Abstract:
:About 50% of the Philadelphia-positive acute leukemias undergo molecular rearrangements outside the now classical bcr sequence (or M-BCR-1) rearranged in chronic myeloid leukemia (CML). Most of the breakpoints on chromosome 22 have been shown to be clustered in a 10.8-kb region of the first intron of the BCR gene (called bcr2 or m-BCR-1). In this report we examined two cases of Ph1 acute lymphoblastic leukemia in adult patients that exhibited breakpoints in a 5-kb segment of the BCR gene first intron, 16 kb upstream of the previously described cluster, suggesting the possibility of a second minor breakpoint cluster. In addition, the breakpoints on chromosome 9 were located in a region just 5' of the c-abl exon la.
journal_name
Bloodjournal_title
Bloodauthors
Chen SJ,Chen Z,Hillion J,Grausz D,Loiseau P,Flandrin G,Berger Rsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
1312-5issue
5eissn
0006-4971issn
1528-0020journal_volume
73pub_type
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