Participation of the urokinase receptor in neutrophil efferocytosis.

abstract：:The antiapoptotic proteins, Bcl-2 and Bcl-X(L), are expressed in most cases of acute myeloid leukemia (AML) and may contribute to drug resistance in AML. We tested the hypothesis that down-regulation of Bcl-2 alone by antisense oligodeoxynucleotides (Bcl-2-AS) induces apoptosis, even in the presence of other antiapopt...

journal_title：Blood

authors： Konopleva M,Tari AM,Estrov Z,Harris D,Xie Z,Zhao S,López-Berestein G,Andreeff M

更新日期：2000-06-15 00:00:00

abstract：:The most common chromosomal abnormality of infant acute lymphoblastic leukemia (ALL) is the t(4;11)(q21;q23) that gives rise to the MLL/AF4 fusion gene. Leukemic blasts expressing MLL/AF4 are arrested at an early progenitor stage with lymphoid or monocytoid characteristics. A novel B-lineage ALL cell line termed B-lin...

journal_title：Blood

authors： Bertrand FE,Vogtenhuber C,Shah N,LeBien TW

更新日期：2001-12-01 00:00:00

abstract：:A recent clinical trial for adrenoleukodystrophy (ALD) showed the efficacy and safety of lentiviral vector (LV) gene transfer in hematopoietic stem progenitor cells. However, several common insertion sites (CIS) were found in patients' cells, suggesting that LV integrations conferred a selective advantage. We performe...

journal_title：Blood

authors： Biffi A,Bartolomae CC,Cesana D,Cartier N,Aubourg P,Ranzani M,Cesani M,Benedicenti F,Plati T,Rubagotti E,Merella S,Capotondo A,Sgualdino J,Zanetti G,von Kalle C,Schmidt M,Naldini L,Montini E

更新日期：2011-05-19 00:00:00

abstract：:Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs). We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarc...

journal_title：Blood

authors： Massa M,Rosti V,Ferrario M,Campanelli R,Ramajoli I,Rosso R,De Ferrari GM,Ferlini M,Goffredo L,Bertoletti A,Klersy C,Pecci A,Moratti R,Tavazzi L

更新日期：2005-01-01 00:00:00

abstract：:The International Immune Tolerance Study was a multicenter, prospective, randomized comparison of high-dose (HD; 200 IU/kg/d) and low-dose (LD; 50 IU/kg 3 times/week) factor VIII regimens in 115 "good-risk," severe high-titer inhibitor hemophilia A subjects. Sixty-six of 115 subjects reached the defined study end poin...

journal_title：Blood

authors： Hay CR,DiMichele DM,International Immune Tolerance Study.

更新日期：2012-02-09 00:00:00

abstract：:Chromosomal translocation involving the BCL6 gene affects not only immunoglobulin (Ig) genes but also a number of non-Ig genes as partners. The molecular anatomy of the BCL6 gene rearrangements in 39 cases with diffuse large B-cell lymphoma (DLBCL) by long-distance polymerase chain reaction-based assays was determined...

journal_title：Blood

authors： Akasaka T,Ueda C,Kurata M,Akasaka H,Yamabe H,Uchiyama T,Ohno H

更新日期：2000-10-15 00:00:00

abstract：:Hepatitis C virus (HCV) infection is not uncommon in cancer patients. Over the past 5 years, treatment of chronic HCV infection in patients with hematologic malignancies has evolved rapidly as safe and effective direct-acting antivirals (DAAs) have become the standard-of-care treatment. Today, chronic HCV infection sh...

journal_title：Blood

authors： Torres HA,McDonald GB

更新日期：2016-09-15 00:00:00

abstract：:The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T (Treg) cells accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg popula...

journal_title：Blood

authors： Shahneh F,Alexandra G,Klein M,Frauhammer F,Bopp T,Schäfer K,Raker V,Becker C

更新日期：2020-09-15 00:00:00

abstract：:Using age-fractionated erythrocytes, warm autoantibodies can be classified into two distinct categories, depending on their reactivity with reticulocyte-enriched (younger) or reticulocyte-poor (older) red cell fractions. The strength of the direct antiglobulin test (DAT) on the age-fractionated red cells of 24 patient...

journal_title：Blood

authors： Branch DR,Shulman IA,Sy Siok Hian AL,Petz LD

更新日期：1984-01-01 00:00:00

abstract：:A qualitative defect of antithrombin III (AT III) has been demonstrated over three generations in eight members of an Italian family by the discrepancy between a normal amount of antigen and decreased antithrombin and anti-Xa activity in the presence or in the absence of heparin. By two-dimensional immunoelectrophores...

journal_title：Blood

authors： Wolf M,Boyer C,Tripodi A,Meyer D,Larrieu MJ,Mannucci PM

更新日期：1985-02-01 00:00:00

abstract：:The human erythrocyte blood group system Cromer consists of high-incidence and low-incidence antigens that reside on decay-accelerating factor (DAF; CD55), a glycosyl-phosphatidylinositol-anchored membrane protein that regulates complement activation on cell surfaces. In the Cromer phenotypes Dr(a-) and Inab there is ...

