Granulated T cell lymphocytosis with neutropenia: malignant or benign chronic lymphoproliferative disorder?

abstract：:IL-25, a member of the IL-17 cytokine family, is known to enhance Th2-like responses associated with increased serum levels of IgE, IgG1, IgA, blood eosinophilia, and eosinophilic infiltrates in various tissues. However, IL-25 also abrogates inflammatory responses driven by Th17 cells. However, the cell types that res...

journal_title：Blood

authors： Caruso R,Stolfi C,Sarra M,Rizzo A,Fantini MC,Pallone F,MacDonald TT,Monteleone G

更新日期：2009-04-09 00:00:00

abstract：:Multiple lines of evidence indicate that thrombopoietin (TPO) substantially impacts the number of hematopoietic stem cells and progenitors of all myeloid lineages. Nevertheless, tpo knock-out mice (T(-)) display thrombocytopenia only; blood erythroid and neutrophil levels are normal despite 60% to 85% reductions in st...

journal_title：Blood

authors： Kaushansky K,Fox N,Lin NL,Liles WC

更新日期：2002-05-15 00:00:00

abstract：:Isolated splenic hairy cells from three untreated patients were cultured in presence of recombinant human interferon alpha-2C (IFN alpha). Ultrastructural cytochemistry and immunophenotype analysis with a large panel of monoclonal antibodies were performed to study cellular modification induced by IFN alpha. Hairy cel...

journal_title：Blood

authors： Baldini L,Cortelezzi A,Polli N,Neri A,Nobili L,Maiolo AT,Lambertenghi-Deliliers G,Polli EE

更新日期：1986-02-01 00:00:00

abstract：:The engraftment of donor bone marrow (BM) cells in nonablated mice is inefficient. Niche availability has been thought to be the reason, and cytoablation with irradiation or cytotoxic agents is routinely used with the belief that this frees the preoccupied niches in recipients. In this study, donor cell redistribution...

journal_title：Blood

authors： Zhong JF,Zhan Y,Anderson WF,Zhao Y

更新日期：2002-11-15 00:00:00

abstract：:The presence of lysosomal enzymes in human platelets is well documented; the identity of the "lysosome," however, has been the subject of some disagreement. In order to determine the time of appearance and subcellular localization of two lysosomal enzymes in megakaryocytes (MK) and platelets, we examined normal human ...

journal_title：Blood

authors： Bentfeld-Barker ME,Bainton DF

更新日期：1982-03-01 00:00:00

abstract：:Scott syndrome, a bleeding disorder caused by defective phospholipid scrambling, has been associated with mutations in the TMEM16F gene. The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects. Whereas stimulation...

journal_title：Blood

authors： van Kruchten R,Mattheij NJ,Saunders C,Feijge MA,Swieringa F,Wolfs JL,Collins PW,Heemskerk JW,Bevers EM

更新日期：2013-03-07 00:00:00

abstract：:The receptor for hyaluronic acid-mediated motility (RHAMM/CD168) has been described as a leukemia-associated antigen. To define T-cell epitopes of RHAMM/CD168 toward specific immunotherapies for acute myeloid leukemia (AML), 10 potential HLA-A2-binding RHAMM/CD168 peptides (R1 to R10) were synthesized based on compute...

journal_title：Blood

authors： Greiner J,Li L,Ringhoffer M,Barth TF,Giannopoulos K,Guillaume P,Ritter G,Wiesneth M,Döhner H,Schmitt M

更新日期：2005-08-01 00:00:00

abstract：:This study aimed to evaluate whether gait speed and grip strength predicted clinical outcomes among older adults with blood cancers. We prospectively recruited 448 patients aged 75 years and older presenting for initial consultation at the myelodysplastic syndrome/leukemia, myeloma, or lymphoma clinic of a large terti...

journal_title：Blood

authors： Liu MA,DuMontier C,Murillo A,Hshieh TT,Bean JF,Soiffer RJ,Stone RM,Abel GA,Driver JA

更新日期：2019-07-25 00:00:00

abstract：:To develop a sensitive and specific assay for minimal residual disease in acute lymphoblastic leukemia (ALL), we exploited the enormous diversity of genomic sequences created by immune receptor gene rearrangements. To isolate clone-specific sequences, we first synthesized oligonucleotides that match conserved variable...

journal_title：Blood

authors： Jonsson OG,Kitchens RL,Scott FC,Smith RG

更新日期：1990-11-15 00:00:00

abstract：:Human promyelocytic leukemia (HL-60) cells were induced to differentiate into macrophage-like cells by treatment with 10(-7) mol/L 1,25-dihydroxyvitamin D3 (VD3). A monoclonal antibody (MoAb, 60B8), reactive with the particulate of the differentiated cells but not of the untreated cells, was isolated. The antigen reco...

