BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.

abstract：:The cell-surface receptor c-kit and its cognate ligand stem-cell factor (SCF) or steel factor (SLF) are important for the maintenance of hematopoiesis both in vitro and in vivo. Transforming growth factor-beta (TGF-beta) has been shown to be a potent inhibitor of SLF-mediated synergistic growth of murine Lin-Sca-1+ pr...

journal_title：Blood

authors： Dubois CM,Ruscetti FW,Stankova J,Keller JR

更新日期：1994-06-01 00:00:00

abstract：:Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from patients, are dependent on Bcr-Abl. In the tr...

journal_title：Blood

authors： Hamilton A,Helgason GV,Schemionek M,Zhang B,Myssina S,Allan EK,Nicolini FE,Müller-Tidow C,Bhatia R,Brunton VG,Koschmieder S,Holyoake TL

更新日期：2012-02-09 00:00:00

abstract：:Memory stem T cells (TSCM) have been proposed as key determinants of immunologic memory. However, their exact contribution to a mounting immune response, as well as the mechanisms and timing of their in vivo generation, are poorly understood. We longitudinally tracked TSCM dynamics in patients undergoing haploidentica...

journal_title：Blood

authors： Cieri N,Oliveira G,Greco R,Forcato M,Taccioli C,Cianciotti B,Valtolina V,Noviello M,Vago L,Bondanza A,Lunghi F,Marktel S,Bellio L,Bordignon C,Bicciato S,Peccatori J,Ciceri F,Bonini C

更新日期：2015-04-30 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is suspected to be a strong mortality determinant of hemolytic disorders. However, direct contribution of acute intravascular hemolysis to fatal PAH has not been investigated. The roles of nitric oxide (NO) insufficiency and platelet activation in hemolysis-associated fatal PAH ha...

journal_title：Blood

authors： Hu W,Jin R,Zhang J,You T,Peng Z,Ge X,Bronson RT,Halperin JA,Loscalzo J,Qin X

更新日期：2010-09-02 00:00:00

abstract：:Through its Src homology 3 (SH3) and SH2 domains, the Src kinase Lyn interacts with a small number of phosphoproteins, such as Shc, Cbl, and Vav, which regulate cell cycle and the cytoskeleton. Using Lyn's Unique, SH3, and SH2 domains as bait in a yeast 2-hybrid screen, we isolated a novel gene product with features o...

journal_title：Blood

authors： Dombrosky-Ferlan P,Grishin A,Botelho RJ,Sampson M,Wang L,Rudert WA,Grinstein S,Corey SJ

更新日期：2003-04-01 00:00:00

abstract：:Strategies that augment a GVL effect without increasing the risk of GVHD are required to improve the outcome after allogeneic stem cell transplantation (SCT). Azacitidine (AZA) up-regulates the expression of tumor Ags on leukemic blasts in vitro and expands the numbers of immunomodulatory T regulatory cells (Tregs) in...

journal_title：Blood

authors： Goodyear OC,Dennis M,Jilani NY,Loke J,Siddique S,Ryan G,Nunnick J,Khanum R,Raghavan M,Cook M,Snowden JA,Griffiths M,Russell N,Yin J,Crawley C,Cook G,Vyas P,Moss P,Malladi R,Craddock CF

更新日期：2012-04-05 00:00:00

abstract：:Mutations in CCAAT/enhancer binding protein alpha (CEBPA) are seen in 5% to 14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations simultaneously carry 2 mutations (CEBPA(double-mut)), usually biallelic, whereas single heterozygous mutations (CEBP...

journal_title：Blood

authors： Wouters BJ,Löwenberg B,Erpelinck-Verschueren CA,van Putten WL,Valk PJ,Delwel R

更新日期：2009-03-26 00:00:00

abstract：:Tumor-associated macrophages (TAM) are important components of the multiple myeloma (MM) microenvironment that support malignant plasma cell survival and resistance to therapy. It has been proposed that macrophages (MØ) retain the capacity to change in response to stimuli that can restore their antitumor functions. He...

journal_title：Blood

authors： Gutiérrez-González A,Martínez-Moreno M,Samaniego R,Arellano-Sánchez N,Salinas-Muñoz L,Relloso M,Valeri A,Martínez-López J,Corbí ÁL,Hidalgo A,García-Pardo Á,Teixidó J,Sánchez-Mateos P

更新日期：2016-11-03 00:00:00

abstract：:The primate erythrocyte (E) complement receptor, CR1, is a transmembrane glycoprotein located in clusters on the surface of E. In vivo studies have demonstrated that during processing and clearance of complement-opsonized immune complexes, large amounts of immunoglobulin G (IgG) can be bound to primate E via CR1 with ...

journal_title：Blood

authors： Reinagel ML,Gezen M,Ferguson PJ,Kuhn S,Martin EN,Taylor RP

更新日期：1997-02-01 00:00:00

abstract：:The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophilic erythroblast. Rema...

journal_title：Blood

authors： Yao H,Goldman DC,Nechiporuk T,Kawane S,McWeeney SK,Tyner JW,Fan G,Kerenyi MA,Orkin SH,Fleming WH,Mandel G

