Toward optimizing pomalidomide therapy in MM patients.

abstract：:In a previous study, we reported that a single injection of cyclophosphamide (CTX) in tumor-bearing mice resulted in tumor eradication when the animals were subsequently injected with tumor-sensitized lymphocytes. Notably, CTX acted by inducing bystander effects on T cells, and the response to the combined CTX/adoptiv...

journal_title：Blood

authors： Schiavoni G,Mattei F,Di Pucchio T,Santini SM,Bracci L,Belardelli F,Proietti E

更新日期：2000-03-15 00:00:00

abstract：:Glycoprotein VI (GPVI) is an essential platelet receptor for collagens that is exclusively expressed in the megakaryocytic lineage. Transcription of the human gene GP6 is driven largely by GATA-binding protein 1 (GATA-1), specificity protein 1 (Sp1), and Friend leukemia integration 1 (Fli-1). In this report, we show t...

journal_title：Blood

authors： Kanaji S,Kanaji T,Jacquelin B,Chang M,Nugent DJ,Komatsu N,Moroi M,Izuhara K,Kunicki TJ

更新日期：2005-05-15 00:00:00

abstract：:The influence of the shape of the red blood cell during stomatocyte-echinocyte transformation on its deformability was studied by microsieving through pores with diameters of 2.6, 4.5, and 6.9 micron. A stomatocytic transformation was produced by chlorpromazine (0.02, 0.1, and 0.5 mmol/L) and an echinocytic transforma...

journal_title：Blood

authors： Reinhart WH,Chien S

更新日期：1986-04-01 00:00:00

abstract：:Early B-cell factor 1 (Ebf1) is a transcription factor with documented dose-dependent functions in normal and malignant B-lymphocyte development. To understand more about the roles of Ebf1 in malignant transformation, we investigated the impact of reduced functional Ebf1 dosage on mouse B-cell progenitors. Gene expres...

journal_title：Blood

authors： Prasad MA,Ungerbäck J,Åhsberg J,Somasundaram R,Strid T,Larsson M,Månsson R,De Paepe A,Lilljebjörn H,Fioretos T,Hagman J,Sigvardsson M

更新日期：2015-06-25 00:00:00

abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...

journal_title：Blood

authors： Marr KA,Crippa F,Leisenring W,Hoyle M,Boeckh M,Balajee SA,Nichols WG,Musher B,Corey L

更新日期：2004-02-15 00:00:00

abstract：:During innate immune responses, the inflammatory CC chemokine receptors CCR1, CCR2, and CCR5 mediate the recruitment of blood monocytes to infected tissues by promoting cell migration in response to chemokines CCL2-5. Toll-like receptors also play an essential role, allowing pathogen recognition by the recruited monoc...

journal_title：Blood

authors： Fox JM,Letellier E,Oliphant CJ,Signoret N

更新日期：2011-02-10 00:00:00

abstract：:Although sickle cell disease (SCD) has a variable clinical course, many patients develop end-organ complications that are associated with significant morbidity and early mortality. Myeloablative allogeneic HSCT (allo-HSCT) is curative but has been historically performed only in children younger than 16 years of age. M...

journal_title：Blood

authors： Hsieh MM,Fitzhugh CD,Tisdale JF

更新日期：2011-08-04 00:00:00

abstract：:Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restrict...

journal_title：Blood

authors： Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E

更新日期：2010-07-15 00:00:00

abstract：:Different forms of interleukin-15 (IL-15) have been identified and shown to elicit different transduction pathways whose impact on hematopoiesis is poorly understood. We demonstrated herein that hematopoietic CD34+ cells constitutively produced endogenous secreted IL-15 (ES-IL-15) that activated different transcriptio...

journal_title：Blood

authors： Giron-Michel J,Caignard A,Fogli M,Brouty-Boyé D,Briard D,van Dijk M,Meazza R,Ferrini S,Lebousse-Kerdilès C,Clay D,Bompais H,Chouaib S,Péault B,Azzarone B

更新日期：2003-07-01 00:00:00

abstract：:IgM-secreting plasma cell tumors are rare variants of typical isotype-switched multiple myeloma with a similar disease outcome. To probe the origin and clonal history of these tumors, we have analyzed V(H) gene sequences in 6 cases. Potentially functional tumor-derived V(H) genes were all derived from V(H)3, with the ...

journal_title：Blood

authors： Sahota SS,Garand R,Mahroof R,Smith A,Juge-Morineau N,Stevenson FK,Bataille R

更新日期：1999-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent progenitor cells that have emerged as a promising tool for clinical application. Further clinical interest has been raised by the observation that MSCs are immunoprivileged and, more important, display immunosuppressive capacities. These properties may be of therapeutic va...