journal_title：Blood

authors： Nozawa R,Kato H,Ito T,Yokota T

更新日期：1988-05-01 00:00:00

abstract：:This study describes a simple and relatively rapid method of purifying Reed-Sternberg (R-S) cells and their morphologic variants from the lymph nodes of patients affected by Hodgkin's disease. Our initial studies defined the optimal procedure for a quantitative disaggregation of Hodgkin's lymph nodes and the densities...

journal_title：Blood

authors： Sitar G,Brusamolino E,Bernasconi C,Ascari E

更新日期：1989-01-01 00:00:00

abstract：:In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve mixed hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning or immunosuppression. The primary limitation to the clinical application of IUHSCTx has been minimal donor cell engraftment, well below therapeutic levels...

journal_title：Blood

authors： Hayashi S,Peranteau WH,Shaaban AF,Flake AW

更新日期：2002-08-01 00:00:00

abstract：:The reactivation of human cytomegalovirus (HCMV) poses a serious health threat to immune compromised individuals. As a treatment strategy, dendritic cell (DC) vaccination trials are ongoing. Recent work suggests that BDCA-3(+) (CD141(+)) subset DCs may be particularly effective in DC vaccination trials. BDCA-3(+) DCs ...

journal_title：Blood

authors： Flinsenberg TW,Compeer EB,Koning D,Klein M,Amelung FJ,van Baarle D,Boelens JJ,Boes M

更新日期：2012-12-20 00:00:00

abstract：:Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19(+) B-cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring re...

journal_title：Blood

authors： Gardner R,Wu D,Cherian S,Fang M,Hanafi LA,Finney O,Smithers H,Jensen MC,Riddell SR,Maloney DG,Turtle CJ

更新日期：2016-05-19 00:00:00

abstract：:In this issue of Blood, Sehgal et al report on the clinical and pharmacodynamics analysis of pomalidomide dosing strategies in multiple myeloma (MM) and their impact on immune activation and cereblon targets. The particular novelty of this study lies in the direct correlation of immune effects triggered by pomalidomid...

journal_title：Blood

authors： Podar K

更新日期：2015-06-25 00:00:00

abstract：:Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of platelet shedding. Despite this, loss of Bcl-x(L) does not prevent the growth and maturation of megakaryocytes, suggesting redundancy with other prosurvival proteins....

journal_title：Blood

authors： Debrincat MA,Josefsson EC,James C,Henley KJ,Ellis S,Lebois M,Betterman KL,Lane RM,Rogers KL,White MJ,Roberts AW,Harvey NL,Metcalf D,Kile BT

更新日期：2012-06-14 00:00:00

abstract：:Protein S is a cofactor for tissue factor pathway inhibitor (TFPI), accelerating the inhibition of activated factor X (FXa). TFPI Kunitz domain 3 residue Glu226 is essential for enhancement of TFPI by protein S. To investigate the complementary functional interaction site on protein S, we screened 44 protein S point, ...

journal_title：Blood

authors： Reglińska-Matveyev N,Andersson HM,Rezende SM,Dahlbäck B,Crawley JT,Lane DA,Ahnström J

更新日期：2014-06-19 00:00:00

abstract：:Rapid exclusion of heparin-induced thrombocytopenia (HIT) is needed to determine which patients can continue to receive heparin. In this prospective management study, 526 participants had a 4Ts score, rapid particle gel immunoassay (platelet factor 4/heparin [PF4/H]-PaGIA), and serotonin-release assay (SRA) performed....

journal_title：Blood

authors： Linkins LA,Bates SM,Lee AY,Heddle NM,Wang G,Warkentin TE

更新日期：2015-07-30 00:00:00

abstract：:Approximately 60% of patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL) are curable with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemoimmunotherapy. Epratuzumab (E) is an unlabeled anti-CD22 monoclonal antibody with efficacy in relapsed DLBCL. This phase 2 trial te...

journal_title：Blood

authors： Micallef IN,Maurer MJ,Wiseman GA,Nikcevich DA,Kurtin PJ,Cannon MW,Perez DG,Soori GS,Link BK,Habermann TM,Witzig TE

更新日期：2011-10-13 00:00:00

abstract：:Erythropoietin (EPO) is the hormone necessary for development of erythrocytes from immature erythroid cells. EPO activates Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family in the EPO-dependent murine erythroid HCD57 cells. Therefore, we tested if JNK activity supported prolif...

journal_title：Blood

authors： Jacobs-Helber SM,Sawyer ST

更新日期：2004-08-01 00:00:00

abstract：:Because there is no known genetic abnormality common to all patients with myeloma, it is important to understand how genetic heterogeneity may lead to differences in signal transduction, cell cycle, and response to therapy. Model cell lines have been used to study the effect that mutations in p53 and ras can have on g...

