Infection of megakaryocytes by human immunodeficiency virus in seropositive patients with immune thrombocytopenic purpura.

abstract：:To determine whether the sensitivity of the human long-term culture-initiating cell (LTC-IC) assay could be increased, we have evaluated a spectrum of different fibroblast cell lines for their abilities to influence the number of cells detectable as LTC-IC, to influence LTC-IC maintenance, and/or to influence LTC-IC d...

journal_title：Blood

authors： Hogge DE,Lansdorp PM,Reid D,Gerhard B,Eaves CJ

更新日期：1996-11-15 00:00:00

abstract：:Rap family GTPases consist of multiple members with substantial functional redundancy. With the use of transgenic mice conditionally expressing a bona fide dominant-negative Rap1 mutant, Rap1A17, capable of inhibiting the activation of all Rap family members in B-lineage cells (mb.1-Rap1A17 Tg), we demonstrate that th...

journal_title：Blood

authors： Katayama Y,Sekai M,Hattori M,Miyoshi I,Hamazaki Y,Minato N

更新日期：2009-08-27 00:00:00

abstract：:The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice)...

journal_title：Blood

authors： Rhodes MM,Kopsombut P,Bondurant MC,Price JO,Koury MJ

更新日期：2005-09-01 00:00:00

abstract：:Regulated adherence of polymorphonuclear leukocytes (PMNs) to endothelium and subendothelial matrix is a critical event for PMN localization at and migration into inflammatory sites. We previously reported that human PMNs stimulated in vitro adhere to laminin, the major glycoprotein of mammalian basement membrane, by ...

journal_title：Blood

authors： Bohnsack JF

更新日期：1992-03-15 00:00:00

abstract：:All-trans retinoic acid (RA) induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL). Nevertheless, most of these patients develop RA resistance and relapse. The mechanisms of RA resistance by APL cells are still unclear. To understand the characteristics of human leukemia, ...

journal_title：Blood

authors： Kizaki M,Matsushita H,Takayama N,Muto A,Ueno H,Awaya N,Kawai Y,Asou H,Kamada N,Ikeda Y

更新日期：1996-09-01 00:00:00

abstract：:Approximately 50% of multi-transfused individuals become refractory to random donor platelets. Recent clinical data suggest that those patients receiving leukocyte-depleted blood products are less likely to become refractory to random donor platelets than recipients of non-leukocyte-depleted products. Leukocyte deplet...

journal_title：Blood

authors： Blajchman MA,Bardossy L,Carmen RA,Goldman M,Heddle NM,Singal DP

更新日期：1992-03-01 00:00:00

abstract：:Idiopathic pneumonia syndrome (IPS) is a major complication after allogeneic bone marrow transplantation (allo-BMT) and involves the infiltration of donor leukocytes and the secretion of inflammatory cytokines. We hypothesized that leukocyte recruitment during IPS is dependent in part upon interactions between chemoki...

journal_title：Blood

authors： Hildebrandt GC,Duffner UA,Olkiewicz KM,Corrion LA,Willmarth NE,Williams DL,Clouthier SG,Hogaboam CM,Reddy PR,Moore BB,Kuziel WA,Liu C,Yanik G,Cooke KR

更新日期：2004-03-15 00:00:00

abstract：:Gimap4, a member of the newly identified GTPase of the immunity-associated protein family (Gimap), is strongly induced by the pre-T-cell receptor in precursor T lymphocytes, transiently shut off in double-positive thymocytes, and reappears after TCR-mediated positive selection. Here, we show that Gimap4 remains expres...

journal_title：Blood

authors： Schnell S,Démollière C,van den Berk P,Jacobs H

更新日期：2006-07-15 00:00:00

abstract：:Most juvenile chronic myelogenous leukemia (JCML) cells have limited long-term proliferative capacity, and only a minority of immature cells give rise to colonies in semisolid cultures. Clonogenic JCML progenitors cannot be maintained in culture because they differentiate, and within a few weeks the leukemic clone is ...

journal_title：Blood

authors： Lapidot T,Grunberger T,Vormoor J,Estrov Z,Kollet O,Bunin N,Zaizov R,Williams DE,Freedman MH

更新日期：1996-10-01 00:00:00

abstract：:This study reports a lentiviral gene transfer protocol for efficient transduction of adult human peripheral blood (PB)-derived CD34+ NOD/SCID-repopulating cells (SRCs) using vesicular stomatitis virus-G protein (VSV-G)-pseudotyped lentiviruses encoding for enhanced green fluorescence protein (eGFP). Lentiviral stocks ...

journal_title：Blood

authors： Scherr M,Battmer K,Blömer U,Schiedlmeier B,Ganser A,Grez M,Eder M

更新日期：2002-01-15 00:00:00

abstract：:To develop a sensitive and specific assay for minimal residual disease in acute lymphoblastic leukemia (ALL), we exploited the enormous diversity of genomic sequences created by immune receptor gene rearrangements. To isolate clone-specific sequences, we first synthesized oligonucleotides that match conserved variable...