journal_title：Blood

authors： Lublin DM,Mallinson G,Poole J,Reid ME,Thompson ES,Ferdman BR,Telen MJ,Anstee DJ,Tanner MJ

更新日期：1994-08-15 00:00:00

abstract：:Serum cobalamin (vitamin B12) and unsaturated B12 binding capacity (UBBC) have been measured in 24 cases of hypereosinophilia: 16 were cases of hypereosinophilic syndrome (HES) and 8 of secondary eosinophilia. The two groups were similar with respect to absolute eosinophil counts. Serum cobalamin and UBBC were found t...

journal_title：Blood

authors： Zittoun J,Farcet JP,Marquet J,Sultan C,Zittoun R

更新日期：1984-04-01 00:00:00

abstract：:Chronic myelocytic leukemia (CML) is a common neoplasm of hematopoietic pluripotent stem cells. Although the evolution from chronic phase to blast crisis (BC) in CML patients is an inevitable clinical feature, little is understood about the mechanisms responsible for the transformation. We have previously performed al...

journal_title：Blood

authors： Mori N,Morosetti R,Spira S,Lee S,Ben-Yehuda D,Schiller G,Landolfi R,Mizoguchi H,Koeffler HP

更新日期：1998-11-01 00:00:00

abstract：:Custom-made monoclonal anti-idiotype antibodies (anti-Id MoAbs) have been tested as a treatment modality in 34 non-Hodgkin's lymphoma (NHL) patients. Partial or complete tumor remissions have been induced with this treatment in 68% of these patients. One mechanism by which anti-idiotype antibodies may have induced the...

journal_title：Blood

authors： Vuist WM,Levy R,Maloney DG

更新日期：1994-02-15 00:00:00

abstract：:Extensive in vitro self-renewal of proerythroblasts from the earliest period of definitive erythropoiesis, as reported by England and co-investigators in this issue of Blood, expands the potential role of self-renewal in mammalian hematopoiesis and suggests a possible source of blood cells for clinical treatments. ...

journal_title：Blood

authors： Koury MJ

更新日期：2011-03-03 00:00:00

abstract：:Through its Src homology 3 (SH3) and SH2 domains, the Src kinase Lyn interacts with a small number of phosphoproteins, such as Shc, Cbl, and Vav, which regulate cell cycle and the cytoskeleton. Using Lyn's Unique, SH3, and SH2 domains as bait in a yeast 2-hybrid screen, we isolated a novel gene product with features o...

journal_title：Blood

authors： Dombrosky-Ferlan P,Grishin A,Botelho RJ,Sampson M,Wang L,Rudert WA,Grinstein S,Corey SJ

更新日期：2003-04-01 00:00:00

abstract：:The terminal differentiation of B cells into antibody-secreting cells (ASCs) is a critical component of adaptive immune responses. However, it is a very sensitive process, which dysfunctions lead to a great variety of lymphoproliferative neoplasia including germinal center-derived lymphomas. To better characterize the...

journal_title：Blood

authors： Pignarre A,Chatonnet F,Caron G,Haas M,Desmots-Loyer F,Fest T

更新日期：2020-11-04 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) inhibits proteases in the blood coagulation cascade that lead to the production of thrombin, including prothrombinase (factor Xa [FXa]/FVa), the catalytic complex that directly generates thrombin. Thus, TFPI and FV are directly linked in regulating the procoagulant response. Stud...

journal_title：Blood

authors： Maroney SA,Westrick RJ,Cleuren AC,Martinez ND,Siebert AE,Zogg M,Ginsburg D,Weiler H,Mast AE

更新日期：2021-01-14 00:00:00

abstract：:Juvenile chronic myelogenous leukemia (JCML), a myeloproliferative disorder of childhood, is distinct from adult-type chronic myelogenous leukemia (CML) and bears resemblance to chronic myelomonocytic leukemia (CMMoL). Since mutations in the N-ras gene have been found at high frequencies in CMMoL, but only rarely in C...

journal_title：Blood

authors： Miyauchi J,Asada M,Sasaki M,Tsunematsu Y,Kojima S,Mizutani S

更新日期：1994-04-15 00:00:00

abstract：:Approximately 50% of multi-transfused individuals become refractory to random donor platelets. Recent clinical data suggest that those patients receiving leukocyte-depleted blood products are less likely to become refractory to random donor platelets than recipients of non-leukocyte-depleted products. Leukocyte deplet...

journal_title：Blood

authors： Blajchman MA,Bardossy L,Carmen RA,Goldman M,Heddle NM,Singal DP

更新日期：1992-03-01 00:00:00

abstract：:The incidence and role of p53 abnormalities have not been reported in splenic lymphoma with villous lymphocytes (SLVL), the leukemic counterpart of splenic marginal zone lymphoma. Because p53 abnormalities correlate with progressive and refractory disease in cancer and isochromosome 17q has been described in SLVL, a l...