journal_title：Blood

authors： Nauta AJ,Westerhuis G,Kruisselbrink AB,Lurvink EG,Willemze R,Fibbe WE

更新日期：2006-09-15 00:00:00

abstract：:The dendritic cell (DC)-specific molecule DC-SIGN is a receptor for the HIV-1 envelope glycoprotein gp120 and is essential for the dissemination of HIV-1. DC-SIGN is expressed by DCs, both monocyte-derived DCs and DCs in several tissues, including mucosa and lymph nodes. To identify a DC-SIGN(+) DC in blood that may b...

journal_title：Blood

authors： Engering A,Van Vliet SJ,Geijtenbeek TB,Van Kooyk Y

更新日期：2002-09-01 00:00:00

abstract：:Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a 20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of acquisition of leukemia-associated mutations were investigated using next-generation deep-sequencing in 31 CN patients who developed leukemia or MDS....

journal_title：Blood

authors： Skokowa J,Steinemann D,Katsman-Kuipers JE,Zeidler C,Klimenkova O,Klimiankou M,Unalan M,Kandabarau S,Makaryan V,Beekman R,Behrens K,Stocking C,Obenauer J,Schnittger S,Kohlmann A,Valkhof MG,Hoogenboezem R,Göhring G,Rein

更新日期：2014-04-03 00:00:00

abstract：:Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of inducing differentiation or proliferation in nonhematopoietic c...

journal_title：Blood

authors： Melemed AS,Ryder JW,Vik TA

更新日期：1997-11-01 00:00:00

abstract：:Defective function of dendritic cells (DC) in cancer has been recently described and may represent one of the mechanisms of tumor evasion from immune system control. We have previously shown in vitro that vascular endothelial growth factor (VEGF), produced by almost all tumors, is one of the tumor-derived factors resp...

journal_title：Blood

authors： Gabrilovich D,Ishida T,Oyama T,Ran S,Kravtsov V,Nadaf S,Carbone DP

更新日期：1998-12-01 00:00:00

abstract：:Angiotensin I-converting enzyme (ACE) inhibitors can affect hematopoiesis by several mechanisms including inhibition of angiotensin II formation and increasing plasma concentrations of AcSDKP (acetyl-N-Ser-Asp-Lys-Pro), an ACE substrate and a negative regulator of hematopoiesis. We tested whether ACE inhibition could ...

journal_title：Blood

authors： Charrier S,Michaud A,Badaoui S,Giroux S,Ezan E,Sainteny F,Corvol P,Vainchenker W

更新日期：2004-08-15 00:00:00

abstract：:Strategies that augment a GVL effect without increasing the risk of GVHD are required to improve the outcome after allogeneic stem cell transplantation (SCT). Azacitidine (AZA) up-regulates the expression of tumor Ags on leukemic blasts in vitro and expands the numbers of immunomodulatory T regulatory cells (Tregs) in...

journal_title：Blood

authors： Goodyear OC,Dennis M,Jilani NY,Loke J,Siddique S,Ryan G,Nunnick J,Khanum R,Raghavan M,Cook M,Snowden JA,Griffiths M,Russell N,Yin J,Crawley C,Cook G,Vyas P,Moss P,Malladi R,Craddock CF

更新日期：2012-04-05 00:00:00

abstract：:Hematopoietic regulation is a complex but dynamic process regulated by intercellular and intracellular interactions within the bone marrow (BM) microenvironment. Through neurokinin-1 (NK-1) and NK-2 receptors, peptides (eg, substance P [SP]) encoded by the preprotachykinin-I gene mediate distinct hematopoietic effects...

journal_title：Blood

authors： Joshi DD,Dang A,Yadav P,Qian J,Bandari PS,Chen K,Donnelly R,Castro T,Gascon P,Haider A,Rameshwar P

更新日期：2001-11-01 00:00:00

abstract：:Programmed cell death or apoptosis is a prominent feature of low-risk myelodysplastic syndromes (MDS), although the underlying mechanism remains controversial. High-risk MDS have less apoptosis associated with increased expression of the prosurvival BCL2-related proteins. To address the mechanism and pathogenic role o...

journal_title：Blood

authors： Slape CI,Saw J,Jowett JB,Aplan PD,Strasser A,Jane SM,Curtis DJ

更新日期：2012-09-20 00:00:00

abstract：:The B-cell leukemia/lymphoma-2 (BCL-2) family of proteins governs the intrinsic pathway of mitochondrial apoptosis. Dysregulation of BCL-2 has long been known to be a crucial part of the pathophysiology of B-cell lymphomas; however, several early attempts to target this pathway therapeutically were unsuccessful becaus...

journal_title：Blood

authors： Davids MS

更新日期：2017-08-31 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) patients exhibit a variable clinical course. To investigate the association between clinicobiologic features and responsiveness of CLL cells to anti-IgM stimulation, we evaluated gene expression changes and modifications in cell-cycle distribution, proliferation, and apoptosis of IgV...