更新日期：2014-05-15 00:00:00

abstract：:In this issue of Blood, Bromberg et al and Greenbaum et al delete the gene encoding the cell adhesion molecule N-cadherin in osteoblastic cells forming the hematopoietic stem cell (HSC) niche to demonstrate that N-cadherin has no role in regulating hematopoiesis. ...

journal_title：Blood

authors： Levesque JP

更新日期：2012-07-12 00:00:00

abstract：:Although plasmacytoid dendritic cells (pDCs) are involved in HIV-1 pathogenesis, the precise mechanism of interaction between pDCs and HIV-1 in vivo is not clear. The conflicting reports in HIV-1-infected patients highlight the importance of studying the interaction between HIV-1 and pDCs in relevant in vivo models. T...

journal_title：Blood

authors： Zhang L,Jiang Q,Li G,Jeffrey J,Kovalev GI,Su L

更新日期：2011-06-09 00:00:00

abstract：:Fetal hemoglobin (HbF) and adult hemoglobin (HbA) synthesis was studied in fetal baboons, Papio cynocephalus, to determine the normal pattern of hemoglobin production during fetal development. Fetuses ranging from 53 to 180 days gestation (term gestation 184 days) were used. Erythroid cells were incubated with 3H-L-le...

journal_title：Blood

authors： De Simone J,Mueller AL

更新日期：1979-01-01 00:00:00

abstract：:CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation. To further characterize mechanisms by which cell-surface signaling might regulate CD10/NEP expression, we determined whether CD10/NEP wa...

journal_title：Blood

authors： Ganju RK,Shpektor RG,Brenner DG,Shipp MA

更新日期：1996-12-01 00:00:00

abstract：:We have analyzed the binding of Sp1, a ubiquitously expressed transactivator, to the promoter region of the gamma genes. Low-affinity Sp1 sites were found at -50 and -200. A high-affinity site was detected at -140, over the CACCC sequence. To analyze the function of these sites, Drosophila SL-2 cells, which lack Sp1, ...

journal_title：Blood

authors： Gumucio DL,Rood KL,Blanchard-McQuate KL,Gray TA,Saulino A,Collins FS

更新日期：1991-10-01 00:00:00

abstract：:The t(11;14)(q13;q32) results in up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma, where it is also associated with a lymphoplasmacytic morphology. We performed an interphase fluorescent in situ hybridization (FISH) study to determine the clinical and biologic significance o...

journal_title：Blood

authors： Fonseca R,Blood EA,Oken MM,Kyle RA,Dewald GW,Bailey RJ,Van Wier SA,Henderson KJ,Hoyer JD,Harrington D,Kay NE,Van Ness B,Greipp PR

更新日期：2002-05-15 00:00:00

abstract：:Forced dimerization or oligomerization has emerged as a powerful mechanism for unleashing the oncogenic properties of chimeric transcription factors in acute leukemias. Fusion of transcriptional regulators with a variety of heterologous partner proteins as a consequence of chromosomal rearrangements induces inappropri...

journal_title：Blood

authors： So CW,Cleary ML

更新日期：2004-08-15 00:00:00

abstract：:Osteoporosis is a frequent problem in disorders characterized by iron overload, such as the thalassemias and hereditary hemochromatosis. The exact role of iron in the development of osteoporosis in these disorders is not established. To define the effect of iron excess in bone, we generated an iron-overloaded mouse by...

journal_title：Blood

authors： Tsay J,Yang Z,Ross FP,Cunningham-Rundles S,Lin H,Coleman R,Mayer-Kuckuk P,Doty SB,Grady RW,Giardina PJ,Boskey AL,Vogiatzi MG

更新日期：2010-10-07 00:00:00

abstract：:Rabbit kidney tissue either from normal rabbits or from rabbits "programmed" by phlebotomy or varying periods of hypoxia was cultured and shown to release into the culture medium an erythropoietically active substance. The cultures established from rabbits programmed by 6-12 hr of hypoxia yielded the highest levels of...

journal_title：Blood

authors： Ogle JW,Lange RD,Dunn CD

更新日期：1978-07-01 00:00:00

abstract：:Human natural killer (NK) cells express Toll-like receptor 9 (TLR9) transcript and, upon exposure to microbial CpG oligodeoxynucleotide (ODN), release cytokines and kill target cells. Here we show that NK cell treatment with CpG ODN results in down-modulation of KIR3DL2 inhibitory receptor from the cell surface and in...

journal_title：Blood

authors： Sivori S,Falco M,Carlomagno S,Romeo E,Soldani C,Bensussan A,Viola A,Moretta L,Moretta A

更新日期：2010-09-09 00:00:00

abstract：:CD8+CD25+ cells, which expressed high levels of Foxp3, glucocorticoid-induced tumor necrosis factor receptor (GITR), CCR8, tumor necrosis factor receptor 2 (TNFR2), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) mRNAs, were identified in the fibrous septa and medullary areas of human thymus. Activated CD8+CD...

