Leptin stimulates fetal and adult erythroid and myeloid development.

abstract：:It was recently shown that bacterial thymus-independent (TI) antigens confer long-lasting immunity and generate memory B lymphocytes. However, reactivation of TI memory B cells is repressed in immunocompetent mice, thus raising the issue of the mechanism whereby TI vaccines confer immune protection. Here, we propose a...

journal_title：Blood

authors： Taillardet M,Haffar G,Mondière P,Asensio MJ,Gheit H,Burdin N,Defrance T,Genestier L

更新日期：2009-11-12 00:00:00

abstract：:Recent studies of retroviral-mediated gene transfer have shown that retroviral integrations themselves may trigger nonmalignant clonal expansion of hematopoietic stem cells (HSCs) in transplant recipients. These observations suggested that previous conclusions of HSC dynamics based on gamma-retroviral gene marking sho...

journal_title：Blood

authors： Gonzalez-Murillo A,Lozano ML,Montini E,Bueren JA,Guenechea G

更新日期：2008-10-15 00:00:00

abstract：:Mammalian erythrocytes undergo a unique maturation process in which they discard their nuclei and organelles and assume a flexible biconcave shape. We found that altered plasma lipoprotein metabolism can profoundly influence these events. Abnormal erythrocyte morphology was observed in hypercholesterolemic mice lackin...

journal_title：Blood

authors： Holm TM,Braun A,Trigatti BL,Brugnara C,Sakamoto M,Krieger M,Andrews NC

更新日期：2002-03-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulates different transc...

journal_title：Blood

authors： Daenthanasanmak A,Iamsawat S,Chakraborty P,Nguyen HD,Bastian D,Liu C,Mehrotra S,Yu XZ

更新日期：2019-01-17 00:00:00

abstract：:The choice of either induction or postremission therapy for adults with acute myeloid leukemia is still largely based on the "one size fits all" principle. Moreover, pretreatment prognostic parameters, especially chromosome and gene abnormalities, may fail in predicting individual patient outcome. Measurement of minim...

journal_title：Blood

authors： Buccisano F,Maurillo L,Del Principe MI,Del Poeta G,Sconocchia G,Lo-Coco F,Arcese W,Amadori S,Venditti A

更新日期：2012-01-12 00:00:00

abstract：:The ability to transfer new genetic material into human hematopoietic cells provides the foundation for characterizing the organization and developmental program of human hematopoietic stem cells. It also provides a valuable model in which to test gene transfer and long-term expression in human hematopoietic cells as ...

journal_title：Blood

authors： Dick JE,Kamel-Reid S,Murdoch B,Doedens M

更新日期：1991-08-01 00:00:00

abstract：:DNA amplification combined with hybridization with 32P-labeled synthetic oligonucleotide probes has been used to identify base substitutions in the 5' promoter region of the A gamma globin gene in members of eleven families from China, Sardinia, Canada, and the United States who had a heterozygosity for the A gamma-be...

journal_title：Blood

authors： Yang KG,Stoming TA,Fei YJ,Liang S,Wong SC,Masala B,Huang RB,Wei ZP,Huisman TH

更新日期：1988-05-01 00:00:00

abstract：:The malaria parasite Plasmodium falciparum releases the ring-infected erythrocyte surface antigen (RESA) inside the red cell on entry. The protein migrates to the host cell membrane, where it binds to spectrin, but neither the nature of the interaction nor its functional consequences have previously been defined. Here...

journal_title：Blood

authors： Pei X,Guo X,Coppel R,Bhattacharjee S,Haldar K,Gratzer W,Mohandas N,An X

更新日期：2007-08-01 00:00:00

abstract：:An immune pathophysiology for acquired aplastic anemia (AA) has been inferred from the responsiveness of the patients to immunosuppressive therapies and experimental laboratory data. To address the transcriptome of hematopoietic cells in AA, we undertook GeneChip analysis of the extremely limited numbers of progenitor...

journal_title：Blood

authors： Zeng W,Chen G,Kajigaya S,Nunez O,Charrow A,Billings EM,Young NS

更新日期：2004-01-01 00:00:00

abstract：:It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries. As these countries go through an epidemiologic transition, with a reduction in childhood and infant mortality due to ...