journal_title：Blood

authors： Jonsson OG,Kitchens RL,Scott FC,Smith RG

更新日期：1990-11-15 00:00:00

abstract：:Identification of prognostic factors for patients with relapsed/refractory Hodgkin lymphoma (HL) is essential for optimizing therapy with risk-adapted approaches. In our phase 2 study of positron emission tomography (PET)-adapted salvage therapy with brentuximab vedotin (BV) and augmented ifosfamide, carboplatin, and ...

journal_title：Blood

authors： Moskowitz AJ,Schöder H,Gavane S,Thoren KL,Fleisher M,Yahalom J,McCall SJ,Cadzin BR,Fox SY,Gerecitano J,Grewal R,Hamlin PA,Horwitz SM,Kumar A,Matasar M,Ni A,Noy A,Palomba ML,Perales MA,Portlock CS,Sauter C,Straus

更新日期：2017-11-16 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207(+) dendritic cells with an inflammatory infiltrate. BRAFV600E remains the only recurrent mutation reported in LCH. In order to evaluate the spectrum of somatic mutations in LCH, whole exome sequ...

journal_title：Blood

authors： Chakraborty R,Hampton OA,Shen X,Simko SJ,Shih A,Abhyankar H,Lim KP,Covington KR,Trevino L,Dewal N,Muzny DM,Doddapaneni H,Hu J,Wang L,Lupo PJ,Hicks MJ,Bonilla DL,Dwyer KC,Berres ML,Poulikakos PI,Merad M,McClain K

更新日期：2014-11-06 00:00:00

abstract：:The MLL gene located at 11q23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute leukemias. Recently, it has become apparent that the MLL gene is very frequently disrupted by chromosomal translocations in patients with secondary leukemias associated with chemotherapeutic r...

journal_title：Blood

authors： Aplan PD,Chervinsky DS,Stanulla M,Burhans WC

更新日期：1996-04-01 00:00:00

abstract：:Blockade of the CD40/CD154 signal is a potential immunomodulatory strategy for T-cell-mediated diseases. As a part of a phase 1, multicenter, dose-escalating trial of humanized monoclonal antibody to CD154 (IDEC-131/E6040) in patients with refractory immune thrombocytopenic purpura (ITP), the autoimmune response to gl...

journal_title：Blood

authors： Kuwana M,Nomura S,Fujimura K,Nagasawa T,Muto Y,Kurata Y,Tanaka S,Ikeda Y

更新日期：2004-02-15 00:00:00

abstract：:Germ-line GATA2 gene mutations, leading to haploinsufficiency, have been identified in patients with familial myelodysplastic syndrome/acute myeloid leukemia, monocytopenia and mycobacterial infections, Emberger syndrome, and dendritic cell, monocyte, B-, and NK-cell deficiency. GATA2 mutations have also been reported...

journal_title：Blood

authors： Ganapathi KA,Townsley DM,Hsu AP,Arthur DC,Zerbe CS,Cuellar-Rodriguez J,Hickstein DD,Rosenzweig SD,Braylan RC,Young NS,Holland SM,Calvo KR

更新日期：2015-01-01 00:00:00

abstract：:The clinical, morphological, immunologic, and cytogenetic features of seven cases of chronic granulated T cell lymphocytosis with neutropenia were studied. The disorder was characterized by moderate blood and bone marrow lymphocytosis, neutropenia, polyclonal hypergammaglobulinemia, splenomegaly, absence of lymphadeno...

journal_title：Blood

authors： McKenna RW,Arthur DC,Gajl-Peczalska KJ,Flynn P,Brunning RD

更新日期：1985-08-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an autoimmune disease with a complex pathogenesis. As in many B cell-related autoimmune diseases, rituximab (RTX) has been shown to increase platelet counts in some ITP patients. From an immunologic standpoint, the mode of action of RTX and the reasons underlying its limited efficacy h...

journal_title：Blood

authors： Audia S,Samson M,Guy J,Janikashvili N,Fraszczak J,Trad M,Ciudad M,Leguy V,Berthier S,Petrella T,Aho-Glélé S,Martin L,Maynadié M,Lorcerie B,Rat P,Cheynel N,Katsanis E,Larmonier N,Bonnotte B

更新日期：2011-10-20 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are widespread in adult organisms and may be involved in tissue maintenance and repair as well as in the regulation of hematopoiesis and immunologic responses. Thus, it is important to discover the factors controlling MSC renewal and differentiation. Here we report that adult MSCs express...

journal_title：Blood

authors： Pevsner-Fischer M,Morad V,Cohen-Sfady M,Rousso-Noori L,Zanin-Zhorov A,Cohen S,Cohen IR,Zipori D

更新日期：2007-02-15 00:00:00

abstract：:In this article, we present evidence that sialic acid-containing surface components play a role in the regulation of erythropoiesis. A 1-hr exposure of mouse bone marrow cells to high concentrations of neuraminidase reduced erythroid colony formation. Coculture of 10(6) untreated thymocytes with neuraminidase-treated ...

