Gene expression profiling in CD34 cells to identify differences between aplastic anemia patients and healthy volunteers.

abstract：:Chemokine stromal derived factor 1 (SDF-1) is involved in trafficking of hematopoietic stem cells (HSCs) from the bone marrow (BM) to peripheral blood (PB) and has been found to enhance postischemia angiogenesis. This study was aimed at investigating whether SDF-1 plays a role in differentiation of BM-derived c-kit(+)...

journal_title：Blood

authors： De Falco E,Porcelli D,Torella AR,Straino S,Iachininoto MG,Orlandi A,Truffa S,Biglioli P,Napolitano M,Capogrossi MC,Pesce M

更新日期：2004-12-01 00:00:00

abstract：:Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular hemostasis and local inflammation. Endothelial activation triggers rapid exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rolling (P-selectin) and pl...

journal_title：Blood

authors： Holthenrich A,Drexler HCA,Chehab T,Naß J,Gerke V

更新日期：2019-09-19 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are specialized DCs that produce high levels of type I IFN upon viral infection. Despite their key immunoregulatory role, little is known about pDC ontogeny or how developmental events regulate their function. We show that mice expressing low levels of the transcription factor Ikaro...

journal_title：Blood

authors： Allman D,Dalod M,Asselin-Paturel C,Delale T,Robbins SH,Trinchieri G,Biron CA,Kastner P,Chan S

更新日期：2006-12-15 00:00:00

abstract：:Apoptosis is an essential process in embryonic tissue remodeling and adult tissue homeostasis. Within the adult hematopoietic system, it allows for tight regulation of hematopoietic cell subsets. Previously, it was shown that B-cell leukemia 2 (Bcl-2) overexpression in the adult increases the viability and activity of...

journal_title：Blood

authors： Orelio C,Harvey KN,Miles C,Oostendorp RA,van der Horn K,Dzierzak E

更新日期：2004-06-01 00:00:00

abstract：:Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for the main...

journal_title：Blood

authors： Quesniaux VF,Clark SC,Turner K,Fagg B

更新日期：1992-09-01 00:00:00

abstract：:A genetic mutation in mice (W/Wv) causes an autosomal recessive disease characterized by hypoplastic anemia which lasts throughout life. Double-dominant W/Wv anemic mice were sublethally irradiated to facilitate repopulation of marrow with transplanted cells and were injected intravenously with suspensions of 5-10 mil...

journal_title：Blood

authors： Dancis J,Jansen V,Brown GF,Gorstein F,Balis ME

更新日期：1977-10-01 00:00:00

abstract：:In order to determine the prognostic significance of thrombocytosis in idiopathic sideroblastic anemia, the clinical courses of 17 patients were reviewed. Six patients (36%) had thrombocytosis, and none developed acute leukemia. Nine patients (53%) had normal platelet counts, and one developed acute leukemia. Two pati...

journal_title：Blood

authors： Streeter RR,Presant CA,Reinhard E

更新日期：1977-09-01 00:00:00

abstract：:We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, foll...

journal_title：Blood

authors： Huang J,Sabater-Lleal M,Asselbergs FW,Tregouet D,Shin SY,Ding J,Baumert J,Oudot-Mellakh T,Folkersen L,Johnson AD,Smith NL,Williams SM,Ikram MA,Kleber ME,Becker DM,Truong V,Mychaleckyj JC,Tang W,Yang Q,Sennblad B,M

更新日期：2012-12-06 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal disorder characterized by the overactivation of T cells and macrophages that excessively produce proinflammatory cytokines, including interferon-γ (IFN-γ). Previously, we reported that the JAK inhibitor ruxolitinib dampens T-cell activation and lessens inflamm...

journal_title：Blood

authors： Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE

更新日期：2019-07-11 00:00:00

abstract：:Beside its classical role in the coagulation cascade, coagulation factor X (FX) is involved in several major biological processes including inflammation and enhancement of virus-induced immune responses. We recently reported that the long circulatory half-life of FX is linked to its interaction with liver-resident mac...

journal_title：Blood

authors： Muczynski V,Bazaa A,Loubière C,Harel A,Cherel G,Denis CV,Lenting PJ,Christophe OD

更新日期：2016-02-11 00:00:00

abstract：:The PI3K/Akt/mTOR pathway has emerged as a critical regulator of dendritic cell (DC) development and function. The kinase mTOR is found in 2 distinct complexes, mTORC1 and mTORC2. In this study, we show that mTORC1 but not mTORC2 is required for epidermal Langerhans cell (LC) homeostasis. Although the initial seeding ...