journal_title：Blood

authors： Weatherall DJ

更新日期：2010-06-03 00:00:00

abstract：:Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to stem-loop structures known as iron-responsive elements (IREs). IREs are located in the 5'- or 3'-untranslated regions (UTRs) of specific mRNAs that encode proteins involved in iron homeostasis. The binding of IRPs to 5' IREs represses trans...

journal_title：Blood

authors： Phillips JD,Kinikini DV,Yu Y,Guo B,Leibold EA

更新日期：1996-04-01 00:00:00

abstract：:We used in vitro DNA amplification by the polymerase chain reaction and nonradioactive probes for prenatal diagnosis of beta thalassemia in Chinese from the Guangdong province. Exact molecular diagnoses were made in all 20 fetuses studied over a 6-month period. We conclude that this method of prenatal diagnosis for be...

journal_title：Blood

authors： Cai SP,Chang CA,Zhang JZ,Saiki RK,Erlich HA,Kan YW

更新日期：1989-02-01 00:00:00

abstract：:In this issue of Blood, Bromberg et al and Greenbaum et al delete the gene encoding the cell adhesion molecule N-cadherin in osteoblastic cells forming the hematopoietic stem cell (HSC) niche to demonstrate that N-cadherin has no role in regulating hematopoiesis. ...

journal_title：Blood

authors： Levesque JP

更新日期：2012-07-12 00:00:00

abstract：:Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restrict...

journal_title：Blood

authors： Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E

更新日期：2010-07-15 00:00:00

abstract：:The platelet collagen receptor glycoprotein (GP) VI-Fc receptor gamma-chain (FcRgamma) complex transduces signals in an immunoreceptorlike manner. We examined a role for the Triton X-100-insoluble membrane rafts in GPVI-FcRgamma complex signaling. Methyl-beta-cyclodextrin (MbetaCD)-induced disruption of the membrane r...

journal_title：Blood

authors： Ezumi Y,Kodama K,Uchiyama T,Takayama H

更新日期：2002-05-01 00:00:00

abstract：:The cellular constituents in lymph nodes and spleens of patients with Hodgkin's disease were studied with a series of monoclonal antibodies directed against human thymocyte, peripheral T-cell, and la antigens. Utilizing both an immunoperoxidase technique on frozen tissue sections and indirect immunofluorescence on cel...

journal_title：Blood

authors： Poppema S,Bhan AK,Reinherz EL,Posner MR,Schlossman SF

更新日期：1982-02-01 00:00:00

abstract：:An inhibitor of procoagulant and fibrinolytic enzymes was derived from cabbage seeds by a procedure using acetone precipitation, ion-exchange chromatography, and gel filtration. The cabbage seed inhibitor was a 10-Kd monomeric protein with intrachain disulfide bonds. This preparation prevented clot formation in whole ...

journal_title：Blood

authors： Carter TH,Everson BA,Ratnoff OD

更新日期：1990-01-01 00:00:00

abstract：:Eighteen patients with relapse of chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation (BMT) were treated with recombinant human alpha 2a interferon (IFN). Relapse was defined as greater than 90% metaphases containing the Philadelphia chromosome (Ph) and hematologic abnormalities consistent ...

journal_title：Blood

authors： Higano CS,Raskind WH,Singer JW

更新日期：1992-09-15 00:00:00

abstract：:By using an enzyme-linked immunosorbent assay, the presence of the soluble form of the interleukin-2 receptor (sIL-2R) was evaluated in the peripheral blood of 54 patients with B cell chronic lymphocytic leukemia (B-CLL). Serum levels of sIL-2R were correlated with clinical features, relevant hematologic and immunolog...

journal_title：Blood

authors： Semenzato G,Foa R,Agostini C,Zambello R,Trentin L,Vinante F,Benedetti F,Chilosi M,Pizzolo G

更新日期：1987-08-01 00:00:00

abstract：:We have previously observed an increased frequency of liver failure in human immunodeficiency virus (HIV)-infected hemophiliacs. The purpose of this study was to quantitate hepatitis C virus (HCV) RNA levels in serial samples from HIV-seropositive (HIV+) and HIV-seronegative (HIV-) hemophiliacs before and after HIV se...

journal_title：Blood

authors： Eyster ME,Fried MW,Di Bisceglie AM,Goedert JJ

更新日期：1994-08-15 00:00:00

abstract：:CD30 is a promising target for antibody-based immunotherapy of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma. To overcome the limitations from currently available murine anti-CD30 monoclonal antibodies (mAbs), a new fully human anti-CD30 antibody was generated. Binding properties were evaluated by recombina...