journal_title：Blood

authors： Rowley M,Liu P,Van Ness B

更新日期：2000-11-01 00:00:00

abstract：:Although the proto-oncogene rhombotin-2 (RBTN-2) is widely expressed in most tissues, it is not expressed in T cells. We investigated the potential for overexpression of RBTN-2 to cause tumors in T cells and other tissues by constructing transgenic mice that expressed RBTN-2 under control of the metallothionein-1 prom...

journal_title：Blood

authors： Neale GA,Rehg JE,Goorha RM

更新日期：1995-10-15 00:00:00

abstract：:The translocation t(8;14)(q24;q32) is the characteristic chromosomal aberration of Burkitt's-type lymphomas and leukemias (BLs). On the molecular level, the t(8;14) juxtaposes the c-myc gene in 8q24 next to the IgH locus in 14q32, resulting in overexpression of the transcription factor c-Myc. The detection of a t(8;14...

journal_title：Blood

authors： Siebert R,Matthiesen P,Harder S,Zhang Y,Borowski A,Zühlke-Jenisch R,Metzke S,Joos S,Weber-Matthiesen K,Grote W,Schlegelberger B

更新日期：1998-02-01 00:00:00

abstract：:The regulatory mechanism of differentiation of granulocyte and macrophage precursor cells (G/M CFU-C) in bone marrow and spleen obtained from nude mice bearing colony-stimulating factor (CSF) producing tumor (G-mice), which developed marked granulocytosis, was studied. In these mice, granulopoiesis is enhanced in the ...

journal_title：Blood

authors： Motoyoshi K,Suda T,Takaku F,Miura Y

更新日期：1983-11-01 00:00:00

abstract：:Autologous T cells targeting Epstein-Barr virus (EBV) latent membrane proteins (LMPs) have shown safety and efficacy in the treatment of patients with type 2 latency EBV-associated lymphomas for whom standard therapies have failed, including high-dose chemotherapy followed by autologous stem-cell rescue. However, the ...

journal_title：Blood

authors： McLaughlin LP,Rouce R,Gottschalk S,Torrano V,Carrum G,Wu MF,Hoq F,Grilley B,Marcogliese AM,Hanley PJ,Gee AP,Brenner MK,Rooney CM,Heslop HE,Bollard CM

更新日期：2018-11-29 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) is an inherited hemorrhagic disease affecting the related subcellular organelles platelet dense granules, lysosomes, and melanosomes. The mouse genes for HPS, pale ear and pearl, orthologous to the human HPS1 and HPS2 (ADTB3A) genes, encode a novel protein of unknown function and the be...

journal_title：Blood

authors： Feng L,Novak EK,Hartnell LM,Bonifacino JS,Collinson LM,Swank RT

更新日期：2002-03-01 00:00:00

abstract：:The loss of body cell mass (bcm) in senescence and wasting is poorly understood. We now show that the plasma cystine/acid soluble thiol ratio, ie, an indicator of the redox state, is increased in old age and cancer patients and correlated with a decrease in bcm and plasma albumin. A cause/effect relationship was sugge...

journal_title：Blood

authors： Hack V,Breitkreutz R,Kinscherf R,Röhrer H,Bärtsch P,Taut F,Benner A,Dröge W

更新日期：1998-07-01 00:00:00

abstract：:The splenic marginal zone (MZ) is comprised of specialized populations of B cells, dendritic cells, and macrophages that are uniquely arrayed outside the white pulp follicles to screen the blood for bacterial and other particulate Ags. Mechanisms responsible for MZ B-cell formation, localization, retention, and functi...

journal_title：Blood

authors： Wang H,Beaty N,Chen S,Qi CF,Masiuk M,Shin DM,Morse HC 3rd

更新日期：2012-01-12 00:00:00

abstract：:Depressed cellular immune function and increased susceptibility to infection characterize familial erythrophagocytic lymphohistiocytosis (FEL), a usually fatal autosomal recessive disease. One component of the immunodeficiency is plasma-mediated inhibition of lymphocyte proliferation. We have tested whether repeated p...

journal_title：Blood

authors： Ladisch S,Ho W,Matheson D,Pilkington R,Hartman G

更新日期：1982-10-01 00:00:00

abstract：:Uniformly adopted response criteria are essential for assessment of therapies incorporating conventional chemotherapy and chemoimmunotherapy regimens. Recently, immunomodulatory agents, such as immune checkpoint inhibitors, have demonstrated impressive activity in a broad range of lymphoma histologies. However, these ...

journal_title：Blood

authors： Cheson BD,Ansell S,Schwartz L,Gordon LI,Advani R,Jacene HA,Hoos A,Barrington SF,Armand P

更新日期：2016-11-24 00:00:00