journal_title：Blood

authors： Kellersch B,Brocker T

更新日期：2013-01-10 00:00:00

abstract：:Hematopoietic stem cell transplantation from unrelated donors is an effective treatment for myeloid malignancies, but its use is usually restricted to young patients without comorbidities. The development of reduced-intensity preparative regimens has allowed the extension of this form of treatment to older and medical...

journal_title：Blood

authors： Wong R,Giralt SA,Martin T,Couriel DR,Anagnostopoulos A,Hosing C,Andersson BS,Cano P,Shahjahan M,Ippoliti C,Estey EH,McMannis J,Gajewski JL,Champlin RE,de Lima M

更新日期：2003-10-15 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) remains a serious complication following allogeneic stem-cell transplantation (SCT), and is mediated by infiltration of alloreactive donor T cells into recipient tissue. Chemokines and their receptors play a central role in controlling the recruitment of T cells into discrete ti...

journal_title：Blood

authors： Piper KP,Horlock C,Curnow SJ,Arrazi J,Nicholls S,Mahendra P,Craddock C,Moss PA

更新日期：2007-12-01 00:00:00

abstract：:Photochemical decontamination (PCD) of platelet concentrates, with adequate preservation of platelet function, has been shown using 8-methoxypsoralen (8-MOP) and long wavelength UV light (UVA). To further evaluate this technique, models for the inactivation of pathogenic human cell-associated viruses and integrated pr...

journal_title：Blood

authors： Lin L,Londe H,Hanson CV,Wiesehahn G,Isaacs S,Cimino G,Corash L

更新日期：1993-07-01 00:00:00

abstract：:Preterm birth affects 1 out of 9 infants in the United States and is the leading cause of long-term neurologic handicap and infant mortality, accounting for 35% of all infant deaths in 2008. Although cytokines including interferon-γ (IFN-γ), interleukin-10 (IL-10), IL-6, and IL-1 are produced in response to in utero i...

journal_title：Blood

authors： Krow-Lucal ER,Kim CC,Burt TD,McCune JM

更新日期：2014-03-20 00:00:00

abstract：:The treatment of multiple myeloma is considered a continuously evolving paradigm as a result of the growing availability of new and highly effective drugs, including first- and second-generation proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. Clinical trials advocate long-term rather than sh...

journal_title：Blood

authors： Delforge M,Ludwig H

更新日期：2017-04-27 00:00:00

abstract：:Numerous studies have suggested that iron (Fe) chelators such as desferrioxamine (DFO) may be useful antitumor agents (Blatt and Stitely, Cancer Res 47:1749, 1987; Becton and Bryles, Cancer Res 48:7189, 1988). Recent work with several analogues of the lipophilic Fe chelator, pyridoxal isonicotinoyl hydrazone (PIH), in...

journal_title：Blood

authors： Richardson DR,Tran EH,Ponka P

更新日期：1995-12-01 00:00:00

abstract：:The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter contains a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor, which consists of alpha and beta subunits. There are at least two genes, alpha A and alpha B, encoding the alpha subunit. alpha B is th...

journal_title：Blood

authors： Takahashi A,Satake M,Yamaguchi-Iwai Y,Bae SC,Lu J,Maruyama M,Zhang YW,Oka H,Arai N,Arai K

更新日期：1995-07-15 00:00:00

abstract：:In ischemic stroke, treatment options are limited. Therapeutic thrombolysis is restricted to the first few hours after stroke, and the utility of current platelet aggregation inhibitors, including GPIIb/IIIa receptor antagonists, and anticoagulants is counterbalanced by the risk of intracerebral bleeding complications...

journal_title：Blood

authors： Stoll G,Kleinschnitz C,Nieswandt B

更新日期：2008-11-01 00:00:00

abstract：:One hundred forty-two patients between the ages of 1 and 17 years who survived disease-free more than 1 year after marrow transplantation for hematologic malignancy had growth and development evaluations from one to 14 years posttransplant (median 4 years). Prior to transplant all children received multiagent chemothe...

journal_title：Blood

authors： Sanders JE,Pritchard S,Mahoney P,Amos D,Buckner CD,Witherspoon RP,Deeg HJ,Doney KC,Sullivan KM,Appelbaum FR

更新日期：1986-11-01 00:00:00

abstract：:Fibrinogen was isolated from the plasma of a 25-year-old female with a history of mild bleeding and several recent moderate to severe hemorrhagic episodes. Coagulability with thrombin approached 100% and varied directly with the time of incubation with the enzyme. High-performance liquid chromatography analysis of thr...