journal_title：Blood

authors： Guarini A,Chiaretti S,Tavolaro S,Maggio R,Peragine N,Citarella F,Ricciardi MR,Santangelo S,Marinelli M,De Propris MS,Messina M,Mauro FR,Del Giudice I,Foà R

更新日期：2008-08-01 00:00:00

abstract：:Hyaluronan-binding function of the CD44 molecule has not been so far detected in myeloid cells. To study pure populations of primitive myeloid cells, we investigated the hyaluronan-binding function of the CD44 molecule from three myeloid cell lines: KG1a, KG1, and HL60. Both KG1a and KG1 cells express the CD34 antigen...

journal_title：Blood

authors： Morimoto K,Robin E,Le Bousse-Kerdiles MC,Li Y,Clay D,Jasmin C,Smadja-Joffe F

更新日期：1994-02-01 00:00:00

abstract：:The effect of FLT3/FLK2 ligand (FL) on the growth of primitive hematopoietic cells was investigated using ThyloSca1+ stem cells. FL was observed to interact with a variety of factors to initiate colony formation by stem cells. When stem cells were stimulated in liquid culture with FL plus interleukin (IL)-3, IL-6, gra...

journal_title：Blood

authors： Hudak S,Hunte B,Culpepper J,Menon S,Hannum C,Thompson-Snipes L,Rennick D

更新日期：1995-05-15 00:00:00

abstract：:Electrolyte disturbances in leukemia can be the result of the disease process or drug therapy. One group of electrolyte abnormalities is related to the stage of the leukemic process. Included in this group are newly diagnosed patients who may show elevated serum potassium, phosphorus, and magnesium--a result of their ...

journal_title：Blood

authors： O'Regan S,Carson S,Chesney RW,Drummond KN

更新日期：1977-03-01 00:00:00

abstract：:The presence of circulating tumor idiotype interferes with the in vivo effectiveness of anti-idiotype antibodies. We developed two assays that permit identification of patients with high levels of serum idiotype without the need for first producing an anti-idiotype antibody. A cell suspension made from the tumor was c...

journal_title：Blood

authors： Miller RA,Lowder JN,Gralow J,Meeker T,Levy R

更新日期：1987-04-01 00:00:00

abstract：:The putative chemokine receptor BLR1 has been identified as the first G-protein-coupled receptor involved in B-cell migration and in microenvironmental homing to B-cell follicles and to germinal centers. In healthy individuals, expression of BLR1 is restricted to all mature recirculating B cells and to a subpopulation...

journal_title：Blood

authors： Förster R,Schweigard G,Johann S,Emrich T,Kremmer E,Nerl C,Lipp M

更新日期：1997-07-15 00:00:00

abstract：:The t(11;14)(q13;q32) translocation and its molecular counterpart, BCL-1 rearrangement, are consistent features of intermediate lymphocytic lymphoma (ILL). Rearrangement is thought to deregulate the nearby PRAD-1/BCL-1 proto-oncogene that is a newly identified member of the cyclin family. To characterize further the a...

journal_title：Blood

authors： Rimokh R,Berger F,Delsol G,Charrin C,Berthéas MF,Ffrench M,Garoscio M,Felman P,Coiffier B,Bryon PA

更新日期：1993-06-01 00:00:00

abstract：:Mice deficient in c-fms-like tyrosine kinase 3 (FLT3) signaling have reductions in early multipotent and lymphoid progenitors, whereas no evident myeloid phenotype has been reported. However, activating mutations of Flt3 are among the most common genetic events in acute myeloid leukemia and mice harboring internal tan...

journal_title：Blood

authors： Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE

更新日期：2010-06-17 00:00:00

abstract：:Natural killer (NK) cell activation is the result of a balance between positive and negative signals triggered by specific membrane receptors. We report here the activation of NK cells induced through the transmembrane glycoprotein CD43 (leukosialin, sialophorin). Engagement of CD43 by specific antibodies stimulated t...

journal_title：Blood

authors： Nieto M,Rodríguez-Fernández JL,Navarro F,Sancho D,Frade JM,Mellado M,Martínez-A C,Cabañas C,Sánchez-Madrid F

更新日期：1999-10-15 00:00:00

abstract：:Childhood acute myeloid leukemia (AML) has a poor prognosis with standard chemotherapy. Allogeneic bone marrow transplantation (BMT) in remission improves the outlook only for the one third of patients with sibling donors. Autologous BMT with a lower morbidity and mortality is available to all. In this study, maximum ...

journal_title：Blood

authors： Tiedemann K,Waters KD,Tauro GP,Tucker D,Ekert H

更新日期：1993-12-15 00:00:00