Abstract:
:Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase inhibitor active clinically in cutaneous T-cell lymphoma and preclinically in leukemia. A phase 1 study was conducted to evaluate the safety and activity of oral vorinostat 100 to 300 mg twice or thrice daily for 14 days followed by 1-week rest. Patients with relapsed or refractory leukemias or myelodysplastic syndromes (MDS) and untreated patients who were not candidates for chemotherapy were eligible. Of 41 patients, 31 had acute myeloid leukemia (AML), 4 chronic lymphocytic leukemia, 3 MDS, 2 acute lymphoblastic leukemia, and 1 chronic myelocytic leukemia. The maximum tolerated dose (MTD) was 200 mg twice daily or 250 mg thrice daily. Dose-limiting toxicities were fatigue, nausea, vomiting, and diarrhea. Common drug-related adverse experiences were diarrhea, nausea, fatigue, and anorexia and were mild/moderate in severity. Grade 3/4 drug-related adverse experiences included fatigue (27%), thrombocytopenia (12%), and diarrhea (10%). There were no drug-related deaths; 7 patients had hematologic improvement response, including 2 complete responses and 2 complete responses with incomplete blood count recovery (all with AML treated at/below MTD). Increased histone acetylation was observed at all doses. Antioxidant gene expression may confer vorinostat resistance. Further evaluation of vorinostat in AML/MDS is warranted.
journal_name
Bloodjournal_title
Bloodauthors
Garcia-Manero G,Yang H,Bueso-Ramos C,Ferrajoli A,Cortes J,Wierda WG,Faderl S,Koller C,Morris G,Rosner G,Loboda A,Fantin VR,Randolph SS,Hardwick JS,Reilly JF,Chen C,Ricker JL,Secrist JP,Richon VM,Frankel SR,Kantarjdoi
10.1182/blood-2007-06-098061subject
Has Abstractpub_date
2008-02-01 00:00:00pages
1060-6issue
3eissn
0006-4971issn
1528-0020pii
blood-2007-06-098061journal_volume
111pub_type
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