journal_title：Blood

authors： Gruszka-Westwood AM,Hamoudi RA,Matutes E,Tuset E,Catovsky D

更新日期：2001-06-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia in which venous thrombosis is the most common cause of death. Here we address the risk factors for thrombosis and the role of warfarin prophylaxis in PNH. The median follow-up of 163 PNH patients was 6 years (range, 0.2-38 years). Of the patient...

journal_title：Blood

authors： Hall C,Richards S,Hillmen P

更新日期：2003-11-15 00:00:00

abstract：:The combination of cyclophosphamide, vincristine, and prednisone (CVP) is one of several standard treatment options for advanced follicular lymphoma. This, like similar chemotherapeutic regimens, induces response rates of 60% to 80%, with a median response duration of under 2 years. Rituximab, a chimeric monoclonal an...

journal_title：Blood

authors： Marcus R,Imrie K,Belch A,Cunningham D,Flores E,Catalano J,Solal-Celigny P,Offner F,Walewski J,Raposo J,Jack A,Smith P

更新日期：2005-02-15 00:00:00

abstract：:The role of T-cell subsets in the induction of tissue factor (TF) production by human monocytes in vitro was investigated. Mitogen stimulation enabled both unfractionated T cells and their CD4+ or CD8+ subsets to promote procoagulant activity (PCA). After mitogen or antigen activation, all seven T-cell clones with Th1...

journal_title：Blood

authors： Del Prete G,De Carli M,Lammel RM,D'Elios MM,Daniel KC,Giusti B,Abbate R,Romagnani S

更新日期：1995-07-01 00:00:00

abstract：:Burkitt lymphoma (BL) is classified into 3 clinical subsets: endemic, sporadic, and immunodeficiency-associated BL. So far, possible differences in their gene expression profiles (GEPs) have not been investigated. We studied GEPs of BL subtypes, other B-cell lymphomas, and B lymphocytes; first, we found that BL is a u...

journal_title：Blood

authors： Piccaluga PP,De Falco G,Kustagi M,Gazzola A,Agostinelli C,Tripodo C,Leucci E,Onnis A,Astolfi A,Sapienza MR,Bellan C,Lazzi S,Tumwine L,Mawanda M,Ogwang M,Calbi V,Formica S,Califano A,Pileri SA,Leoncini L

更新日期：2011-03-31 00:00:00

abstract：:We have analyzed the reactivation of fetal hemoglobin (HbF) synthesis under rigorous in vitro conditions, ie, in mature erythroblasts generated by erythroid burst-forming units (BFU-E) stringently purified from normal adult peripheral blood and grown in fetal calf serum(FCS)-free semisolid or liquid phase culture. In ...

journal_title：Blood

authors： Peschle C,Gabbianelli M,Testa U,Pelosi E,Barberi T,Fossati C,Valtieri M,Leone L

更新日期：1993-01-15 00:00:00

abstract：:Minimal residual disease (MRD) negativity, defined as <1 chronic lymphocytic leukemia (CLL) cell detectable per 10 000 leukocytes, has been shown to independently predict for clinical outcome in patients receiving combination chemoimmunotherapy in the frontline setting. However, the long-term prognostic value of MRD s...

journal_title：Blood

authors： Kwok M,Rawstron AC,Varghese A,Evans PA,O'Connor SJ,Doughty C,Newton DJ,Moreton P,Hillmen P

更新日期：2016-12-15 00:00:00

abstract：:By using a cDNA clone of the myeloperoxidase (MPO) gene, we have studied, by Northern blot analysis, the level of MPO mRNA in eight cases of acute lymphoblastic leukemia (ALL). The blast cell populations studied were characterized by morphologic, cytochemical, immunochemical, and molecular criteria. With all the metho...

journal_title：Blood

authors： Ferrari S,Mariano MT,Tagliafico E,Sarti M,Ceccherelli G,Selleri L,Merli F,Narni F,Donelli A,Torelli G

更新日期：1988-09-01 00:00:00

abstract：:It is widely accepted that the serum of healthy individuals contains natural antibodies only against those blood group A or B antigens that are not expressed on the individual's red blood cells. The mechanisms involved in tolerance to autologous blood group antigens remain unclear. In the present study, we show that I...

journal_title：Blood

authors： Spalter SH,Kaveri SV,Bonnin E,Mani JC,Cartron JP,Kazatchkine MD

更新日期：1999-06-15 00:00:00

abstract：:Antiplatelet factor 4 (PF4) antibodies have an important role in the most frequent drug-induced immune disorder, heparin-induced thrombocytopenia (HIT). In this issue of Blood, Sachais and coworkers propose a new feature that may explain why only some anti-PF4 antibodies are pathogenic.(1) In addition to epitope speci...

journal_title：Blood

authors： Greinacher A,Krauel K,Jensch I

更新日期：2012-08-02 00:00:00