journal_title：Blood

authors： Cosmi L,Liotta F,Lazzeri E,Francalanci M,Angeli R,Mazzinghi B,Santarlasci V,Manetti R,Vanini V,Romagnani P,Maggi E,Romagnani S,Annunziato F

更新日期：2003-12-01 00:00:00

abstract：:Bcr-Abl tyrosine kinase activity initiates a number of intracellular signaling cascades that result in leukemogenesis. Imatinib mesylate, a specific Bcr-Abl tyrosine kinase inhibitor, has been highly successful in the treatment of chronic myelogenous leukemia (CML). However, the emergence of imatinib resistance and th...

journal_title：Blood

authors： Gu JJ,Santiago L,Mitchell BS

更新日期：2005-04-15 00:00:00

abstract：:Inactivation of the retinoblastoma tumor-suppressor gene (RB-1) has been associated with tumorigenicity in various human malignancies. In chronic lymphoid leukemias of B-cell origin (B-CLL) an involvement of RB-1 has been suggested based on cytogenetic data. We examined RB-1 and its chromosomal locus 13q14 in 35 cases...

journal_title：Blood

authors： Stilgenbauer S,Döhner H,Bulgay-Mörschel M,Weitz S,Bentz M,Lichter P

更新日期：1993-04-15 00:00:00

abstract：:Pharmaceutical preparations of normal human immunoglobulin (IgG) are known to contain high-avidity and neutralizing antibodies (Ab) to the cytokines interleukin (IL)-1alpha, IL-6, and interferon (IFN)alpha. To test for other cytokine Ab, 23 batches of IgG were tested for saturable binding to eight 125I-labeled recombi...

journal_title：Blood

authors： Svenson M,Hansen MB,Ross C,Diamant M,Rieneck K,Nielsen H,Bendtzen K

更新日期：1998-03-15 00:00:00

abstract：:This study describes a simple and relatively rapid method of purifying Reed-Sternberg (R-S) cells and their morphologic variants from the lymph nodes of patients affected by Hodgkin's disease. Our initial studies defined the optimal procedure for a quantitative disaggregation of Hodgkin's lymph nodes and the densities...

journal_title：Blood

authors： Sitar G,Brusamolino E,Bernasconi C,Ascari E

更新日期：1989-01-01 00:00:00

abstract：:The tyrosine kinase receptor fetal liver kinase 1 (Flk-1) plays a crucial role in vasculogenesis and angiogenesis, but its target genes remain elusive. Comparing Flk-1(+/+) with Flk-1(-/-) embryonic stem (ES) cells, we identified transcripts regulated by the vascular endothelial growth factor A (VEGF-A)/Flk-1 pathway ...

journal_title：Blood

authors： Zippo A,De Robertis A,Bardelli M,Galvagni F,Oliviero S

更新日期：2004-06-15 00:00:00

abstract：:HLA-G is a major histocompatibility complex class Ib molecule whose constitutive tissue distribution is restricted mainly to trophoblast cells at the maternal-fetal interface during pregnancy. In this study, we demonstrated the ability of the soluble HLA-G1 (sHLA-G1) isoform to inhibit fibroblast growth factor-2 (FGF2...

journal_title：Blood

authors： Fons P,Chabot S,Cartwright JE,Lenfant F,L'Faqihi F,Giustiniani J,Herault JP,Gueguen G,Bono F,Savi P,Aguerre-Girr M,Fournel S,Malecaze F,Bensussan A,Plouët J,Le Bouteiller P

更新日期：2006-10-15 00:00:00

abstract：:Four patients with lymphoproliferative disease of granular lymphocytes (LDGL) coexpressing CD3 and the natural killer (NK)-related "p58" receptor for HLA-C alleles were studied. These CD3+p58+ LDGLs have been detected among a series of 44 CD3+ LDGLs analyzed. Two patients with LDGL (GI and BA) expressed only the p58 m...

journal_title：Blood

authors： Cambiaggi A,Orengo AM,Meazza R,Sforzini S,Tazzari PL,Lauria F,Raspadori D,Zambello R,Semenzato G,Moretta L,Ferrini S

更新日期：1996-03-15 00:00:00

abstract：:We prospectively evaluated 169 patients with a number of screening studies performed between 71 to 121 days after allogeneic marrow transplantation to detect the development of chronic graft-versus-host disease (GVHD). Group 1 patients (n = 78) were asymptomatic and had normal physical examinations at the time of scre...

journal_title：Blood

authors： Loughran TP Jr,Sullivan K,Morton T,Beckham C,Schubert M,Witherspoon R,Sale G,Sanders J,Fisher L,Shulman H

更新日期：1990-07-01 00:00:00

abstract：:Protein S is a cofactor for tissue factor pathway inhibitor (TFPI), accelerating the inhibition of activated factor X (FXa). TFPI Kunitz domain 3 residue Glu226 is essential for enhancement of TFPI by protein S. To investigate the complementary functional interaction site on protein S, we screened 44 protein S point, ...

journal_title：Blood

authors： Reglińska-Matveyev N,Andersson HM,Rezende SM,Dahlbäck B,Crawley JT,Lane DA,Ahnström J

更新日期：2014-06-19 00:00:00