journal_title：Blood

authors： Siebenlist KR,Prchal JT,Mosesson MW

更新日期：1988-03-01 00:00:00

abstract：:Collagen binding to glycoprotein VI (GPVI) induces signals critical for platelet activation in thrombosis. Both ligand-induced GPVI signaling through its coassociated Fc-receptor gamma-chain (FcRgamma) immunoreceptor tyrosine-activation motif (ITAM) and the calmodulin inhibitor, W7, dissociate calmodulin from GPVI and...

journal_title：Blood

authors： Gardiner EE,Karunakaran D,Arthur JF,Mu FT,Powell MS,Baker RI,Hogarth PM,Kahn ML,Andrews RK,Berndt MC

更新日期：2008-01-01 00:00:00

abstract：:Prophylactic treatment in severe hemophilia is very effective but is limited by cost issues. The implementation of 2 different prophylactic regimens in The Netherlands and Sweden since the 1970s may be considered a natural experiment. We compared the costs and outcomes of Dutch intermediate- and Swedish high-dose prop...

journal_title：Blood

authors： Fischer K,Steen Carlsson K,Petrini P,Holmström M,Ljung R,van den Berg HM,Berntorp E

更新日期：2013-08-15 00:00:00

abstract：:The SJL/J mouse strain has a high spontaneous incidence of a B-cell neoplasm, reticulum cell neoplasm type B (RCN B). In addition, following irradiation, 10% to 30% of these mice develop acute myelomonocytic leukemia (radiation-induced acute myeloid leukemia [RI-AML]), an incidence that can be increased to 50% by trea...

journal_title：Blood

authors： Haran-Ghera N,Krautghamer R,Lapidot T,Peled A,Dominguez MG,Stanley ER

更新日期：1997-04-01 00:00:00

abstract：:Binding of platelets to fibrinogen via integrin alphaIIbbeta3 stimulates cytoskeletal reorganization and spreading. These responses depend on tyrosine phosphorylation of multiple proteins by Src family members and Syk. Among Src substrates in platelets is adhesion- and degranulation-promoting adapter protein (ADAP), a...

journal_title：Blood

authors： Kasirer-Friede A,Ruggeri ZM,Shattil SJ

更新日期：2010-03-18 00:00:00

abstract：:Deep venous thrombosis (DVT) remains a common and serious cardiovascular problem with both fatal and long-term consequences. The consequences of DVT include the development of postthrombotic syndrome in 25% to 60% of DVT patients. Despite the clinical importance of venous thrombus resolution, the cellular and molecula...

journal_title：Blood

authors： Mukhopadhyay S,Antalis TM,Nguyen KP,Hoofnagle MH,Sarkar R

更新日期：2017-06-15 00:00:00

abstract：:A simple and reliable cytogenetic test for Fanconi's anemia (FA) that is based on the hypersensitivity of FA cells to mitomycin C (MC) is described. Equal volumes of whole blood from a patient in whom the diagnosis of FA is suspected and from a normal person of the opposite sex are co-cultured in phytohemagglutinin-co...

journal_title：Blood

authors： German J,Schonberg S,Caskie S,Warburton D,Falk C,Ray JH

更新日期：1987-06-01 00:00:00

abstract：:R115777 is a potent farnesyltransferase (FTase) inhibitor with substantial antitumor activity in preclinical models. We conducted a phase 1 study (3 + 3 design) of R115777 in patients with myelodysplastic syndrome (MDS). R115777 was administered twice daily (3-weeks-on/1-week-off schedule for 8 weeks) (starting dosage...

journal_title：Blood

authors： Kurzrock R,Kantarjian HM,Cortes JE,Singhania N,Thomas DA,Wilson EF,Wright JJ,Freireich EJ,Talpaz M,Sebti SM

更新日期：2003-12-15 00:00:00

abstract：:Lymphocyte kinetic studies employing 51-chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the nonrecirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recircula...

journal_title：Blood

authors： Fauci AS,Dale DC

更新日期：1975-08-01 00:00:00

abstract：:Erdheim-Chester disease (ECD) pathophysiology remains largely unknown. Its treatment is not codified and usually disappointing. Interferon (IFN)-α therapy lacks efficacy for some life-threatening manifestations and has a poor tolerance profile. Because interleukin (IL)-1Ra synthesis is naturally induced after stimulat...

journal_title：Blood

authors： Aouba A,Georgin-Lavialle S,Pagnoux C,Martin Silva N,Renand A,Galateau-Salle F,Le Toquin S,Bensadoun H,Larousserie F,Silvera S,Provost N,Candon S,Seror R,de Menthon M,Hermine O,Guillevin L,Bienvenu B

更新日期：2010-11-18 00:00:00