journal_title：Blood

authors： Borchmann P,Treml JF,Hansen H,Gottstein C,Schnell R,Staak O,Zhang HF,Davis T,Keler T,Diehl V,Graziano RF,Engert A

更新日期：2003-11-15 00:00:00

abstract：:Acute myeloid leukemia (AML) is an aggressive malignancy with a relapse rate approaching 50%, despite aggressive chemotherapy. New therapies for AML are targeted at signal transduction pathways known to support blast survival, such as the Stat3 pathway. Aberrant activation of Stat3 has been demonstrated in many differ...

journal_title：Blood

authors： Redell MS,Ruiz MJ,Alonzo TA,Gerbing RB,Tweardy DJ

更新日期：2011-05-26 00:00:00

abstract：:A prominent feature of most if not all cancers is a striking genetic instability, leading to ongoing accrual of mutational changes, some of which underlie tumor progression, including acquisition of invasiveness, drug resistance, and metastasis. Thus, the molecular basis for the generation of this genetic diversity in...

journal_title：Blood

authors： Shammas MA,Shmookler Reis RJ,Koley H,Batchu RB,Li C,Munshi NC

更新日期：2009-03-05 00:00:00

abstract：:The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice leads to embryonic lethality before embryonic day 10 (E10.0). EPCR is detected in the giant trophoblast cells at the feto-maternal boundary from E7.5 and weakly...

journal_title：Blood

authors： Li W,Zheng X,Gu JM,Ferrell GL,Brady M,Esmon NL,Esmon CT

更新日期：2005-10-15 00:00:00

abstract：:It is difficult to imagine a greater challenge to the transplantation of haploidentical cells than thalassemia. ...

journal_title：Blood

authors： Woolfrey A

更新日期：2010-02-11 00:00:00

abstract：:Although virtually all pediatric patients with acute myeloid leukemia (AML) achieve a complete remission after initial induction therapy, 30%-40% of patients will encounter a relapse and have a dismal prognosis. To prevent relapses, personalized treatment strategies are currently being developed, which target specific...

journal_title：Blood

authors： Bachas C,Schuurhuis GJ,Hollink IH,Kwidama ZJ,Goemans BF,Zwaan CM,van den Heuvel-Eibrink MM,de Bont ES,Reinhardt D,Creutzig U,de Haas V,Assaraf YG,Kaspers GJ,Cloos J

更新日期：2010-10-14 00:00:00

abstract：:Iron is a transition metal whose physicochemical properties make it the focus of vital biologic processes in virtually all living organisms. Among numerous roles, iron is essential for oxygen transport, cellular respiration, and DNA synthesis. Paradoxically, the same characteristics that biochemistry exploits make iro...

journal_title：Blood

authors： Sheftel AD,Zhang AS,Brown C,Shirihai OS,Ponka P

更新日期：2007-07-01 00:00:00

abstract：:We took advantage of the proliferative and permissive environment of the developing preimmune fetus to develop a noninjury large animal model in sheep, in which the transplantation of defined populations of human hematopoietic stem cells resulted in the establishment of human hematopoiesis and led to the formation of ...

journal_title：Blood

authors： Almeida-Porada G,Porada CD,Chamberlain J,Torabi A,Zanjani ED

更新日期：2004-10-15 00:00:00

abstract：:Thrombin Metz and normal thrombin, resulting from activation of the respective prothrombins by factor Xa in the presence of calcium, phospholipid, and factor Va, were purified by chromatography on sulfopropyl Sephadex. By physicochemical criteria, thrombin Metz is identical to normal thrombin. Its functional propertie...

journal_title：Blood

authors： Rabiet MJ,Jandrot-Perrus M,Boissel JP,Elion J,Josso F

更新日期：1984-04-01 00:00:00

abstract：:Kinetic studies have been carried out to investigate the functional heterogeneity previously observed in populations of human marrow or peripheral blood cells separated by velocity sedimentation. The results obtained confirm the earlier results, in that slowly-sedimenting cells were found to stimulate both colony form...

journal_title：Blood

authors： Niho Y,Till JE,McCulloch EA

更新日期：1975-06-01 00:00:00