Abstract:
:Multiple myeloma (MM) is one of the most common hematologic malignancies. Despite extensive therapeutical approaches, cures remain rare exceptions. An important issue for future immunologic treatments is the characterization of appropriate tumor-associated antigens. Recently, a highly glycosylated mucin MUC1 was detected on a majority of multiple myeloma cell lines. We analyzed bone marrow and peripheral blood of 68 patients with HLA-A2-positive myeloma for the presence and functional activity of CD8 T cells specific for the MUC1-derived peptide LLLLTVLTV. Forty-four percent of the patients with MM contained elevated frequencies of MUC1-specific CD8 T cells in freshly isolated samples from peripheral blood (PB) or bone marrow (BM) compared with corresponding samples from healthy donors. BM-residing T cells possessed a higher functional capacity upon specific reactivation than PB-derived T cells with regard to interferon gamma (IFN-gamma) secretion, perforin production, and cytotoxicity.
journal_name
Bloodjournal_title
Bloodauthors
Choi C,Witzens M,Bucur M,Feuerer M,Sommerfeldt N,Trojan A,Ho A,Schirrmacher V,Goldschmidt H,Beckhove Pdoi
10.1182/blood-2004-01-0366subject
Has Abstractpub_date
2005-03-01 00:00:00pages
2132-4issue
5eissn
0006-4971issn
1528-0020pii
2004-01-0366journal_volume
105pub_type
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