journal_title：Blood

authors： LaRussa VF,Sieber F,Sensenbrenner LL,Sharkis SJ

更新日期：1984-04-01 00:00:00

abstract：:CXCR4 chemokine receptors retain hematopoietic progenitors and leukemia cells within the marrow microenvironment. We prospectively evaluated the prognostic implication of CXCR4 in 90 consecutive patients with acute myelogenous leukemia (AML) by flow cytometry. Patients were divided into groups with low (n=32), interme...

journal_title：Blood

authors： Spoo AC,Lübbert M,Wierda WG,Burger JA

更新日期：2007-01-15 00:00:00

abstract：:The majority of diffuse large B-cell lymphoma (DLBCL) tumors contain mutations in histone-modifying enzymes (HMEs), indicating a potential therapeutic benefit of histone deacetylase inhibitors (HDIs), and preclinical data suggest that HDIs augment the effect of rituximab. In this randomized phase 2 study, we evaluated...

journal_title：Blood

authors： Assouline SE,Nielsen TH,Yu S,Alcaide M,Chong L,MacDonald D,Tosikyan A,Kukreti V,Kezouh A,Petrogiannis-Haliotis T,Albuquerque M,Fornika D,Alamouti S,Froment R,Greenwood CM,Oros KK,Camglioglu E,Sharma A,Christodoulopoul

更新日期：2016-07-14 00:00:00

abstract：:About 50% of the Philadelphia-positive acute leukemias undergo molecular rearrangements outside the now classical bcr sequence (or M-BCR-1) rearranged in chronic myeloid leukemia (CML). Most of the breakpoints on chromosome 22 have been shown to be clustered in a 10.8-kb region of the first intron of the BCR gene (cal...

journal_title：Blood

authors： Chen SJ,Chen Z,Hillion J,Grausz D,Loiseau P,Flandrin G,Berger R

更新日期：1989-04-01 00:00:00

abstract：:We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, foll...

journal_title：Blood

authors： Huang J,Sabater-Lleal M,Asselbergs FW,Tregouet D,Shin SY,Ding J,Baumert J,Oudot-Mellakh T,Folkersen L,Johnson AD,Smith NL,Williams SM,Ikram MA,Kleber ME,Becker DM,Truong V,Mychaleckyj JC,Tang W,Yang Q,Sennblad B,M

更新日期：2012-12-06 00:00:00

abstract：:Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication in hematopoietic stem cell transplant (HSCT) recipients. To determine the impact of pretransplantation hyperferritinemia on the risk of SOS after HSC transplantation, we retrospectively studied 427 HSCT recipients (179 autologous and 248 allogenei...

journal_title：Blood

authors： Maradei SC,Maiolino A,de Azevedo AM,Colares M,Bouzas LF,Nucci M

更新日期：2009-08-06 00:00:00

abstract：:A technique has been developed for handling human bone marrow cells intended for the examination of DNA repair synthesis. DNA-repair synthesis, induced by melphalan and nitrogen mustard, was measured as the incorporation of 3H-thymidine, registered by autoradiography as unscheduled DNA synthesis (UDS). Comparison of v...

journal_title：Blood

authors： Lewensohn R,Ringborg U

更新日期：1979-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) is associated with the B-cell lymphoproliferative disorders mixed cryoglobulinemia (MC) and non-Hodgkin lymphoma. We have previously reported that HCV(+)MC(+) patients have clonal expansions of hypermutated, rheumatoid factor-bearing marginal zone-like IgM(+)CD27(+) peripheral B cells using the...

journal_title：Blood

authors： Charles ED,Brunetti C,Marukian S,Ritola KD,Talal AH,Marks K,Jacobson IM,Rice CM,Dustin LB

更新日期：2011-05-19 00:00:00

abstract：:While studying patient plasma containing an unusual pattern of von Willebrand factor (VWF) multimers, we discovered a previously unreported phenomenon: heavy predominance of dimeric VWF. Genomic analysis revealed a new congenital mutation (Tyr87Ser) that altered the final stages of VWF biosynthesis. This mutation in t...

journal_title：Blood

authors： Rosenberg JB,Haberichter SL,Jozwiak MA,Vokac EA,Kroner PA,Fahs SA,Kawai Y,Montgomery RR

更新日期：2002-09-01 00:00:00

abstract：:We found an unusual fc gamma receptor IIIa (CD16) phenotype on the natural killer (NK) cells of a 3-year-old boy, who suffered from recurrent viral respiratory tract infections since birth. He also had severe clinical problems after Bacille Calmette-Geérin (BCG) vaccination and following Epstein-Barr virus and Varicel...

journal_title：Blood

authors： de Vries E,Koene HR,Vossen JM,Gratama JW,von dem Borne AE,Waaijer JL,Haraldsson A,de Haas M,van Tol MJ

更新日期：1996-10-15 00:00:00

abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...

journal_title：Blood

authors： Marr KA,Crippa F,Leisenring W,Hoyle M,Boeckh M,Balajee SA,Nichols WG,Musher B,Corey L

更新日期：2004-02-15 00:00:00