：1988-11-01 00:00:00

abstract：:We analyzed the effect of aspirin, salicylate, and other nonsteroidal antiinflammatory drugs (NSAIDs) on the viability of B-chronic lymphocytic leukemia (B-CLL) cells. Aspirin induced a decrease in cell viability in a dose- and time-dependent manner. The mean IC50 for cells from 5 patients was 5.9 +/- 1.13 mmol/L (ran...

journal_title：Blood

authors： Bellosillo B,Piqué M,Barragán M,Castaño E,Villamor N,Colomer D,Montserrat E,Pons G,Gil J

更新日期：1998-08-15 00:00:00

abstract：:Platelets contain and release several matrix metalloproteinases (MMPs). Among these, active MMP-2 enhances platelet aggregation by favoring the activation of phosphatidylinositol 3- kinase (PI3K) and contributes to arterial thrombosis. The platelet surface target of MMP-2 and the mechanism through which it primes plat...

journal_title：Blood

authors： Sebastiano M,Momi S,Falcinelli E,Bury L,Hoylaerts MF,Gresele P

更新日期：2017-02-16 00:00:00

abstract：UNLABELLED:Better methods to characterize normal human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facilitate improving recovery rates in transplanted patients.We now show that 5-fold more human myeloid cells are produced in sublethally irradiated NOD/SCID-IL-2Receptor-γchain-n...

journal_title：Blood

authors： Miller PH,Cheung AM,Beer PA,Knapp DJ,Dhillon K,Rabu G,Rostamirad S,Humphries RK,Eaves CJ

更新日期：2013-01-31 00:00:00

abstract：:Although mycosis fungoides (MF) is typically an indolent disease, patients with advanced-stage disease (stages IIB-IVB), including Sézary syndrome (SS), often have a poor outcome. A 31-year, retrospective analysis of our cutaneous lymphoma database, of 297 patients with MF and SS, was undertaken to study long-term out...

journal_title：Blood

authors： Arulogun SO,Prince HM,Ng J,Lade S,Ryan GF,Blewitt O,McCormack C

更新日期：2008-10-15 00:00:00

abstract：:The incidence of follicular lymphoma (FL) in industrialized countries has been increasing since the 1950s. Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism, including methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS or MTR), serine hydroxymethyltransferase (SHMT)...

journal_title：Blood

authors： Niclot S,Pruvot Q,Besson C,Savoy D,Macintyre E,Salles G,Brousse N,Varet B,Landais P,Taupin P,Junien C,Baudry-Bluteau D

更新日期：2006-07-01 00:00:00

abstract：:Whereas the chimeric type I anti-CD20 Ab rituximab has improved outcomes for patients with B-cell malignancies significantly, many patients with non-Hodgkin lymphoma (NHL) remain incurable. Obinutuzumab (GA101) is a glycoengineered, humanized anti-CD20 type II Ab that has demonstrated superior activity against type I ...

journal_title：Blood

authors： Salles G,Morschhauser F,Lamy T,Milpied N,Thieblemont C,Tilly H,Bieska G,Asikanius E,Carlile D,Birkett J,Pisa P,Cartron G

更新日期：2012-05-31 00:00:00

abstract：:CREB-binding protein (CBP) and the closely related adenovirus E1A-associated 300-kD protein (p300) function as coactivators of transcription factors such as CREB, c-Fos, c-Jun, c-Myb, and several nuclear receptors. To study the roles of CBP in embryonic development, we generated CBP homozygous mutant mouse embryos tha...

journal_title：Blood

authors： Oike Y,Takakura N,Hata A,Kaname T,Akizuki M,Yamaguchi Y,Yasue H,Araki K,Yamamura K,Suda T

更新日期：1999-05-01 00:00:00

abstract：:Myeloma bone disease is due to interactions of myeloma cells with the bone marrow microenvironment, and is associated with pathologic fractures, neurologic symptoms and hypercalcemia. Adjacent to myeloma cells, the formation and activation of osteoclasts is increased, which results in enhanced bone resorption. The rec...

