Abstract:
:The splenic marginal zone (MZ) is comprised of specialized populations of B cells, dendritic cells, and macrophages that are uniquely arrayed outside the white pulp follicles to screen the blood for bacterial and other particulate Ags. Mechanisms responsible for MZ B-cell formation, localization, retention, and function are understood to include antigenic specificity, transcription factors, integrins, and surface receptors for soluble ligands such as S1P. Here, we add to this repertoire by demonstrating that the receptor for CXCL12, CXCR7, is expressed on MZ but not on follicular B cells. Treatment of mice with CXCR7 inhibitors led to disruption of MZ architecture, reduced numbers of MZ B cells, and altered granulocyte homeostasis associated with increasing serum levels of CXCL12. CXCR7 thus appears to function as a scavenger receptor for CXCL12 on MZ B cells.
journal_name
Bloodjournal_title
Bloodauthors
Wang H,Beaty N,Chen S,Qi CF,Masiuk M,Shin DM,Morse HC 3rddoi
10.1182/blood-2011-03-343608subject
Has Abstractpub_date
2012-01-12 00:00:00pages
465-8issue
2eissn
0006-4971issn
1528-0020pii
blood-2011-03-343608journal_volume
119pub_type
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