journal_title：Blood

authors： Sezer O,Heider U,Zavrski I,Kühne CA,Hofbauer LC

更新日期：2003-03-15 00:00:00

abstract：:Recent studies of retroviral-mediated gene transfer have shown that retroviral integrations themselves may trigger nonmalignant clonal expansion of hematopoietic stem cells (HSCs) in transplant recipients. These observations suggested that previous conclusions of HSC dynamics based on gamma-retroviral gene marking sho...

journal_title：Blood

authors： Gonzalez-Murillo A,Lozano ML,Montini E,Bueren JA,Guenechea G

更新日期：2008-10-15 00:00:00

abstract：:We have studied the effect of prostaglandin I2 on platelet turnover, attachment to the subendothelium, and secretion following balloon deendothelialization of the rabbit aorta. Survival of 51Cr-labeled platelets in the balloon-injured animals remained normal. Thirty minutes after injury, there were 4.52 X 10(6) platel...

journal_title：Blood

authors： Adelman B,Stemerman MB,Mennell D,Handin RI

更新日期：1981-08-01 00:00:00

abstract：:We tested baseline positron emission tomography (PET)/computed tomography (CT) as a measure of total tumor burden to better identify high-risk patients with early-stage Hodgkin lymphoma (HL). Patients with stage I-II HL enrolled in the standard arm (combined modality treatment) of the H10 trial (NCT00433433) with avai...

journal_title：Blood

authors： Cottereau AS,Versari A,Loft A,Casasnovas O,Bellei M,Ricci R,Bardet S,Castagnoli A,Brice P,Raemaekers J,Deau B,Fortpied C,Raveloarivahy T,Van Zele E,Chartier L,Vander Borght T,Federico M,Hutchings M,Ricardi U,Andre M

更新日期：2018-03-29 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MT...

journal_title：Blood

authors： Madani A,Choukroun V,Soulier J,Cacheux V,Claisse JF,Valensi F,Daliphard S,Cazin B,Levy V,Leblond V,Daniel MT,Sigaux F,Stern MH

更新日期：1996-03-01 00:00:00

abstract：:Chemotherapy depletes T cells in AIDS patients on HAART, but preexisting lymphopenia limits the scale compared with non-AIDS patients. Thus T-cell recovery time to baseline may be rapid, but the risk of additional AIDS-related complications persists. ...

journal_title：Blood

authors： Little RF

更新日期：2008-04-15 00:00:00

abstract：:Under normal conditions, platelets do not adhere to endothelium. However, when platelets or endothelial cells are stimulated by thrombin or cytokines, respectively, platelets bind avidly to endothelium. Because there is accumulating evidence that endothelial cells may become apoptotic under certain proinflammatory or ...

journal_title：Blood

authors： Bombeli T,Schwartz BR,Harlan JM

更新日期：1999-06-01 00:00:00

abstract：:Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs). We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarc...

journal_title：Blood

authors： Massa M,Rosti V,Ferrario M,Campanelli R,Ramajoli I,Rosso R,De Ferrari GM,Ferlini M,Goffredo L,Bertoletti A,Klersy C,Pecci A,Moratti R,Tavazzi L

更新日期：2005-01-01 00:00:00

abstract：:Inhibition of the tissue factor pathway has been shown to attenuate the activation of coagulation and to prevent death in a gram-negative bacteremia primate model of sepsis. It has been suggested that tissue factor influences inflammatory cascades other than the coagulation system. The authors sought to determine the ...

journal_title：Blood

authors： de Jonge E,Dekkers PE,Creasey AA,Hack CE,Paulson SK,Karim A,Kesecioglu J,Levi M,van Deventer SJ,van Der Poll T

更新日期：2000-02-15 00:00:00

abstract：:Red cell concentrates (RCC) are stored for 35 to 42 days in plastic containers manufactured with the liquid plasticizer di(2-ethylhexyl)phthalate (DEHP). DEHP leaches from the polyvinylchloride (PVC) plastic bag, then binds to and stabilizes the RC membrane. This study was undertaken to determine the deformability of ...

journal_title：Blood

authors： Labow RS,Card RT,Rock G

更新日期：1987-07-01 00:00:00

abstract：:Mutations in a recently identified gene HJV (also called HFE2, or repulsive guidance molecule C, RgmC) are the major cause of juvenile hemochromatosis (JH). The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cel...

journal_title：Blood

authors： Lin L,Goldberg YP,Ganz T

更新日期：2005-10-15 00:00:00